bupivacaine has been researched along with Arrhythmias, Cardiac in 92 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, to our knowledge, it remains unknown whether EA could alleviate bupivacaine-induced cardiotoxicity." | 7.83 | Electroacupuncture pretreatment induces rapid tolerance to bupivacaine cardiotoxicity in rats. ( Gao, JL; Han, FF; Li, XX; Li, YL; Wang, XM; Zhang, DH; Zhang, HJ; Zhao, QL, 2016) |
| " The purpose of this study was to investigate the effects of sevoflurane and isoflurane on bupivacaine-induced arrhythmias and seizures in rats." | 7.69 | Sevoflurane is equivalent to isoflurane for attenuating bupivacaine-induced arrhythmias and seizures in rats. ( Fukuda, H; Hirabayashi, Y; Mitsuhata, H; Saitoh, K; Shimizu, R, 1996) |
| "Toxic systemic reactions to bupivacaine usually involve a number of factors, including hypoxia and acidosis." | 7.68 | Severe hypoxia enhances central nervous system and cardiovascular toxicity of bupivacaine in lightly anesthetized pigs. ( Badgwell, JM; Bessire, A; Dryden, CF; Heavner, JE; Huemer, G; Sanghani, V, 1992) |
| "Intraventricular conduction disorders and reentrant arrhythmias in dogs can be produced by high plasma bupivacaine concentrations." | 7.68 | Enhancement by hyponatremia and hyperkalemia of ventricular conduction and rhythm disorders caused by bupivacaine. ( Bertix, L; Couzon, P; Faucon, G; Freysz, M; Mazze, R; Timour, Q, 1990) |
| " To investigate the mechanisms by which bupivacaine may act within the CNS to produce cardiovascular toxicity, we studied four groups of halothane-anesthetized rabbits in which infusion of intracerebroventricular (icv) bupivacaine or intravenous (iv) phenylephrine resulted in dysrhythmias and hypertension." | 7.68 | Hexamethonium and midazolam terminate dysrhythmias and hypertension caused by intracerebroventricular bupivacaine in rabbits. ( Artu, AA; Bernards, CM, 1991) |
| "We studied the effects of pretreatment with hypertonic solutions on the conduction disturbances and cardiac arrhythmias caused by iv injection of bupivacaine in anesthetized mongrel dogs." | 7.67 | Hypertonic NaCl antagonizes cardiac arrhythmia induced by bupivacaine. ( Rocha-e-Silva, M; Scalabrini, A; Simonetti, MP; Velasco, IT, 1989) |
| "High concentrations of bupivacaine and profound hypothermia individually cause intraventricular conduction disturbances and reentrant arrhythmias." | 7.67 | Potentiation by mild hypothermia of ventricular conduction disturbances and reentrant arrhythmias induced by bupivacaine in dogs. ( Bertrix, L; Cohen, S; Faucon, G; Freysz, M; Mazze, RI; Samii, K; Timour, Q, 1989) |
| "Time of arrhythmia, 50% mean arterial pressure- and 50% heart rate-reduction, and asystole were recorded, and ropivacaine doses were calculated." | 5.72 | Effects of nalbuphine on the cardiotoxicity of ropivacaine in rats. ( Huang, S; Jiao, J; Sun, S; Wang, C; Yu, X, 2022) |
| "However, several reports of ventricular arrhythmias (VA) due to ropivacaine toxicity have been documented." | 5.72 | Effects of intravenous lipid emulsions on the reversal of pacing-induced ventricular arrhythmias and electrophysiological alterations in an animal model of ropivacaine toxicity. ( Almendral, J; Anadón, MJ; Fernández, I; García, S; Quintela, O; Rodríguez, L; Varela, O; Zaballos, M, 2022) |
| "Remifentanil is a selective, ultra-short-acting, µ-opioid receptor agonist opioid." | 5.48 | Effects of Remifentanil Pretreatment on Bupivacaine Cardiotoxicity in Rats. ( Ayoğlu, H; Pişkin, Ö, 2018) |
| "The incidence of reperfusion arrhythmias was decreased at all concentrations." | 5.30 | Proarrhythmic and antiarrhythmic effects of bupivacaine in an in vitro model of myocardial ischemia and reperfusion. ( Babatasi, G; Bricard, H; Ducouret, P; Flais, F; Gérard, JL; Khayat, A; Picard, S; Potier, JC; Rouet, R, 1998) |
| "Although Volatile Induction and Maintenance of Anesthesia (VIMA) with sevoflurane might prolong the QTc interval and did not result in arrhythmia, selective spinal anesthesia with bupivacaine was not associated with alterations in the QT interval or arrhythmia." | 5.14 | The effects of volatile induction and maintenance of anesthesia and selective spinal anesthesia on QT interval, QT dispersion, and arrhythmia incidence. ( Alkent, ZP; Basaran, M; Dikmen, B; Ekin, A; Ornek, D; Ornek, E, 2010) |
| "To determine if epinephrine (EPI) added to a solution of bupivacaine (BUP) injected for use in superficial cervical plexus blockade (SCPB) lowers plasma BUP concentrations after injection and whether this addition of EPI resulted in tachycardia, cardiac arrhythmias, or both." | 5.09 | Plasma bupivacaine concentrations and effects of epinephrine after superficial cervical plexus blockade in patients undergoing carotid endarterectomy. ( Butterworth, JF; Colonna, DM; Harwood, TN; Samuel, M, 1999) |
| "Our data illustrate differences in calcium dynamics between anesthetics and how calcium may mitigate bupivacaine cardiotoxicity." | 4.12 | Local Anesthetic Cardiac Toxicity Is Mediated by Cardiomyocyte Calcium Dynamics. ( Coles, JG; Estrada, M; Lonnqvist, PA; Maynes, JT; Plakhotnik, J; Zhang, L, 2022) |
| "The aim of this article is to investigate the effects of bupivacaine and its S (-)-enantiomer, levobupivacaine, on cardiac arrhythmias in patients." | 4.02 | Comparison Between the Effects of Bupivacaine and Levobupivacaine for Spinal Anesthesia on QT Dispersion. ( Akçay, M; Göğüş, N; İkeda, ÖC; Pehlivan, VF, 2021) |
| "Bupivacaine cardiotoxicity mainly manifests as inhibition of the cardiac sodium channel, which slows conduction, particularly at the ventricular level." | 3.91 | Comparative Effects of Sodium Bicarbonate and Intravenous Lipid Emulsions on Reversing Bupivacaine-Induced Electrophysiological Toxicity in a Porcine Experimental Model. ( Almendral, J; Anadón Baselga, MJ; Callejo, D; López-Menchaca, R; Melone, A; Quintela, O; Sevilla, R; Varela, O; Zaballos, M, 2019) |
| " However, to our knowledge, it remains unknown whether EA could alleviate bupivacaine-induced cardiotoxicity." | 3.83 | Electroacupuncture pretreatment induces rapid tolerance to bupivacaine cardiotoxicity in rats. ( Gao, JL; Han, FF; Li, XX; Li, YL; Wang, XM; Zhang, DH; Zhang, HJ; Zhao, QL, 2016) |
| " Cardiotoxicity is an ominous complication of cocaine and cocaethylene overdose for which no specific antidote exists." | 3.81 | Cardiac depression induced by cocaine or cocaethylene is alleviated by lipid emulsion more effectively than by sulfobutylether-β-cyclodextrin. ( Feinstein, DL; Fettiplace, MR; Kowal, K; Lin, B; Lis, K; Pichurko, A; Ripper, R; Rubinstein, I; Schwartz, D; Weinberg, G, 2015) |
| " Fatal cardiac arrhythmias occurred in, respectively, 3 of 11, 2 of 12, and 2 of 13 conscious sheep infused with bupivacaine, levobupivacaine, and ropivacaine; in 1 of 9 with prilocaine, electromechanical dissociation (followed by polymorphic ventricular tachycardia) caused death." | 3.74 | The effects of general anesthesia on the central nervous and cardiovascular system toxicity of local anesthetics. ( Copeland, SE; Gu, XQ; Ladd, LA; Mather, LE, 2008) |
| "The effects of various hypertonic solutions on the intraventricular conduction, ventricular repolarization and the arrhythmias caused by the intravenous (iv) injection of bupivacaine (6." | 3.72 | Effects of hypertonic sodium chloride solution on the electrophysiologic alterations caused by bupivacaine in the dog heart. ( Corregiari, F; Rocha e Silva, M; Scalabrini, A, 2003) |
| " Fifteen minutes later, each group was randomly subdivided into two equal groups and an infusion of bupivacaine or ropivacaine, 3 mg kg(-1) min(-1), was given until cardiac arrest (asystole) occurred." | 3.72 | Effects of clonidine pre-treatment on bupivacaine and ropivacaine cardiotoxicity in rats. ( Aydin, Y; Gulec, S; Senturk, Y; Uzuner, K; Yelken, B, 2004) |
| "5-2% sevoflurane anesthesia, 0." | 3.69 | Amrinone is superior to epinephrine in reversing bupivacaine-induced cardiovascular depression in sevoflurane-anesthetized dogs. ( Fukuda, H; Hirabayashi, Y; Saitoh, K; Shimizu, R, 1995) |
| " The purpose of this study was to investigate the effects of sevoflurane and isoflurane on bupivacaine-induced arrhythmias and seizures in rats." | 3.69 | Sevoflurane is equivalent to isoflurane for attenuating bupivacaine-induced arrhythmias and seizures in rats. ( Fukuda, H; Hirabayashi, Y; Mitsuhata, H; Saitoh, K; Shimizu, R, 1996) |
| "Intraventricular conduction disorders and reentrant arrhythmias in dogs can be produced by high plasma bupivacaine concentrations." | 3.68 | Enhancement by hyponatremia and hyperkalemia of ventricular conduction and rhythm disorders caused by bupivacaine. ( Bertix, L; Couzon, P; Faucon, G; Freysz, M; Mazze, R; Timour, Q, 1990) |
| " To investigate the mechanisms by which bupivacaine may act within the CNS to produce cardiovascular toxicity, we studied four groups of halothane-anesthetized rabbits in which infusion of intracerebroventricular (icv) bupivacaine or intravenous (iv) phenylephrine resulted in dysrhythmias and hypertension." | 3.68 | Hexamethonium and midazolam terminate dysrhythmias and hypertension caused by intracerebroventricular bupivacaine in rabbits. ( Artu, AA; Bernards, CM, 1991) |
| "Toxic systemic reactions to bupivacaine usually involve a number of factors, including hypoxia and acidosis." | 3.68 | Severe hypoxia enhances central nervous system and cardiovascular toxicity of bupivacaine in lightly anesthetized pigs. ( Badgwell, JM; Bessire, A; Dryden, CF; Heavner, JE; Huemer, G; Sanghani, V, 1992) |
| "In this model, clonidine given prophylactically delays the toxic manifestations of bupivacaine overdose and does not accentuate the subsequent hypotension." | 3.68 | Clonidine pretreatment reduces the systemic toxicity of intravenous bupivacaine in rats. ( De Kock, M; Henin, D; Le Polain, B; Scholtes, JL; Vandewalle, F, 1993) |
| " Four percent bupivacaine produced arrhythmias in 5 of 10 cats in two groups and apnea in 4 of 6 cats." | 3.67 | Duration and toxicity of bupivacaine for topical anesthesia of the airway in the cat. ( Ford, DJ; Raj, PP; Singh, P; Watters, C, 1984) |
| "We studied the effects of pretreatment with hypertonic solutions on the conduction disturbances and cardiac arrhythmias caused by iv injection of bupivacaine in anesthetized mongrel dogs." | 3.67 | Hypertonic NaCl antagonizes cardiac arrhythmia induced by bupivacaine. ( Rocha-e-Silva, M; Scalabrini, A; Simonetti, MP; Velasco, IT, 1989) |
| "High concentrations of bupivacaine and profound hypothermia individually cause intraventricular conduction disturbances and reentrant arrhythmias." | 3.67 | Potentiation by mild hypothermia of ventricular conduction disturbances and reentrant arrhythmias induced by bupivacaine in dogs. ( Bertrix, L; Cohen, S; Faucon, G; Freysz, M; Mazze, RI; Samii, K; Timour, Q, 1989) |
| "Comparative study of antiarrhythmic properties of marcaine and lidocaine was made on aconitine- and strophanthine-induced experimental arrhythmias and in rhythm disorders induced by electrical stimulation of the ventricles." | 3.66 | [Anti-arrhythmia properties of marcaine]. ( Berdiaev, SIu; Darinskiĭ, NV; Dzhaparidze, MM; Liubushkina, TE; Senova, ZP, 1983) |
| "BACKGROUND Cardiac arrhythmia is a significant cause of morbidity and mortality." | 2.84 | Effects on QTc Interval of 2 Different Doses of Spinal Anesthesia in Inguinal Hernia Operations. ( Hanbeyoglu, O; Ozcan, S; Urfalioglu, A; Yazar, FM, 2017) |
| " Adverse events (AEs) were monitored for up to 36 days after administration." | 2.79 | The safety of liposome bupivacaine, a novel local analgesic formulation. ( Onel, E; Ramamoorthy, SL; Sinatra, R; Viscusi, ER, 2014) |
| "However, several reports of ventricular arrhythmias (VA) due to ropivacaine toxicity have been documented." | 1.72 | Effects of intravenous lipid emulsions on the reversal of pacing-induced ventricular arrhythmias and electrophysiological alterations in an animal model of ropivacaine toxicity. ( Almendral, J; Anadón, MJ; Fernández, I; García, S; Quintela, O; Rodríguez, L; Varela, O; Zaballos, M, 2022) |
| "Time of arrhythmia, 50% mean arterial pressure- and 50% heart rate-reduction, and asystole were recorded, and ropivacaine doses were calculated." | 1.72 | Effects of nalbuphine on the cardiotoxicity of ropivacaine in rats. ( Huang, S; Jiao, J; Sun, S; Wang, C; Yu, X, 2022) |
| "Remifentanil is a selective, ultra-short-acting, µ-opioid receptor agonist opioid." | 1.48 | Effects of Remifentanil Pretreatment on Bupivacaine Cardiotoxicity in Rats. ( Ayoğlu, H; Pişkin, Ö, 2018) |
| " Labour analgesia and surgical anesthesia were provided with a lumbar epidural dosed with varying concentrations of bupivacaine." | 1.33 | Cesarean section in a patient with familial cardiomyopathy and a cardioverter-defibrillator. ( Dolak, JA; Frost, DA, 2006) |
| "Phenytoin also has been used to treat bupivacaine cardiotoxicity." | 1.31 | Bupivacaine-induced QRS prolongation is enhanced by lidocaine and by phenytoin in rabbit hearts. ( Kariya, N; Mazoit, JX; Pelle-Lancien, E; Simon, L, 2002) |
| "Levobupivacaine was found to cause smaller changes in indices of cardiac contractility and the QTc interval of the electrocardiogram and also to have less depressant effect on the electroencephalogram." | 1.31 | Cardiac and CNS toxicity of levobupivacaine: strengths of evidence for advantage over bupivacaine. ( Gristwood, RW, 2002) |
| "Bupivacaine seizure doses in 7-NI and L-NAME pretreated animals were similar to control but significantly different from each other." | 1.31 | Nitric oxide modulation affects the tissue distribution and toxicity of bupivacaine. ( Heavner, JE; Shi, B, 2000) |
| " The timing of the occurrence of local anesthetic-induced toxic events (defined as the first QRS modification, dysrhythmia, seizures, moderate and severe bradycardia and hypotension, final systole) was recorded and the dose calculated." | 1.31 | The comparative toxicity of ropivacaine and bupivacaine at equipotent doses in rats. ( Cuignet, O; De Kock, M; Dewinde, V; Dony, P; Gautier, P; Lavand'homme, P; Legrand, E; Vanderick, B, 2000) |
| "Hypotension and arrhythmias were treated with epinephrine, open-chest massage, and advanced cardiac life support protocols, respectively." | 1.31 | Cardiac resuscitation after incremental overdosage with lidocaine, bupivacaine, levobupivacaine, and ropivacaine in anesthetized dogs. ( Butterworth, J; Deal, DD; Groban, L; James, RL; Vernon, JC, 2001) |
| "Bupivacaine was infused at a constant rate of 2 mg x kg(-1) x min(-1) while electrocardiogram, electroencephalogram, and invasive arterial pressure were continuously monitored." | 1.30 | A comparison of the effects of propofol and sevoflurane on the systemic toxicity of intravenous bupivacaine in rats. ( Kobayashi, T; Ohmura, S; Ohta, T; Yamamoto, K, 1999) |
| "The incidence of reperfusion arrhythmias was decreased at all concentrations." | 1.30 | Proarrhythmic and antiarrhythmic effects of bupivacaine in an in vitro model of myocardial ischemia and reperfusion. ( Babatasi, G; Bricard, H; Ducouret, P; Flais, F; Gérard, JL; Khayat, A; Picard, S; Potier, JC; Rouet, R, 1998) |
| " In the in vivo study, the dose-response curve for the 50% lethal dose (LD50) of bupivacaine was determined for rats." | 1.30 | The effects of verapamil and nimodipine on bupivacaine-induced cardiotoxicity in rats: an in vivo and in vitro study. ( Adsan, H; Onaran, O; Tulunay, M, 1998) |
| "Doses for arrhythmias and asystole as well as plasma bupivacaine concentrations at arrhythmia onset were dramatically smaller in L-NAME-pretreated rats than in the other two groups." | 1.30 | Modification of bupivacaine toxicity by nonselective versus neuronal nitric oxide synthesis inhibition. ( Heavner, JE; Shi, B, 1997) |
| "Doses were chosen to avoid convulsions (smaller dose 6." | 1.30 | Cardiovascular and central nervous system effects of intravenous levobupivacaine and bupivacaine in sheep. ( Huang, YF; Mather, LE; Pryor, ME; Veering, BT, 1998) |
| "Bupivacaine is a potent local anesthetic widely used for prolonged local and regional anesthesia." | 1.29 | Stereoselective block of cardiac sodium channels by bupivacaine in guinea pig ventricular myocytes. ( Bennett, PB; Hondeghem, LM; Snyders, DJ; Tamargo, J; Valenzuela, C, 1995) |
| " In this rat model, desbutylbupivacaine was about half as toxic as bupivacaine judged by cardiac parameters, and clearly less toxic to the central nervous system than bupivacaine." | 1.28 | Acute cardiovascular and central nervous system toxicity of bupivacaine and desbutylbupivacaine in the rat. ( Heavner, JE; Rosenberg, PH, 1992) |
| " Three minutes after pretreatment, group 1 (n = 11), group 3 (n = 10), and their respective control groups (n = 11 and n = 9) received intravenous bupivacaine LD50 (median lethal dose)." | 1.28 | Nimodipine reduces the toxicity of intravenous bupivacaine in rats. ( Horn, JL; Hyman, SA; Kambam, JR; Kinney, WW; Skelley, CC, 1992) |
| "Bupivacaine was injected in 2 doses: 3." | 1.28 | Hypertonic NaCl solution prevents bupivacaine-induced cardiovascular toxicity. ( Rocha e Silva, M; Scalabrini, A; Simonetti, Mdos P; Velasco, IT, 1992) |
| "The influence of age and volatile anesthetic agents on plasma concentrations and toxic effects of bupivacaine were studied in 2-day-old, 2-week-old, and 2-month-old pigs." | 1.28 | Bupivacaine toxicity in young pigs is age-dependent and is affected by volatile anesthetics. ( Badgwell, JM; Heavner, JE; Kytta, J, 1990) |
| "No ventricular arrhythmias were observed in this group." | 1.28 | Comparative systemic toxicity of convulsant and supraconvulsant doses of intravenous ropivacaine, bupivacaine, and lidocaine in the conscious dog. ( Arthur, GR; Covino, BG; Feldman, HS, 1989) |
| "Potentiation of bupivacaine arrhythmia in myocyte cultures suggests that this effect is at least partly mediated at the myocyte level." | 1.28 | Progesterone potentiation of bupivacaine arrhythmogenicity in pentobarbital-anesthetized rats and beating rat heart cell cultures. ( Baum, VC; Curran, MA; Miletich, DJ, 1992) |
| "To determine what effect the addition of epinephrine has on bupivacaine toxicity, toxic doses of bupivacaine were administered to awake spontaneously breathing pigs." | 1.28 | Effect of epinephrine on central nervous system and cardiovascular system toxicity of bupivacaine in pigs. ( Bernards, CM; Brown, DL; Carpenter, RL; Kenter, ME; Rupp, SM; Thompson, GE, 1989) |
| " These results suggest that the CNS is the primary target organ for the toxic effects of both highly lipid-soluble and highly protein-bound local anesthetics (i." | 1.27 | Comparative CNS toxicity of lidocaine, etidocaine, bupivacaine, and tetracaine in awake dogs following rapid intravenous administration. ( Covino, BG; Feldman, HS; Giasi, R; Liu, PL; Patterson, MK, 1983) |
| "Serious arrhythmias (ventricular or supraventricular tachycardia) were noted in all groups, but the incidence was significantly higher in the group of rats given diazepam pretreatment than in the other three groups." | 1.27 | Does diazepam really reduce the cardiotoxic effects of intravenous bupivacaine? ( Denson, DD; Forsberg, T; Gregg, RV; Sehlhorst, CS; Stuebing, RC; Turner, PA, 1988) |
| "In the absence of arrhythmias, the spontaneous rate decreased less than 30% with lidocaine up to 50 micrograms/ml, and with bupivacaine up to 5 micrograms/ml." | 1.27 | The electrophysiologic actions of lidocaine and bupivacaine in the isolated, perfused canine heart. ( Bradley, EL; Wheeler, DM; Woods, WT, 1988) |
| " The toxic dose was significantly less in the six-week-old group than younger or older animals." | 1.27 | The influence of age on the cardiovascular toxicity of intravenous bupivacaine in young dogs. ( Bell, B; Brown, TC; Edwards, J; Riquelme, CM, 1987) |
| "No ventricular arrhythmias were observed after the ICV infusion of saline or with intravenous doses of bupivacaine as large as 1." | 1.27 | Cardiac dysrhythmias induced by infusion of local anesthetics into the lateral cerebral ventricle of cats. ( Heavner, JE, 1986) |
| "In all animals in whom ventricular arrhythmias were associated with lidocaine, the arrhythmias spontaneously reverted to normal sinus rhythm." | 1.27 | Cardiovascular toxicity of local anesthetics: an alternative hypothesis. ( Behbehani, MM; Coyle, DE; Denson, DD; Thomas, RD, 1986) |
| "min-1 decreased the seizure dosage of etidocaine but had no effect on that of bupivacaine." | 1.26 | Relation of etidocaine and bupivacaine toxicity to rate of infusion in rhesus monkeys. ( Embro, WJ; Malagodi, MH; Munson, ES, 1977) |
| "Diazepam pretreatment raised the seizure threshold of bupivacaine." | 1.25 | Central nervous system effects of bupivacaine. ( Jenkins, LC; Robinson, WM, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (32.61) | 18.7374 |
| 1990's | 30 (32.61) | 18.2507 |
| 2000's | 16 (17.39) | 29.6817 |
| 2010's | 12 (13.04) | 24.3611 |
| 2020's | 4 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Kalinin, DV | 1 |
| Pantsurkin, VI | 1 |
| Syropyatov, BY | 1 |
| Kalinina, SA | 1 |
| Rudakova, IP | 1 |
| Vakhrin, MI | 1 |
| Dolzhenko, AV | 1 |
| Wang, C | 1 |
| Sun, S | 1 |
| Jiao, J | 1 |
| Yu, X | 1 |
| Huang, S | 1 |
| Zaballos, M | 2 |
| Fernández, I | 1 |
| Rodríguez, L | 1 |
| García, S | 1 |
| Varela, O | 2 |
| Quintela, O | 2 |
| Anadón, MJ | 1 |
| Almendral, J | 2 |
| Plakhotnik, J | 1 |
| Zhang, L | 1 |
| Estrada, M | 1 |
| Coles, JG | 1 |
| Lonnqvist, PA | 1 |
| Maynes, JT | 1 |
| Pehlivan, VF | 1 |
| Akçay, M | 1 |
| İkeda, ÖC | 1 |
| Göğüş, N | 1 |
| Pişkin, Ö | 1 |
| Ayoğlu, H | 1 |
| Callejo, D | 1 |
| Sevilla, R | 1 |
| López-Menchaca, R | 1 |
| Melone, A | 1 |
| Anadón Baselga, MJ | 1 |
| Viscusi, ER | 1 |
| Sinatra, R | 1 |
| Onel, E | 1 |
| Ramamoorthy, SL | 1 |
| Admani, B | 1 |
| Essajee, F | 1 |
| Fettiplace, MR | 1 |
| Pichurko, A | 1 |
| Ripper, R | 1 |
| Lin, B | 1 |
| Kowal, K | 1 |
| Lis, K | 1 |
| Schwartz, D | 1 |
| Feinstein, DL | 1 |
| Rubinstein, I | 1 |
| Weinberg, G | 1 |
| Gao, JL | 1 |
| Li, YL | 1 |
| Wang, XM | 1 |
| Zhao, QL | 1 |
| Zhang, HJ | 1 |
| Han, FF | 1 |
| Li, XX | 1 |
| Zhang, DH | 1 |
| Hanbeyoglu, O | 1 |
| Urfalioglu, A | 1 |
| Yazar, FM | 1 |
| Ozcan, S | 1 |
| Ngeow, WC | 1 |
| Owczuk, R | 1 |
| Steffek, M | 1 |
| Wujtewicz, MA | 1 |
| Szymanowicz, W | 1 |
| Twardowski, P | 1 |
| Marjanski, T | 1 |
| Wojciechowski, J | 1 |
| Zienciuk, A | 1 |
| Rzyman, W | 1 |
| Wujtewicz, M | 1 |
| Garneau, SY | 1 |
| Deschamps, A | 1 |
| Couture, P | 1 |
| Levesque, S | 1 |
| Babin, D | 1 |
| Lambert, J | 1 |
| Tardif, JC | 1 |
| Perrault, LP | 1 |
| Denault, AY | 1 |
| Ornek, E | 1 |
| Ornek, D | 1 |
| Alkent, ZP | 1 |
| Ekin, A | 1 |
| Basaran, M | 1 |
| Dikmen, B | 1 |
| Sintra Grilo, L | 1 |
| Carrupt, PA | 1 |
| Abriel, H | 1 |
| Daina, A | 1 |
| Gu, Y | 1 |
| Wang, L | 1 |
| Wang, X | 1 |
| Tang, Y | 1 |
| Cao, F | 1 |
| Fang, Y | 1 |
| Bozkurt, P | 1 |
| Süzer, O | 1 |
| Ekici, E | 1 |
| Demirci, O | 1 |
| Kaya, G | 1 |
| Hacibekiroğlu, M | 1 |
| Scalabrini, A | 3 |
| Corregiari, F | 1 |
| Rocha e Silva, M | 2 |
| Phillips, N | 1 |
| Priestley, M | 1 |
| Denniss, AR | 1 |
| Uther, JB | 1 |
| Belyamani, L | 1 |
| Kriet, M | 1 |
| Laktaoui, A | 1 |
| Azendour, H | 1 |
| Drissi, M | 1 |
| Haimeur, CH | 1 |
| Drissi, NK | 1 |
| Terhazaz, A | 1 |
| Atmani, M | 1 |
| Gulec, S | 1 |
| Aydin, Y | 1 |
| Uzuner, K | 1 |
| Yelken, B | 1 |
| Senturk, Y | 1 |
| Frost, DA | 1 |
| Dolak, JA | 1 |
| Copeland, SE | 1 |
| Ladd, LA | 1 |
| Gu, XQ | 1 |
| Mather, LE | 2 |
| Ford, DJ | 1 |
| Singh, P | 1 |
| Watters, C | 1 |
| Raj, PP | 1 |
| Dzhaparidze, MM | 1 |
| Berdiaev, SIu | 1 |
| Darinskiĭ, NV | 1 |
| Senova, ZP | 1 |
| Liubushkina, TE | 1 |
| Kotelko, DM | 1 |
| Shnider, SM | 2 |
| Dailey, PA | 1 |
| Brizgys, RV | 1 |
| Levinson, G | 2 |
| Shapiro, WA | 1 |
| Koike, M | 2 |
| Rosen, MA | 2 |
| Liu, PL | 1 |
| Feldman, HS | 2 |
| Giasi, R | 1 |
| Patterson, MK | 1 |
| Covino, BG | 4 |
| Chapin, JC | 1 |
| Kushins, LG | 1 |
| Munson, ES | 2 |
| Schick, LM | 1 |
| Valenzuela, C | 1 |
| Snyders, DJ | 1 |
| Bennett, PB | 1 |
| Tamargo, J | 1 |
| Hondeghem, LM | 1 |
| Saitoh, K | 2 |
| Hirabayashi, Y | 2 |
| Shimizu, R | 2 |
| Fukuda, H | 2 |
| Bacsik, CJ | 1 |
| Swift, JQ | 1 |
| Hargreaves, KM | 1 |
| Bernards, CM | 3 |
| Artru, AA | 1 |
| De Kock, M | 2 |
| Le Polain, B | 1 |
| Henin, D | 1 |
| Vandewalle, F | 1 |
| Scholtes, JL | 1 |
| Mitsuhata, H | 1 |
| Shi, B | 2 |
| Heavner, JE | 6 |
| Huang, YF | 1 |
| Pryor, ME | 1 |
| Veering, BT | 1 |
| Adsan, H | 1 |
| Tulunay, M | 1 |
| Onaran, O | 1 |
| Picard, S | 1 |
| Rouet, R | 1 |
| Flais, F | 1 |
| Ducouret, P | 1 |
| Babatasi, G | 1 |
| Khayat, A | 1 |
| Potier, JC | 1 |
| Bricard, H | 1 |
| Gérard, JL | 1 |
| Lenfant, F | 1 |
| Volot, F | 1 |
| Freysz, M | 4 |
| Wilkening, M | 1 |
| Ohmura, S | 2 |
| Ohta, T | 2 |
| Yamamoto, K | 2 |
| Kobayashi, T | 2 |
| Harwood, TN | 1 |
| Butterworth, JF | 1 |
| Colonna, DM | 1 |
| Samuel, M | 1 |
| Alsarraf, R | 1 |
| Sie, KC | 1 |
| Dony, P | 1 |
| Dewinde, V | 1 |
| Vanderick, B | 1 |
| Cuignet, O | 1 |
| Gautier, P | 1 |
| Legrand, E | 1 |
| Lavand'homme, P | 1 |
| Groban, L | 1 |
| Deal, DD | 1 |
| Vernon, JC | 1 |
| James, RL | 1 |
| Butterworth, J | 1 |
| Kawada, M | 1 |
| Simon, L | 1 |
| Kariya, N | 1 |
| Pelle-Lancien, E | 1 |
| Mazoit, JX | 1 |
| Gristwood, RW | 1 |
| Malagodi, MH | 1 |
| Embro, WJ | 1 |
| Stratmann, D | 1 |
| Götte, A | 1 |
| Meyer-Hamme, K | 1 |
| Watermann, WF | 1 |
| Robinson, WM | 1 |
| Jenkins, LC | 1 |
| Baum, VC | 1 |
| Miletich, DJ | 1 |
| Curran, MA | 1 |
| McCloskey, JJ | 1 |
| Haun, SE | 1 |
| Deshpande, JK | 1 |
| Rosenberg, PH | 1 |
| Hyman, SA | 1 |
| Kinney, WW | 3 |
| Horn, JL | 1 |
| Skelley, CC | 1 |
| Kambam, JR | 3 |
| Dryden, CF | 1 |
| Sanghani, V | 1 |
| Huemer, G | 1 |
| Bessire, A | 1 |
| Badgwell, JM | 2 |
| Simonetti, Mdos P | 1 |
| Velasco, IT | 2 |
| Artu, AA | 1 |
| Moore, DC | 1 |
| Kopacz, DJ | 1 |
| Wright, W | 2 |
| Kashimoto, S | 1 |
| Kume, M | 1 |
| Kumazawa, T | 1 |
| Matsuda, F | 1 |
| Solomon, D | 1 |
| Bunegin, L | 1 |
| Albin, M | 1 |
| Clyburn, PA | 1 |
| Rosen, M | 1 |
| Vickers, MD | 1 |
| Timour, Q | 3 |
| Mazze, R | 1 |
| Couzon, P | 2 |
| Bertix, L | 1 |
| Faucon, G | 3 |
| Lacombe, P | 1 |
| Blaise, G | 1 |
| Plante, F | 1 |
| Hollmann, C | 1 |
| Kytta, J | 1 |
| Wilson, IH | 1 |
| Richmond, MN | 1 |
| Strike, PW | 1 |
| Arthur, GR | 1 |
| Bertrix, L | 2 |
| Loufoua-Moundanga, J | 1 |
| Mazze, RI | 1 |
| Cohen, S | 1 |
| Samii, K | 1 |
| Simonetti, MP | 1 |
| Rocha-e-Silva, M | 1 |
| Carpenter, RL | 1 |
| Kenter, ME | 1 |
| Brown, DL | 1 |
| Rupp, SM | 1 |
| Thompson, GE | 1 |
| Reiz, S | 1 |
| Häggmark, S | 1 |
| Johansson, G | 1 |
| Nath, S | 1 |
| Gregg, RV | 1 |
| Turner, PA | 1 |
| Denson, DD | 2 |
| Stuebing, RC | 1 |
| Sehlhorst, CS | 1 |
| Forsberg, T | 1 |
| Moller, RA | 1 |
| Wheeler, DM | 1 |
| Bradley, EL | 1 |
| Woods, WT | 1 |
| Eledjam, JJ | 1 |
| de la Coussaye, JE | 1 |
| Brugada, J | 1 |
| Masse, C | 1 |
| Desh, G | 1 |
| Sassine, A | 1 |
| d'Athis, F | 1 |
| Riquelme, CM | 1 |
| Bell, B | 1 |
| Edwards, J | 1 |
| Brown, TC | 1 |
| Emperaire-Le Pouleuf, N | 1 |
| Ottomani, A | 1 |
| Kasten, GW | 2 |
| Thomas, RD | 1 |
| Behbehani, MM | 1 |
| Coyle, DE | 1 |
| Martin, ST | 1 |
| Thigpen, JW | 1 |
| Foutz, SE | 1 |
| Ikeogu, MO | 1 |
| Virneberg, H | 1 |
| Nolte, H | 1 |
| Sakio, H | 1 |
| Yoshida, Y | 1 |
| Shimamura, K | 1 |
| Boettner, RB | 1 |
| Dunbar, RW | 1 |
| Haley, JV | 1 |
| Morrow, DH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Use of Liposomal Bupivacaine for Pain Control Following Mastectomy and Breast Reconstruction[NCT03722927] | Phase 4 | 3 participants (Actual) | Interventional | 2018-06-14 | Completed | ||
| Study for the Evaluation of the Effectiveness of Stellate Ganglion Blockade in Preventing Postoperative Atrial Fibrillation[NCT03269383] | Phase 4 | 0 participants (Actual) | Interventional | 2019-12-31 | Withdrawn (stopped due to Lack of funding and other logistical issues) | ||
| Efficiency of Intravenous Lidocaine to Reduce Coughing and the Hemodynamic Changes Associated to Tracheal Extubation[NCT03731429] | Phase 4 | 144 participants (Anticipated) | Interventional | 2019-04-05 | Recruiting | ||
| Red Blood Cell Validation of Magnesium Deficiency as Determined by a Muscle Stretch Test[NCT04130620] | 50 participants (Actual) | Observational | 2021-10-15 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Frequency of postoperative opioid related adverse effects within the first week of surgery will be recorded. This includes nausea, vomiting, pruritus, allergy, respiratory depression. (NCT03722927)
Timeframe: Postoperatively, 1 week
| Intervention | Participants (Count of Participants) |
|---|---|
| Bupivacaine Group | 0 |
| Liposomal Bupivacaine Group | 0 |
The length of stay for hospitalization after mastectomy and breast reconstruction will be recorded. (NCT03722927)
Timeframe: up to 47 Hours
| Intervention | days (Mean) |
|---|---|
| Bupivacaine Group | 1 |
| Liposomal Bupivacaine Group | 1 |
This will be measured by the number of doses within the first month postoperatively and recorded on pain medication daily diary kept by subject. (NCT03722927)
Timeframe: 1 Month
| Intervention | Number of morphine doses (Number) |
|---|---|
| Bupivacaine Group | 0 |
| Liposomal Bupivacaine Group | 20 |
Readmission rates to the hospital within 2 months after mastectomy and breast reconstruction will be recorded (NCT03722927)
Timeframe: Month 2
| Intervention | Participants (Count of Participants) |
|---|---|
| Bupivacaine Group | 0 |
| Liposomal Bupivacaine Group | 0 |
This will be measured every 12 hours for the first 48 hours postoperatively by the level of breast pain associated with arm movements while eating on a scale of 0-10 with higher scores denoting worse outcomes. (NCT03722927)
Timeframe: 48 hours
| Intervention | score on a scale (Mean) |
|---|---|
| 12 hours | |
| Bupivacaine Group | 4 |
This will be measured every 12 hours for the first 48 hours postoperatively by the level of breast pain associated with arm movements while eating on a scale of 0-10 with higher scores denoting worse outcomes. (NCT03722927)
Timeframe: 48 hours
| Intervention | score on a scale (Mean) | |||
|---|---|---|---|---|
| 12 hours | 24 hours | 36 hours | 48 hours | |
| Liposomal Bupivacaine Group | 3.5 | 4 | 3.5 | 2 |
2 reviews available for bupivacaine and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Toxic systemic reactions of bupivacaine and etidocaine.
Topics: Anesthesia, Dental; Anesthesia, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Cardiovascular Sy | 1995 |
Recent advances in local anaesthesia.
Topics: Acidosis; Anesthesia, Local; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Cardiov | 1986 |
7 trials available for bupivacaine and Arrhythmias, Cardiac
| Article | Year |
|---|---|
The safety of liposome bupivacaine, a novel local analgesic formulation.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anesthetics, Local; Arrhythmias, Cardiac; Bupivacaine; | 2014 |
Effects on QTc Interval of 2 Different Doses of Spinal Anesthesia in Inguinal Hernia Operations.
Topics: Adult; Anesthesia, Spinal; Anesthetics, Local; Arrhythmias, Cardiac; Arterial Pressure; Bupivacaine; | 2017 |
The effects of volatile induction and maintenance of anesthesia and selective spinal anesthesia on QT interval, QT dispersion, and arrhythmia incidence.
Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Anesthetics, Local; Arrhythmias, Cardiac; Bupivaca | 2010 |
[Peribulbar anesthesia: comparing 1% ropivacaine and a mixture of 0.5% bupivacaine--2% lidocaine].
Topics: Aged; Amides; Anesthetics, Combined; Anesthetics, Local; Arrhythmias, Cardiac; Bupivacaine; Cataract | 2003 |
Plasma bupivacaine concentrations and effects of epinephrine after superficial cervical plexus blockade in patients undergoing carotid endarterectomy.
Topics: Aged; Aged, 80 and over; Anesthetics, Local; Arrhythmias, Cardiac; Arteries; Bupivacaine; Cervical P | 1999 |
Comparison of the respiratory effects of i.v. infusions of morphine and regional analgesia by extradural block.
Topics: Abdomen; Adult; Aged; Analgesia, Epidural; Arrhythmias, Cardiac; Bupivacaine; Female; Humans; Infusi | 1990 |
Regional analgesia with bupivacaine in dental anaesthesia.
Topics: Adolescent; Adult; Anesthesia, Conduction; Anesthesia, Dental; Anesthesia, General; Arrhythmias, Car | 1986 |
83 other studies available for bupivacaine and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Synthesis, local anaesthetic and antiarrhythmic activities of N-alkyl derivatives of proline anilides.
Topics: Alkanes; Amides; Anesthetics, Local; Anilides; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac | 2013 |
Effects of nalbuphine on the cardiotoxicity of ropivacaine in rats.
Topics: Amides; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Cardiotoxicity; Heart Arrest | 2022 |
Effects of intravenous lipid emulsions on the reversal of pacing-induced ventricular arrhythmias and electrophysiological alterations in an animal model of ropivacaine toxicity.
Topics: Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Disease Models, Animal; Fat Emulsion | 2022 |
Local Anesthetic Cardiac Toxicity Is Mediated by Cardiomyocyte Calcium Dynamics.
Topics: Amides; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Calcium; Cardiotoxicity; Fem | 2022 |
Comparison Between the Effects of Bupivacaine and Levobupivacaine for Spinal Anesthesia on QT Dispersion.
Topics: Adult; Anesthesia, Spinal; Anesthetics, Local; Arrhythmias, Cardiac; Bupivacaine; Female; Heart Rate | 2021 |
Effects of Remifentanil Pretreatment on Bupivacaine Cardiotoxicity in Rats.
Topics: Anesthetics, Local; Animals; Antidotes; Arrhythmias, Cardiac; Arterial Pressure; Bupivacaine; Cardio | 2018 |
Comparative Effects of Sodium Bicarbonate and Intravenous Lipid Emulsions on Reversing Bupivacaine-Induced Electrophysiological Toxicity in a Porcine Experimental Model.
Topics: Action Potentials; Anesthetics, Local; Animals; Antidotes; Arrhythmias, Cardiac; Bupivacaine; Cardio | 2019 |
Successful resuscitation of a three month old child with intralipid infusion, presumed to have bupivacaine induced seizures and cardiovascular complications: case report.
Topics: Anesthetics, Local; Arrhythmias, Cardiac; Bupivacaine; Fat Emulsions, Intravenous; Humans; Infant; M | 2010 |
Cardiac depression induced by cocaine or cocaethylene is alleviated by lipid emulsion more effectively than by sulfobutylether-β-cyclodextrin.
Topics: Animals; Arrhythmias, Cardiac; beta-Cyclodextrins; Bupivacaine; Cardiotoxicity; Cocaine; Coronary Ci | 2015 |
Electroacupuncture pretreatment induces rapid tolerance to bupivacaine cardiotoxicity in rats.
Topics: Anesthetics, Local; Animals; Arrhythmias, Cardiac; Arterial Pressure; Blood Pressure; Bupivacaine; C | 2016 |
Contemporary periodontal surgery.
Topics: Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Arrhythmias, Cardiac; Bupivacaine; Centra | 2008 |
Effects of thoracic epidural anaesthesia on cardiac repolarization.
Topics: Adrenergic Fibers; Adult; Aged; Anesthesia, Epidural; Anesthetics, Local; Arrhythmias, Cardiac; Auto | 2009 |
Preliminary experience in the use of preoperative echo-guided left stellate ganglion block in patients undergoing cardiac surgery.
Topics: Aged; Anesthesia, General; Anesthetics, Local; Arrhythmias, Cardiac; Autonomic Nerve Block; Blood Pr | 2011 |
Block of the hERG channel by bupivacaine: Electrophysiological and modeling insights towards stereochemical optimization.
Topics: Action Potentials; Anesthetics, Local; Anti-Allergic Agents; Arrhythmias, Cardiac; Binding Sites; Bu | 2011 |
Assessment of ventricular electrophysiological characteristics at periinfarct zone of postmyocardial infarction in rabbits following stellate ganglion block.
Topics: Action Potentials; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Autonomic Nerve Block; Bupivac | 2012 |
Effects of bupivacaine used with sevoflurane on the rhythm and contractility in the isolated rat heart.
Topics: Anesthetics, Inhalation; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Atrioventricular Node; B | 2003 |
Effects of hypertonic sodium chloride solution on the electrophysiologic alterations caused by bupivacaine in the dog heart.
Topics: Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Dogs; Electrophysiology; Female; Hea | 2003 |
Brugada-type electrocardiographic pattern induced by epidural bupivacaine.
Topics: Aged; Anesthesia, Epidural; Anesthetics, Local; Arrhythmias, Cardiac; Blood Pressure; Bundle-Branch | 2003 |
Effects of clonidine pre-treatment on bupivacaine and ropivacaine cardiotoxicity in rats.
Topics: Adrenergic alpha-Agonists; Amides; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Blood Pressure | 2004 |
Cesarean section in a patient with familial cardiomyopathy and a cardioverter-defibrillator.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Anesthesia, Epidu | 2006 |
The effects of general anesthesia on the central nervous and cardiovascular system toxicity of local anesthetics.
Topics: Acid-Base Equilibrium; Amides; Anesthetics, Inhalation; Anesthetics, Local; Animals; Arrhythmias, Ca | 2008 |
Duration and toxicity of bupivacaine for topical anesthesia of the airway in the cat.
Topics: Anesthesia, Local; Animals; Apnea; Arrhythmias, Cardiac; Bupivacaine; Cats; Cough; Female; Lidocaine | 1984 |
[Anti-arrhythmia properties of marcaine].
Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bupivacaine; Cats; Electric Stimul | 1983 |
Bupivacaine-induced cardiac arrhythmias in sheep.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Cardiac Output; Electrocardiography; Fem | 1984 |
Comparative CNS toxicity of lidocaine, etidocaine, bupivacaine, and tetracaine in awake dogs following rapid intravenous administration.
Topics: Acetanilides; Animals; Arrhythmias, Cardiac; Bupivacaine; Cardiovascular System; Cats; Central Nervo | 1983 |
Lidocaine, bupivacaine, etidocaine, and epinephrine-induced arrhythmias during halothane anesthesia in dogs.
Topics: Acetanilides; Anesthesia, Inhalation; Animals; Arrhythmias, Cardiac; Bupivacaine; Dogs; Epinephrine; | 1980 |
Stereoselective block of cardiac sodium channels by bupivacaine in guinea pig ventricular myocytes.
Topics: Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Electrophysiology; Female; Guinea Pi | 1995 |
Amrinone is superior to epinephrine in reversing bupivacaine-induced cardiovascular depression in sevoflurane-anesthetized dogs.
Topics: Amrinone; Anesthesia; Anesthetics; Animals; Arrhythmias, Cardiac; Bupivacaine; Dogs; Epinephrine; Et | 1995 |
Effect of intracerebroventricular picrotoxin and muscimol on intravenous bupivacaine toxicity. Evidence supporting central nervous system involvement in bupivacaine cardiovascular toxicity.
Topics: Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Central Nervous | 1993 |
Clonidine pretreatment reduces the systemic toxicity of intravenous bupivacaine in rats.
Topics: Anesthesia, Epidural; Animals; Arrhythmias, Cardiac; Bupivacaine; Clonidine; Electroencephalography; | 1993 |
Sevoflurane is equivalent to isoflurane for attenuating bupivacaine-induced arrhythmias and seizures in rats.
Topics: Anesthetics, Inhalation; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivaca | 1996 |
Modification of bupivacaine toxicity by nonselective versus neuronal nitric oxide synthesis inhibition.
Topics: Anesthetics, Local; Animals; Arrhythmias, Cardiac; Brain; Bupivacaine; Enzyme Inhibitors; Female; Ne | 1997 |
Cardiovascular and central nervous system effects of intravenous levobupivacaine and bupivacaine in sheep.
Topics: Anesthetics, Local; Animals; Arrhythmias, Cardiac; Blood Pressure; Brain; Bupivacaine; Cardiac Outpu | 1998 |
The effects of verapamil and nimodipine on bupivacaine-induced cardiotoxicity in rats: an in vivo and in vitro study.
Topics: Anesthetics, Local; Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Calcium Channel Bloc | 1998 |
Proarrhythmic and antiarrhythmic effects of bupivacaine in an in vitro model of myocardial ischemia and reperfusion.
Topics: Action Potentials; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Dose-Response Rel | 1998 |
[Does flumazenil correct disorders of intracardiac conduction induced by accidental intravenous injection of bupivacaine?].
Topics: Anesthetics, Local; Antidotes; Arrhythmias, Cardiac; Bupivacaine; Female; Flumazenil; Heart Conducti | 1996 |
A comparison of the effects of propofol and sevoflurane on the systemic toxicity of intravenous bupivacaine in rats.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Anesthetics, Local; Animals; Arrhythmias, Cardiac | 1999 |
Brain stem stroke associated with bupivacaine injection for adenotonsillectomy.
Topics: Adenoidectomy; Adolescent; Anesthetics, Local; Arrhythmias, Cardiac; Brain Stem; Bupivacaine; Female | 2000 |
Nitric oxide modulation affects the tissue distribution and toxicity of bupivacaine.
Topics: Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Drug Interactions; Enzyme Inhibitors | 2000 |
The comparative toxicity of ropivacaine and bupivacaine at equipotent doses in rats.
Topics: Amides; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Electrocardi | 2000 |
Cardiac resuscitation after incremental overdosage with lidocaine, bupivacaine, levobupivacaine, and ropivacaine in anesthetized dogs.
Topics: Amides; Anesthetics, Local; Anilides; Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Ca | 2001 |
Systemic toxicity and resuscitation in bupivacaine-, levobupivacaine-, or ropivacaine-infused rats.
Topics: Adrenergic alpha-Agonists; Amides; Anesthesia; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bl | 2001 |
Bupivacaine-induced QRS prolongation is enhanced by lidocaine and by phenytoin in rabbit hearts.
Topics: Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Drug Synergism; Electrocardiography; | 2002 |
Cardiac and CNS toxicity of levobupivacaine: strengths of evidence for advantage over bupivacaine.
Topics: Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Calcium Channels; Central Nervous Sy | 2002 |
Relation of etidocaine and bupivacaine toxicity to rate of infusion in rhesus monkeys.
Topics: Acetanilides; Animals; Arrhythmias, Cardiac; Bupivacaine; Central Nervous System; Etidocaine; Haplor | 1977 |
[Spinal anaesthesia using bupivacain--clinical experience of more than 6000 cases (author's transl)].
Topics: Aged; Anesthesia, Spinal; Arrhythmias, Cardiac; Bradycardia; Bupivacaine; Dyspnea; Epinephrine; Fema | 1979 |
Central nervous system effects of bupivacaine.
Topics: Amygdala; Anesthesia, General; Animals; Arrhythmias, Cardiac; Blood Pressure; Brain; Bupivacaine; Ca | 1975 |
Progesterone potentiation of bupivacaine arrhythmogenicity in pentobarbital-anesthetized rats and beating rat heart cell cultures.
Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Bupivacaine; Cells, Cultured; Drug Synergism; Epinephrine | 1992 |
Bupivacaine toxicity secondary to continuous caudal epidural infusion in children.
Topics: Anesthesia, Caudal; Arrhythmias, Cardiac; Bupivacaine; Child; Child, Preschool; Female; Humans; Infa | 1992 |
Acute cardiovascular and central nervous system toxicity of bupivacaine and desbutylbupivacaine in the rat.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Depression, Chemical; Electroencephalogr | 1992 |
Nimodipine reduces the toxicity of intravenous bupivacaine in rats.
Topics: Animals; Apnea; Arrhythmias, Cardiac; Body Weight; Bupivacaine; Cardiovascular System; Drug Interact | 1992 |
Severe hypoxia enhances central nervous system and cardiovascular toxicity of bupivacaine in lightly anesthetized pigs.
Topics: Anesthesia, Inhalation; Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Electroencephalo | 1992 |
Hypertonic NaCl solution prevents bupivacaine-induced cardiovascular toxicity.
Topics: Animals; Arrhythmias, Cardiac; Bupivacaine; Dogs; Female; Heart Conduction System; Heart Ventricles; | 1992 |
Hexamethonium and midazolam terminate dysrhythmias and hypertension caused by intracerebroventricular bupivacaine in rabbits.
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Blood Pressure; Brain; Bupivacaine; Halotha | 1991 |
If ventricular conduction and rhythm disorders are caused by bupivacaine, it is doubtful that intraoperative hyponatremia and hyperkalemia enhance them.
Topics: Animals; Arrhythmias, Cardiac; Bupivacaine; Humans; Hyperkalemia; Hyponatremia; Intraoperative Perio | 1991 |
Continuous spinal anaesthesia for abdominal surgery in a patient receiving amiodarone.
Topics: Adenocarcinoma; Amiodarone; Anesthesia, Spinal; Arrhythmias, Cardiac; Bupivacaine; Colon; Colonic Ne | 1991 |
Propranolol pretreatment reduces cardiorespiratory toxicity due to plain, but not epinephrine-containing, intravenous bupivacaine in rats.
Topics: Animals; Apnea; Arrhythmias, Cardiac; Bupivacaine; Electrocardiography; Epinephrine; Heart; Injectio | 1991 |
Functional and metabolic effects of bupivacaine and lignocaine in the rat heart-lung preparation.
Topics: Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Bupivacaine; Cardiac Output; Glycogen; Heart; | 1990 |
Nicardipine reduces the cardio-respiratory toxicity of intravenously administered bupivacaine in rats.
Topics: Analysis of Variance; Anesthesia, Conduction; Animals; Apnea; Arrhythmias, Cardiac; Bupivacaine; Hea | 1990 |
The effect of magnesium sulfate administration on cerebral and cardiac toxicity of bupivacaine in dogs.
Topics: Animals; Arrhythmias, Cardiac; Brain; Bupivacaine; Dogs; Electrocardiography; Electroencephalography | 1990 |
Enhancement by hyponatremia and hyperkalemia of ventricular conduction and rhythm disorders caused by bupivacaine.
Topics: Animals; Arrhythmias, Cardiac; Bupivacaine; Dogs; Electrocardiography; Female; Glycine; Heart Conduc | 1990 |
Treatment with isoproterenol of bupivacaine toxicity.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Dose-Response Relationship, Drug; Electr | 1990 |
Bupivacaine toxicity in young pigs is age-dependent and is affected by volatile anesthetics.
Topics: Aging; Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Cardiac Output; Drug Interactions | 1990 |
Comparative systemic toxicity of convulsant and supraconvulsant doses of intravenous ropivacaine, bupivacaine, and lidocaine in the conscious dog.
Topics: Amides; Animals; Arrhythmias, Cardiac; Bupivacaine; Carbon Dioxide; Dogs; Dose-Response Relationship | 1989 |
[Effects of hypo- and hypernatremia on depression of ventricular conduction and arrhythmia induced by bupivacaine].
Topics: Animals; Arrhythmias, Cardiac; Bupivacaine; Dogs; Heart Conduction System; Hypernatremia; Hyponatrem | 1989 |
Potentiation by mild hypothermia of ventricular conduction disturbances and reentrant arrhythmias induced by bupivacaine in dogs.
Topics: Animals; Arrhythmias, Cardiac; Bupivacaine; Dogs; Electrocardiography; Female; Heart Conduction Syst | 1989 |
Hypertonic NaCl antagonizes cardiac arrhythmia induced by bupivacaine.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Dogs; Female; Male; Preanesthetic Medica | 1989 |
Effect of epinephrine on central nervous system and cardiovascular system toxicity of bupivacaine in pigs.
Topics: Animals; Arrhythmias, Cardiac; Bupivacaine; Cardiovascular System; Central Nervous System; Dose-Resp | 1989 |
Cardiotoxicity of ropivacaine--a new amide local anaesthetic agent.
Topics: Amides; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Depression, Chemical; Electr | 1989 |
Does diazepam really reduce the cardiotoxic effects of intravenous bupivacaine?
Topics: Acidosis, Respiratory; Animals; Arrhythmias, Cardiac; Blood Gas Analysis; Blood Pressure; Bupivacain | 1988 |
Cardiac electrophysiologic effects of lidocaine and bupivacaine.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Bupivacaine; Dose-Response Relationship, Drug; Hea | 1988 |
The electrophysiologic actions of lidocaine and bupivacaine in the isolated, perfused canine heart.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Bupivacaine; Dogs; Heart; Heart Rate; In Vitro Tec | 1988 |
[Cardiac toxicity of bupivacaine and diazepam. Experimental study in the anesthetized dog].
Topics: Anesthesia, Intravenous; Animals; Arrhythmias, Cardiac; Bupivacaine; Diazepam; Dogs; Drug Interactio | 1988 |
The influence of age on the cardiovascular toxicity of intravenous bupivacaine in young dogs.
Topics: Age Factors; Animals; Arrhythmias, Cardiac; Bupivacaine; Dogs; Dose-Response Relationship, Drug; Ele | 1987 |
[Neurotoxicity and cardiotoxicity of bupivacaine on the Papio papio baboon].
Topics: Animals; Arrhythmias, Cardiac; Bupivacaine; Diazepam; Drug Interactions; Hypertension; Papio; Seizur | 1987 |
Amide local anesthetic alterations of effective refractory period temporal dispersion: relationship to ventricular arrhythmias.
Topics: Amides; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Dogs; Electrocardiography; E | 1986 |
Cardiac dysrhythmias induced by infusion of local anesthetics into the lateral cerebral ventricle of cats.
Topics: Anesthetics, Local; Animals; Arrhythmias, Cardiac; Blood Pressure; Brain; Bupivacaine; Cats; Heart R | 1986 |
Cardiovascular toxicity of local anesthetics: an alternative hypothesis.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Bradycardia; Brain; Bupivacaine; Electric Stimulation | 1986 |
Bupivacaine cardiovascular toxicity: comparison of treatment with bretylium and lidocaine.
Topics: Animals; Arrhythmias, Cardiac; Bretylium Compounds; Bupivacaine; Dogs; Electrocardiography; Heart Ve | 1985 |
Bupivacaine-induced cardiotoxicity in hypoxic and acidotic sheep.
Topics: Acidosis, Respiratory; Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Dose-Response Rel | 1985 |
[The behaviour of the cardiac rhythm during general and regional anaesthesia].
Topics: Anesthesia, Inhalation; Anesthesia, Local; Arrhythmia, Sinus; Arrhythmias, Cardiac; Atropine; Bupiva | 1973 |
[Clinical experience in the use of bupivacaine as an anti-arrhythmia agent].
Topics: Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bupivacaine; Child; Child, Preschool; Humans; Li | 1973 |
A comparison of the antiarrhythmic effects of bupivacaine and lidocaine.
Topics: Animals; Arrhythmias, Cardiac; Bupivacaine; Dogs; Lidocaine | 1972 |