bupivacaine has been researched along with Acidosis in 25 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Acidosis: A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We studied the incidence of material hypotension with spinal bupivacaine or levobupivacaine (L-bupivacaine) and the spread after epidural saline injection." | 9.14 | [Maternal hypotension with low doses of spinal bupivacaine or levobupivacaine and epidural volume expansion with saline for cesarean section]. ( Alsina, E; Díez, J; Gilsanz, F; Guasch, E, 2010) |
| "In this animal study pretreatment with bupivacaine attenuated the progression of myocardial acidosis during ventricular fibrillation." | 7.72 | The effect of bupivacaine on myocardial tissue hypoxia and acidosis during ventricular fibrillation. ( Feinstein, D; Hoffman, W; Paisanthasan, C; Weinberg, G, 2004) |
| "The effects of lactic acidosis on bupivacaine serum protein binding was studied in a group of term parturients and a group of nonpregnant female control subjects." | 7.67 | Bupivacaine protein binding in the term parturient: effects of lactic acidosis. ( Coyle, DE; Denson, DD; Knapp, R; Myers, JA; Santos, D; Thompson, GA; Turner, PA, 1984) |
| "To test the hypothesis that acidosis can increase the toxicity of bupivacaine more than that of lidocaine by increasing the distribution into the brain, myocardium, or both, studies were performed to measure the in vivo tissue:blood partition coefficients during continuous steady state intravenous infusions of these agents in anesthetized sheep during normal acid-base status and during combined respiratory-metabolic acidosis." | 7.67 | The influence of acidosis on the distribution of lidocaine and bupivacaine into the myocardium and brain of the sheep. ( Mather, LE; Nancarrow, C; Plummer, JL; Runciman, WB; Upton, RN, 1987) |
| " The aim of this study was to compare the effects of lidocaine and bupivacaine on the intrinsic pacemaker activity of in vitro sinoatrial nodal cells of the adult and neonatal guinea pig in the presence and absence of hypoxia and acidosis." | 7.67 | Comparison of lidocaine and bupivacaine depression of sinoatrial nodal activity during hypoxia and acidosis in adult and neonatal guinea pigs. ( Bosnjak, ZJ; Kampine, JP; Stowe, DF, 1986) |
| " Therefore, tissue acidosis may result in ionization and "trapping" of the basic local anaesthetics The following study was done in the pregnant ewe to determine if the highly protein-bound local anaesthetic bupivacaine demonstrates ion-trapping in the acidotic foetus." | 7.66 | The effect of foetal acidosis on bupivacaine levels in utero. ( Biehl, D; Meatherall, R; Pickering, B, 1981) |
| "We report a patient with chronic renal failure and ischemic heart disease who developed clinically significant methemoglobinemia after an axillary block with bupivacaine and additional injection of lidocaine in the operative field." | 5.30 | Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field. ( Dieterich, HJ; Mühlbauer, B; Schroeder, TH, 1999) |
| " We studied the incidence of material hypotension with spinal bupivacaine or levobupivacaine (L-bupivacaine) and the spread after epidural saline injection." | 5.14 | [Maternal hypotension with low doses of spinal bupivacaine or levobupivacaine and epidural volume expansion with saline for cesarean section]. ( Alsina, E; Díez, J; Gilsanz, F; Guasch, E, 2010) |
| "In this animal study pretreatment with bupivacaine attenuated the progression of myocardial acidosis during ventricular fibrillation." | 3.72 | The effect of bupivacaine on myocardial tissue hypoxia and acidosis during ventricular fibrillation. ( Feinstein, D; Hoffman, W; Paisanthasan, C; Weinberg, G, 2004) |
| " Since a mixed acidosis results during a systemic toxicity reaction to bupivacaine, the influences of an acidic pH, resulting from the addition of lactic acid, also was examined." | 3.67 | The influence of lactic acid on the serum protein binding of bupivacaine: species differences. ( Arthur, GR; Bridenbaugh, PO; Coyle, DE; Denson, DD; Myers, JA; Thompson, GA, 1984) |
| "The effects of lactic acidosis on bupivacaine serum protein binding was studied in a group of term parturients and a group of nonpregnant female control subjects." | 3.67 | Bupivacaine protein binding in the term parturient: effects of lactic acidosis. ( Coyle, DE; Denson, DD; Knapp, R; Myers, JA; Santos, D; Thompson, GA; Turner, PA, 1984) |
| "To test the hypothesis that acidosis can increase the toxicity of bupivacaine more than that of lidocaine by increasing the distribution into the brain, myocardium, or both, studies were performed to measure the in vivo tissue:blood partition coefficients during continuous steady state intravenous infusions of these agents in anesthetized sheep during normal acid-base status and during combined respiratory-metabolic acidosis." | 3.67 | The influence of acidosis on the distribution of lidocaine and bupivacaine into the myocardium and brain of the sheep. ( Mather, LE; Nancarrow, C; Plummer, JL; Runciman, WB; Upton, RN, 1987) |
| " The aim of this study was to compare the effects of lidocaine and bupivacaine on the intrinsic pacemaker activity of in vitro sinoatrial nodal cells of the adult and neonatal guinea pig in the presence and absence of hypoxia and acidosis." | 3.67 | Comparison of lidocaine and bupivacaine depression of sinoatrial nodal activity during hypoxia and acidosis in adult and neonatal guinea pigs. ( Bosnjak, ZJ; Kampine, JP; Stowe, DF, 1986) |
| "Bradycardia and hypotension were the first major signs of toxicity from a 250 mg bupivacaine axillary brachial plexus block experienced by a patient with chronic renal failure, who had an anion gap acidosis and hyperkalaemia." | 3.66 | Bupivacaine cardiotoxicity in a patient with renal failure. ( Aldrete, JA; Gould, DB, 1983) |
| " Therefore, tissue acidosis may result in ionization and "trapping" of the basic local anaesthetics The following study was done in the pregnant ewe to determine if the highly protein-bound local anaesthetic bupivacaine demonstrates ion-trapping in the acidotic foetus." | 3.66 | The effect of foetal acidosis on bupivacaine levels in utero. ( Biehl, D; Meatherall, R; Pickering, B, 1981) |
| "We report a patient with chronic renal failure and ischemic heart disease who developed clinically significant methemoglobinemia after an axillary block with bupivacaine and additional injection of lidocaine in the operative field." | 1.30 | Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field. ( Dieterich, HJ; Mühlbauer, B; Schroeder, TH, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (56.00) | 18.7374 |
| 1990's | 4 (16.00) | 18.2507 |
| 2000's | 5 (20.00) | 29.6817 |
| 2010's | 2 (8.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Heinonen, JA | 1 |
| Skrifvars, MB | 1 |
| Haasio, J | 1 |
| Backman, JT | 1 |
| Rosenberg, PH | 1 |
| Litonius, E | 1 |
| Guasch, E | 1 |
| Gilsanz, F | 1 |
| Díez, J | 1 |
| Alsina, E | 1 |
| Punke, MA | 1 |
| Licher, T | 1 |
| Pongs, O | 1 |
| Friederich, P | 1 |
| Weinberg, G | 1 |
| Paisanthasan, C | 1 |
| Feinstein, D | 1 |
| Hoffman, W | 1 |
| Coleman, LS | 1 |
| Cooper, DW | 1 |
| Gibb, SC | 1 |
| Meek, T | 1 |
| Owen, S | 1 |
| Kokri, MS | 1 |
| Malik, AT | 1 |
| Koneti, KK | 1 |
| Coyle, DE | 3 |
| Denson, DD | 3 |
| Thompson, GA | 3 |
| Myers, JA | 3 |
| Arthur, GR | 2 |
| Bridenbaugh, PO | 1 |
| Sage, DJ | 1 |
| Feldman, HS | 1 |
| Datta, S | 1 |
| Ferretti, AM | 1 |
| Norway, SB | 1 |
| Covino, BG | 2 |
| Santos, D | 1 |
| Turner, PA | 1 |
| Knapp, R | 1 |
| Moore, DC | 2 |
| Crawford, RD | 2 |
| Scurlock, JE | 1 |
| Gould, DB | 1 |
| Aldrete, JA | 1 |
| Thompson, GE | 1 |
| Pickering, B | 1 |
| Biehl, D | 1 |
| Meatherall, R | 1 |
| Weinberg, GL | 1 |
| Laurito, CE | 1 |
| Geldner, P | 1 |
| Pygon, BH | 1 |
| Burton, BK | 1 |
| Väisänen, O | 1 |
| Parviainen, I | 1 |
| Ruokonen, E | 1 |
| Hippeläinen, M | 1 |
| Berg, E | 1 |
| Hendolin, H | 1 |
| Takala, J | 1 |
| Schroeder, TH | 1 |
| Dieterich, HJ | 1 |
| Mühlbauer, B | 1 |
| Buckler, KJ | 1 |
| Williams, BA | 1 |
| Honore, E | 1 |
| Palazzo, MG | 1 |
| Kalso, EA | 1 |
| Argiras, E | 1 |
| Madgwick, R | 1 |
| Sear, JW | 1 |
| Nancarrow, C | 1 |
| Runciman, WB | 1 |
| Mather, LE | 1 |
| Upton, RN | 1 |
| Plummer, JL | 1 |
| Bosnjak, ZJ | 1 |
| Stowe, DF | 1 |
| Kampine, JP | 1 |
| Sjöstrand, U | 1 |
| Widman, B | 1 |
| Thalme, B | 1 |
| Belfrage, P | 1 |
| Raabe, N | 1 |
| Hickl, EJ | 1 |
| Gennser, G | 1 |
1 review available for bupivacaine and Acidosis
| Article | Year |
|---|---|
Recent advances in local anaesthesia.
Topics: Acidosis; Anesthesia, Local; Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Cardiov | 1986 |
3 trials available for bupivacaine and Acidosis
| Article | Year |
|---|---|
[Maternal hypotension with low doses of spinal bupivacaine or levobupivacaine and epidural volume expansion with saline for cesarean section].
Topics: Acidosis; Adult; Analgesia, Epidural; Analgesia, Obstetrical; Anesthesia, Epidural; Anesthetics, Loc | 2010 |
Effect of intravenous vasopressor on spread of spinal anaesthesia and fetal acid-base equilibrium.
Topics: Acid-Base Equilibrium; Acidosis; Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Lo | 2007 |
Epidural analgesia with bupivacaine does not improve splanchnic tissue perfusion after aortic reconstruction surgery.
Topics: Acidosis; Aged; Analgesia, Epidural; Anesthetics, Local; Aorta, Abdominal; Aortic Diseases; Bupivaca | 1998 |
21 other studies available for bupivacaine and Acidosis
| Article | Year |
|---|---|
Intravenous lipid emulsion for levobupivacaine intoxication in acidotic and hypoxaemic pigs.
Topics: Acidosis; Anesthetics, Local; Animals; Bupivacaine; Carbon Dioxide; Electrocardiography; Fat Emulsio | 2016 |
Inhibition of human TREK-1 channels by bupivacaine.
Topics: Acidosis; Anesthetics, Local; Animals; Bicarbonates; Buffers; Bupivacaine; CHO Cells; Cricetinae; El | 2003 |
The effect of bupivacaine on myocardial tissue hypoxia and acidosis during ventricular fibrillation.
Topics: Acidosis; Anesthetics, Local; Animals; Blood Gas Analysis; Blood Pressure; Bupivacaine; Carbon Dioxi | 2004 |
Bupivacaine and ventricular fibrillation.
Topics: Acidosis; Anesthetics, Local; Bupivacaine; Humans; Microcirculation; Myocardium; Ventricular Fibrill | 2004 |
The influence of lactic acid on the serum protein binding of bupivacaine: species differences.
Topics: Acidosis; Animals; Binding Sites; Blood Proteins; Bupivacaine; Dogs; Female; Haplorhini; Humans; Hyd | 1984 |
The influence of diazepam on the serum protein binding of bupivacaine at normal and acidic pH.
Topics: Acidosis; Bupivacaine; Chromatography, Gas; Diazepam; Drug Interactions; Female; Half-Life; Humans; | 1984 |
Influence of lidocaine and bupivacaine on isolated guinea pig atria in the presence of acidosis and hypoxia.
Topics: Acidosis; Animals; Bupivacaine; Guinea Pigs; Heart Atria; Heart Rate; Hypoxia; In Vitro Techniques; | 1984 |
Bupivacaine protein binding in the term parturient: effects of lactic acidosis.
Topics: Absorption; Acidosis; Adult; Bupivacaine; Female; Humans; Kinetics; Lactates; Orosomucoid; Pregnancy | 1984 |
Severe hypoxia and acidosis following local anesthetic-induced convulsions.
Topics: Acidosis; Adolescent; Adult; Anesthesia, Local; Blood; Bupivacaine; Carbon Dioxide; Female; Humans; | 1980 |
Bupivacaine cardiotoxicity in a patient with renal failure.
Topics: Acidosis; Brachial Plexus; Bradycardia; Bupivacaine; Heart; Humans; Hyperkalemia; Hypotension; Kidne | 1983 |
Long-acting local anesthetic drugs and convulsions with hypoxia and acidosis.
Topics: Acidosis; Adult; Anesthetics, Local; Bupivacaine; Female; Humans; Hypoxia; Middle Aged; Seizures | 1982 |
The effect of foetal acidosis on bupivacaine levels in utero.
Topics: Acidosis; Animals; Bupivacaine; Female; Fetal Diseases; Hemodynamics; Humans; Hydrogen-Ion Concentra | 1981 |
Malignant ventricular dysrhythmias in a patient with isovaleric acidemia receiving general and local anesthesia for suction lipectomy.
Topics: Acidosis; Adolescent; Anesthesia, General; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Carni | 1997 |
Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field.
Topics: Acidosis; Alkalies; Anesthetics, Local; Antidotes; Axilla; Bupivacaine; Drug Interactions; Female; H | 1999 |
An oxygen-, acid- and anaesthetic-sensitive TASK-like background potassium channel in rat arterial chemoreceptor cells.
Topics: Acidosis; Anesthetics; Animals; Barium; Bupivacaine; Carotid Arteries; Cells, Cultured; Chemorecepto | 2000 |
First pass lung uptake of bupivacaine: effect of acidosis in an intact rabbit lung model.
Topics: Acidosis; Animals; Biotransformation; Bupivacaine; Cardiac Output; Lung; Models, Biological; Rabbits | 1991 |
The influence of acidosis on the distribution of lidocaine and bupivacaine into the myocardium and brain of the sheep.
Topics: Acidosis; Acidosis, Respiratory; Animals; Brain; Bupivacaine; Female; Hydrogen-Ion Concentration; Li | 1987 |
Comparison of lidocaine and bupivacaine depression of sinoatrial nodal activity during hypoxia and acidosis in adult and neonatal guinea pigs.
Topics: Acidosis; Action Potentials; Age Factors; Animals; Animals, Newborn; Bupivacaine; Depression, Chemic | 1986 |
Distribution of bupivacaine in the rabbit under normal and acidotic conditions.
Topics: Acidosis; Anesthesia, Inhalation; Animals; Bile; Blood; Blood Volume; Bupivacaine; Chromatography, T | 1973 |
Lumbar epidural analgesia in labour. I. Acid-base balance and clinical condition of mother, fetus and newborn child.
Topics: Acidosis; Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Blood; Body Temperature; Bradycardia | 1974 |
[The effect of paracervical block on the fetus].
Topics: Acidosis; Anesthesia, Conduction; Anesthesia, Obstetrical; Anesthetics, Local; Asphyxia Neonatorum; | 1972 |