bupivacaine has been researched along with ACL Injuries in 16 studies
Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.
Excerpt | Relevance | Reference |
---|---|---|
"This requires a patient friendly postoperative pain management." | 2.73 | Pre- versus postoperative intraarticular application of local anesthetics and opioids versus femoral nerve block in anterior cruciate ligament repair. ( Entholzner, E; Hein, W; Hube, R; Mayr, HO; Weig, TG, 2007) |
"Clonidine has been shown to prolong sensory analgesia when given as an adjunct to peripheral nerve blocks but has not been evaluated when given in conjunction with a femoral-sciatic nerve block." | 2.71 | The addition of clonidine to bupivacaine in combined femoral-sciatic nerve block for anterior cruciate ligament reconstruction. ( Couture, DJ; Cuniff, HM; Maye, JP; Pellegrini, J, 2004) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 3 (18.75) | 18.2507 |
2000's | 7 (43.75) | 29.6817 |
2010's | 3 (18.75) | 24.3611 |
2020's | 3 (18.75) | 2.80 |
Authors | Studies |
---|---|
Aldrich, LA | 1 |
Upchurch, DA | 1 |
Roush, JK | 1 |
Scaglione, J | 1 |
Carver, J | 1 |
Reader, B | 1 |
Barletta, M | 1 |
Kleine, S | 1 |
Astur, DC | 1 |
Aleluia, V | 1 |
Veronese, C | 1 |
Astur, N | 1 |
Oliveira, SG | 1 |
Arliani, GG | 1 |
Badra, R | 1 |
Kaleka, CC | 1 |
Amaro, JT | 1 |
Cohen, M | 1 |
Schuster, M | 1 |
Engelhardt, L | 1 |
Erler, W | 1 |
Dienert, B | 1 |
Wagner, M | 1 |
Birnbaum, J | 1 |
Volk, T | 1 |
Yari, M | 1 |
Saeb, M | 1 |
Golfam, P | 1 |
Makhloogh, Z | 1 |
Alford, JW | 1 |
Fadale, PD | 1 |
Couture, DJ | 1 |
Cuniff, HM | 1 |
Maye, JP | 1 |
Pellegrini, J | 1 |
Shaw, AD | 1 |
DiBartolo, G | 1 |
Clatworthy, M | 1 |
Mayr, HO | 1 |
Entholzner, E | 1 |
Hube, R | 1 |
Hein, W | 1 |
Weig, TG | 1 |
Sibanda, S | 1 |
Hughes, JM | 1 |
Pawson, PE | 1 |
Kelly, G | 1 |
Bellenger, CR | 1 |
Cappellino, A | 1 |
Jokl, P | 1 |
Ruwe, PA | 1 |
Smith, LJ | 1 |
Stepien, RL | 1 |
Frost, S | 1 |
Grossfeld, S | 1 |
Kirkley, A | 1 |
Litchfield, B | 1 |
Fowler, P | 1 |
Amendola, A | 1 |
Follak, N | 1 |
Ganzer, D | 1 |
Lynch, J | 1 |
Trojan, S | 1 |
Arhelger, S | 1 |
Krings-Ernst, I | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Prospective Assessment of Intraoperative Intra-articular Morphine and Clonidine Injection in Hip Arthroscopy on Postoperative Pain Management[NCT02530151] | Phase 4 | 70 participants (Actual) | Interventional | 2015-11-30 | Completed | ||
A Prospective Triple-masked Randomized Controlled Trial Measuring Analgesia Duration of Dexamethasone, Buprenorphine, or Clonidine With Ropivacaine for Interscalene Nerve Block[NCT03117140] | Phase 4 | 160 participants (Actual) | Interventional | 2013-12-31 | Completed | ||
Effect of Volume of Local Anesthetic for Adductor Canal Block on Quadriceps Muscle Function: A Dose Finding Study[NCT02541552] | Phase 3 | 26 participants (Actual) | Interventional | 2015-04-30 | Completed | ||
Sciatic Peripheral Nerve Blockade for Pain Control Following Hamstring Autograft Harvest in Adolescents: A Comparison of Two Techniques[NCT02947633] | 140 participants (Anticipated) | Interventional | 2015-03-31 | Enrolling by invitation | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
The total usage of opioid medication (mEq) for pain relief in the intraoperative period and again through the postoperative recovery period from arrival in the PACU through 7 days post op (NCT02530151)
Timeframe: Recorded intraoperatively, during PACU stay, 6 hours post discharge, 18 hours post discharge, 24 hours post discharge, 48 hours post discharge, and at 7 days post discharge
Intervention | milligram morphine equivalents (mEq) (Mean) | ||||||
---|---|---|---|---|---|---|---|
Intraoperative | PACU | 6 hours Post Discharge | 18 hours Post Discharge | 24 hours Post Discharge | 48 hours Post Discharge | 7 days Post Discharge | |
Morphine With Clonidine | 57.3 | 37.0 | 5.5 | 14.5 | 19.5 | 27.7 | 50.7 |
Normal Saline | 56.0 | 40.1 | 5.3 | 13.8 | 20.0 | 35.6 | 73.8 |
The Quality of Recovery questionnaire (QoR-15) is a 15 question patient reported outcome measure used to evaluate the quality of recovery following surgical anesthesia concerning pain, physical function, and psychological factors; reported as a summative score with each question graded between 0-10 (Range:0-150) with higher scores indicating improved physical/psychological recovery or infrequent symptoms (NCT02530151)
Timeframe: Preoperative to 24 hrs. post operatively
Intervention | score on a scale (Mean) | |
---|---|---|
Preoperative QoR-15 Score | Change in QoR-15 Score at 24 hrs. Post Op | |
Morphine With Clonidine | 123 | -22 |
Normal Saline | 131 | -20 |
Patients will rate their pain (0-10) on the Visual Analog Scale with higher scores for the VAS indicated elevated pain intensity reported by the patient for the indicated time point (NCT02530151)
Timeframe: Immediately preoperative (5-10 minutes before surgery), immediately postoperative (5-10 minutes after surgery), 1 hr post operatively
Intervention | score on a scale (Mean) | ||
---|---|---|---|
Preoperative VAS Pain Score | Immediate Post Op VAS Pain Score | 1 hr. Post Op VAS Pain Score | |
Morphine With Clonidine | 2 | 3 | 4 |
Normal Saline | 2 | 4 | 5 |
Patients are assessed from needle removal to when they are no longer able to feel cold on the blocked extremity (NCT03117140)
Timeframe: Day one
Intervention | minutes (Median) |
---|---|
Plain Ropivacaine | 6 |
Ropivacaine + Buprenorphine | 3 |
Ropivacaine + Clonidine | 6 |
Ropivacaine + Dexamethasone | 4.5 |
Patients are called 1-3 days post-operatively to assess when the analgesia of their nerve block wore off (NCT03117140)
Timeframe: 1-3 days post-operative
Intervention | minutes (Median) |
---|---|
Plain Ropivacaine | 911 |
Ropivacaine + Buprenorphine | 1026.5 |
Ropivacaine + Clonidine | 1181 |
Ropivacaine + Dexamethasone | 982 |
Patients are called 1-3 days post-operatively to assess when motor component of their nerve block wore off (NCT03117140)
Timeframe: Day 1-3
Intervention | minutes (Median) |
---|---|
Plain Ropivacaine | 1120 |
Ropivacaine + Buprenorphine | 1198 |
Ropivacaine + Clonidine | 1090 |
Ropivacaine + Dexamethasone | 1143.5 |
Blood pressure changes in Second Stage Recovery Area for patients was looked at (NCT03117140)
Timeframe: Post-op Day 0 (baseline)
Intervention | Participants (Count of Participants) |
---|---|
Plain Ropivacaine | 5 |
Ropivacaine + Buprenorphine | 1 |
Ropivacaine + Clonidine | 5 |
Ropivacaine + Dexamethasone | 0 |
Patients are called 1-3 days post-operatively to assess if they had any side effects of the adjuvants such as nausea, vomiting or itching. There blood pressure is looked at pre-op and compared to post-op. Any prolonged PACU (Post Anesthesia Care Unit) stay for sedation is recorded. (NCT03117140)
Timeframe: 1-3 days
Intervention | Participants (Count of Participants) |
---|---|
Plain Ropivacaine | 1 |
Ropivacaine + Buprenorphine | 2 |
Ropivacaine + Clonidine | 2 |
Ropivacaine + Dexamethasone | 0 |
Patients itching was assessed post-op in the PACU. (NCT03117140)
Timeframe: Post-op day 0 (baseline)
Intervention | Participants (Count of Participants) |
---|---|
Plain Ropivacaine | 5 |
Ropivacaine + Buprenorphine | 2 |
Ropivacaine + Clonidine | 6 |
Ropivacaine + Dexamethasone | 3 |
Patients are called 1-3 days post-operatively to assess if they had any side effects of the adjuvants such as nausea, vomiting or itching. There blood pressure is looked at pre-op and compared to post-op. Any prolonged PACU (Post Anesthesia Care Unit) stay for sedation is recorded. (NCT03117140)
Timeframe: 1-3 days
Intervention | Participants (Count of Participants) |
---|---|
Plain Ropivacaine | 4 |
Ropivacaine + Buprenorphine | 9 |
Ropivacaine + Clonidine | 2 |
Ropivacaine + Dexamethasone | 3 |
PACU (Post-Anesthesia Care Unit) assessment of nausea (NCT03117140)
Timeframe: Post-op day 0 (Baseline)
Intervention | Participants (Count of Participants) |
---|---|
Plain Ropivacaine | 4 |
Ropivacaine + Buprenorphine | 9 |
Ropivacaine + Clonidine | 2 |
Ropivacaine + Dexamethasone | 9 |
Vomiting in PACU (Post-Anesthesia Care Unit) for patients was looked at (NCT03117140)
Timeframe: Post-op Day 0 (Baseline)
Intervention | Participants (Count of Participants) |
---|---|
Plain Ropivacaine | 0 |
Ropivacaine + Buprenorphine | 1 |
Ropivacaine + Clonidine | 0 |
Ropivacaine + Dexamethasone | 0 |
Blood pressure changes in PACU (Post-Anesthesia Care Unit) for patients was looked at (NCT03117140)
Timeframe: Post-op Day 0 (baseline)
Intervention | Participants (Count of Participants) |
---|---|
Plain Ropivacaine | 8 |
Ropivacaine + Buprenorphine | 3 |
Ropivacaine + Clonidine | 7 |
Ropivacaine + Dexamethasone | 2 |
Patients are called 1-3 days post-operatively to assess pain. Pain score is 0-10 scale with 0 is no pain and 10 is most severe pain. (NCT03117140)
Timeframe: Day 1-3
Intervention | units on a scale (Median) |
---|---|
Plain Ropivacaine | 4 |
Ropivacaine + Buprenorphine | 3 |
Ropivacaine + Clonidine | 4 |
Ropivacaine + Dexamethasone | 3 |
Patients are called 1-3 days post-operatively to assess if they had any side effects of the adjuvants such as nausea, vomiting or itching. There blood pressure is looked at pre-op and compared to post-op. Any prolonged PACU (Post Anesthesia Care Unit) stay for sedation is recorded. (NCT03117140)
Timeframe: 1-3 days
Intervention | Participants (Count of Participants) |
---|---|
Plain Ropivacaine | 0 |
Ropivacaine + Buprenorphine | 3 |
Ropivacaine + Clonidine | 2 |
Ropivacaine + Dexamethasone | 1 |
Patients are called 1-3 days post-operatively to assess when the sensory component of their nerve block wore off (NCT03117140)
Timeframe: Day 1-3
Intervention | minutes (Median) |
---|---|
Plain Ropivacaine | 923.5 |
Ropivacaine + Buprenorphine | 982 |
Ropivacaine + Clonidine | 940.5 |
Ropivacaine + Dexamethasone | 1066 |
Surgical length was recorded (NCT03117140)
Timeframe: Post op Day 0 (Baseline)
Intervention | minutes (Median) |
---|---|
Plain Ropivacaine | 68.5 |
Ropivacaine + Buprenorphine | 65 |
Ropivacaine + Clonidine | 73.5 |
Ropivacaine + Dexamethasone | 71 |
Surgical position was recorded (NCT03117140)
Timeframe: Post-op Day 0 (Baseline)
Intervention | Participants (Count of Participants) | ||
---|---|---|---|
Beach Chair | Lateral | Supine | |
Plain Ropivacaine | 38 | 2 | 0 |
Ropivacaine + Buprenorphine | 31 | 6 | 3 |
Ropivacaine + Clonidine | 31 | 7 | 2 |
Ropivacaine + Dexamethasone | 32 | 6 | 2 |
11 trials available for bupivacaine and ACL Injuries
Article | Year |
---|---|
Blinded, randomized, placebo-controlled study of the efficacy of bupivacaine liposomal suspension using static bodyweight distribution and subjective pain scoring in dogs after tibial plateau leveling osteotomy surgery.
Topics: Analgesics, Opioid; Animals; Anterior Cruciate Ligament Injuries; Bupivacaine; Dog Diseases; Dogs; O | 2023 |
Blinded, randomized, placebo-controlled study of the efficacy of bupivacaine liposomal suspension using static bodyweight distribution and subjective pain scoring in dogs after tibial plateau leveling osteotomy.
Topics: Animals; Anterior Cruciate Ligament Injuries; Bupivacaine; Dog Diseases; Dogs; Osteotomy; Pain, Post | 2023 |
A prospective double blinded randomized study of anterior cruciate ligament reconstruction with hamstrings tendon and spinal anesthesia with or without femoral nerve block.
Topics: Adolescent; Adult; Amides; Anesthesia, Spinal; Anesthetics, Local; Anterior Cruciate Ligament; Anter | 2014 |
[Levobupivacaine vs. ropivacaine for continuous femoral analgesia after anterior cruciate ligament reconstruction].
Topics: Adult; Amides; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Local; Anterior Cruci | 2011 |
Analgesic efficacy of intra-articular morphine after arthroscopic knee surgery in sport injury patients.
Topics: Adult; Analgesics, Opioid; Anesthetics, Local; Anterior Cruciate Ligament; Anterior Cruciate Ligamen | 2013 |
Evaluation of postoperative bupivacaine infusion for pain management after anterior cruciate ligament reconstruction.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anterior Cruciate Li | 2003 |
The addition of clonidine to bupivacaine in combined femoral-sciatic nerve block for anterior cruciate ligament reconstruction.
Topics: Adult; Analgesics; Anesthetics, Local; Anterior Cruciate Ligament; Anterior Cruciate Ligament Injuri | 2004 |
Pre- versus postoperative intraarticular application of local anesthetics and opioids versus femoral nerve block in anterior cruciate ligament repair.
Topics: Administration, Oral; Adult; Ambulatory Surgical Procedures; Analgesia; Analgesics, Opioid; Anesthes | 2007 |
The effects of preoperative extradural bupivacaine and morphine on the stress response in dogs undergoing femoro-tibial joint surgery.
Topics: Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Local; Animals; Anterior Cruciate Ligament; Ant | 2006 |
The efficacy of femoral nerve block in pain reduction for outpatient hamstring anterior cruciate ligament reconstruction: a double-blind, prospective, randomized trial.
Topics: Adolescent; Adult; Ambulatory Care; Analysis of Variance; Anterior Cruciate Ligament; Anterior Cruci | 2000 |
Postoperative analgesic value of the intra-articular instillation of bupivacaine and morphine after arthroscopic knee surgery.
Topics: Analgesics, Opioid; Anesthetics, Local; Anterior Cruciate Ligament; Anterior Cruciate Ligament Injur | 2001 |
5 other studies available for bupivacaine and ACL Injuries
Article | Year |
---|---|
Incidence of postoperative administration of opioids in dogs undergoing a tibial plateau leveling osteotomy after intra-operative liposomal bupivacaine administration with or without morphine epidural.
Topics: Analgesics, Opioid; Anesthetics; Animals; Anterior Cruciate Ligament; Anterior Cruciate Ligament Inj | 2023 |
Daystay hamstring ACL reconstruction performed under regional anaesthesia.
Topics: Ambulatory Care; Anesthesia, Spinal; Anesthetics, Local; Anterior Cruciate Ligament; Anterior Crucia | 2005 |
Regional anesthesia in knee arthroscopy: a new technique involving femoral and sciatic nerve blocks in knee arthroscopy.
Topics: Adult; Anesthesia, Conduction; Anesthetics, Local; Anterior Cruciate Ligament; Anterior Cruciate Lig | 1996 |
Anesthesia case of the month. Anesthesia in a dog with tricuspid insufficiency and atrial fibrillation.
Topics: Analgesics, Opioid; Anesthesia; Anesthesia, Epidural; Anesthetics, Intravenous; Anesthetics, Local; | 1999 |
Intermittent femoral nerve blockade for anterior cruciate ligament repair. Use of a catheter technique in 208 patients.
Topics: Adult; Aged; Anterior Cruciate Ligament; Anterior Cruciate Ligament Injuries; Bupivacaine; Catheters | 1991 |