buformin and Diabetes Mellitus studies

Buformin: An oral hypoglycemic agent that inhibits gluconeogenesis, increases glycolysis, and decreases glucose oxidation.
buformin : A member of the class of biguanides that is biguanide substituted by a butyl group at position 1. It is an antidiabetic drug with potential antitumor effect.

Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.

Research Excerpts

Excerpt	Relevance	Reference
"We report two diabetic patients who developed lactic acidosis following the use of Buformin."	7.67	[Lactic acidosis in diabetic patients associated with buformin]. ( Díaz, RA; Hernández, G; Huidobro, F; Jimenez, R; Pérez, H; Torres, H; Videla, C, 1989)
" All the patients had taken guanidine derivates (phenformine, buformine) because of diabetes mellitus."	7.65	[Lactic acidosis after administration of guanidine derivatives (buformine, phenformine) (author's transl)]. ( Butt, H; Reitinger, J, 1977)
"The paper presents an analysis of clinical symptoms, signs and laboratory data of 330 diabetic patients who developed lactic acidosis after having been treated with biguanides (phenformin, buformin, metformin)."	4.75	Lactic acidosis in biguanide-treated diabetics: a review of 330 cases. ( Eggstein, M; Luft, D; Schmülling, RM, 1978)
"We report two diabetic patients who developed lactic acidosis following the use of Buformin."	3.67	[Lactic acidosis in diabetic patients associated with buformin]. ( Díaz, RA; Hernández, G; Huidobro, F; Jimenez, R; Pérez, H; Torres, H; Videla, C, 1989)
" In Austria, the association of lactic acidosis with biguanide therapy has led to a cancellation of the registration of buformin and phenformin."	3.66	[Biguanides: reasons for withdrawal of drugs and remaining indications]. ( Bolzano, K, 1978)
" All the patients had taken guanidine derivates (phenformine, buformine) because of diabetes mellitus."	3.65	[Lactic acidosis after administration of guanidine derivatives (buformine, phenformine) (author's transl)]. ( Butt, H; Reitinger, J, 1977)
"A survey of the literature leads to the conclusion that lactic acidosis should be considered as a side effect of therapy with biguanides."	3.65	[The importance of lactate acidosis as a side effect of biguanide therapy]. ( Förster, H, 1976)
"E."	1.26	[Drug interaction during therapy with tolbutamide. The influence of some commonly used drugs on plasma level and half life in diabetic out-patients (author's transl)]. ( Grille, W; Johnsen, K; Kolenda, KD, 1979)
" We, therefore, consider a preventive administration of biguanides to be effective in long term or high dosage administration of glucocorticoides."	1.26	[Antagonistic action of prednisolone and buformin in the carbohydrate metabolism of healthy persons (author's transl)]. ( Bottermann, P; Ermler, R; Schweigart, U, 1976)

Timeframe	Studies, this research(%)	All Research%
pre-1990	45 (95.74)	18.7374
1990's	2 (4.26)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
BLOECH, J	1
LENHARDT, A	1
LUEDTKE, E	2
BANYASZ, T	1
JACKER, HJ	1
Lefebvre, P	2
Mosora, F	2
Lacroix, M	2
Luyckx, A	2
Pirnay, F	2
Krzentowski, G	1
Müller, P	1
Fischer, H	1
Sorger, D	1
Rojas Hidalgo, E	1
Irsigler, K	2
Kaspar, L	1
Kritz, H	2
Strohfeldt, P	1
Strubel-Obermaier, U	1
Kettl, H	1
Angeli, G	1
Baraldi, B	1
Ciaramelli, F	1
Luft, D	1
Schmülling, RM	1
Eggstein, M	1
Standl, E	1
Janka, HU	1
Standl, A	1
Haslbeck, M	1
Mehnert, H	1
Offerhaus, L	1
Quartarone, M	1
Saitta, A	1
Caruso, G	1
Monacciani, U	1
Perdichizzi, G	1
Squadrito, G	1
Teuscher, A	1
Pilger, E	2
Schmid, P	2
Goebel, R	2
Tatoń, J	1
Kowalik-Borówka, E	1
Brunová, E	3
Kocián, J	1
Slabochová, Z	3
Vondra, K	3
Kolenda, KD	1
Grille, W	1
Johnsen, K	1
Panzram, G	1
Adolph, W	1
Althoff, PH	1
Fassbinder, W	1
Neubauer, M	1
Koch, KM	1
Schöffling, K	1
Nattrass, M	1
Alberti, KG	1
Hrubá, F	1
Nováková, V	1
Bejblová, O	1
Regal, H	1
Foltin, E	1
Durante, F	1
Scaffidi, A	1
Rotolo, G	1
Rini, GB	1
Bass, A	1
Teisinger, J	1
Vítek, V	1
Deppermann, D	1
Heidland, A	1
Ritz, E	1
Hörl, W	1
Bolzano, K	1
Bruneder, H	1
Klein, HJ	1
Bottermann, P	1
Schweigart, U	1
Ermler, R	1
Butt, H	1
Reitinger, J	1
Caspary, WF	1
Zavada, I	1
Reimold, W	1
Deuticke, U	1
Emrich, D	1
Willms, B	1
Botha, JL	1
Vinik, AI	1
Jackson, WP	1
Thimme, W	1
Buschmann, HJ	1
Dissmann, W	1
Amft, R	1
Gutsche, H	1
Blumenbach, L	1
Losert, W	1
Wiemann, H	1
Förster, H	1
Berger, W	1
Mehnert-Aner, S	1
Mülly, K	1
Heierli, C	1
Ritz, R	1
Leone, S	1
Modicano, V	1
Scapellato, L	1
Clavadetscher, P	1
Bischof, P	1
Wegmann, T	1
Keszthelyi, B	1
Tóth, A	1
Novotny, S	1
Fónay, K	1
Jávor, T	1
Past, T	1
Bero, T	1
Kovsh, OIa	1
Musel', IG	1
Iavorkovskiĭ, LL	1
García de los Ríos, M	2
Huidobro, F	1
Videla, C	1
Hernández, G	1
Torres, H	1
Jimenez, R	1
Pérez, H	1
Díaz, RA	1
Aylwin, CG	1
López, G	1
Vial, T	1
Pinto, JL	1
Ojeda, A	1
Orellana, JL	1

Article	Year
[Antidiabetic biguanides and lactic acidosis]. Revista clinica espanola, 1997, Volume: 197, Issue:8 Topics: Acidosis, Lactic; Biguanides; Buformin; Diabetes Mellitus; Humans; Hypoglycemic Agents; Models, Biol	1997
Lactic acidosis in biguanide-treated diabetics: a review of 330 cases. Diabetologia, 1978, Volume: 14, Issue:2 Topics: Acidosis; Biguanides; Buformin; Diabetes Complications; Diabetes Mellitus; Humans; Hypoglycemic Agen	1978

Article	Year
[The biguanides in the treatment of late florid diabetes of recent diagnosis: controlled trial of delayed-action buformin and placebo]. La Clinica terapeutica, 1977, Jun-15, Volume: 81, Issue:5 Topics: Adult; Biguanides; Buformin; Clinical Trials as Topic; Delayed-Action Preparations; Diabetes Mellitu	1977
[The course of asymptomatic diabetes under varying preventive therapy--concluding report of a 5-year prospective study]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1977, Oct-01, Volume: 32, Issue:19 Topics: Buformin; Carbutamide; Diabetes Mellitus; Diet, Diabetic; Female; Germany, East; Humans; Male; Middl	1977
[The risk of lacticate acidosis: a comparison of the 3 biguanides in treatment of diabetics (authors' transl)]. Wiener klinische Wochenschrift, 1978, May-12, Volume: 90, Issue:10 Topics: Acidosis; Biguanides; Buformin; Diabetes Mellitus; Exercise Test; Female; Humans; Lactates; Male; Me	1978
Association of lactic acidosis with biguanide therapy. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1977, Aug-13, Volume: 52, Issue:8 Topics: Biguanides; Buformin; Depression, Chemical; Diabetes Mellitus; Humans; Lactates; Metabolic Clearance	1977

Article	Year
[Diabetes therapy with butylbiguanide Silubin. Clinical results in 129 treated patients]. Die Medizinische Welt, 1963, Jan-19, Volume: 3 Topics: Buformin; Diabetes Mellitus; Humans; Hypoglycemic Agents	1963
[INFLUENCING RENAL FUNCTION BY N 1,N-BUTYLBIGUANIDE. I. THE EFFECT ON THE MAXIMAL TUBULAR GLUCOSE RE-ABSORPTION]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1963, Volume: 18 Topics: Buformin; Diabetes Mellitus; Glucose; Glycosuria; Humans; Hypoglycemic Agents; Kidney Tubules; Nephr	1963
[OUR EXPERIENCES IN THE TREATMENT OF DIABETICS WITH BUTYLBIGUANIDE]. Orvosi hetilap, 1964, Oct-04, Volume: 105 Topics: Buformin; Carbutamide; Diabetes Mellitus; Drug Therapy; Humans; Hypoglycemic Agents	1964
[ON THE EFFECT OF N1,N-BUTYLBIGUANIDE ON RENAL FUNCTION. II. CHANGES IN INULIN- AND PAH-CLEARANCE]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1964, Jul-01, Volume: 19 Topics: Buformin; Diabetes Mellitus; Glycosuria; Glycosuria, Renal; Humans; Hypoglycemic Agents; Inulin; Kid	1964
[NEW PHARMACOLOGIC PRODUCTS. 2. BUFORMIN FOR ORAL THERAPY OF DIABETES]. Pharmazeutische Praxis, 1964, Volume: 10 Topics: Buformin; Diabetes Mellitus; Drug Therapy; Hypoglycemic Agents	1964
[Glucose naturally marked with 13C for metabolic studies in man]. Bulletin et memoires de l'Academie royale de medecine de Belgique, 1982, Volume: 137, Issue:3 Topics: Basal Metabolism; Buformin; Carbohydrate Metabolism; Carbon Isotopes; Diabetes Mellitus; Glucose; Hu	1982
[Vitamin B12-level in serum of diabetics receiving long-term buformin therapy]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1981, Mar-15, Volume: 36, Issue:6 Topics: Biguanides; Buformin; Diabetes Mellitus; Female; Humans; Intestinal Absorption; Male; Vitamin B 12;	1981
Dichloracetate in biguanide-induced lacticacidosis. Lancet (London, England), 1977, Nov-12, Volume: 2, Issue:8046 Topics: Acetates; Aged; Animals; Biguanides; Buformin; Diabetes Mellitus; Diabetic Ketoacidosis; Dichloroace	1977
[Effect of buformin on the metabolism of skeletal muscles in diabetic rats]. Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1976, Volume: 82 Pt 1 Topics: Animals; Biguanides; Buformin; Diabetes Mellitus; Muscles; Rats; Streptozocin	1976
[The effect of combined therapy with buformin and dichloracetate on blood lactate concentrations in diabetics]. Klinische Wochenschrift, 1977, Oct-01, Volume: 55, Issue:19 Topics: Acetates; Aged; Biguanides; Buformin; Diabetes Mellitus; Diabetic Ketoacidosis; Dichloroacetic Acid;	1977
[Biguanides and lactate acidosis; consequences for registration advice]. Nederlands tijdschrift voor geneeskunde, 1979, Feb-24, Volume: 123, Issue:8 Topics: Acidosis; Biguanides; Buformin; Diabetes Mellitus; Drug and Narcotic Control; Humans; Lactates; Neth	1979
[Behavior of IRI and some blood lipid indices after buformin administration]. Minerva medica, 1979, May-07, Volume: 70, Issue:22 Topics: Aged; Antigens; Biguanides; Blood Glucose; Buformin; Cholesterol; Diabetes Mellitus; Female; Humans;	1979
[The biological effect of purely synthetic human insulin in patients with diabetes mellitus]. Schweizerische medizinische Wochenschrift, 1979, May-19, Volume: 109, Issue:20 Topics: Adult; Aged; Buformin; Chlorpropamide; Diabetes Mellitus; Diabetes Mellitus, Type 1; Female; Hormone	1979
[Effect of biguanids on the lactate metabolism. Studies in diabetics under submaximal ergometric exercise (author's transl)]. Medizinische Klinik, 1979, Jun-01, Volume: 74, Issue:22 Topics: Biguanides; Blood Glucose; Buformin; Diabetes Mellitus; Humans; Lactates; Male; Membrane Potentials;	1979
[Indications and contraindications to the diabetes mellitus therapy by biguanide derivatives in the light of the metabolic and epidemiologic studies (author's transl)]. Przeglad lekarski, 1979, Volume: 36, Issue:7 Topics: Adult; Aged; Biguanides; Buformin; Diabetes Mellitus; Humans; Metformin; Middle Aged; Phenformin	1979
[Buformin-influenced calcium absorption (author's transl)]. Casopis lekaru ceskych, 1979, Aug-03, Volume: 118, Issue:31 Topics: Adult; Aged; Biguanides; Buformin; Calcium; Diabetes Mellitus; Female; Humans; Intestinal Absorption	1979
[Drug interaction during therapy with tolbutamide. The influence of some commonly used drugs on plasma level and half life in diabetic out-patients (author's transl)]. Medizinische Klinik, 1979, Dec-14, Volume: 74, Issue:50 Topics: Buformin; Diabetes Mellitus; Digoxin; Drug Interactions; Enzyme Inhibitors; Half-Life; Humans; Methy	1979
[Haemodialysis in the treatment of biguanide-induced lactate acidosis (author's transl)]. Deutsche medizinische Wochenschrift (1946), 1978, Jan-13, Volume: 103, Issue:2 Topics: Acidosis; Acute Kidney Injury; Adult; Aged; Anuria; Biguanides; Buformin; Diabetes Mellitus; Female;	1978
Oxidation of an exogenous glucose load using naturally labelled 13C-glucose. Effect of butylbiguanide therapy in obese mildly diabetic subjects. Diabetologia, 1978, Jan-14, Volume: 14, Issue:1 Topics: Adult; Biguanides; Blood Glucose; Buformin; Carbon Dioxide; Carbon Isotopes; Diabetes Mellitus; Fatt	1978
Biguanides. Diabetologia, 1978, Volume: 14, Issue:2 Topics: Biguanides; Buformin; Diabetes Mellitus; Humans; Hypoglycemic Agents; Lactates; Metformin; Phenformi	1978
[Follow-up study on the effects of buformin on the serum vitamin B-12 level and on the motility of the stomach and small intestine in diabetics]. Vnitrni lekarstvi, 1978, Volume: 24, Issue:3 Topics: Biguanides; Buformin; Diabetes Mellitus; Female; Follow-Up Studies; Gastrointestinal Motility; Human	1978
[Results of a clinical study of a group of hospitalized diabetics under treatment with depot buformin]. Minerva medica, 1978, May-12, Volume: 69, Issue:24 Topics: Adult; Aged; Biguanides; Blood Glucose; Buformin; Diabetes Mellitus; Female; Humans; Lipids; Male; M	1978
[A contribution to the study of the effect of bigvanides in the skeletal muscle of diabetics (author's transl)]. Casopis lekaru ceskych, 1978, Jul-28, Volume: 117, Issue:29-30 Topics: Aged; Biguanides; Buformin; Diabetes Mellitus; Female; Humans; Male; Middle Aged; Muscles	1978
[Lactic acidosis--a possible complication in buformin-treated diabetics (author's transl)]. Klinische Wochenschrift, 1978, Sep-01, Volume: 56, Issue:17 Topics: Acidosis; Biguanides; Buformin; Diabetes Mellitus; Humans; Kinetics; Lactates; Pyruvates; Renal Dial	1978
[Biguanides: reasons for withdrawal of drugs and remaining indications]. Acta medica Austriaca, 1978, Volume: 5, Issue:3 Topics: Acidosis; Austria; Biguanides; Buformin; Diabetes Mellitus; Humans; Lactates; Legislation, Drug; Met	1978
[Blood lactate and biguanide therapy: comparison between phenformin, metformin and buformin in 408 senile diabetics]. Acta medica Austriaca, 1978, Volume: 5, Issue:3 Topics: Aged; Biguanides; Buformin; Diabetes Mellitus; Female; Humans; Lactates; Male; Metformin; Phenformin	1978
[Effect of biguanide therapy on lactate metabolism during graded submaximal ergometric testing]. Acta medica Austriaca, 1978, Volume: 5, Issue:3 Topics: Biguanides; Buformin; Diabetes Mellitus; Humans; Lactates; Metformin; Phenformin; Physical Exertion	1978
[Antagonistic action of prednisolone and buformin in the carbohydrate metabolism of healthy persons (author's transl)]. Medizinische Klinik, 1976, Feb-13, Volume: 71, Issue:7 Topics: Biguanides; Buformin; Carbohydrate Metabolism; Diabetes Mellitus; Drug Combinations; Glucose; Glucos	1976
[Lactic acidosis after administration of guanidine derivatives (buformine, phenformine) (author's transl)]. Medizinische Klinik, 1977, Apr-22, Volume: 72, Issue:16 Topics: Acidosis; Aged; Bicarbonates; Biguanides; Buformin; Diabetes Mellitus; Female; Glomerular Filtration	1977
Alteration of bile acid metabolism and vitamin-B12-absorption in diabetics on biguanides. Diabetologia, 1977, Volume: 13, Issue:3 Topics: Biguanides; Buformin; Carbon Dioxide; Cholic Acids; Diabetes Mellitus; Doxycycline; Feces; Female; G	1977
[Lactic acidosis and biguanid therapy (author's transl)]. Medizinische Klinik, 1976, Sep-03, Volume: 71, Issue:36 Topics: Acidosis; Aged; Anti-Bacterial Agents; Bicarbonates; Biguanides; Buffers; Buformin; Diabetes Mellitu	1976
[Concentration of 14C-1-butylbiguanide in plasma of diabetic patients and its elimination after administration of a new Galenical formulation (author's transl)]. Arzneimittel-Forschung, 1976, Volume: 26, Issue:6 Topics: Aged; Biguanides; Buformin; Delayed-Action Preparations; Diabetes Mellitus; Female; Humans; Kinetics	1976
[The importance of lactate acidosis as a side effect of biguanide therapy]. Fortschritte der Medizin, 1976, Dec-16, Volume: 94, Issue:35-36 Topics: Acidosis; Biguanides; Buformin; Diabetes Mellitus; Drug Therapy, Combination; Ethanol; Humans; Kidne	1976
[10 cases of lactic acidosis during biguanide therapy (buformin and phenformin)]. Schweizerische medizinische Wochenschrift, 1976, Dec-11, Volume: 106, Issue:50 Topics: Acidosis; Biguanides; Buformin; Diabetes Mellitus; Glucagon; Humans; Lactates; Liver; Metformin; Phe	1976
[Clinical use of a new hypoglycemic agent: buformin]. La Clinica terapeutica, 1976, Sep-30, Volume: 78, Issue:6 Topics: Adolescent; Adult; Aged; Biguanides; Buformin; Diabetes Mellitus; Drug Evaluation; Female; Humans; M	1976
[Lactic acidosis after administration of buformine (author's transl)]. Deutsche medizinische Wochenschrift (1946), 1976, Feb-13, Volume: 101, Issue:7 Topics: Acidosis; Aged; Bicarbonates; Biguanides; Buformin; Diabetes Mellitus; Diabetic Coma; Female; Humans	1976
[Vitamin B 12 absorption disorders in diabetic patients treated with adebit]. Orvosi hetilap, 1976, Apr-18, Volume: 117, Issue:16 Topics: Adult; Aged; Biguanides; Buformin; Diabetes Mellitus; Female; Humans; Intestinal Absorption; Male; M	1976
[B12 (folic)-deficient anemia in a diabetic patient receiving buformin long term]. Vrachebnoe delo, 1991, Issue:1 Topics: Anemia; Buformin; Chronic Disease; Diabetes Complications; Diabetes Mellitus; Folic Acid Deficiency;	1991
[Lactic acidosis in diabetic patients associated with buformin]. Revista medica de Chile, 1989, Volume: 117, Issue:6 Topics: Acidosis, Lactic; Buformin; Diabetes Mellitus; Diabetic Ketoacidosis	1989
[Lactic acidosis in diabetic patients associated with buformin]. Revista medica de Chile, 1989, Volume: 117, Issue:1 Topics: Acidosis, Lactic; Aged; Bicarbonates; Biguanides; Buformin; Diabetes Mellitus; Diabetic Angiopathies	1989
[Failure of oral hypoglycemic agents: clinical experiences in 20 years' follow-up]. Revista medica de Chile, 1988, Volume: 116, Issue:8 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Blood Glucose; Body Weight; Buformin; Diabetes	1988

buformin and Diabetes Mellitus

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