bufalin has been researched along with Cancer of Liver in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (3.45) | 29.6817 |
| 2010's | 18 (62.07) | 24.3611 |
| 2020's | 10 (34.48) | 2.80 |
| Authors | Studies |
|---|---|
| Itokawa, H; Kamano, Y; Katsuyama, M; Morita, H; Nogawa, T; Pettit, GR; Saito, K; Segawa, T; Takeya, K; Yamashita, A; Yukita, A | 1 |
| Fang, K; Liang, X; Qiu, Y; Sun, M; Wang, Y; Wu, C; Xu, K; Yin, P; Yuan, Z; Zhan, Y; Zhu, R | 1 |
| Cui, X; Fu, R; Guo, F; Li, J; Liu, J; Wang, F; Wu, W; Xu, L; Yu, F | 1 |
| Cao, X; He, J; Kou, S; Li, F; Liu, J; Tang, Y; Xue, J; Yang, Y; Ye, M | 1 |
| Feng, H; Gao, Y; Guo, J; Han, Q; Ji, L; Li, F; Li, M; Li, Y; Sheng, J; Sun, X; Tang, Y; Wang, L; Yu, Z; Zhang, J; Zheng, Y | 1 |
| Huang, CJ; Meng, ZQ; Qian, L; Wang, D; Xie, L; Zhang, CY; Zhao, YK; Zhu, Y; Zhuang, L | 1 |
| Cheng, AS; Feng, H; Gao, Y; Huang, L; Jiang, Y; Le, F; Li, M; Sun, X; Yu, DY; Yu, Z; Zhang, X; Zheng, C; Zhou, Z; Zhu, X; Zhuo, Y | 1 |
| Lian, X; Shu, C; Wu, Y; Yi, X; Zhang, J; Zhu, J | 1 |
| Li, H; Qin, J; Sheng, X; Zhang, J; Zhao, H; Zhao, Y; Zhu, P | 1 |
| Guo, Q; Liu, D; Liu, Y; Tu, PF; Yang, H; Zeng, KW; Zhao, MM; Zheng, XK | 1 |
| Gou, H; Huang, RC; Su, YH; Zhang, FL | 1 |
| Cheng, AS; Feng, H; Gao, Y; Huang, L; Jiang, Y; Le, F; Li, M; Sun, X; Yu, Z; Zhang, X; Zheng, C; Zhou, Z; Zhu, X; Zhuo, Y | 1 |
| Chi, H; Meng, Z; Wang, H; Zhang, C | 1 |
| Li, Q; Qin, J; Sheng, X; Zhu, P | 1 |
| Cai, F; Ma, L; Tao, Y; Xu, X; Yang, Z; Yu, Y | 1 |
| Hsu, CM; Tsai, FJ; Tsai, Y; Wan, L | 1 |
| Qiu, DZ; Wu, WZ; Yang, YK; Zhang, ZJ | 1 |
| Chang, JB; Chang, SJ; Chen, YY; Chung, JG; Hsu, SC; Kuo, CL; Lee, CH; Lin, JJ; Liu, JY; Lu, HF; Wu, PP | 1 |
| Han, J; Hu, F; Liu, T; Liu, Y; Ming, X; Pan, S; Zhai, B; Zhuang, L | 1 |
| Cheng, BB; Fang, FF; Gu, W; Huang, F; Li, B; Liu, L | 1 |
| Wu, WZ; Yang, YK; Zhang, ZJ | 1 |
| Fang, T; Hu, F; Jin, X; Pan, S; Sun, X; Xu, L; Yan, H; Zhai, B; Zhao, D | 1 |
| Gai, JQ; Ni, L; Qin, JM; Sheng, X; Sun, K; Zhao, W | 1 |
| Chi, H; Jiang, F; Meng, Z; Ning, Z; Wang, H; Xu, L; Zang, K; Zhang, C; Zhu, X | 1 |
| Cohen, L; Gao, Y; Li, H; Liu, L; Meng, Z; Wang, P; Yang, P; Zhu, X | 1 |
| Cui, X; Gao, B; Inagaki, Y; Kokudo, N; Li, A; Qi, F; Tang, W; Xu, H | 1 |
| Cohen, L; Gao, Y; Gu, K; Li, HX; Meng, ZQ; Wang, P; Xu, LT; Xu, LY; Yang, PY | 1 |
| Amagaya, S; Chiang, JH; Chung, JG; Huang, WW; Lin, JK; Lin, MW; Lu, CC; Peng, SF; Tsai, SC; Tseng, MT; Tung, TT; Wai-Shan Chung, C; Yang, JS | 1 |
| Bi, LL; Li, X; Miao, Q; Miao, S; Wang, SW; Xie, YH; Yang, Q; Zhang, J; Zhang, S | 1 |
29 other study(ies) available for bufalin and Cancer of Liver
| Article | Year |
|---|---|
QSAR evaluation of the Ch'an Su and related bufadienolides against the colchicine-resistant primary liver carcinoma cell line PLC/PRF/5(1).
Topics: Antineoplastic Agents; Bufanolides; Colchicine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Liver Neoplasms; Models, Molecular; Quantitative Structure-Activity Relationship; Tumor Cells, Cultured | 2002 |
Bufalin suppresses tumour microenvironment-mediated angiogenesis by inhibiting the STAT3 signalling pathway.
Topics: Angiogenesis Inhibitors; Animals; Bufanolides; Cell Movement; Cell Proliferation; Human Umbilical Vein Endothelial Cells; Humans; Liver Neoplasms; Mice; Mice, Nude; Neovascularization, Pathologic; STAT3 Transcription Factor; Tumor Microenvironment | 2021 |
Bufalin enhances the killing efficacy of NK cells against hepatocellular carcinoma by inhibiting MICA shedding.
Topics: Antineoplastic Agents; Apoptosis; Bufanolides; Carcinoma, Hepatocellular; Cell Survival; Gene Expression Regulation, Neoplastic; Histocompatibility Antigens Class I; Humans; Killer Cells, Natural; Liver Neoplasms | 2021 |
Alisol B 23-Acetate Increases the Antitumor Effect of Bufalin on Liver Cancer through Inactivating Wnt/
Topics: Apoptosis; beta Catenin; Bufanolides; Cell Line, Tumor; Cholestenones; Glycogen Synthase Kinase 3 beta; Humans; Liver Neoplasms | 2022 |
Bufalin stimulates antitumor immune response by driving tumor-infiltrating macrophage toward M1 phenotype in hepatocellular carcinoma.
Topics: Animals; Bufanolides; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytokines; Humans; Immunity; Liver Neoplasms; Macrophages; Mice; NF-kappa B; Phenotype; Tumor Microenvironment | 2022 |
Bufalin Inhibits Tumorigenesis and SREBP-1-Mediated Lipogenesis in Hepatocellular Carcinoma via Modulating the ATP1A1/CA2 Axis.
Topics: Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Humans; Lipogenesis; Liver Neoplasms; Sodium-Potassium-Exchanging ATPase; Sterol Regulatory Element Binding Protein 1 | 2023 |
Bufalin inhibits hepatitis B virus-associated hepatocellular carcinoma development through androgen receptor dephosphorylation and cell cycle-related kinase degradation.
Topics: Animals; beta Catenin; Bufanolides; Carcinogenesis; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Glycogen Synthase Kinase 3 beta; Hepatitis B virus; Liver Neoplasms; Mice, Nude; Mice, Transgenic; Models, Biological; Phosphorylation; Proteolysis; Receptors, Androgen; Signal Transduction; Sorafenib; Trans-Activators; Viral Regulatory and Accessory Proteins | 2020 |
Response Surface Methodology to Optimize the Combination Treatment of Paclitaxel, Bufalin and Cinobufagin for Hepatoma Therapy.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Bufanolides; Carcinoma, Hepatocellular; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; Liver Neoplasms; Molecular Conformation; Paclitaxel; Surface Properties; Tumor Cells, Cultured | 2021 |
Effect of PI3K/AKT/mTOR Signaling Pathway on Regulating and Controlling the Anti-Invasion and Metastasis of Hepatoma Cells by Bufalin.
Topics: Antineoplastic Agents; Bufanolides; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Humans; Liver Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Patents as Topic; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases | 2021 |
Therapeutic potential of targeting membrane-spanning proteoglycan SDC4 in hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Bufanolides; Carcinoma, Hepatocellular; Chick Embryo; Female; Humans; Liver Neoplasms; Mice; Mice, Nude; Syndecan-4; Transfection | 2021 |
Design of dual targeting immunomicelles loaded with bufalin and study of their anti-tumor effect on liver cancer.
Topics: Animals; Antineoplastic Agents; Bufanolides; Cell Line, Tumor; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude | 2021 |
Bufalin suppresses hepatocarcinogenesis by targeting β-catenin/TCF signaling via cell cycle-related kinase.
Topics: Animals; beta Catenin; Bufanolides; Carcinogenesis; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Female; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Liver Neoplasms; Medicine, Chinese Traditional; Mice; Mice, Nude; Signal Transduction; T Cell Transcription Factor 1; Xenograft Model Antitumor Assays | 2018 |
Synergistic anti-hepatoma effect of bufalin combined with sorafenib via mediating the tumor vascular microenvironment by targeting mTOR/VEGF signaling.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bufanolides; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Culture Media, Conditioned; Drug Synergism; Gene Expression Regulation, Neoplastic; Human Umbilical Vein Endothelial Cells; Humans; Liver Neoplasms; Mice; Niacinamide; Phenylurea Compounds; Signal Transduction; Sorafenib; TOR Serine-Threonine Kinases; Tumor Microenvironment; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2018 |
The biological role of autophagy in regulating and controlling the proliferation of liver cancer cells induced by bufalin.
Topics: Adenine; Autophagy; Beclin-1; Bufanolides; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chloroquine; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Microtubule-Associated Proteins | 2018 |
Bufalin inhibits cell proliferation and migration of hepatocellular carcinoma cells via APOBEC3F induced intestinal immune network for IgA production signaling pathway.
Topics: Bufanolides; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cytosine Deaminase; Dose-Response Relationship, Drug; Humans; Immunoglobulin A; Intestinal Mucosa; Liver Neoplasms; Signal Transduction; Structure-Activity Relationship | 2018 |
Bufalin induces G2/M phase arrest and triggers autophagy via the TNF, JNK, BECN-1 and ATG8 pathway in human hepatoma cells.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 8 Family; Beclin-1; Bufanolides; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Line, Tumor; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; MAP Kinase Signaling System; Membrane Proteins; Microfilament Proteins; Tumor Necrosis Factor-alpha | 2013 |
Bufalin, a component in Chansu, inhibits proliferation and invasion of hepatocellular carcinoma cells.
Topics: Antineoplastic Agents; beta Catenin; Bufanolides; Carcinoma, Hepatocellular; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Liver Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Signal Transduction | 2013 |
Bufalin inhibits migration and invasion in human hepatocellular carcinoma SK-Hep1 cells through the inhibitions of NF-kB and matrix metalloproteinase-2/-9-signaling pathways.
Topics: Antineoplastic Agents; Bufanolides; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Humans; Liver Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; NF-kappa B; Signal Transduction | 2015 |
Blocking autophagy enhances the apoptosis effect of bufalin on human hepatocellular carcinoma cells through endoplasmic reticulum stress and JNK activation.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Bufanolides; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Down-Regulation; Drugs, Chinese Herbal; Endoplasmic Reticulum Stress; Enzyme Activation; Humans; Liver Neoplasms; MAP Kinase Kinase 4; Up-Regulation | 2014 |
Reversal effect of bufalin on multidrug resistance in human hepatocellular carcinoma BEL-7402/5-FU cells.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; bcl-2-Associated X Protein; bcl-X Protein; Bufanolides; Calcium Channel Blockers; Carcinoma, Hepatocellular; Cell Survival; Down-Regulation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorouracil; G1 Phase Cell Cycle Checkpoints; Humans; Liver Neoplasms; Medicine, Chinese Traditional; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Thymidylate Synthase; Verapamil | 2014 |
Bufalin attenuates the stage and metastatic potential of hepatocellular carcinoma in nude mice.
Topics: Animals; Apoptosis; beta Catenin; Bufanolides; Cadherins; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Liver Neoplasms; Lung Neoplasms; Male; Mice; Mice, Nude; Necrosis; Neoplasm Staging; Proto-Oncogene Proteins c-akt; Signal Transduction; Survival Analysis; Xenograft Model Antitumor Assays | 2014 |
Bufalin Reverses Resistance to Sorafenib by Inhibiting Akt Activation in Hepatocellular Carcinoma: The Role of Endoplasmic Reticulum Stress.
Topics: Apoptosis; Bufanolides; Carcinoma, Hepatocellular; Cell Proliferation; Drug Resistance, Neoplasm; Endoplasmic Reticulum Stress; Hep G2 Cells; Humans; Liver Neoplasms; Niacinamide; Phenylurea Compounds; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; Sorafenib | 2015 |
The effect and mechanism of bufalin on regulating hepatocellular carcinoma cell invasion and metastasis via Wnt/β-catenin signaling pathway.
Topics: Bufanolides; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Liver Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Phosphorylation; Wnt Signaling Pathway | 2016 |
Bufalin suppresses hepatocellular carcinoma invasion and metastasis by targeting HIF-1α via the PI3K/AKT/mTOR pathway.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Bufanolides; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases; Transforming Growth Factor beta1; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2016 |
Na+/K+-ATPase α3 mediates sensitivity of hepatocellular carcinoma cells to bufalin.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Bufanolides; Carcinoma, Hepatocellular; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Prognosis; RNA, Small Interfering; Sodium-Potassium-Exchanging ATPase; Tumor Cells, Cultured | 2011 |
Bufalin and cinobufagin induce apoptosis of human hepatocellular carcinoma cells via Fas- and mitochondria-mediated pathways.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Bufanolides; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Liver Neoplasms; Mitochondria; Signal Transduction | 2011 |
Bufalin enhances the anti-proliferative effect of sorafenib on human hepatocellular carcinoma cells through downregulation of ERK.
Topics: Antineoplastic Agents; Benzenesulfonates; Blotting, Western; Bufanolides; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chromones; Drug Synergism; Gene Expression Regulation, Enzymologic; Humans; Liver Neoplasms; Microscopy, Electron, Transmission; Morpholines; Niacinamide; Phenylurea Compounds; Pyridines; Sorafenib | 2012 |
Bufalin increases sensitivity to AKT/mTOR-induced autophagic cell death in SK-HEP-1 human hepatocellular carcinoma cells.
Topics: Animals; Autophagy; Bufanolides; Bufo bufo; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases; Venoms | 2012 |
Anticancer effects of bufalin on human hepatocellular carcinoma HepG2 cells: roles of apoptosis and autophagy.
Topics: AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Blotting, Western; Bufanolides; Carcinoma, Hepatocellular; Cell Proliferation; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Liver Neoplasms; Membrane Proteins; Microscopy, Confocal; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Molecular Structure; Phosphorylation; Signal Transduction; TOR Serine-Threonine Kinases | 2013 |