bumetanide has been researched along with Muscle Contraction in 17 studies
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To test the hypothesis that inhibition of the Na-K-2Cl transporter with bumetanide will reduce the susceptibility to decreases in muscle force in a mouse model of hypokalemic periodic paralysis (HypoPP)." | 7.79 | Bumetanide prevents transient decreases in muscle force in murine hypokalemic periodic paralysis. ( Cannon, SC; Mi, W; Wu, F, 2013) |
| "To test the hypothesis that inhibition of the Na-K-2Cl transporter with bumetanide will reduce the susceptibility to decreases in muscle force in a mouse model of hypokalemic periodic paralysis (HypoPP)." | 3.79 | Bumetanide prevents transient decreases in muscle force in murine hypokalemic periodic paralysis. ( Cannon, SC; Mi, W; Wu, F, 2013) |
| "The bumetanide concentrations used had little effect on outflow facility or on aqueous humor formation in normal monkeys, on intraocular pressure in organ-cultured human eyes, or on contraction of bovine ciliary muscle and trabecular meshwork strips." | 3.69 | Anterior segment physiology after bumetanide inhibition of Na-K-Cl cotransport. ( Clark, AF; Gabelt, BT; Kaufman, PL; Wiederholt, M, 1997) |
| "The study was designed to assess the effect of two loop diuretics, bumetanide (10 and 100 microM) and frusemide (100 microM), on smooth muscle contraction induced by toluene diisocyanate (0." | 3.68 | Effect of bumetanide on toluene diisocyanate induced contractions in guinea pig airways. ( Boniotti, A; Ciaccia, A; Di Stefano, A; Fabbri, LM; Maggi, CA; Mapp, CE; Papi, A; Saetta, M, 1993) |
| " In the presence of [Mg2+]o, substitution of foreign anions resulted in alterations in the agonist contractile dose-response curves; EC50s were increased whereas maximum tensions were depressed." | 1.28 | Interactions of magnesium and chloride ions on tone and contractility of vascular muscle. ( Altura, BM; Altura, BT; Carella, A; Zhang, A, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (17.65) | 18.2507 |
| 2000's | 10 (58.82) | 29.6817 |
| 2010's | 4 (23.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, F | 1 |
| Mi, W | 1 |
| Cannon, SC | 1 |
| Smagliy, LV | 1 |
| Gusakova, SV | 1 |
| Birulina, YG | 1 |
| Kovalev, IV | 2 |
| Orlov, SN | 3 |
| Murphy, KT | 1 |
| Nielsen, OB | 1 |
| Clausen, T | 2 |
| Jing, Y | 1 |
| Dowdy, JA | 1 |
| Van Scott, MR | 1 |
| Fedan, JS | 1 |
| Koltsova, SV | 1 |
| Luneva, OG | 1 |
| Lavoie, JL | 1 |
| Tremblay, J | 1 |
| Maksimov, GV | 1 |
| Hamet, P | 1 |
| Cho, HM | 1 |
| Lee, DY | 1 |
| Kim, HY | 1 |
| Lee, HA | 1 |
| Seok, YM | 1 |
| Kim, IK | 1 |
| Baskakov, MB | 1 |
| Anfinogenova, YD | 1 |
| Borodin, YL | 1 |
| Kilin, AA | 1 |
| Minochenko, IL | 1 |
| Popov, AG | 1 |
| Kapilevich, LV | 1 |
| Medvedev, MA | 1 |
| Jiang, G | 1 |
| Akar, F | 2 |
| Cobbs, SL | 1 |
| Lomashvilli, K | 1 |
| Lakkis, R | 1 |
| Gordon, FJ | 1 |
| Sutliff, RL | 1 |
| O'Neill, WC | 1 |
| Oriowo, MA | 1 |
| Kaneda, T | 1 |
| Sakaguchi, R | 1 |
| Shimizu, K | 1 |
| Urakawa, N | 1 |
| Nakajyo, S | 1 |
| Dayioglu, E | 1 |
| Buharalioglu, CK | 1 |
| Saracoglu, F | 1 |
| Mapp, CE | 1 |
| Boniotti, A | 1 |
| Papi, A | 1 |
| Maggi, CA | 1 |
| Di Stefano, A | 1 |
| Saetta, M | 1 |
| Ciaccia, A | 1 |
| Fabbri, LM | 1 |
| Gabelt, BT | 1 |
| Wiederholt, M | 1 |
| Clark, AF | 1 |
| Kaufman, PL | 1 |
| Tomita, T | 1 |
| Hata, T | 1 |
| Wong, JA | 1 |
| Gosmanov, AR | 1 |
| Schneider, EG | 1 |
| Thomason, DB | 1 |
| Zhang, A | 1 |
| Carella, A | 1 |
| Altura, BT | 1 |
| Altura, BM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomised, Double-blind, Placebo-controlled, Phase II Clinical Trial With a Cross-over Design Assessing Efficacy of a Single Dose of Bumetanide in Reducing Focal Attack Severity in Hypokalaemic Periodic Paralysis Assessed Using the McManis Protocol[NCT02582476] | Phase 2 | 12 participants (Anticipated) | Interventional | 2015-01-31 | Terminated (stopped due to Slow enrolment and end of funding) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
17 other studies available for bumetanide and Muscle Contraction
| Article | Year |
|---|---|
Bumetanide prevents transient decreases in muscle force in murine hypokalemic periodic paralysis.
Topics: Animals; Bumetanide; Female; Gene Knock-In Techniques; Hypokalemic Periodic Paralysis; Male; Mice; M | 2013 |
[THE ROLE OF HYDROGEN SULFIDE IN VOLUME-DEPENDENT MECHANISMS OF REGULATION OF VASCULAR SMOOTH MUSCLE CELLS CONTRACTILE ACTIVITY].
Topics: Animals; Aorta, Thoracic; Bumetanide; Cell Size; Hydrogen Sulfide; Hypertonic Solutions; Hypotonic S | 2015 |
Analysis of exercise-induced Na+-K+ exchange in rat skeletal muscle in vivo.
Topics: Animals; Binding Sites; Bumetanide; Cell Membrane Permeability; Enzyme Inhibitors; Female; Male; Mus | 2008 |
Simultaneous measurement of mechanical responses and transepithelial potential difference and resistance, in guinea-pig isolated, perfused trachea using a novel apparatus: pharmacological characterization.
Topics: Amiloride; Animals; Bronchodilator Agents; Bumetanide; Electrophysiology; Epithelial Cells; Epitheli | 2008 |
HCO3-dependent impact of Na+,K+,2Cl- cotransport in vascular smooth muscle excitation-contraction coupling.
Topics: Animals; Bicarbonates; Bumetanide; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle, Smoot | 2009 |
In isolated skeletal muscle, excitation may increase extracellular K+ 10-fold; how can contractility be maintained?
Topics: Animals; Anthracenes; Bumetanide; Cell Membrane Permeability; Chloride Channels; Diffusion; Electric | 2011 |
Upregulation of the Na(+)-K(+)-2Cl(-) cotransporter 1 via histone modification in the aortas of angiotensin II-induced hypertensive rats.
Topics: Angiotensin II; Animals; Aorta; Blood Pressure; Blotting, Western; Bumetanide; Chromatin Immunopreci | 2012 |
Effect of Na+,K+,2Cl- cotransport inhibitor bumetanide on electrical and contractile activity of smooth muscle cells in guinea pig ureter.
Topics: Action Potentials; Animals; Bumetanide; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Musc | 2003 |
Blood pressure regulates the activity and function of the Na-K-2Cl cotransporter in vascular smooth muscle.
Topics: Animals; Aortic Coarctation; Blood Pressure; Bumetanide; Cardiomegaly; Diuretics; Enzyme Inhibitors; | 2004 |
Chloride channels and alpha1-adrenoceptor-mediated pulmonary artery smooth muscle contraction: effect of pulmonary hypertension.
Topics: Animals; Bumetanide; Calcium Channel Blockers; Chloride Channels; Chloride-Bicarbonate Antiporters; | 2004 |
Effects of high-K+, Na+-deficient solution on contractility of the smooth muscles of the bovine trachea.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetazolamide; Animals; Bumetanide; Calcium; Cattl | 2006 |
The effects of bumetanide on human umbilical artery contractions.
Topics: Adolescent; Adult; Bumetanide; Female; Histamine; Humans; Muscle Contraction; Muscle, Smooth, Vascul | 2007 |
Effect of bumetanide on toluene diisocyanate induced contractions in guinea pig airways.
Topics: Acetylcholine; Animals; Bronchi; Bumetanide; Electric Stimulation; Furosemide; Guinea Pigs; In Vitro | 1993 |
Anterior segment physiology after bumetanide inhibition of Na-K-Cl cotransport.
Topics: Aged; Animals; Anterior Eye Segment; Aqueous Humor; Bumetanide; Carrier Proteins; Cattle; Chlorides; | 1997 |
Effects of removal of Na(+) and Cl(-) on spontaneous electrical activity, slow wave, in the circular muscle of the guinea-pig gastric antrum.
Topics: Animals; Bumetanide; Calcium; Carrier Proteins; Chlorides; Diuretics; Female; Furosemide; Guinea Pig | 2000 |
Insulin-independent, MAPK-dependent stimulation of NKCC activity in skeletal muscle.
Topics: Adrenergic Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonis | 2001 |
Interactions of magnesium and chloride ions on tone and contractility of vascular muscle.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfo | 1991 |