bumetanide and Blood Pressure, High studies

Research Excerpts

Excerpt	Relevance	Reference
"In CKD stage 4-5 KDIGO without renal replacement therapy, bumetanide in combination with chlorthalidone is more effective in treating volume overload and hypertension than bumetanide with placebo."	9.51	Effect of the combination of bumetanide plus chlorthalidone on hypertension and volume overload in patients with chronic kidney disease stage 4-5 KDIGO without renal replacement therapy: a double-blind randomized HEBE-CKD trial. ( Cabrera-Barron, R; Chida-Romero, JA; Dehesa-López, E; Madero, M; Martin-Alemañy, G; Perez-Navarro, LM; Solis-Jimenez, F; Valdez-Ortiz, R, 2022)
"1 Twelve patients with mild hypertension were treated with bumetanide for a six-month period."	9.04	Lack of effect of bumetanide on body potassium content in hypertension. ( Bewsher, PD; Murchison, LE, 1975)
"The effect of bumetanide on absolute and fractional sodium excretion, creatinine clearance, and plasma renin activity (PRA) was studied in eight patients with essential hypertension before and after indomethacin."	7.66	Influence of indomethacin on the natriuretic and renin-stimulating effect of bumetanide in essential hypertension. ( Arzilli, F; Magagna, A; Pedrinelli, R; Salvetti, A; Sassano, P, 1980)
"In CKD stage 4-5 KDIGO without renal replacement therapy, bumetanide in combination with chlorthalidone is more effective in treating volume overload and hypertension than bumetanide with placebo."	5.51	Effect of the combination of bumetanide plus chlorthalidone on hypertension and volume overload in patients with chronic kidney disease stage 4-5 KDIGO without renal replacement therapy: a double-blind randomized HEBE-CKD trial. ( Cabrera-Barron, R; Chida-Romero, JA; Dehesa-López, E; Madero, M; Martin-Alemañy, G; Perez-Navarro, LM; Solis-Jimenez, F; Valdez-Ortiz, R, 2022)
"The behaviour of active (AR) and inactive (IR) renin was studied in 48 hypertensive patients (37 with uncomplicated essential hypertension and 11 with reno-vascular hypertension) treated with indomethacin alone or with AR stimulating (bumetanide, tienilic acid, captopril) and inhibiting (atenolol) drugs before and after indomethacin addition."	5.05	Effects of prostaglandins inhibition on changes in active and inactive renin induced by antihypertensive drugs. ( Arzilli, F; Pedrinelli, R; Salvetti, A; Sassano, P; Turini, F, 1982)
"1 Twelve patients with mild hypertension were treated with bumetanide for a six-month period."	5.04	Lack of effect of bumetanide on body potassium content in hypertension. ( Bewsher, PD; Murchison, LE, 1975)
"The Na(+)-K(+)-2Cl(-) cotransporter 1 (NKCC1) is one of several transporters that have been implicated for development of hypertension since NKCC1 activity is elevated in hypertensive aorta and vascular contractions are inhibited by bumetanide, an inhibitor of NKCC1."	3.76	Promoter hypomethylation upregulates Na+-K+-2Cl- cotransporter 1 in spontaneously hypertensive rats. ( Baek, I; Cho, HM; Hong, SH; Kim, IK; Lee, DY; Lee, HA; Seok, YM; Yang, E, 2010)
" Pump activity appears higher and furosemide or bumetanide sensitive Na+ efflux lower in SHR compared to WKY suggesting a similar abnormality in SHR genetic hypertension as in human hypertension."	3.66	Furosemide and bumetanide-sensitive Na+ fluxes in erythrocytes from genetically hypertensive rats (SHR). ( De Mendonca, M; Garay, R; Grichois, ML; Herubel, A; Knorr, A; Meyer, P; Toumi, K, 1981)
"The effect of bumetanide on absolute and fractional sodium excretion, creatinine clearance, and plasma renin activity (PRA) was studied in eight patients with essential hypertension before and after indomethacin."	3.66	Influence of indomethacin on the natriuretic and renin-stimulating effect of bumetanide in essential hypertension. ( Arzilli, F; Magagna, A; Pedrinelli, R; Salvetti, A; Sassano, P, 1980)
"Forty patients with congestive heart failure or hypertensive heart disease were given long-term maintenance treatment with a combined bumetanide/slow-release potassium supplement preparation ('Burinex K')."	3.65	Patient tolerance of long-term diuretic/potassium supplement therapy. ( Singh, BB; Watt, DA, 1976)
"The inhibition of dose-response curves by bumetanide, an inhibitor of NKCC1, as well as the expression of Nkcc1 mRNA and protein was comparable between 5-week-old SHR and age-matched WKY, but greater in 18-week-old SHR than in age-matched WKY."	1.37	Expression of Na+-K+ -2Cl- cotransporter 1 is epigenetically regulated during postnatal development of hypertension. ( Cho, HM; Han, HS; Kim, HY; Kim, IK; Lee, HA, 2011)
" administration, the pharmacokinetic and pharmacodynamic parameters of bumetanide did not vary significantly between SHRs and the control Wistar rats."	1.29	Pharmacokinetics and pharmacodynamics of bumetanide after intravenous and oral administration to spontaneously hypertensive rats and DOCA-salt induced hypertensive rats. ( Han, KS; Kim, ND; Lee, MG; Lee, SH, 1993)

Research

Studies (51)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Change in Diastolic Blood Pressure

Change in Extracellular Water

Timeframe	Studies, this research(%)	All Research%
pre-1990	24 (47.06)	18.7374
1990's	16 (31.37)	18.2507
2000's	7 (13.73)	29.6817
2010's	3 (5.88)	24.3611
2020's	1 (1.96)	2.80

Authors	Studies
Solis-Jimenez, F	1
Perez-Navarro, LM	1
Cabrera-Barron, R	1
Chida-Romero, JA	1
Martin-Alemañy, G	1
Dehesa-López, E	1
Madero, M	1
Valdez-Ortiz, R	1
Lee, HA	3
Baek, I	1
Seok, YM	2
Yang, E	1
Cho, HM	3
Lee, DY	2
Hong, SH	1
Kim, IK	3
Kim, HY	2
Han, HS	1
Vokurková, M	1
Dobesová, Z	3
Kunes, J	3
Zicha, J	5
Jiang, G	1
Akar, F	1
Cobbs, SL	1
Lomashvilli, K	1
Lakkis, R	1
Gordon, FJ	1
Sutliff, RL	1
O'Neill, WC	1
Bell, AM	1
Nolen, JD	1
Knudson, CM	1
Raife, TJ	1
De Mendonca, M	3
Grichois, ML	2
Toumi, K	1
Herubel, A	1
Knorr, A	3
Garay, R	2
Meyer, P	2
Bönner, G	1
Unger, T	1
Rascher, W	1
Speck, G	1
Ganten, D	1
Gross, F	1
Salvetti, A	2
Pedrinelli, R	2
Sassano, P	2
Arzilli, F	2
Turini, F	1
Ben-Ishay, D	1
Garay, RP	5
Kokubu, T	1
Hiwada, K	1
Shishido, M	1
Murakami, E	1
Hashimoto, H	1
Wester, PO	1
Magagna, A	1
Luque Otero, M	2
Fernández Pinilla, C	2
Bórquez, M	1
Fernández Cruz, A	4
Humair, L	1
McMurchie, EJ	1
Burnard, SL	1
Patten, GS	1
King, RA	1
Howe, PR	1
Head, RJ	1
Bin Talib, HK	1
Han, KS	1
Lee, SH	1
Lee, MG	1
Kim, ND	1
Davis, JP	2
Chipperfield, AR	2
Harper, AA	2
Parés, I	1
de la Sierra, A	2
Coca, A	2
Lluch, MM	1
Urbano-Márquez, A	1
Vincent, M	1
van der Heijden, M	1
Donders, SH	1
Cleophas, TJ	1
Niemeyer, MG	1
van der Meulen, J	1
Bernink, PJ	1
de Planque, BA	1
van der Wall, EE	1
Alvarez-Guerra, M	2
Nazaret, C	2
Michea, L	1
Irribarra, V	1
Goecke, IA	1
Marusic, ET	1
Yan, Y	1
Dempsey, RJ	1
Sun, D	1
Godfraind, T	1
de la Fuente, A	1
Nielsen, K	1
Arrigoni-Martelli, E	1
Vichi, FL	1
de Oliveira, AC	1
Fariña, FR	1
Bernardes F, J	1
Martins, JD	1
Mazotti, L	1
Dahlberg, A	1
Fagerberg, SE	1
Murchison, LE	1
Bewsher, PD	1
Singh, BB	1
Watt, DA	1
Yokomatsu, M	1
Fujito, K	1
Numahata, H	1
Koide, H	1
Ferrari, P	3
Torielli, L	2
Salardi, S	2
Rizzo, A	1
Bianchi, G	3
Talib, HK	2
Klír, P	1
Kren, V	1
Pravenec, M	1
Masereel, B	1
Ferrandi, M	1
Pirotte, B	1
Schynts, M	1
Parenti, P	1
Delarge, J	1
Cirillo, M	1
Salvati, P	1
Ferrario, RG	1
Garthoff, B	1
Morich, F	1
Kazda, S	1
Aguilera, MT	1
Urbano Márquez, A	1
Senn, N	1
Wilcox, CS	1
Loon, NR	1
Ameer, B	1
Limacher, MC	1
Ng, LL	1
Harker, M	1
Abel, ED	1
Tokushige, A	1
Kino, M	1
Tamura, H	1
Hopp, L	1
Searle, BM	1
Aviv, A	1
Darlington, LG	1
Delva, P	1
De Gasperi, M	1
Degan, M	1
Covi, G	1
Lechi, A	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Chlortalidone and Bumetanide in Advanced Chronic Kidney Disease: HEBE-CKD Trial[NCT03923933]	Phase 2	34 participants (Actual)	Interventional	2019-06-18	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	mmHg (Mean)
Placebo	-3.4
Treatment Grup	-13.5

Decrease in extracellular water measured by bioelectrical impedance analysis (NCT03923933)
Timeframe: Change from Basal to day 28

Change in Extracellular Water / Total Body Water Ratio

Intervention	litres (Mean)
Placebo	-0.15
Treatment Grup	2.55

Decrease in extracellular water / total body water ratio measured by bioelectrical impedance analysis (NCT03923933)
Timeframe: Change from Basal to day 28

Change in Mean Arterial Pressure

Intervention	percentage of ECW/TBW (Mean)
Placebo	-0.24
Treatment Grup	-2.92

decrease in blood pressure compared wit baseline measure (mmhg) (NCT03923933)
Timeframe: Change from Basal to day 28

Change in Systolic Blood Pressure

Change in the Fractional Excretion of Sodium

Intervention	mmHg (Mean)
Placebo	-5.4
Treatment Grup	-18.1

Intervention	mmHg (Mean)
Placebo	-10
Treatment Grup	-26.1

Increase in the fractional excretion of sodium compared with the baseline measure (NCT03923933)
Timeframe: Change from Basal to day 28

Change in Total Body Water

Intervention	percentage of sodium excreted (Mean)
Placebo	-0.348
Treatment Grup	0.598

Measured by bioelectrical impedance analysis, compared to the initial measurement (NCT03923933)
Timeframe: Change from Basal to day 28

Article	Year
Effect of the combination of bumetanide plus chlorthalidone on hypertension and volume overload in patients with chronic kidney disease stage 4-5 KDIGO without renal replacement therapy: a double-blind randomized HEBE-CKD trial. BMC nephrology, 2022, 09-20, Volume: 23, Issue:1 Topics: Aged; Bumetanide; Chlorthalidone; Humans; Hypertension; Middle Aged; Renal Insufficiency, Chronic; R	2022
Effects of prostaglandins inhibition on changes in active and inactive renin induced by antihypertensive drugs. Clinical and experimental hypertension. Part A, Theory and practice, 1982, Volume: 4, Issue:11-12 Topics: Adult; Atenolol; Bumetanide; Captopril; Cold Temperature; Diuretics; Enzyme Precursors; Female; Glyc	1982
Urinary zinc excretion during treatment with different diuretics. Acta medica Scandinavica, 1980, Volume: 208, Issue:3 Topics: Adult; Aged; Bendroflumethiazide; Bumetanide; Chlorthalidone; Clinical Trials as Topic; Diuretics; F	1980
A randomized, placebo-controlled study of loop diuretics in patients with essential hypertension: the bumetanide and furosemide on lipid profile (BUFUL) clinical study report. Journal of clinical pharmacology, 1998, Volume: 38, Issue:7 Topics: Adult; Aged; Antihypertensive Agents; Bumetanide; Cross-Over Studies; Diuretics; Double-Blind Method	1998
[Antihypertensive effects of bumetanide treatment]. Lakartidningen, 1976, Oct-27, Volume: 73, Issue:44 Topics: Aged; Bumetanide; Clinical Trials as Topic; Diuretics; Drug Evaluation; Female; Humans; Hypertension	1976
Lack of effect of bumetanide on body potassium content in hypertension. British journal of clinical pharmacology, 1975, Volume: 2, Issue:1 Topics: Adult; Body Composition; Bumetanide; Diuretics; Female; Humans; Hypertension; Liver; Male; Middle Ag	1975
Renal and hemodynamic responses to bumetanide in hypertension: effects of nitrendipine. Kidney international, 1989, Volume: 36, Issue:4 Topics: Bumetanide; Diuretics; Drug Interactions; Female; Hemodynamics; Humans; Hypertension; Male; Middle A	1989

Article	Year
Promoter hypomethylation upregulates Na+-K+-2Cl- cotransporter 1 in spontaneously hypertensive rats. Biochemical and biophysical research communications, 2010, May-28, Volume: 396, Issue:2 Topics: Adrenergic alpha-Agonists; Animals; Aorta; Base Sequence; Bumetanide; DNA Methylation; Epigenesis, G	2010
Expression of Na+-K+ -2Cl- cotransporter 1 is epigenetically regulated during postnatal development of hypertension. American journal of hypertension, 2011, Volume: 24, Issue:12 Topics: Animals; Aorta; Bumetanide; DNA (Cytosine-5-)-Methyltransferases; Epigenomics; Gene Expression Regul	2011
Upregulation of the Na(+)-K(+)-2Cl(-) cotransporter 1 via histone modification in the aortas of angiotensin II-induced hypertensive rats. Hypertension research : official journal of the Japanese Society of Hypertension, 2012, Volume: 35, Issue:8 Topics: Angiotensin II; Animals; Aorta; Blood Pressure; Blotting, Western; Bumetanide; Chromatin Immunopreci	2012
Membrane ion transport in erythrocytes of salt hypertensive Dahl rats and their F2 hybrids: the importance of cholesterol. Hypertension research : official journal of the Japanese Society of Hypertension, 2003, Volume: 26, Issue:5 Topics: Animals; Biological Transport; Blood Pressure; Bumetanide; Cholesterol; Diuretics; Enzyme Inhibitors	2003
Blood pressure regulates the activity and function of the Na-K-2Cl cotransporter in vascular smooth muscle. American journal of physiology. Heart and circulatory physiology, 2004, Volume: 286, Issue:4 Topics: Animals; Aortic Coarctation; Blood Pressure; Bumetanide; Cardiomegaly; Diuretics; Enzyme Inhibitors;	2004
Severe citrate toxicity complicating volunteer apheresis platelet donation. Journal of clinical apheresis, 2007, Volume: 22, Issue:1 Topics: Adult; Blood Donors; Bumetanide; Citric Acid; Female; Humans; Hypertension; Hypocalcemia; Plateletph	2007
Furosemide and bumetanide-sensitive Na+ fluxes in erythrocytes from genetically hypertensive rats (SHR). Clinical and experimental hypertension, 1981, Volume: 3, Issue:4 Topics: 4-Chloromercuribenzenesulfonate; Animals; Biological Transport, Active; Bumetanide; Erythrocytes; Fu	1981
The renal kallikrein-kinin system in spontaneously hypertensive rats. Agents and actions, 1984, Volume: 15, Issue:3-4 Topics: Angiotensin II; Animals; Blood Pressure; Body Weight; Bumetanide; Erythrocyte Indices; Hypertension;	1984
Erythrocytic sodium ion transport systems in primary and secondary hypertension of the rat. Kidney international. Supplement, 1982, Volume: 11 Topics: Animals; Bumetanide; Erythrocytes; Female; Furosemide; Hypertension; Hypertension, Renal; Hypertensi	1982
Reduced responses of renin release to three different stimuli in essential hypertensive patients of stage II (WHO stage classification). Clinical and experimental hypertension, 1980, Volume: 2, Issue:2 Topics: Adult; Blood Pressure; Bumetanide; Depression, Chemical; Diet, Sodium-Restricted; Female; Humans; Hy	1980
Influence of indomethacin on the natriuretic and renin-stimulating effect of bumetanide in essential hypertension. Clinical pharmacology and therapeutics, 1980, Volume: 28, Issue:6 Topics: Adult; Blood Pressure; Bumetanide; Creatinine; Diuretics; Drug Interactions; Female; Heart Rate; Hum	1980
[The effect of therapeutic diuresis in carbohydrate tolerance in essential hypertension (author's transl)]. Medicina clinica, 1981, Jun-10, Volume: 77, Issue:1 Topics: Adult; Blood Glucose; Bumetanide; Carbohydrate Metabolism; Diuretics; Female; Humans; Hypertension;	1981
[Bumetanide in renal insufficiency]. Schweizerische medizinische Wochenschrift, 1982, Feb-27, Volume: 112, Issue:9 Topics: Aged; Bumetanide; Diuretics; Female; Heart Failure; Humans; Hypertension; Kidney Failure, Chronic; L	1982
Depressed cheek cell sodium transport in human hypertension. Blood pressure, 1994, Volume: 3, Issue:5 Topics: Amiloride; Biological Transport; Body Mass Index; Bumetanide; Carrier Proteins; Cheek; Epithelium; F	1994
Red cell ouabain-resistant Na+ and K+ transport in Wistar, Brown Norway and spontaneously hypertensive rats. Physiological research, 1993, Volume: 42, Issue:6 Topics: Animals; Bumetanide; Cell Membrane Permeability; Drug Resistance; Erythrocytes; Hypertension; Ion Tr	1993
Pharmacokinetics and pharmacodynamics of bumetanide after intravenous and oral administration to spontaneously hypertensive rats and DOCA-salt induced hypertensive rats. Biopharmaceutics & drug disposition, 1993, Volume: 14, Issue:6 Topics: Administration, Oral; Animals; Body Weight; Bumetanide; Desoxycorticosterone; Dose-Response Relation	1993
Accumulation of intracellular chloride by (Na-K-Cl) co-transport in rat arterial smooth muscle is enhanced in deoxycorticosterone acetate (DOCA)/salt hypertension. Journal of molecular and cellular cardiology, 1993, Volume: 25, Issue:3 Topics: Animals; Bumetanide; Chlorides; Desoxycorticosterone; Femoral Artery; Hypertension; Ion Transport; M	1993
Detection of a circulating inhibitor of the Na(+)-K(+)-Cl(-) cotransport system in plasma and urine after high salt intake. American journal of hypertension, 1995, Volume: 8, Issue:10 Pt 1 Topics: Adult; Aged; Blood; Blood Physiological Phenomena; Bumetanide; Carrier Proteins; Diet, Sodium-Restri	1995
Relationship of red blood cell ion transport alterations and serum lipid abnormalities in Lyon genetically hypertensive rats. Canadian journal of physiology and pharmacology, 1997, Volume: 75, Issue:9 Topics: Animals; Blood Pressure; Bumetanide; Cell Membrane Permeability; Chlorides; Cholesterol; Erythrocyte	1997
Activation of two inward chloride transport systems in rat femoral arterial smooth muscle in deoxycorticosterone acetate/salt hypertension. Clinical science (London, England : 1979), 1997, Volume: 93, Issue:4 Topics: Acetazolamide; Animals; Anions; Bumetanide; Chloride Channels; Desoxycorticosterone; Diuretics; Hype	1997
The erythrocyte Na,K,Cl cotransporter and its circulating inhibitor in Dahl salt-sensitive rats. Journal of hypertension, 1998, Volume: 16, Issue:10 Topics: Animals; Bumetanide; Carrier Proteins; Chlorides; Diuretics; Erythrocyte Membrane; Humans; Hypertens	1998
Reduced Na-K pump but increased Na-K-2Cl cotransporter in aorta of streptozotocin-induced diabetic rat. American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:2 Topics: Animals; Aorta; Biological Transport; Blotting, Western; Bumetanide; Carrier Proteins; Diabetes Mell	2001
Na+-K+-Cl- cotransporter in rat focal cerebral ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2001, Volume: 21, Issue:6 Topics: Animals; Astrocytes; Autoradiography; Brain Chemistry; Brain Edema; Bumetanide; Carrier Proteins; Ce	2001
Renal Na-K-Cl cotransporter NKCC2 in Dahl salt-sensitive rats. Journal of hypertension, 2002, Volume: 20, Issue:4 Topics: Animals; Bumetanide; Chlorides; Cytosol; Diuretics; Hypertension; In Vitro Techniques; Ion Transport	2002
[Treatment of arterial hypertension with bumetanide and clonidine]. Revista clinica espanola, 1979, Dec-31, Volume: 155, Issue:6 Topics: Administration, Oral; Adult; Aged; Blood Pressure; Bumetanide; Clonidine; Diuretics; Drug Therapy, C	1979
Effects on rat urinary kallikrein excretion of bumetanide, bendroflumethiazide and hydralazine. Acta pharmacologica et toxicologica, 1977, Volume: 40, Issue:2 Topics: Administration, Oral; Animals; Bendroflumethiazide; Bumetanide; Diuretics; Hydralazine; Hypertension	1977
[Bumetanide in the treatment of congestive heart failure and arterial hypertension]. Arquivos brasileiros de cardiologia, 1978, Volume: 31, Issue:4 Topics: Body Weight; Bumetanide; Diuresis; Diuretics; Drug Therapy, Combination; Heart Failure; Humans; Hype	1978
Patient tolerance of long-term diuretic/potassium supplement therapy. Current medical research and opinion, 1976, Volume: 4, Issue:2 Topics: Adult; Aged; Bumetanide; Diuretics; Drug Combinations; Female; Heart Diseases; Heart Failure; Humans	1976
Erythrocyte sodium ion transport system in DOC-salt, Goldblatt, and spontaneously hypertensive rats. Scandinavian journal of clinical and laboratory investigation, 1992, Volume: 52, Issue:6 Topics: Animals; Bumetanide; Erythrocytes; Hypertension; Hypertension, Renovascular; Ion Transport; Male; Ou	1992
Na+/K+/Cl- cotransport in resealed ghosts from erythrocytes of the Milan hypertensive rats. Biochimica et biophysica acta, 1992, Oct-19, Volume: 1111, Issue:1 Topics: Animals; Bumetanide; Cell Membrane Permeability; Chlorides; Erythrocyte Membrane; Hypertension; In V	1992
Association of red blood cell sodium leak with blood pressure in recombinant inbred strains. Hypertension (Dallas, Tex. : 1979), 1992, Volume: 20, Issue:4 Topics: Analysis of Variance; Animals; Biological Transport; Blood Pressure; Bumetanide; Erythrocytes; Furos	1992
Na+,2Cl-,K+ cotransport system as a marker of antihypertensive activity of new torasemide derivatives. European journal of pharmacology, 1992, Sep-04, Volume: 219, Issue:3 Topics: Animals; Blood Pressure; Bumetanide; Chlorine; Diuretics; Erythrocytes; Hypertension; In Vitro Techn	1992
Red cell sodium in DOCA-salt hypertension: a Brattleboro study. Life sciences, 1992, Volume: 50, Issue:14 Topics: Animals; Biological Transport, Active; Blood Pressure; Bumetanide; Desoxycorticosterone; Erythrocyte	1992
Sodium transport kinetics in erythrocytes and inside-out vesicles from Milan rats. Journal of hypertension, 1991, Volume: 9, Issue:8 Topics: Animals; Bumetanide; Cytoplasm; Erythrocyte Membrane; Erythrocytes; Hypertension; Male; Rats; Rats,	1991
Diuretic effect of bumetanide in isolated perfused kidneys of Milan hypertensive rats. Kidney international, 1990, Volume: 37, Issue:4 Topics: Animals; Bumetanide; Diuresis; Diuretics; Hypertension; Kidney; Male; Perfusion; Potassium; Rats; Re	1990
Chronic treatment with nifedipine prevents development of hypertension and abnormal red cell Na+ transport in Dahl-S-rats. Archives internationales de pharmacodynamie et de therapie, 1985, Volume: 275, Issue:2 Topics: Animals; Bumetanide; Erythrocyte Membrane; Erythrocytes; Female; Hypertension; In Vitro Techniques;	1985
Abnormal erythrocyte sodium leak in a subset of essential hypertensive patients. Klinische Wochenschrift, 1989, Jan-04, Volume: 67, Issue:1 Topics: Adult; Aged; Biological Transport; Bumetanide; Erythrocytes; Female; Humans; Hypertension; Ion Chann	1989
Regulation of Na+ and K+ contents in rat thymocytes. The American journal of physiology, 1989, Volume: 257, Issue:1 Pt 1 Topics: Animals; Biological Transport; Blood Coagulation Factors; Bumetanide; Dinoprostone; Hypertension; Is	1989
Mechanisms of leucocyte sodium influx in essential hypertension. Clinical science (London, England : 1979), 1988, Volume: 75, Issue:5 Topics: Amiloride; Bumetanide; Female; Humans; Hypertension; Leukocytes; Male; Sodium	1988
Bumetanide-sensitive sodium-22 transport in vascular smooth muscle cell of the spontaneously hypertensive rat. Hypertension (Dallas, Tex. : 1979), 1986, Volume: 8, Issue:5 Topics: Animals; Biological Transport, Active; Bumetanide; Calcium; Diuretics; Erythrocytes; Hypertension; K	1986
Study to compare the relative hyperuricaemic effects of frusemide and bumetanide. Advances in experimental medicine and biology, 1986, Volume: 195 Pt A Topics: Aged; Bumetanide; Diuretics; Edema; Female; Furosemide; Heart Failure; Humans; Hypertension; Male; M	1986
Kinetics of bumetanide-sensitive Na+-K+ co-transport in erythrocytes of essential hypertensive patients. Clinical science (London, England : 1979), 1985, Volume: 69, Issue:5 Topics: Adolescent; Adult; Biological Transport; Bumetanide; Cell Membrane Permeability; Diuretics; Erythroc	1985
Na+ leak in erythrocytes from essential hypertensive patients. Clinical science (London, England : 1979), 1985, Volume: 69, Issue:5 Topics: Adult; Aged; Biological Transport; Bumetanide; Calcium; Cell Membrane Permeability; Erythrocytes; Fe	1985

bumetanide and Blood Pressure, High