bupivacaine and Addiction, Opioid

bupivacaine has been researched along with Addiction, Opioid in 25 studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Research

Studies (25)

Authors

Clinical Trials (11)

Trial Overview

Trial Outcomes

Narcotic Utilization

Record of number of narcotic pain pills utilized by patients . This was reported as a total from post op day 1 to 4. The number listed is an average from each patient, from the total pills taken at home. (NCT04114058)
Timeframe: total pill taken over the course of days 1-4 post op.

Total Number of at Home Falls.

number of falls occurring at home after discharge. This is the total number of falls of all patients in each group, over the first 7 days post op. This is not reported as a mean. (NCT04114058)
Timeframe: Post op days 1-7

Visual Analogue Scale

pain scale Questionnaire 0 equals no pain at all and 10 equals the worst. The out come measure time frame is reported as the average VAS score of the first 4 day post op. (NCT04114058)
Timeframe: post op days 1-4 (Average VAS score of first 4 days of post op)

Urinary Retention

Number of patients who had post-void residual (PVR) >150cc's at voiding trial prior to discharge (NCT03907033)
Timeframe: At voiding trial prior to discharge from hospital, approximately 72 hours

Emesis at 24, 48, and 72 Hours Post-surgery Completion

Number of times the patient vomited (NCT03907033)
Timeframe: 24, 48, and 72 hours post-surgery

Nausea at 24, 48, and 72 Hours Post-surgery Completion

Number of times patient reported feeling nauseous (NCT03907033)
Timeframe: 24, 48, and 72 hours post-surgery

Patient Satisfaction With Pain Management at 72 Hours and 7-10 Days Post Surgery

Assessed on 0-10 scale (0 being worst level of satisfaction, 10 being best level) (NCT03907033)
Timeframe: 72 hours and 7-10 days post surgery

Total Post-surgical Analgesic Medication Use

Participants post-surgical analgesic medication use of Ibuprofen and acetaminophen measured in milligrams (mg) (NCT03907033)
Timeframe: First 72 hours following surgery completion

Total Post-surgical Opioid Medication Use

Participants post-surgical analgesic medication use of IV hydrocodone and oxycodone measured in morphine equivalents (ME) (NCT03907033)
Timeframe: First 72 hours following surgery completion

VAS Pain Score at 24, 48, and 72 Hours Post-surgery Completion

Scale Ranges from 0 (no pain) to 10 (extreme pain) (NCT03907033)
Timeframe: 24, 48, and 72 hours post-surgery completion

Area Under The Curve (AUC) of Visual Analog Scale (VAS) Pain Intensity Scores From 12 to 48 Hours

"AUC of VAS pain intensity scores from 12 to 48 hours, which represents total pain experienced from 12 to 48 hours. Visual Analog Scale (VAS) is a pain scale. The VAS was presented as a straight 10 cm line, where 0 cm is no pain and 10 cm is the worst pain possible. Patients were asked, How much pain are you experiencing right now? Please place a vertical mark on the line below to indicate the level of pain you are experiencing right now." (NCT02713490)
Timeframe: From 12-48 hours

Overall Benefit of Analgesia Score at 48 Hours

"The overall benefit of analgesic score (OBAS) comprises seven questions to assess pain intensity, adverse effects, and patients' satisfaction with analgesia (eg, Please rate your current pain at rest on a scale between 0=minimal pain and 4=maximum imaginable pain). Overall scores ranged between 0- 28. OBAS measures patients' benefit from postoperative pain therapy. A lower composite score indicates greater benefit from the therapy." (NCT02713490)
Timeframe: 48 hours

Percentage of Opioid-free Subjects at 48 Hours

(NCT02713490)
Timeframe: 48 hours

Total Postsurgical Opioid Consumption Through 48 Hours

Total postsurgical opioid consumption (converted to oral morphine equivalents) through 48 hours (NCT02713490)
Timeframe: 0-48 hours

Time to First Opioid Rescue in the First 48 Hours

Time to first opioid rescue was estimated from Kaplan-Meier analysis and presented as quartiles (ie, time to rescue for the first 25% / 50% / 75% of subjects within each treatment group). (NCT02713490)
Timeframe: 48 hours

Hospital Readmission

Readmission to hospital will be noted (NCT03270514)
Timeframe: From end of surgery assessed up to 30 days post-operatively

Mortality

Mortality will be noted at specific timepoints (NCT03270514)
Timeframe: From end of surgery assessed up to 30 days post-operatively

Non-invasive Ventilation (NIV) Requirement

Episodes of NIV such as upper airway masks or similar devices will be quantified (NCT03270514)
Timeframe: From time of end of surgery to 72 hours post-operatively or until hospital discharge

Patient Satisfaction

Patient will give an assessment regarding pain management on a scale of 0 - 10 with 0 indicating the lowest satisfaction with pain management and 10 indicating the highest satisfaction with pain management (NCT03270514)
Timeframe: Given at the time of discharge up to 30 days post-operatively

Patient Time to Mobilization

The time it takes until patient ambulates will be measured (NCT03270514)
Timeframe: From time of end of surgery to time of mobilization up to 72 hours or discharge, *assessed up to 120 hours*

Patient Time to Oral Intake

The time it takes until the patient is able to/medically cleared to consume food or liquid will be measured (NCT03270514)
Timeframe: From time of end of surgery to time of oral intake up to 72 hours post-operatively or until hospital discharge

Patient Time to Out of Bed to Chair

The time it takes until the patient advances from bedrest to out of bed (OOB) to chair will be measured (NCT03270514)
Timeframe: From time of end of surgery to time of mobilization up to 72 hours post-operatively

Post-operative Nausea and Vomiting

Whether a patient experiences at least one episode of nausea and emesis will be measured (NCT03270514)
Timeframe: From time of end of surgery to 72 hours post-operatively

Re-intubation

Instances of re-intubation will be recorded (NCT03270514)
Timeframe: From time of end of surgery to patient discharge up to one week

Time to Extubation

The time it takes until the patient is extubated post-operatively will be measured (NCT03270514)
Timeframe: From the end of surgery until the patient is extubated up to 72 hours post-operatively

Use of Incentive Spirometry

Frequency of incentive spirometry will be measured (NCT03270514)
Timeframe: From time of end of surgery to 72 hours post-operatively

Length of Hospital and ICU Stay

Length of both hospital and ICU stay will be measured (NCT03270514)
Timeframe: From date of surgery assessed up to 30 day post-operatively

Post-operative Pain Intensity

Postoperative pain scores evaluated by numeric rating scale or (NRS) where 0- no pain and 10- worst pain, at rest and at movement (NCT03270514)
Timeframe: NRS scores will be evaluated every 4 hours until 24 hours post-operatively, every 8 hours until 48 hours post-operatively, and every 12 hours for 72 hours post-operatively

Serum Cortisol Levels

Stress response suppression as a result of treatment will be evaluated by comparing hormone levels between the groups. Serum cortisol levels will be taken to measure this. (NCT03270514)
Timeframe: Measured 8, 48, and 72 hours post-operatively

Total Narcotic Consumption

All narcotics administered in the first 0-8, 8-24, 24-48, and 48-72 hours and the total narcotics administered in the 0-72 hours postoperative period(PCA narcotics, nurse-administered IV narcotics, and oral narcotics). All narcotics will be converted to total IV morphine equivalent for comparison between two groups. (NCT03270514)
Timeframe: 0-72 hours post-operative period

Trials

10 trials available for bupivacaine and Addiction, Opioid

Other Studies

15 other studies available for bupivacaine and Addiction, Opioid