Page last updated: 2024-10-24

bupivacaine and Adhesions, Tissue

bupivacaine has been researched along with Adhesions, Tissue in 6 studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to assess the value of peridural thoracic analgesia (ATP) to prevent pain observed during pleural symphysis with tetracycline (STP) for pneumothorax (PNO)."7.68[Pleural symphysis with tetracyclines for pneumothorax. The value of thoracic peridural analgesia]. ( Dermine, H; Guyon, F; Laaban, JP; Poirier, T; Rochemaure, J; Vuong, TK, 1990)
"Both Bupivacaine concentrations effectively produced the desired muscle hypertrophy and fibrosis, so the lower concentration may be used for muscle strengthening to correct strabismus."4.12Histopathological changes in extraocular muscles of rabbits following injection of bupivacaine 5mg/Ml versus 7.5mg/Ml. ( Abdel-Salam, LO; Kassem, RR; Mohamed Abdel-Moneim El-Mofty, R, 2022)
"The aim of this study was to assess the value of peridural thoracic analgesia (ATP) to prevent pain observed during pleural symphysis with tetracycline (STP) for pneumothorax (PNO)."3.68[Pleural symphysis with tetracyclines for pneumothorax. The value of thoracic peridural analgesia]. ( Dermine, H; Guyon, F; Laaban, JP; Poirier, T; Rochemaure, J; Vuong, TK, 1990)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19901 (16.67)18.7374
1990's1 (16.67)18.2507
2000's2 (33.33)29.6817
2010's1 (16.67)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Mohamed Abdel-Moneim El-Mofty, R1
Kassem, RR1
Abdel-Salam, LO1
Rosen, MJ1
Duperier, T1
Marks, J1
Onders, R1
Hardacre, J1
Ponsky, J1
Ermlich, B1
Laughinghouse, M1
Ozturk, E1
Yilmazlar, A1
Berhuni, S1
Yilmazlar, T1
Shaw, IC1
Stevens, J1
Krishnamurthy, S1
Poirier, T1
Laaban, JP1
Guyon, F1
Vuong, TK1
Dermine, H1
Rochemaure, J1
Ehring, E1
Boekstegers, A1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
TAP) Block in Morbid Obese Patients Undergoing Laparoscopic Gastric Bypass Surgery: A Prospective,Randomized, Blinded Study[NCT01075087]19 participants (Actual)Interventional2010-03-31Completed
The Effect of Systemic Intraoperative Lidocaine on Postoperative Pain and Quality of Recovery on Morbid Obese Patients Undergoing Laparoscopic Gastric Bypass Surgery[NCT01180660]51 participants (Actual)Interventional2010-06-30Completed
The Effect of Pre-operative Transversus Abdominis Plane (TAP) Block in the Quality of Recovery of Patients Undergoing Laparoscopic Hysterectomy: a Prospective, Randomized, Blinded Study[NCT01074229]75 participants (Actual)Interventional2010-03-31Completed
The Effect of Pre Operative Transversus Abdominis Plane (TAP) Block in the Quality of Recovery of Patients Undergoing Outpatient Laparoscopic Gynecological Surgery: A Prospective, Randomized Blinded Study[NCT01075074]75 participants (Actual)Interventional2010-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

24 Hour Total Opioid Consumption.

24 Hour total opioid consumption translated into IV morphine equivalents. (NCT01075087)
Timeframe: 24 hours

Interventionmiligram IV morphine equivalents (Median)
Placebo13
Active Comparator7.5

Quality of Recovery 40 Score

Quality of Recovery 40 Score at 24 hours postoperative. (NCT01075087)
Timeframe: 24 hours post operatively

Interventionunits on scale 40 (low) - 200 (high) (Median)
Placebo170
Active Comparator175.5

24 Hour Total Opioid Consumption

24 hour total opioid consumption using IV morphine equivalents (NCT01180660)
Timeframe: 24 hours post surgery

Interventionmiligrams (Median)
Lidocaine26
Placebo36

Quality of Recovery 40 on the Day After Surgery

"Quality of Recovery 40 on the Day After Surgery. The survey is a quality of recovery tool and a score of 40 is low and 200 is high.~The minimum score is 40 which is minimum recovery score and them maximum score is 200 which is considered better recovery." (NCT01180660)
Timeframe: 24 hours

Interventionunits on scale 40 (low) - 200 (high) (Median)
Lidocaine165
Placebo146

24 Total Morphine Consumption

Total 24 total morphine consumption post operative. (NCT01074229)
Timeframe: 1 day

Interventionmiligrams of morphine (Mean)
Placebo22.75
20 cc of 0.5% Ropivacaine12.5
20 cc of 0.25% Ropivacaine17.5

QoR40 on the Day After Surgery

QoR40 on the day after surgery. Quality of recovery is based on a score of 40-200. 40 being a poor recovery and 200 being a good recovery score. (NCT01074229)
Timeframe: 1 day

Interventionunits on a scale (Median)
PLACEBO152
20 cc of 0.5% Ropivacaine180
20 cc of 0.25% Ropivacaine180

Opioid Pain Medications Consumed During the First 24 Hours Post Surgery

Opioid consumption in oral morphine equivalents taken by the subject for pain during the first 24 hours post hospital discharge (NCT01075074)
Timeframe: 24 hours

InterventionmEq of PO morphine equivalent (Mean)
Ropivacaine 0.5%40
Normal Saline78
Ropivacaine 0.25%39

Pain Burden During Early Recovery From Anesthesia

Area under the numeric rating scale for pain versus time (min) curve during the post anesthesia care admission. Numeric rating scale 0 to 10 with 0 equals no pain and 10 equals worst pain imaginable. (NCT01075074)
Timeframe: Post Operative

Interventionscore on a scale * minutes (Median)
Ropivacaine 0.5%210
Normal Saline405
Ropivacaine 0.25%210

The Quality of Recovery Questionnaire (QoR40) on the Day (24 Hours) After Surgery

The quality of recovery questionnaire (QOR40) is a 40 question assessment of patient recovery following surgery. It evaluates 5 domains of recovery: pain, emotional status, physical comfort, physical independence, and support. Each question is scores on a 1 to 5 Likert scale with total scores ranging for 40, representing poor recovery, to 200, representing outstanding recovery. (NCT01075074)
Timeframe: 24 hours after surgery

Interventionunits on a scale (Median)
Ropivacaine 0.5%172
Normal Saline157
Ropivacaine 0.25%173

Time to Hospital Discharge Readiness

Elapsed time from post anesthesia care unit to readiness to hospital discharge. Assessment were made using the modified post anesthetic discharge scoring system. This assess 5 criteria: vital signs, activity and mental status, pain nausea and/or vomiting, surgical bleed, and intake and output. A score greater than or equal to 9 (on a 0 to 10 scale) is considered ready for discharge. (NCT01075074)
Timeframe: 24 hours

Interventionminutes (Median)
Ropivacaine 0.5%90
Normal Saline120
Ropivacaine 0.25%90

Trials

2 trials available for bupivacaine and Adhesions, Tissue

ArticleYear
Prospective randomized double-blind placebo-controlled trial of postoperative elastomeric pain pump devices used after laparoscopic ventral hernia repair.
    Surgical endoscopy, 2009, Volume: 23, Issue:12

    Topics: Administration, Cutaneous; Administration, Oral; Analgesia, Patient-Controlled; Anesthetics, Local;

2009
The influence of intraperitoneal bupivacaine on pain following major laparoscopic gynaecological procedures.
    Anaesthesia, 2001, Volume: 56, Issue:11

    Topics: Adult; Analgesics; Anesthetics, Local; Bupivacaine; Double-Blind Method; Drug Administration Schedul

2001
The influence of intraperitoneal bupivacaine on pain following major laparoscopic gynaecological procedures.
    Anaesthesia, 2001, Volume: 56, Issue:11

    Topics: Adult; Analgesics; Anesthetics, Local; Bupivacaine; Double-Blind Method; Drug Administration Schedul

2001
The influence of intraperitoneal bupivacaine on pain following major laparoscopic gynaecological procedures.
    Anaesthesia, 2001, Volume: 56, Issue:11

    Topics: Adult; Analgesics; Anesthetics, Local; Bupivacaine; Double-Blind Method; Drug Administration Schedul

2001
The influence of intraperitoneal bupivacaine on pain following major laparoscopic gynaecological procedures.
    Anaesthesia, 2001, Volume: 56, Issue:11

    Topics: Adult; Analgesics; Anesthetics, Local; Bupivacaine; Double-Blind Method; Drug Administration Schedul

2001
The influence of intraperitoneal bupivacaine on pain following major laparoscopic gynaecological procedures.
    Anaesthesia, 2001, Volume: 56, Issue:11

    Topics: Adult; Analgesics; Anesthetics, Local; Bupivacaine; Double-Blind Method; Drug Administration Schedul

2001
The influence of intraperitoneal bupivacaine on pain following major laparoscopic gynaecological procedures.
    Anaesthesia, 2001, Volume: 56, Issue:11

    Topics: Adult; Analgesics; Anesthetics, Local; Bupivacaine; Double-Blind Method; Drug Administration Schedul

2001
The influence of intraperitoneal bupivacaine on pain following major laparoscopic gynaecological procedures.
    Anaesthesia, 2001, Volume: 56, Issue:11

    Topics: Adult; Analgesics; Anesthetics, Local; Bupivacaine; Double-Blind Method; Drug Administration Schedul

2001
The influence of intraperitoneal bupivacaine on pain following major laparoscopic gynaecological procedures.
    Anaesthesia, 2001, Volume: 56, Issue:11

    Topics: Adult; Analgesics; Anesthetics, Local; Bupivacaine; Double-Blind Method; Drug Administration Schedul

2001
The influence of intraperitoneal bupivacaine on pain following major laparoscopic gynaecological procedures.
    Anaesthesia, 2001, Volume: 56, Issue:11

    Topics: Adult; Analgesics; Anesthetics, Local; Bupivacaine; Double-Blind Method; Drug Administration Schedul

2001
The influence of intraperitoneal bupivacaine on pain following major laparoscopic gynaecological procedures.
    Anaesthesia, 2001, Volume: 56, Issue:11

    Topics: Adult; Analgesics; Anesthetics, Local; Bupivacaine; Double-Blind Method; Drug Administration Schedul

2001
The influence of intraperitoneal bupivacaine on pain following major laparoscopic gynaecological procedures.
    Anaesthesia, 2001, Volume: 56, Issue:11

    Topics: Adult; Analgesics; Anesthetics, Local; Bupivacaine; Double-Blind Method; Drug Administration Schedul

2001
The influence of intraperitoneal bupivacaine on pain following major laparoscopic gynaecological procedures.
    Anaesthesia, 2001, Volume: 56, Issue:11

    Topics: Adult; Analgesics; Anesthetics, Local; Bupivacaine; Double-Blind Method; Drug Administration Schedul

2001
The influence of intraperitoneal bupivacaine on pain following major laparoscopic gynaecological procedures.
    Anaesthesia, 2001, Volume: 56, Issue:11

    Topics: Adult; Analgesics; Anesthetics, Local; Bupivacaine; Double-Blind Method; Drug Administration Schedul

2001
The influence of intraperitoneal bupivacaine on pain following major laparoscopic gynaecological procedures.
    Anaesthesia, 2001, Volume: 56, Issue:11

    Topics: Adult; Analgesics; Anesthetics, Local; Bupivacaine; Double-Blind Method; Drug Administration Schedul

2001
The influence of intraperitoneal bupivacaine on pain following major laparoscopic gynaecological procedures.
    Anaesthesia, 2001, Volume: 56, Issue:11

    Topics: Adult; Analgesics; Anesthetics, Local; Bupivacaine; Double-Blind Method; Drug Administration Schedul

2001
The influence of intraperitoneal bupivacaine on pain following major laparoscopic gynaecological procedures.
    Anaesthesia, 2001, Volume: 56, Issue:11

    Topics: Adult; Analgesics; Anesthetics, Local; Bupivacaine; Double-Blind Method; Drug Administration Schedul

2001

Other Studies

4 other studies available for bupivacaine and Adhesions, Tissue

ArticleYear
Histopathological changes in extraocular muscles of rabbits following injection of bupivacaine 5mg/Ml versus 7.5mg/Ml.
    Cutaneous and ocular toxicology, 2022, Volume: 41, Issue:3

    Topics: Bupivacaine; Fibrosis; Humans; Hyperemia; Hypertrophy; Inflammation; Oculomotor Muscles; Strabismus;

2022
The effectiveness of local anesthetics in preventing postoperative adhesions in rat models.
    Techniques in coloproctology, 2010, Volume: 14, Issue:4

    Topics: Anesthetics, Local; Animals; Bupivacaine; Female; Laparotomy; Lidocaine; Models, Animal; Postoperati

2010
[Pleural symphysis with tetracyclines for pneumothorax. The value of thoracic peridural analgesia].
    Revue des maladies respiratoires, 1990, Volume: 7, Issue:2

    Topics: Adult; Analgesia, Epidural; Blood Pressure; Bupivacaine; Female; Fentanyl; Humans; Injections; Male;

1990
[Morphologic and histologic changes caused by continuous peridural analgesia in a cancer patient].
    Regional-Anaesthesie, 1986, Volume: 9, Issue:2

    Topics: Adenocarcinoma; Anesthesia, Epidural; Bupivacaine; Catheters, Indwelling; Colonic Neoplasms; Fentany

1986