bupivacaine has been researched along with Acute Pain in 16 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Acute Pain: Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, character, and timing.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We induced peritonitis in rats using carrageenan and measured cellular activation in spinal cord and NTS under the following conditions, that is, a parietal nerve block with bupivacaine, a chemical right vagotomy, and i." | 8.02 | Acute Visceral Pain in Rats: Vagal Nerve Block Compared to Bupivacaine Administered Intramuscularly. ( Ben Rehouma, M; Benhamou, D; Bouchouareb, M; Hamdi, L; Kfoury, T; Mazoit, JX; Soued, M, 2021) |
| "Furthermore, acute postoperative pain is an important risk factor for chronic postsurgical pain." | 6.87 | Preperitoneal Bupivacaine Infiltration Reduces Postoperative Opioid Consumption, Acute Pain, and Chronic Postsurgical Pain After Bariatric Surgery: a Randomized Controlled Trial. ( Aarts, EO; Boerboom, SL; de Haes, A; Geurts, JW; Janssen, IMC; Kamphuis, ET; Vd Wetering, L, 2018) |
| "Both ESB and PVB were effective in controlling acute pain and persistent herpetic pain after 6 months (which was evident by lower NRS for pain and doses of pregabalin and acetaminophen), but ESB is safer (no reported pneumothorax and hypotension)." | 5.51 | Ultrasound-Guided Erector Spinae Block Versus Ultrasound-Guided Thoracic Paravertebral Block for Pain Relief in Patients With Acute Thoracic Herpes Zoster: A Randomized Controlled Trial. ( Abdelwahab, EH; Afandy, ME; Fattooh, NH; Hodeib, AA; Marof, HM, 2022) |
| " Five RCTs suggest that both benzocaine 10% and 20% may increase the number of people experiencing pain reduction compared with placebo when managing acute irreversible pulpitis (low certainty)." | 5.41 | Injectable and topical local anesthetics for acute dental pain: 2 systematic reviews. ( Azab, M; Brignardello-Petersen, R; Carrasco-Labra, A; Diaz Martinez, JP; He, L; Hersh, EV; Ibrahim, S; Miroshnychenko, A; Moore, PA; Polk, DE; Roldan, Y; Tamilselvan, D; Tampi, M; Urquhart, O, 2023) |
| "We induced peritonitis in rats using carrageenan and measured cellular activation in spinal cord and NTS under the following conditions, that is, a parietal nerve block with bupivacaine, a chemical right vagotomy, and i." | 4.02 | Acute Visceral Pain in Rats: Vagal Nerve Block Compared to Bupivacaine Administered Intramuscularly. ( Ben Rehouma, M; Benhamou, D; Bouchouareb, M; Hamdi, L; Kfoury, T; Mazoit, JX; Soued, M, 2021) |
| " Prespecified key secondary outcomes included SPI48 and SPI72, percentage of opioid-free patients through 24, 48, and 72 hours, and adverse events, which were tested sequentially to control for multiplicity (ie, if the first variable failed to reach significance, no subsequent variables were declared statistically significant)." | 3.30 | A randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of a bupivacaine hydrochloride implant in patients undergoing abdominoplasty. ( Beaton, AC; Folkerth, S; Leiman, D; Minkowitz, HS; Niebler, G; Salazar, H; Singla, N; Skuban, N; Solanki, D; Vaughn, B, 2023) |
| "Furthermore, acute postoperative pain is an important risk factor for chronic postsurgical pain." | 2.87 | Preperitoneal Bupivacaine Infiltration Reduces Postoperative Opioid Consumption, Acute Pain, and Chronic Postsurgical Pain After Bariatric Surgery: a Randomized Controlled Trial. ( Aarts, EO; Boerboom, SL; de Haes, A; Geurts, JW; Janssen, IMC; Kamphuis, ET; Vd Wetering, L, 2018) |
| "The frequency of neuropathic pain was assessed using the Douleur Neuropathique 4-question survey (DN4) in the first and second postoperative months." | 2.78 | Effect of the addition of clonidine to locally administered bupivacaine on acute and chronic postmastectomy pain. ( Abdel-Ghaffar, HS; Mohamed, SA, 2013) |
| "Ketamine is an effective and safe multimodal analgesic in patients undergoing breast surgery, administered both intravenously and when added to bupivacaine in paravertebral blocks." | 2.72 | The Effect of Ketamine on Acute and Chronic Wound Pain in Patients Undergoing Breast Surgery: A Meta-Analysis and Systematic Review. ( Bi, Y; Liu, B; Ma, J; Ye, Y; Zhang, X; Zhu, Y, 2021) |
| "The outcomes observed were migraine pain before and after administration within the same initial encounter of receiving an occipital nerve block using a numeric pain rating scale, injection direction, medications used, duration of effect and frequency of additional injections, and adverse reactions." | 1.56 | Evaluation of Occipital Nerve Blocks for Acute Pain Relief of Migraines. ( Dang, T; Ebied, AM; Nguyen, DT, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (43.75) | 24.3611 |
| 2020's | 9 (56.25) | 2.80 |
| Authors | Studies |
|---|---|
| Abdelwahab, EH | 1 |
| Hodeib, AA | 1 |
| Marof, HM | 1 |
| Fattooh, NH | 1 |
| Afandy, ME | 1 |
| Miroshnychenko, A | 1 |
| Ibrahim, S | 1 |
| Azab, M | 1 |
| Roldan, Y | 1 |
| Diaz Martinez, JP | 1 |
| Tamilselvan, D | 1 |
| He, L | 1 |
| Urquhart, O | 1 |
| Tampi, M | 1 |
| Polk, DE | 1 |
| Moore, PA | 1 |
| Hersh, EV | 1 |
| Carrasco-Labra, A | 1 |
| Brignardello-Petersen, R | 1 |
| Beaton, AC | 1 |
| Solanki, D | 1 |
| Salazar, H | 1 |
| Folkerth, S | 1 |
| Singla, N | 1 |
| Minkowitz, HS | 1 |
| Leiman, D | 1 |
| Vaughn, B | 1 |
| Skuban, N | 1 |
| Niebler, G | 1 |
| Zengin, EN | 1 |
| Zengin, M | 1 |
| Yiğit, H | 1 |
| Sazak, H | 1 |
| Şekerci, S | 1 |
| Alagöz, A | 1 |
| Ratnasekara, V | 1 |
| Weinberg, L | 1 |
| Johnston, SA | 1 |
| Fletcher, L | 1 |
| Nugraha, P | 1 |
| Cox, DRA | 1 |
| Hu, R | 1 |
| Meyer, I | 1 |
| Yoshino, O | 1 |
| Perini, MV | 1 |
| Muralidharan, V | 1 |
| Nikfarjam, M | 1 |
| Lee, DK | 1 |
| Ebied, AM | 1 |
| Nguyen, DT | 1 |
| Dang, T | 1 |
| Bi, Y | 1 |
| Ye, Y | 1 |
| Zhu, Y | 1 |
| Ma, J | 1 |
| Zhang, X | 1 |
| Liu, B | 1 |
| Cinar, HU | 1 |
| Celik, HK | 1 |
| Celik, B | 1 |
| Ben Rehouma, M | 1 |
| Kfoury, T | 1 |
| Hamdi, L | 1 |
| Bouchouareb, M | 1 |
| Soued, M | 1 |
| Benhamou, D | 1 |
| Mazoit, JX | 1 |
| Boerboom, SL | 1 |
| de Haes, A | 1 |
| Vd Wetering, L | 1 |
| Aarts, EO | 1 |
| Janssen, IMC | 1 |
| Geurts, JW | 1 |
| Kamphuis, ET | 1 |
| Koning, MV | 1 |
| Veerkamp, RAM | 1 |
| Calder, K | 1 |
| Chung, B | 1 |
| O'Brien, C | 1 |
| Lalonde, DH | 1 |
| Wang, L | 1 |
| Bauer, M | 1 |
| Curry, R | 1 |
| Larsson, A | 1 |
| Sessler, DI | 1 |
| Eisenach, JC | 1 |
| Yamamoto, T | 1 |
| Frenkel, O | 1 |
| Mansour, K | 1 |
| Fischer, JW | 1 |
| Mohamed, SA | 1 |
| Abdel-Ghaffar, HS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Use of Long-acting Local Analgesia in Bariatrics: A Randomized Controlled Trial[NCT03975283] | Phase 4 | 80 participants (Anticipated) | Interventional | 2019-08-31 | Not yet recruiting | ||
| Efficacy of Combined Periportal and Preperitoneal Local Anesthetic Infiltration (CPPLAI) in Laparoscopic Sleeve Gastrectomy Patients[NCT04680923] | 120 participants (Actual) | Interventional | 2020-12-08 | Completed | |||
| Effect of Intrathecal Ketorolac on Mechanical Hypersensitivity After Total Hip Arthroplasty[NCT00621530] | Phase 2 | 62 participants (Actual) | Interventional | 2008-03-31 | Terminated (stopped due to Terminated due to discontinuation of Acular PF (investigational medication)) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Hyperalgesia (using a von Frey filament) and allodynia (using a cotton swab) were evaluated around the surgical site 48 hours after surgery. (NCT00621530)
Timeframe: 48 hours
| Intervention | area in centimeters squared (Median) |
|---|---|
| Ketorolac | 0 |
| Placebo | 0 |
Pain was assessed 2 days, and 2 and 6 months after surgery using a validated questionnaire wherein subjects rate the degree to which adjectives describe the emotional component of their pain experience. This is termed the McGill Pain Affective Score and is scored from 0 to 12 with 12 being the highest pain emotional impact. (NCT00621530)
Timeframe: 6 months
| Intervention | units on a scale (Mean) | ||
|---|---|---|---|
| Postoperative: 2 days | Postoperative: 2 months | Postoperative: 6 months | |
| Ketorolac | 2.3 | 0.4 | 0.1 |
| Placebo | 2.3 | 0.5 | 0.4 |
Pain was assessed 2 days and 2 and 6 months after surgery using a validated questionnaire wherein subjects rate the degree to which adjectives describe the intensity of their pain experience. This is termed the McGill Pain Intensity Score and is scored from 0 to 33 with 33 being the highest pain intensity. (NCT00621530)
Timeframe: 6 months
| Intervention | units on a scale (Mean) | ||
|---|---|---|---|
| Postoperative: 2 days | Postoperative: 2 months | Postoperative: 6 months | |
| Ketorolac | 11 | 2.3 | 1.4 |
| Placebo | 10 | 3.1 | 1.2 |
Pain was assessed 2 days, and 2 and 6 months after surgery using a validated questionnaire to assess the degree of neuropathic characteristics of pain. This is termed the Neuropathic Pain Symptom Inventory which is scored 0-100 with 100 being the worst possible pain. (NCT00621530)
Timeframe: 6 months
| Intervention | units on a scale (Mean) | ||
|---|---|---|---|
| Postoperative: 2 days | Postoperative: 2 months | Postoperative: 6 months | |
| Ketorolac | 13 | 2.9 | 2.4 |
| Placebo | 21 | 4.5 | 1.4 |
Pain was assessed preoperatively, 2 days, and 2 and 6 months after surgery using a 0-10 (10 being worse) verbal Present Pain Intensity (PPI) scale (NCT00621530)
Timeframe: 6 months
| Intervention | units on a scale (Mean) | |||
|---|---|---|---|---|
| Preoperative | Postoperative: 2 days | Postoperative: 2 months | Postoperative: 6 months | |
| Ketorolac | 1.7 | 2.1 | 0.6 | 0.4 |
| Placebo | 1.6 | 2.5 | 0.2 | 0.1 |
2 reviews available for bupivacaine and Acute Pain
| Article | Year |
|---|---|
Injectable and topical local anesthetics for acute dental pain: 2 systematic reviews.
Topics: Acute Pain; Anesthesia, Local; Anesthetics, Local; Benzocaine; Bupivacaine; Epinephrine; Humans; Lid | 2023 |
The Effect of Ketamine on Acute and Chronic Wound Pain in Patients Undergoing Breast Surgery: A Meta-Analysis and Systematic Review.
Topics: Acute Pain; Analgesics; Analgesics, Opioid; Breast Neoplasms; Bupivacaine; Chronic Pain; Female; Hum | 2021 |
7 trials available for bupivacaine and Acute Pain
| Article | Year |
|---|---|
Ultrasound-Guided Erector Spinae Block Versus Ultrasound-Guided Thoracic Paravertebral Block for Pain Relief in Patients With Acute Thoracic Herpes Zoster: A Randomized Controlled Trial.
Topics: Acetaminophen; Acute Pain; Antiviral Agents; Bupivacaine; Dexamethasone; Herpes Zoster; Humans; Midd | 2022 |
A randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of a bupivacaine hydrochloride implant in patients undergoing abdominoplasty.
Topics: Abdominoplasty; Acute Pain; Adult; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Double-Blind | 2023 |
Comparison of the effects of one-level and bi-level pre-incisional erector spinae plane block on postoperative acute pain in video-assisted thoracoscopic surgery; a prospective, randomized, double-blind trial.
Topics: Acute Pain; Analgesia, Patient-Controlled; Analgesics, Opioid; Bupivacaine; Cough; Drug-Related Side | 2023 |
Preperitoneal Bupivacaine Infiltration Reduces Postoperative Opioid Consumption, Acute Pain, and Chronic Postsurgical Pain After Bariatric Surgery: a Randomized Controlled Trial.
Topics: Acute Pain; Adult; Analgesics, Opioid; Anesthetics, Local; Bariatric Surgery; Bupivacaine; Humans; O | 2018 |
Preperitoneal Bupivacaine Infiltration Reduces Postoperative Opioid Consumption, Acute Pain, and Chronic Postsurgical Pain After Bariatric Surgery: a Randomized Controlled Trial.
Topics: Acute Pain; Adult; Analgesics, Opioid; Anesthetics, Local; Bariatric Surgery; Bupivacaine; Humans; O | 2018 |
Preperitoneal Bupivacaine Infiltration Reduces Postoperative Opioid Consumption, Acute Pain, and Chronic Postsurgical Pain After Bariatric Surgery: a Randomized Controlled Trial.
Topics: Acute Pain; Adult; Analgesics, Opioid; Anesthetics, Local; Bariatric Surgery; Bupivacaine; Humans; O | 2018 |
Preperitoneal Bupivacaine Infiltration Reduces Postoperative Opioid Consumption, Acute Pain, and Chronic Postsurgical Pain After Bariatric Surgery: a Randomized Controlled Trial.
Topics: Acute Pain; Adult; Analgesics, Opioid; Anesthetics, Local; Bariatric Surgery; Bupivacaine; Humans; O | 2018 |
Bupivacaine digital blocks: how long is the pain relief and temperature elevation?
Topics: Acute Pain; Adult; Anesthetics, Local; Body Temperature; Bupivacaine; Epinephrine; Female; Fingers; | 2013 |
Intrathecal ketorolac does not improve acute or chronic pain after hip arthroplasty: a randomized controlled trial.
Topics: Acute Pain; Anesthesia, Spinal; Arthroplasty, Replacement, Hip; Bupivacaine; Chronic Pain; Double-Bl | 2014 |
Effect of the addition of clonidine to locally administered bupivacaine on acute and chronic postmastectomy pain.
Topics: Acute Pain; Administration, Topical; Adult; Analgesics; Anesthetics, Local; Breast Neoplasms; Bupiva | 2013 |
7 other studies available for bupivacaine and Acute Pain
| Article | Year |
|---|---|
Multimodal intrathecal analgesia (MITA) with morphine for reducing postoperative opioid use and acute pain following hepato-pancreato-biliary surgery: A multicenter retrospective study.
Topics: Acute Pain; Analgesia; Analgesics, Opioid; Bupivacaine; Clonidine; Humans; Morphine; Opioid-Related | 2023 |
Evaluation of Occipital Nerve Blocks for Acute Pain Relief of Migraines.
Topics: Acute Pain; Adult; Aged; Anesthetics, Local; Bupivacaine; Dexamethasone; Female; Florida; Glucocorti | 2020 |
The efficacy of the ON-Q elastomeric pump system in post-thoracotomy acute pain control.
Topics: Acute Pain; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Humans; Pain Management; Pain, Post | 2021 |
Acute Visceral Pain in Rats: Vagal Nerve Block Compared to Bupivacaine Administered Intramuscularly.
Topics: Acute Pain; Anesthetics, Local; Animals; Bupivacaine; Carrageenan; CD11b Antigen; Disease Models, An | 2021 |
Dual epidural catheters for acute pain management of a patient with rib and tibial plateau fractures.
Topics: Acute Pain; Analgesia, Epidural; Anesthetics, Local; Bupivacaine; Catheters; Fracture Fixation, Inte | 2019 |
When will we get a new class of analgesic agent based on animal study data?
Topics: Acute Pain; Bupivacaine; Chronic Pain; Humans; Ketorolac | 2014 |
Ultrasound-guided femoral nerve block for pain control in an infant with a femur fracture due to nonaccidental trauma.
Topics: Acute Pain; Analgesia; Anesthetics, Local; Bupivacaine; Child Abuse; Combined Modality Therapy; Fema | 2012 |