Page last updated: 2024-10-24

bupivacaine and ACL Injuries

bupivacaine has been researched along with ACL Injuries in 16 studies

Bupivacaine: A widely used local anesthetic agent.
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.

Research Excerpts

ExcerptRelevanceReference
"This requires a patient friendly postoperative pain management."2.73Pre- versus postoperative intraarticular application of local anesthetics and opioids versus femoral nerve block in anterior cruciate ligament repair. ( Entholzner, E; Hein, W; Hube, R; Mayr, HO; Weig, TG, 2007)
"Clonidine has been shown to prolong sensory analgesia when given as an adjunct to peripheral nerve blocks but has not been evaluated when given in conjunction with a femoral-sciatic nerve block."2.71The addition of clonidine to bupivacaine in combined femoral-sciatic nerve block for anterior cruciate ligament reconstruction. ( Couture, DJ; Cuniff, HM; Maye, JP; Pellegrini, J, 2004)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (18.75)18.2507
2000's7 (43.75)29.6817
2010's3 (18.75)24.3611
2020's3 (18.75)2.80

Authors

AuthorsStudies
Aldrich, LA1
Upchurch, DA1
Roush, JK1
Scaglione, J1
Carver, J1
Reader, B1
Barletta, M1
Kleine, S1
Astur, DC1
Aleluia, V1
Veronese, C1
Astur, N1
Oliveira, SG1
Arliani, GG1
Badra, R1
Kaleka, CC1
Amaro, JT1
Cohen, M1
Schuster, M1
Engelhardt, L1
Erler, W1
Dienert, B1
Wagner, M1
Birnbaum, J1
Volk, T1
Yari, M1
Saeb, M1
Golfam, P1
Makhloogh, Z1
Alford, JW1
Fadale, PD1
Couture, DJ1
Cuniff, HM1
Maye, JP1
Pellegrini, J1
Shaw, AD1
DiBartolo, G1
Clatworthy, M1
Mayr, HO1
Entholzner, E1
Hube, R1
Hein, W1
Weig, TG1
Sibanda, S1
Hughes, JM1
Pawson, PE1
Kelly, G1
Bellenger, CR1
Cappellino, A1
Jokl, P1
Ruwe, PA1
Smith, LJ1
Stepien, RL1
Frost, S1
Grossfeld, S1
Kirkley, A1
Litchfield, B1
Fowler, P1
Amendola, A1
Follak, N1
Ganzer, D1
Lynch, J1
Trojan, S1
Arhelger, S1
Krings-Ernst, I1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prospective Assessment of Intraoperative Intra-articular Morphine and Clonidine Injection in Hip Arthroscopy on Postoperative Pain Management[NCT02530151]Phase 470 participants (Actual)Interventional2015-11-30Completed
A Prospective Triple-masked Randomized Controlled Trial Measuring Analgesia Duration of Dexamethasone, Buprenorphine, or Clonidine With Ropivacaine for Interscalene Nerve Block[NCT03117140]Phase 4160 participants (Actual)Interventional2013-12-31Completed
Effect of Volume of Local Anesthetic for Adductor Canal Block on Quadriceps Muscle Function: A Dose Finding Study[NCT02541552]Phase 326 participants (Actual)Interventional2015-04-30Completed
Sciatic Peripheral Nerve Blockade for Pain Control Following Hamstring Autograft Harvest in Adolescents: A Comparison of Two Techniques[NCT02947633]140 participants (Anticipated)Interventional2015-03-31Enrolling by invitation
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Opioid Consumption in the Acute Postoperative Period

The total usage of opioid medication (mEq) for pain relief in the intraoperative period and again through the postoperative recovery period from arrival in the PACU through 7 days post op (NCT02530151)
Timeframe: Recorded intraoperatively, during PACU stay, 6 hours post discharge, 18 hours post discharge, 24 hours post discharge, 48 hours post discharge, and at 7 days post discharge

,
Interventionmilligram morphine equivalents (mEq) (Mean)
IntraoperativePACU6 hours Post Discharge18 hours Post Discharge24 hours Post Discharge48 hours Post Discharge7 days Post Discharge
Morphine With Clonidine57.337.05.514.519.527.750.7
Normal Saline56.040.15.313.820.035.673.8

Quality of Recovery (QoR-15) Scores for Patient Reported Recovery Following Surgery

The Quality of Recovery questionnaire (QoR-15) is a 15 question patient reported outcome measure used to evaluate the quality of recovery following surgical anesthesia concerning pain, physical function, and psychological factors; reported as a summative score with each question graded between 0-10 (Range:0-150) with higher scores indicating improved physical/psychological recovery or infrequent symptoms (NCT02530151)
Timeframe: Preoperative to 24 hrs. post operatively

,
Interventionscore on a scale (Mean)
Preoperative QoR-15 ScoreChange in QoR-15 Score at 24 hrs. Post Op
Morphine With Clonidine123-22
Normal Saline131-20

Visual Analog Scale (VAS) Pain Scores

Patients will rate their pain (0-10) on the Visual Analog Scale with higher scores for the VAS indicated elevated pain intensity reported by the patient for the indicated time point (NCT02530151)
Timeframe: Immediately preoperative (5-10 minutes before surgery), immediately postoperative (5-10 minutes after surgery), 1 hr post operatively

,
Interventionscore on a scale (Mean)
Preoperative VAS Pain ScoreImmediate Post Op VAS Pain Score1 hr. Post Op VAS Pain Score
Morphine With Clonidine234
Normal Saline245

Block Set up Time

Patients are assessed from needle removal to when they are no longer able to feel cold on the blocked extremity (NCT03117140)
Timeframe: Day one

Interventionminutes (Median)
Plain Ropivacaine6
Ropivacaine + Buprenorphine3
Ropivacaine + Clonidine6
Ropivacaine + Dexamethasone4.5

Duration of Analgesia

Patients are called 1-3 days post-operatively to assess when the analgesia of their nerve block wore off (NCT03117140)
Timeframe: 1-3 days post-operative

Interventionminutes (Median)
Plain Ropivacaine911
Ropivacaine + Buprenorphine1026.5
Ropivacaine + Clonidine1181
Ropivacaine + Dexamethasone982

Motor Duration of Block

Patients are called 1-3 days post-operatively to assess when motor component of their nerve block wore off (NCT03117140)
Timeframe: Day 1-3

Interventionminutes (Median)
Plain Ropivacaine1120
Ropivacaine + Buprenorphine1198
Ropivacaine + Clonidine1090
Ropivacaine + Dexamethasone1143.5

Number of Patient With Blood Pressure Changes in the Second Stage Recovery Area

Blood pressure changes in Second Stage Recovery Area for patients was looked at (NCT03117140)
Timeframe: Post-op Day 0 (baseline)

InterventionParticipants (Count of Participants)
Plain Ropivacaine5
Ropivacaine + Buprenorphine1
Ropivacaine + Clonidine5
Ropivacaine + Dexamethasone0

Number of Patients Reporting Itching at Home

Patients are called 1-3 days post-operatively to assess if they had any side effects of the adjuvants such as nausea, vomiting or itching. There blood pressure is looked at pre-op and compared to post-op. Any prolonged PACU (Post Anesthesia Care Unit) stay for sedation is recorded. (NCT03117140)
Timeframe: 1-3 days

InterventionParticipants (Count of Participants)
Plain Ropivacaine1
Ropivacaine + Buprenorphine2
Ropivacaine + Clonidine2
Ropivacaine + Dexamethasone0

Number of Patients Reporting Itching in the PACU

Patients itching was assessed post-op in the PACU. (NCT03117140)
Timeframe: Post-op day 0 (baseline)

InterventionParticipants (Count of Participants)
Plain Ropivacaine5
Ropivacaine + Buprenorphine2
Ropivacaine + Clonidine6
Ropivacaine + Dexamethasone3

Number of Patients Reporting Nausea at Home

Patients are called 1-3 days post-operatively to assess if they had any side effects of the adjuvants such as nausea, vomiting or itching. There blood pressure is looked at pre-op and compared to post-op. Any prolonged PACU (Post Anesthesia Care Unit) stay for sedation is recorded. (NCT03117140)
Timeframe: 1-3 days

InterventionParticipants (Count of Participants)
Plain Ropivacaine4
Ropivacaine + Buprenorphine9
Ropivacaine + Clonidine2
Ropivacaine + Dexamethasone3

Number of Patients Reporting Nausea in the PACU

PACU (Post-Anesthesia Care Unit) assessment of nausea (NCT03117140)
Timeframe: Post-op day 0 (Baseline)

InterventionParticipants (Count of Participants)
Plain Ropivacaine4
Ropivacaine + Buprenorphine9
Ropivacaine + Clonidine2
Ropivacaine + Dexamethasone9

Number of Patients Vomiting in the PACU (Post-Anesthesia Care Unit)

Vomiting in PACU (Post-Anesthesia Care Unit) for patients was looked at (NCT03117140)
Timeframe: Post-op Day 0 (Baseline)

InterventionParticipants (Count of Participants)
Plain Ropivacaine0
Ropivacaine + Buprenorphine1
Ropivacaine + Clonidine0
Ropivacaine + Dexamethasone0

Number of Patients With Blood Pressure (BP) Changes in the PACU

Blood pressure changes in PACU (Post-Anesthesia Care Unit) for patients was looked at (NCT03117140)
Timeframe: Post-op Day 0 (baseline)

InterventionParticipants (Count of Participants)
Plain Ropivacaine8
Ropivacaine + Buprenorphine3
Ropivacaine + Clonidine7
Ropivacaine + Dexamethasone2

Pain Score Reported by Patients at First Phone Call

Patients are called 1-3 days post-operatively to assess pain. Pain score is 0-10 scale with 0 is no pain and 10 is most severe pain. (NCT03117140)
Timeframe: Day 1-3

Interventionunits on a scale (Median)
Plain Ropivacaine4
Ropivacaine + Buprenorphine3
Ropivacaine + Clonidine4
Ropivacaine + Dexamethasone3

Patient Reporting Vomiting at Home

Patients are called 1-3 days post-operatively to assess if they had any side effects of the adjuvants such as nausea, vomiting or itching. There blood pressure is looked at pre-op and compared to post-op. Any prolonged PACU (Post Anesthesia Care Unit) stay for sedation is recorded. (NCT03117140)
Timeframe: 1-3 days

InterventionParticipants (Count of Participants)
Plain Ropivacaine0
Ropivacaine + Buprenorphine3
Ropivacaine + Clonidine2
Ropivacaine + Dexamethasone1

Sensory Duration of Block

Patients are called 1-3 days post-operatively to assess when the sensory component of their nerve block wore off (NCT03117140)
Timeframe: Day 1-3

Interventionminutes (Median)
Plain Ropivacaine923.5
Ropivacaine + Buprenorphine982
Ropivacaine + Clonidine940.5
Ropivacaine + Dexamethasone1066

Surgical Length

Surgical length was recorded (NCT03117140)
Timeframe: Post op Day 0 (Baseline)

Interventionminutes (Median)
Plain Ropivacaine68.5
Ropivacaine + Buprenorphine65
Ropivacaine + Clonidine73.5
Ropivacaine + Dexamethasone71

Surgical Position

Surgical position was recorded (NCT03117140)
Timeframe: Post-op Day 0 (Baseline)

,,,
InterventionParticipants (Count of Participants)
Beach ChairLateralSupine
Plain Ropivacaine3820
Ropivacaine + Buprenorphine3163
Ropivacaine + Clonidine3172
Ropivacaine + Dexamethasone3262

Trials

11 trials available for bupivacaine and ACL Injuries

ArticleYear
Blinded, randomized, placebo-controlled study of the efficacy of bupivacaine liposomal suspension using static bodyweight distribution and subjective pain scoring in dogs after tibial plateau leveling osteotomy surgery.
    Veterinary surgery : VS, 2023, Volume: 52, Issue:5

    Topics: Analgesics, Opioid; Animals; Anterior Cruciate Ligament Injuries; Bupivacaine; Dog Diseases; Dogs; O

2023
Blinded, randomized, placebo-controlled study of the efficacy of bupivacaine liposomal suspension using static bodyweight distribution and subjective pain scoring in dogs after tibial plateau leveling osteotomy.
    Veterinary surgery : VS, 2023, Volume: 52, Issue:8

    Topics: Animals; Anterior Cruciate Ligament Injuries; Bupivacaine; Dog Diseases; Dogs; Osteotomy; Pain, Post

2023
A prospective double blinded randomized study of anterior cruciate ligament reconstruction with hamstrings tendon and spinal anesthesia with or without femoral nerve block.
    The Knee, 2014, Volume: 21, Issue:5

    Topics: Adolescent; Adult; Amides; Anesthesia, Spinal; Anesthetics, Local; Anterior Cruciate Ligament; Anter

2014
[Levobupivacaine vs. ropivacaine for continuous femoral analgesia after anterior cruciate ligament reconstruction].
    Schmerz (Berlin, Germany), 2011, Volume: 25, Issue:1

    Topics: Adult; Amides; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthetics, Local; Anterior Cruci

2011
Analgesic efficacy of intra-articular morphine after arthroscopic knee surgery in sport injury patients.
    Journal of injury & violence research, 2013, Volume: 5, Issue:2

    Topics: Adult; Analgesics, Opioid; Anesthetics, Local; Anterior Cruciate Ligament; Anterior Cruciate Ligamen

2013
Evaluation of postoperative bupivacaine infusion for pain management after anterior cruciate ligament reconstruction.
    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 2003, Volume: 19, Issue:8

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anterior Cruciate Li

2003
The addition of clonidine to bupivacaine in combined femoral-sciatic nerve block for anterior cruciate ligament reconstruction.
    AANA journal, 2004, Volume: 72, Issue:4

    Topics: Adult; Analgesics; Anesthetics, Local; Anterior Cruciate Ligament; Anterior Cruciate Ligament Injuri

2004
Pre- versus postoperative intraarticular application of local anesthetics and opioids versus femoral nerve block in anterior cruciate ligament repair.
    Archives of orthopaedic and trauma surgery, 2007, Volume: 127, Issue:4

    Topics: Administration, Oral; Adult; Ambulatory Surgical Procedures; Analgesia; Analgesics, Opioid; Anesthes

2007
The effects of preoperative extradural bupivacaine and morphine on the stress response in dogs undergoing femoro-tibial joint surgery.
    Veterinary anaesthesia and analgesia, 2006, Volume: 33, Issue:4

    Topics: Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Local; Animals; Anterior Cruciate Ligament; Ant

2006
The efficacy of femoral nerve block in pain reduction for outpatient hamstring anterior cruciate ligament reconstruction: a double-blind, prospective, randomized trial.
    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 2000, Volume: 16, Issue:3

    Topics: Adolescent; Adult; Ambulatory Care; Analysis of Variance; Anterior Cruciate Ligament; Anterior Cruci

2000
Postoperative analgesic value of the intra-articular instillation of bupivacaine and morphine after arthroscopic knee surgery.
    Archives of orthopaedic and trauma surgery, 2001, Volume: 121, Issue:5

    Topics: Analgesics, Opioid; Anesthetics, Local; Anterior Cruciate Ligament; Anterior Cruciate Ligament Injur

2001

Other Studies

5 other studies available for bupivacaine and ACL Injuries

ArticleYear
Incidence of postoperative administration of opioids in dogs undergoing a tibial plateau leveling osteotomy after intra-operative liposomal bupivacaine administration with or without morphine epidural.
    BMC veterinary research, 2023, Jul-31, Volume: 19, Issue:1

    Topics: Analgesics, Opioid; Anesthetics; Animals; Anterior Cruciate Ligament; Anterior Cruciate Ligament Inj

2023
Daystay hamstring ACL reconstruction performed under regional anaesthesia.
    The Knee, 2005, Volume: 12, Issue:4

    Topics: Ambulatory Care; Anesthesia, Spinal; Anesthetics, Local; Anterior Cruciate Ligament; Anterior Crucia

2005
Regional anesthesia in knee arthroscopy: a new technique involving femoral and sciatic nerve blocks in knee arthroscopy.
    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 1996, Volume: 12, Issue:1

    Topics: Adult; Anesthesia, Conduction; Anesthetics, Local; Anterior Cruciate Ligament; Anterior Cruciate Lig

1996
Anesthesia case of the month. Anesthesia in a dog with tricuspid insufficiency and atrial fibrillation.
    Journal of the American Veterinary Medical Association, 1999, Feb-01, Volume: 214, Issue:3

    Topics: Analgesics, Opioid; Anesthesia; Anesthesia, Epidural; Anesthetics, Intravenous; Anesthetics, Local;

1999
Intermittent femoral nerve blockade for anterior cruciate ligament repair. Use of a catheter technique in 208 patients.
    Acta anaesthesiologica Belgica, 1991, Volume: 42, Issue:4

    Topics: Adult; Aged; Anterior Cruciate Ligament; Anterior Cruciate Ligament Injuries; Bupivacaine; Catheters

1991