bupivacaine has been researched along with Apnea in 35 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Apnea: A transient absence of spontaneous respiration.
| Excerpt | Relevance | Reference |
|---|---|---|
| " On the first postoperative night, the breathing pattern was studied with a new noninvasive monitoring device measuring respiratory frequency and apnea." | 7.71 | Apnea and bradypnea in patients receiving epidural bupivacaine-morphine for postoperative pain relief as assessed by a new monitoring method. ( Flisberg, P; Jakobsson, J; Lundberg, J, 2002) |
| "After a retro-bulbar block for glaucoma surgery, a 60-year-old man developed loss of consciousness, apnea with hypotension and bradycardia-features of brainstem anesthesia." | 3.83 | Brainstem Anesthesia after Retrobulbar Block: A Case Report and Review of Literature. ( Gebreal, GW; Tolesa, K, 2016) |
| " Next, during continuous intravenous infusion of equipotent doses of bupivacaine, dextromethorphan, and dextrorphan (n = 8 in each group), we observed the time to seizure, apnea, and complete cardiac arrest." | 3.77 | Systemic dextromethorphan and dextrorphan are less toxic in rats than bupivacaine at equianesthetic doses. ( Chen, YC; Chen, YW; Hung, CH; Liu, TY; Wang, JJ, 2011) |
| " On the first postoperative night, the breathing pattern was studied with a new noninvasive monitoring device measuring respiratory frequency and apnea." | 3.71 | Apnea and bradypnea in patients receiving epidural bupivacaine-morphine for postoperative pain relief as assessed by a new monitoring method. ( Flisberg, P; Jakobsson, J; Lundberg, J, 2002) |
| " Systemic effects (contralateral leg analgesia, seizures, respiratory distress, apnea) were quantified." | 3.70 | Sciatic nerve blockade in infant, adolescent, and adult rats: a comparison of ropivacaine with bupivacaine. ( Berde, CB; Hu, D; Kohane, DS; Rifai, N; Sankar, WN; Shubina, M, 1998) |
| " One minute after performing a second stellate ganglion block the patient showed signs of apnea and paralysis of the upper extremities and face, with no involvement of oculomotor muscles or the lower extremities, and no loss of consciousness." | 3.70 | [A possibility of central diffusion during stellate ganglion blockade: "the sheath of the spinal rachidian nerve"]. ( Escudero, A; Fas, MJ; Ortiz, M; Roca, G; Soriano, C; Vidal, F, 1999) |
| " Arterial blood samples were obtained before infusion and at the onset of toxic manifestations, which appeared in the following sequence: convulsions, hypotension, apnea, and circulatory collapse." | 3.69 | Comparative systemic toxicity of ropivacaine and bupivacaine in nonpregnant and pregnant ewes. ( Arthur, GR; De Armas, P; Finster, M; Morishima, HO; Santos, AC; Wlody, D, 1995) |
| " Four percent bupivacaine produced arrhythmias in 5 of 10 cats in two groups and apnea in 4 of 6 cats." | 3.67 | Duration and toxicity of bupivacaine for topical anesthesia of the airway in the cat. ( Ford, DJ; Raj, PP; Singh, P; Watters, C, 1984) |
| " Resuscitation was performed using open-chest heart massage, bretylium for ventricular tachycardia, and epinephrine with atropine for electromechanical dissociation and bradycardia." | 3.67 | Successful cardiovascular resuscitation after massive intravenous bupivacaine overdosage in anesthetized dogs. ( Kasten, GW; Martin, ST, 1985) |
| "The effects of inhalation of 100 breaths of bupivacaine hydrochloride (5 percent solution in saline) on the cough reflex, the Breuer-Hering inflation, reflex, and the duration of apnea and bronchoconstriction produced by histamine aerosol were studied in nine anesthetized dogs." | 3.65 | Inhibition of respiratory reflexes by local anesthetic aerosols in dogs and rabbits. ( Boushey, HA; Dain, DS; Gold, WM, 1975) |
| "Awake regional anaesthesia for inguinal hernia repair in former preterm infants is suggested to avoid life-threatening respiratory complications known to occur after general anaesthesia." | 1.31 | Apnoea in a former preterm infant after caudal bupivacaine with clonidine for inguinal herniorrhaphy. ( Fellmann, C; Gerber, AC; Weiss, M, 2002) |
| "The case of cardiopulmonary arrest we report is rare in the literature." | 1.31 | [Cardiorespiratory arrest: a rare complication of subdural block]. ( Bermejo, S; Escolano, F; Montes, A; Sánchez, JC; Silva Costa-Gomes, T, 2002) |
| " Three minutes after pretreatment, group 1 (n = 11), group 3 (n = 10), and their respective control groups (n = 11 and n = 9) received intravenous bupivacaine LD50 (median lethal dose)." | 1.28 | Nimodipine reduces the toxicity of intravenous bupivacaine in rats. ( Horn, JL; Hyman, SA; Kambam, JR; Kinney, WW; Skelley, CC, 1992) |
| " Our data suggest that epinephrine or phenylephrine added to bupivacaine may be more toxic to cardiorespiratory systems than plain bupivacaine or epinephrine alone or phenylephrine alone when injected intravenously in rats." | 1.28 | Epinephrine and phenylephrine increase cardiorespiratory toxicity of intravenously administered bupivacaine in rats. ( Holaday, DA; Kambam, JR; Kinney, WW; Matsuda, F; Wright, W, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (17.14) | 18.7374 |
| 1990's | 18 (51.43) | 18.2507 |
| 2000's | 9 (25.71) | 29.6817 |
| 2010's | 2 (5.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tolesa, K | 1 |
| Gebreal, GW | 1 |
| Chen, YW | 1 |
| Wang, JJ | 1 |
| Liu, TY | 1 |
| Chen, YC | 1 |
| Hung, CH | 1 |
| Fellmann, C | 1 |
| Gerber, AC | 1 |
| Weiss, M | 1 |
| Sites, BD | 1 |
| Blike, G | 1 |
| Cravero, J | 1 |
| Andeweg, S | 1 |
| Beach, M | 1 |
| Hussain, AS | 1 |
| Siddiqui, MS | 1 |
| Hamdard, F | 1 |
| Mayhew, JF | 1 |
| Celik, JB | 1 |
| Reisli, R | 1 |
| Sarkilar, G | 1 |
| Okesli, S | 1 |
| Grefkens, JM | 1 |
| Bürger, K | 1 |
| Kachko, L | 1 |
| Simhi, E | 1 |
| Tzeitlin, E | 1 |
| Efrat, R | 1 |
| Tarabikin, E | 1 |
| Peled, E | 1 |
| Metzner, I | 1 |
| Katz, J | 1 |
| Ford, DJ | 1 |
| Singh, P | 1 |
| Watters, C | 1 |
| Raj, PP | 1 |
| Edge, KR | 1 |
| Davis, A | 1 |
| Santos, AC | 1 |
| Arthur, GR | 1 |
| Wlody, D | 1 |
| De Armas, P | 1 |
| Morishima, HO | 1 |
| Finster, M | 1 |
| Ostermeier, AM | 1 |
| Roizen, MF | 1 |
| Hautkappe, M | 1 |
| Klock, PA | 1 |
| Klafta, JM | 1 |
| Katsiris, S | 1 |
| Williams, S | 1 |
| Leighton, BL | 1 |
| Halpern, S | 1 |
| Kohane, DS | 1 |
| Sankar, WN | 1 |
| Shubina, M | 1 |
| Hu, D | 1 |
| Rifai, N | 1 |
| Berde, CB | 1 |
| Kunst, G | 1 |
| Linderkamp, O | 1 |
| Holle, R | 1 |
| Motsch, J | 1 |
| Martin, E | 1 |
| Carvalho, JC | 1 |
| Soriano, C | 1 |
| Ortiz, M | 1 |
| Fas, MJ | 1 |
| Escudero, A | 1 |
| Roca, G | 1 |
| Vidal, F | 1 |
| William, JM | 1 |
| Stoddart, PA | 1 |
| Williams, SA | 1 |
| Wolf, AR | 1 |
| Flisberg, P | 1 |
| Jakobsson, J | 1 |
| Lundberg, J | 1 |
| Silva Costa-Gomes, T | 1 |
| Montes, A | 1 |
| Sánchez, JC | 1 |
| Bermejo, S | 1 |
| Escolano, F | 1 |
| Dain, DS | 1 |
| Boushey, HA | 1 |
| Gold, WM | 1 |
| Orser, B | 1 |
| MacDonald, J | 1 |
| Hyman, SA | 1 |
| Kinney, WW | 4 |
| Horn, JL | 1 |
| Skelley, CC | 1 |
| Kambam, JR | 4 |
| Smart, NG | 1 |
| Gibson, P | 1 |
| Murrell, D | 1 |
| Paech, M | 1 |
| Wright, W | 3 |
| Matsuda, F | 2 |
| Holaday, DA | 1 |
| Riley, RH | 1 |
| Desparmet, JF | 1 |
| Kao, YJ | 1 |
| Zavisca, F | 1 |
| Enty, D | 1 |
| Kasten, GW | 1 |
| Martin, ST | 1 |
| Sehhati, G | 1 |
| Frey, R | 1 |
| Mildner, R | 1 |
| Gillies, ID | 1 |
| Morgan, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Postoperative Management of Obstructive Sleep Apnea With CPAP vs. an Autoadjusting CPAP Device: a Randomized Controlled Single Center Trial[NCT00588848] | 11 participants (Actual) | Interventional | 2008-01-31 | Terminated (stopped due to Difficulty with enrollment) | |||
| The Effect of Acute Intravenous Morphine Administration on Sleep Disordered Breathing (SDB) in Patients With Moderate Obstructive Sleep Apnoea (OSA): A Paired Design Trial[NCT03127800] | Phase 3 | 6 participants (Actual) | Interventional | 2016-05-20 | Terminated (stopped due to Difficulties with recruitment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Events are defined as apneas and hypopneas. AHI values are typically categorized as 5-14.9 events/hr = mild; 15-29.9 events/hr = moderate; and >= 30 events/hr = severe (NCT00588848)
Timeframe: On postoperative night number 1 from 2200 to 0600. Study participation will end within 72 hours of admission.
| Intervention | events per hour (Mean) |
|---|---|
| AUTOCPAP | 2.1 |
| CPAP | 1.2 |
Predefined cardiopulmonary complications: Myocardial Infarction, Arrhythmia, new onset Heart Failure, Stroke (NCT00588848)
Timeframe: 72 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Autoadjusting CPAP (VPAP Auto) | 0 |
| CPAP Arm (Usual Care) | 0 |
(NCT00588848)
Timeframe: On postoperative night number 1 from 2200 to 0600. Study participation will end within 72 hours of admission.
| Intervention | Percentage of time < 90% saturation (Mean) |
|---|---|
| AUTOCPAP | 10.5 |
| CPAP | 7.1 |
1 review available for bupivacaine and Apnea
| Article | Year |
|---|---|
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea.
Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe | 1997 |
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea.
Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe | 1997 |
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea.
Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe | 1997 |
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea.
Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe | 1997 |
2 trials available for bupivacaine and Apnea
| Article | Year |
|---|---|
The proportion of high risk preterm infants with postoperative apnea and bradycardia is the same after general and spinal anesthesia.
Topics: Anesthesia, General; Anesthesia, Spinal; Anesthetics, Inhalation; Anesthetics, Local; Apnea; Bradyca | 1999 |
Post-operative recovery after inguinal herniotomy in ex-premature infants: comparison between sevoflurane and spinal anaesthesia.
Topics: Anesthesia, Spinal; Anesthetics, Inhalation; Anesthetics, Local; Apnea; Bradycardia; Bupivacaine; He | 2001 |
32 other studies available for bupivacaine and Apnea
| Article | Year |
|---|---|
Brainstem Anesthesia after Retrobulbar Block: A Case Report and Review of Literature.
Topics: Anesthetics, Local; Apnea; Brain Stem; Bupivacaine; Glaucoma; Humans; Hypotension; Male; Middle Aged | 2016 |
Systemic dextromethorphan and dextrorphan are less toxic in rats than bupivacaine at equianesthetic doses.
Topics: Anesthetics, Local; Animals; Apnea; Bupivacaine; Dextromethorphan; Dextrorphan; Dose-Response Relati | 2011 |
Apnoea in a former preterm infant after caudal bupivacaine with clonidine for inguinal herniorrhaphy.
Topics: Anesthesia, Caudal; Anesthetics, Combined; Apnea; Bupivacaine; Clonidine; Hernia, Inguinal; Humans; | 2002 |
Single-dose caudal anaesthesia for two infants undergoing diagnostic brain magnetic resonance imaging: high risk and nonhigh risk.
Topics: Anesthesia, Caudal; Anesthetics, Local; Apnea; Brain; Bupivacaine; Craniofacial Abnormalities; Epile | 2003 |
Postoperative apnoea in an ex-premature infant: is it only related to clonidine?
Topics: Analgesics; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Local; Apnea; Bupivacaine; Clonidi | 2003 |
Respiratory arrest after intrathecal injection of sufentanil and bupivacaine.
Topics: Adult; Anesthetics, Intravenous; Anesthetics, Local; Apnea; Bupivacaine; Drug Combinations; Humans; | 2004 |
Total spinal anaesthesia after an attempted brachial plexus block using the posterior approach.
Topics: Aged; Anesthesia, Spinal; Anesthetics, Local; Apnea; Arthroplasty, Replacement; Brachial Plexus; Bup | 2006 |
Spinal anesthesia in neonates and infants - a single-center experience of 505 cases.
Topics: Anesthesia, Spinal; Anesthetics, Local; Apnea; Body Weight; Bradycardia; Bupivacaine; Female; Gestat | 2007 |
Duration and toxicity of bupivacaine for topical anesthesia of the airway in the cat.
Topics: Anesthesia, Local; Animals; Apnea; Arrhythmias, Cardiac; Bupivacaine; Cats; Cough; Female; Lidocaine | 1984 |
Brainstem anaesthesia following a peribulbar block for eye surgery.
Topics: Aged; Apnea; Brain Stem; Bupivacaine; Cataract Extraction; Eye; Humans; Injections; Lenses, Intraocu | 1995 |
Comparative systemic toxicity of ropivacaine and bupivacaine in nonpregnant and pregnant ewes.
Topics: Amides; Animals; Apnea; Blood Pressure; Bupivacaine; Dose-Response Relationship, Drug; Double-Blind | 1995 |
Respiratory arrest following intrathecal injection of sufentanil and bupivacaine in a parturient.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthesia, Epidural; Anesth | 1998 |
Sciatic nerve blockade in infant, adolescent, and adult rats: a comparison of ropivacaine with bupivacaine.
Topics: Aging; Amides; Anesthetics, Local; Animals; Apnea; Behavior, Animal; Bupivacaine; Dose-Response Rela | 1998 |
Respiratory arrest following intrathecal sufentanil.
Topics: Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthetics, Local; Apnea; Bupivaca | 1999 |
[A possibility of central diffusion during stellate ganglion blockade: "the sheath of the spinal rachidian nerve"].
Topics: Adult; Anesthetics, Local; Apnea; Autonomic Nerve Block; Bupivacaine; Diffusion; Facial Paralysis; F | 1999 |
Apnea and bradypnea in patients receiving epidural bupivacaine-morphine for postoperative pain relief as assessed by a new monitoring method.
Topics: Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Apnea; | 2002 |
[Cardiorespiratory arrest: a rare complication of subdural block].
Topics: Aged; Anesthesia, Epidural; Anesthetics, Local; Apnea; Arthroplasty, Replacement, Hip; Bradycardia; | 2002 |
Inhibition of respiratory reflexes by local anesthetic aerosols in dogs and rabbits.
Topics: Aerosols; Airway Resistance; Anesthesia, Local; Animals; Apnea; Bronchi; Bupivacaine; Constriction; | 1975 |
Propranolol protection from bupivacaine toxicity.
Topics: Animals; Apnea; Bupivacaine; Calcium Channels; Heart Arrest; Propranolol; Rats; Rats, Inbred Strains | 1992 |
Nimodipine reduces the toxicity of intravenous bupivacaine in rats.
Topics: Animals; Apnea; Arrhythmias, Cardiac; Body Weight; Bupivacaine; Cardiovascular System; Drug Interact | 1992 |
Epidural LA/opioid.
Topics: Analgesia, Epidural; Apnea; Bupivacaine; Fentanyl; Humans; Lumbar Vertebrae; Respiratory Insufficien | 1991 |
Complications of epidural analgesia.
Topics: Adult; Analgesia, Epidural; Apnea; Bupivacaine; Child; Fentanyl; Humans; Infant; Respiratory Insuffi | 1991 |
Epidural bupivacaine-fentanyl infusions.
Topics: Analgesia, Epidural; Apnea; Bupivacaine; Fentanyl; Humans; Respiratory Insufficiency | 1991 |
Propranolol pretreatment reduces cardiorespiratory toxicity due to plain, but not epinephrine-containing, intravenous bupivacaine in rats.
Topics: Animals; Apnea; Arrhythmias, Cardiac; Bupivacaine; Electrocardiography; Epinephrine; Heart; Injectio | 1991 |
Nicardipine reduces the cardio-respiratory toxicity of intravenously administered bupivacaine in rats.
Topics: Analysis of Variance; Anesthesia, Conduction; Animals; Apnea; Arrhythmias, Cardiac; Bupivacaine; Hea | 1990 |
Epinephrine and phenylephrine increase cardiorespiratory toxicity of intravenously administered bupivacaine in rats.
Topics: Animals; Apnea; Bupivacaine; Drug Interactions; Epinephrine; Heart Rate; Injections, Intravenous; Ma | 1990 |
Respiratory arrest following interpleural block in a narcotized patient.
Topics: Aged; Anesthesia, Conduction; Anesthesia, Intravenous; Apnea; Bupivacaine; Humans; Injections; Male; | 1990 |
Total spinal anesthesia after caudal anesthesia in an infant.
Topics: Anesthesia, Caudal; Anesthesia, Epidural; Anesthesia, Spinal; Apnea; Bupivacaine; Heart Rate; Humans | 1990 |
Haemodynamic decompensation during caesarean section.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Apnea; Bradycardia; Bupivacaine; Cesarean Sect | 1989 |
Successful cardiovascular resuscitation after massive intravenous bupivacaine overdosage in anesthetized dogs.
Topics: Animals; Apnea; Atropine; Bradycardia; Bupivacaine; Dogs; Electrocardiography; Epinephrine; Female; | 1985 |
[Complications of regional anaesthesia and their treatment (author's transl)].
Topics: Adrenal Cortex Hormones; Anesthesia, Local; Apnea; Barbiturates; Bradycardia; Bupivacaine; Diagnosis | 1973 |
Accidental total spinal analgesia with bupivacaine.
Topics: Aged; Anesthesia, Epidural; Anesthesia, Spinal; Apnea; Blood Pressure; Bupivacaine; Female; Humans; | 1973 |