bumetanide has been researched along with Cystic Fibrosis in 21 studies
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of the loop diuretic bumetanide on Cl- transport in the human reabsorptive sweat duct (RSD) was studied to determine the properties of Cl- transport in this tissue with an emphasis on its role in cystic fibrosis." | 7.67 | Effects of bumetanide on chloride transport in human eccrine sweat ducts: implications for cystic fibrosis. ( Quinton, PM; Reddy, MM, 1987) |
| " In our pursuit to identify potent modulators of Cl(-) secretion that may be useful to overcome the Cl(-) secretory defect in cystic fibrosis (CF), we have identified chlorzoxazone [5-chloro-2(3H)-benzoxazolone], a clinically used centrally acting muscle relaxant, as a stimulator of Cl(-) secretion in several epithelial cell types, including T84, Calu-3, and human bronchial epithelium." | 3.70 | Stimulation of Cl(-) secretion by chlorzoxazone. ( Bridges, RJ; Devor, DC; Gerlach, AC; Gondor, M; Pilewski, JM; Singh, AK, 2000) |
| "To investigate cellular mechanisms involved in the regulation of basolateral Na-K-Cl cotransport in airway epithelia, we determined saturable basolateral [3H]bumetanide binding, a measure of functioning cotransporters, in primary cultures of canine tracheal and human nasal epithelial cells, including cells from patients with cystic fibrosis (CF)." | 3.68 | Dual mechanisms for Na-K-Cl cotransport regulation in airway epithelial cells. ( Haas, M; McBrayer, DG; Yankaskas, JR, 1993) |
| "Cystic fibrosis (CF) airway epithelia exhibit raised transepithelial Na+ transport rates, as determined by open-circuit isotope fluxes and estimates of the amiloride-sensitive equivalent short-circuit current (Ieq)." | 3.68 | Transcellular sodium transport in cultured cystic fibrosis human nasal epithelium. ( Boucher, RC; Willumsen, NJ, 1991) |
| "The effect of the loop diuretic bumetanide on Cl- transport in the human reabsorptive sweat duct (RSD) was studied to determine the properties of Cl- transport in this tissue with an emphasis on its role in cystic fibrosis." | 3.67 | Effects of bumetanide on chloride transport in human eccrine sweat ducts: implications for cystic fibrosis. ( Quinton, PM; Reddy, MM, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (9.52) | 18.7374 |
| 1990's | 10 (47.62) | 18.2507 |
| 2000's | 5 (23.81) | 29.6817 |
| 2010's | 4 (19.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chung, WJ | 1 |
| Goeckeler-Fried, JL | 1 |
| Havasi, V | 1 |
| Chiang, A | 1 |
| Rowe, SM | 1 |
| Plyler, ZE | 1 |
| Hong, JS | 1 |
| Mazur, M | 1 |
| Piazza, GA | 1 |
| Keeton, AB | 1 |
| White, EL | 1 |
| Rasmussen, L | 1 |
| Weissman, AM | 1 |
| Denny, RA | 1 |
| Brodsky, JL | 1 |
| Sorscher, EJ | 1 |
| Abdullah, LH | 1 |
| Evans, JR | 1 |
| Wang, TT | 1 |
| Ford, AA | 1 |
| Makhov, AM | 1 |
| Nguyen, K | 1 |
| Coakley, RD | 1 |
| Griffith, JD | 1 |
| Davis, CW | 2 |
| Ballard, ST | 2 |
| Kesimer, M | 1 |
| Saint-Criq, V | 1 |
| Kim, SH | 1 |
| Katzenellenbogen, JA | 1 |
| Harvey, BJ | 1 |
| Jeong, JH | 1 |
| Joo, NS | 1 |
| Hwang, PH | 1 |
| Wine, JJ | 1 |
| Garcia, MA | 1 |
| Yang, N | 1 |
| Quinton, PM | 3 |
| Trout, L | 2 |
| Townsley, MI | 1 |
| Bowden, AL | 1 |
| Tarran, R | 1 |
| Donaldson, SH | 1 |
| Boucher, RC | 3 |
| Grubb, BR | 1 |
| Faller, DP | 2 |
| Egan, DA | 1 |
| Ryan, MP | 2 |
| Slotki, IN | 1 |
| Breuer, WV | 1 |
| Greger, R | 1 |
| Cabantchik, ZI | 1 |
| O'Reilly, CM | 1 |
| Haas, M | 1 |
| McBrayer, DG | 1 |
| Yankaskas, JR | 1 |
| Clarke, LL | 1 |
| Harline, MC | 1 |
| Devor, DC | 2 |
| Pilewski, JM | 2 |
| Singh, AK | 1 |
| Gerlach, AC | 1 |
| Gondor, M | 1 |
| Bridges, RJ | 1 |
| Liedtke, CM | 1 |
| Papay, R | 1 |
| Cole, TS | 1 |
| Smith, SN | 1 |
| Alton, EW | 1 |
| Geddes, DM | 1 |
| Bell, CL | 1 |
| Willumsen, NJ | 2 |
| Reddy, MM | 1 |
21 other studies available for bumetanide and Cystic Fibrosis
| Article | Year |
|---|---|
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regu | 2016 |
Defective postsecretory maturation of MUC5B mucin in cystic fibrosis airways.
Topics: Amiloride; Animals; Bronchi; Bumetanide; Cells, Cultured; Cystic Fibrosis; Humans; In Vitro Techniqu | 2017 |
Non-genomic estrogen regulation of ion transport and airway surface liquid dynamics in cystic fibrosis bronchial epithelium.
Topics: Amiloride; Bronchi; Bumetanide; Cell Line; Colforsin; Cyclic AMP; Cystic Fibrosis; Epithelial Cells; | 2013 |
Mucociliary clearance and submucosal gland secretion in the ex vivo ferret trachea.
Topics: Analgesics, Non-Narcotic; Angiogenesis Inhibitors; Animals; Bronchodilator Agents; Bumetanide; Calci | 2014 |
Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator-dependent bicarbonate secretion.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Bicarbonates; Bumetanide; Cystic Fibrosis | 2009 |
Disruptive effects of anion secretion inhibitors on airway mucus morphology in isolated perfused pig lung.
Topics: Adrenergic beta-Agonists; Algorithms; Amiloride; Animals; Anions; Bethanechol; Bicarbonates; Bronchi | 2003 |
Soluble mediators, not cilia, determine airway surface liquid volume in normal and cystic fibrosis superficial airway epithelia.
Topics: Adenosine; Adenosine Triphosphate; Aprotinin; Bronchi; Bumetanide; Cells, Cultured; Chlorides; Cilia | 2006 |
Ion transport across the jejunum in normal and cystic fibrosis mice.
Topics: Animals; Bicarbonates; Bumetanide; Chlorides; Colforsin; Cyclic AMP; Cystic Fibrosis; Electric Condu | 1995 |
Evidence for location of the CFTR in human placental apical membrane vesicles.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine Triphosphate; Anions; Bumetanide; Cell M | 1995 |
Long-term cAMP activation of Na(+)-K(+)-2Cl- cotransporter activity in HT-29 human adenocarcinoma cells.
Topics: Adenocarcinoma; Bumetanide; Carrier Proteins; Chlorides; Colforsin; Colonic Neoplasms; Cyclic AMP; C | 1993 |
Amiloride-sensitive sodium uptake into human placental brush border membrane vesicles.
Topics: Amiloride; Biological Transport, Active; Bumetanide; Cystic Fibrosis; Female; Humans; In Vitro Techn | 1994 |
Dual mechanisms for Na-K-Cl cotransport regulation in airway epithelial cells.
Topics: Adenosine Triphosphate; Animals; Bumetanide; Carrier Proteins; Cells, Cultured; Cystic Fibrosis; Dog | 1993 |
CFTR is required for cAMP inhibition of intestinal Na+ absorption in a cystic fibrosis mouse model.
Topics: Animals; Bicarbonates; Bumetanide; Calcium; Calcium Channel Blockers; Chlorides; Cyclic AMP; Cystic | 1996 |
UTP inhibits Na+ absorption in wild-type and DeltaF508 CFTR-expressing human bronchial epithelia.
Topics: Amiloride; Biological Transport; Bronchi; Bumetanide; Calcium; Cells, Cultured; Chlorides; Cystic Fi | 1999 |
Stimulation of Cl(-) secretion by chlorzoxazone.
Topics: Amiloride; Anions; Bronchi; Bumetanide; Cell Membrane; Cells, Cultured; Charybdotoxin; Chlorine; Chl | 2000 |
Modulation of Na-K-2Cl cotransport by intracellular Cl(-) and protein kinase C-delta in Calu-3 cells.
Topics: Acetophenones; Adrenergic alpha-Agonists; Benzopyrans; Biological Transport; Bumetanide; Cells, Cult | 2002 |
Ion transport characteristics of the murine trachea and caecum.
Topics: Amiloride; Animals; Bumetanide; Cecum; Chlorides; Colforsin; Cystic Fibrosis; Electric Conductivity; | 1992 |
T84 cells: anion selectivity demonstrates expression of Cl- conductance affected in cystic fibrosis.
Topics: Amiloride; Anions; Azides; Bumetanide; Chlorides; Colforsin; Colonic Neoplasms; Cyclic AMP; Cystic F | 1992 |
Transcellular sodium transport in cultured cystic fibrosis human nasal epithelium.
Topics: Adolescent; Adult; Amiloride; Amphotericin B; Biological Transport; Bumetanide; Cells, Cultured; Chi | 1991 |
Cellular Cl- transport in cultured cystic fibrosis airway epithelium.
Topics: Adolescent; Adult; Amiloride; Biological Transport; Bumetanide; Cells, Cultured; Child; Child, Presc | 1989 |
Effects of bumetanide on chloride transport in human eccrine sweat ducts: implications for cystic fibrosis.
Topics: Absorption; Bumetanide; Cystic Fibrosis; Diuretics; Eccrine Glands; Epithelium; Humans; In Vitro Tec | 1987 |