bumetanide has been researched along with Hypoxia-Ischemia, Brain in 9 studies
Hypoxia-Ischemia, Brain: A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Preclinical data suggest that the loop-diuretic bumetanide might be an effective treatment for neonatal seizures." | 9.20 | Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial. ( Blennow, M; Boylan, GB; Chiron, C; Cross, JH; de Vries, LS; Hallberg, B; Hellström-Westas, L; Jullien, V; Livingstone, V; Mangum, B; Marlow, N; Murphy, B; Murray, D; Pons, G; Pressler, RM; Rennie, J; Swarte, R; Toet, MC; Vanhatalo, S; Zohar, S, 2015) |
| "Total seizure burden varied widely, with much higher seizure burden in treatment versus control groups (median = 3." | 7.01 | A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures. ( Bergin, AM; Dong, M; Fortuno, CR; Hayes, B; Jensen, FE; Krishnamoorthy, K; O'Reilly, D; Rofeberg, V; Singh, A; Soul, JS; Staley, KJ; Stopp, C; Vinks, AA; Wypij, D, 2021) |
| "Preclinical data suggest that the loop-diuretic bumetanide might be an effective treatment for neonatal seizures." | 5.20 | Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial. ( Blennow, M; Boylan, GB; Chiron, C; Cross, JH; de Vries, LS; Hallberg, B; Hellström-Westas, L; Jullien, V; Livingstone, V; Mangum, B; Marlow, N; Murphy, B; Murray, D; Pons, G; Pressler, RM; Rennie, J; Swarte, R; Toet, MC; Vanhatalo, S; Zohar, S, 2015) |
| "Total seizure burden varied widely, with much higher seizure burden in treatment versus control groups (median = 3." | 3.01 | A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures. ( Bergin, AM; Dong, M; Fortuno, CR; Hayes, B; Jensen, FE; Krishnamoorthy, K; O'Reilly, D; Rofeberg, V; Singh, A; Soul, JS; Staley, KJ; Stopp, C; Vinks, AA; Wypij, D, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Machado, DN | 1 |
| Durán-Carabali, LE | 1 |
| Odorcyk, FK | 1 |
| Carvalho, AVS | 1 |
| Martini, APR | 1 |
| Schlemmer, LM | 1 |
| de Mattos, MM | 1 |
| Bernd, GP | 1 |
| Dalmaz, C | 1 |
| Netto, CA | 1 |
| Soul, JS | 1 |
| Bergin, AM | 1 |
| Stopp, C | 1 |
| Hayes, B | 1 |
| Singh, A | 1 |
| Fortuno, CR | 1 |
| O'Reilly, D | 1 |
| Krishnamoorthy, K | 1 |
| Jensen, FE | 1 |
| Rofeberg, V | 1 |
| Dong, M | 1 |
| Vinks, AA | 1 |
| Wypij, D | 1 |
| Staley, KJ | 1 |
| Glass, HC | 1 |
| Pressler, RM | 2 |
| Boylan, GB | 2 |
| Marlow, N | 2 |
| Blennow, M | 2 |
| Chiron, C | 2 |
| Cross, JH | 2 |
| de Vries, LS | 2 |
| Hallberg, B | 2 |
| Hellström-Westas, L | 2 |
| Jullien, V | 2 |
| Livingstone, V | 1 |
| Mangum, B | 2 |
| Murphy, B | 2 |
| Murray, D | 2 |
| Pons, G | 2 |
| Rennie, J | 2 |
| Swarte, R | 1 |
| Toet, MC | 2 |
| Vanhatalo, S | 1 |
| Zohar, S | 2 |
| Thoresen, M | 1 |
| Sabir, H | 1 |
| Hu, JJ | 1 |
| Yang, XL | 1 |
| Luo, WD | 1 |
| Han, S | 1 |
| Yin, J | 1 |
| Liu, WH | 1 |
| He, XH | 1 |
| Peng, BW | 1 |
| Liu, Y | 1 |
| Shangguan, Y | 1 |
| Barks, JD | 1 |
| Silverstein, FS | 1 |
| Busse, S | 1 |
| Breder, J | 1 |
| Dinkel, K | 1 |
| Reymann, KG | 1 |
| Schröder, UH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| NEMO1: An Open Label Exploratory Dose Finding and Pharmacokinetic Clinical Trial of Bumetanide for the Treatment of Neonatal Seizure Using Medication Off-patent[NCT01434225] | Phase 1/Phase 2 | 14 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for bumetanide and Hypoxia-Ischemia, Brain
| Article | Year |
|---|---|
A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures.
Topics: Anticonvulsants; Bumetanide; Double-Blind Method; Drug Therapy, Combination; Electroencephalography; | 2021 |
Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial.
Topics: Bumetanide; Drug Administration Schedule; Drug Synergism; Early Termination of Clinical Trials; Feas | 2015 |
7 other studies available for bumetanide and Hypoxia-Ischemia, Brain
| Article | Year |
|---|---|
Bumetanide Attenuates Cognitive Deficits and Brain Damage in Rats Subjected to Hypoxia-Ischemia at Two Time Points of the Early Postnatal Period.
Topics: Animals; Animals, Newborn; Brain; Bumetanide; Cognition; Hypoxia; Hypoxia-Ischemia, Brain; Ischemia; | 2023 |
Bumetanide for treatment of seizures in neonates.
Topics: Bumetanide; Female; Humans; Hypoxia-Ischemia, Brain; Male; Phenobarbital; Seizures | 2015 |
Epilepsy: Neonatal seizures still lack safe and effective treatment.
Topics: Bumetanide; Female; Humans; Hypoxia-Ischemia, Brain; Male; Phenobarbital; Seizures | 2015 |
Bumetanide for neonatal seizures-back from the cotside.
Topics: Bumetanide; Female; Humans; Hypoxia-Ischemia, Brain; Male; Phenobarbital; Seizures | 2015 |
Bumetanide reduce the seizure susceptibility induced by pentylenetetrazol via inhibition of aberrant hippocampal neurogenesis in neonatal rats after hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Anticonvulsants; Bumetanide; Cell Movement; Cell Proliferation; Electroen | 2017 |
Bumetanide augments the neuroprotective efficacy of phenobarbital plus hypothermia in a neonatal hypoxia-ischemia model.
Topics: Animals; Animals, Newborn; Bumetanide; Disease Models, Animal; Drug Synergism; Hypothermia, Induced; | 2012 |
Inhibitors of cation-chloride-cotransporters affect hypoxic/hypoglycemic injury in hippocampal slices.
Topics: Age Factors; Animals; Bumetanide; Carboxylic Acids; Cation Transport Proteins; Cell Death; Diuretics | 2005 |