bupivacaine has been researched along with Apnea, Sleep in 5 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Albrecht, E | 1 |
| Bayon, V | 1 |
| Hirotsu, C | 1 |
| Al Ja'bari, A | 1 |
| Heinzer, R | 1 |
| Moss, JR | 1 |
| Cofer, S | 1 |
| Hersey, S | 1 |
| Goudy, S | 1 |
| Werkhaven, J | 1 |
| Swanson, E | 1 |
| Mantle, C | 1 |
| Stowell, N | 1 |
| Byrne, D | 1 |
| Wang, L | 1 |
| Labadie, R | 1 |
| Deegan, PC | 1 |
| Mulloy, E | 1 |
| McNicholas, WT | 1 |
| Ostermeier, AM | 1 |
| Roizen, MF | 1 |
| Hautkappe, M | 1 |
| Klock, PA | 1 |
| Klafta, JM | 1 |
| Clyburn, PA | 1 |
| Rosen, M | 1 |
| Vickers, MD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Intrathecal Morphine on Sleep Apnea Syndrome After Hip Arthroplasty Performed Under Spinal Anaesthesia[NCT02566226] | Phase 4 | 60 participants (Actual) | Interventional | 2015-11-30 | Completed | ||
| Pediatric Tonsillectomy Pain Reduction Study, a Randomized, Placebo Controlled, Double-Blind Clinical Trial Using Clonidine and Local Anesthetics[NCT00678379] | Phase 3 | 120 participants (Actual) | Interventional | 2008-04-30 | Completed | ||
| Postoperative Management of Obstructive Sleep Apnea With CPAP vs. an Autoadjusting CPAP Device: a Randomized Controlled Single Center Trial[NCT00588848] | 11 participants (Actual) | Interventional | 2008-01-31 | Terminated (stopped due to Difficulty with enrollment) | |||
| The Effect of Acute Intravenous Morphine Administration on Sleep Disordered Breathing (SDB) in Patients With Moderate Obstructive Sleep Apnoea (OSA): A Paired Design Trial[NCT03127800] | Phase 3 | 6 participants (Actual) | Interventional | 2016-05-20 | Terminated (stopped due to Difficulties with recruitment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The median number of intravenous fentanyl doses administered in the PACU due to pain (NCT00678379)
Timeframe: in recovery room
| Intervention | number of doses (Median) |
|---|---|
| Normal Saline | 3.0 |
| Lidocaine (1%) + Bupivacaine 0.5% | 3 |
| Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg | 3 |
The total number of intravenous fentanyl doses given PACU which will be compared between the three randomized groups (arms) (NCT00678379)
Timeframe: Post-operative thru day 7
| Intervention | number of doses (Median) |
|---|---|
| Normal Saline | 12 |
| Lidocaine (1%) + Bupivacaine 0.5% | 12 |
| Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg | 14 |
(NCT00678379)
Timeframe: Day of Surgery
| Intervention | minutes (Median) |
|---|---|
| Normal Saline | 122 |
| Lidocaine (1%) + Bupivacaine 0.5% | 111 |
| Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg | 120 |
Visual analog pain scale range is 0-10 with 0=no pain and 10 = worst pain ever (NCT00678379)
Timeframe: in recovery room; post-operative days 1,3,5 & 7
| Intervention | pain score (Mean) | ||||
|---|---|---|---|---|---|
| In recovery room | day 1 | day 3 | day 5 | day 7 | |
| Lidocaine (1%) + Bupivacaine 0.5% | 3 | 4 | 2.5 | 2 | 2 |
| Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg | 3 | 5 | 3 | 3 | 2 |
| Normal Saline | 3 | 3 | 3 | 3 | 2.5 |
The number and percent of patients whose post-operative diet has to a regular diet on post-operative days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| post-op day 1 | post-op day 3 | post op day 5 | post op day 7 | |
| Lidocaine (1%) + Bupivacaine 0.5% | 4 | 8 | 18 | 26 |
| Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg | 1 | 12 | 14 | 22 |
| Normal Saline | 7 | 18 | 21 | 24 |
The number and percent of patients whose post-operative diet has only advanced to a soft diet on post-operative days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| post-op day 1 | post-op day 3 | post op day 5 | post op day 7 | |
| Lidocaine (1%) + Bupivacaine 0.5% | 22 | 26 | 17 | 10 |
| Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg | 26 | 18 | 18 | 14 |
| Normal Saline | 26 | 18 | 13 | 13 |
The number and percent of patients whose post-operative diet has advanced to liquids only on post-op days 1, 3, 5 & 7 (NCT00678379)
Timeframe: post-operative days 1,3,5 & 7.
| Intervention | Participants (Count of Participants) | |||
|---|---|---|---|---|
| post-op day 1 | post-op day 3 | post op day 5 | post op day 7 | |
| Lidocaine (1%) + Bupivacaine 0.5% | 33 | 13 | 10 | 11 |
| Lidocaine 1% + Bupivacaine o.5% + Clondine 25mcg | 30 | 23 | 19 | 10 |
| Normal Saline | 16 | 8 | 13 | 6 |
Events are defined as apneas and hypopneas. AHI values are typically categorized as 5-14.9 events/hr = mild; 15-29.9 events/hr = moderate; and >= 30 events/hr = severe (NCT00588848)
Timeframe: On postoperative night number 1 from 2200 to 0600. Study participation will end within 72 hours of admission.
| Intervention | events per hour (Mean) |
|---|---|
| AUTOCPAP | 2.1 |
| CPAP | 1.2 |
Predefined cardiopulmonary complications: Myocardial Infarction, Arrhythmia, new onset Heart Failure, Stroke (NCT00588848)
Timeframe: 72 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Autoadjusting CPAP (VPAP Auto) | 0 |
| CPAP Arm (Usual Care) | 0 |
(NCT00588848)
Timeframe: On postoperative night number 1 from 2200 to 0600. Study participation will end within 72 hours of admission.
| Intervention | Percentage of time < 90% saturation (Mean) |
|---|---|
| AUTOCPAP | 10.5 |
| CPAP | 7.1 |
1 review available for bupivacaine and Apnea, Sleep
| Article | Year |
|---|---|
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea.
Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe | 1997 |
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea.
Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe | 1997 |
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea.
Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe | 1997 |
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea.
Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe | 1997 |
4 trials available for bupivacaine and Apnea, Sleep
| Article | Year |
|---|---|
Intrathecal morphine and sleep apnoea severity in patients undergoing hip arthroplasty: a randomised, controlled, triple-blinded trial.
Topics: Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Local; Art | 2020 |
Comparison of clonidine, local anesthetics, and placebo for pain reduction in pediatric tonsillectomy.
Topics: Adenoids; Adolescent; Age Factors; Analgesics; Anesthetics, Local; Bupivacaine; Child; Child, Presch | 2011 |
Topical oropharyngeal anesthesia in patients with obstructive sleep apnea.
Topics: Bupivacaine; Humans; Lidocaine; Male; Middle Aged; Respiration; Respiratory Function Tests; Sleep Ap | 1995 |
Comparison of the respiratory effects of i.v. infusions of morphine and regional analgesia by extradural block.
Topics: Abdomen; Adult; Aged; Analgesia, Epidural; Arrhythmias, Cardiac; Bupivacaine; Female; Humans; Infusi | 1990 |