bufadienolide and Cardiotoxicity

bufadienolide has been researched along with Cardiotoxicity* in 1 studies

Other Studies

1 other study(ies) available for bufadienolide and Cardiotoxicity

Article	Year
Fibroblast Activation Protein α Activated Tripeptide Bufadienolide Antitumor Prodrug with Reduced Cardiotoxicity. Journal of medicinal chemistry, 2017, 07-13, Volume: 60, Issue:13 Bufadienolides are the major pharmacologic constituents of traditional Chinese medicine Chan'su, which is frequently used clinically for cancer treatment in China. Motivated by reducing or avoiding the cardiac toxicity of bufadienolides, we have designed, synthesized, and evaluated the fibroblast activation protein α (FAPα) activated tripeptide arenobufagin prodrugs with the purpose of improving the safety of arenobufagin (a representative bufadienolide). Among these FAPα-activated prodrugs, 3f exhibited the best hydrolytic efficiency by recombinant human FAPα (rhFAPα) and was activated in tumors. The LD Topics: Animals; Antineoplastic Agents; Bufanolides; Cardiotoxicity; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Endopeptidases; Female; Gelatinases; Humans; Membrane Proteins; Mice; Mice, Inbred BALB C; Molecular Structure; Neoplasms, Experimental; Oligopeptides; Prodrugs; Recombinant Proteins; Serine Endopeptidases; Structure-Activity Relationship	2017

Article

Year

Fibroblast Activation Protein α Activated Tripeptide Bufadienolide Antitumor Prodrug with Reduced Cardiotoxicity.

Journal of medicinal chemistry, 2017, 07-13, Volume: 60, Issue:13

Bufadienolides are the major pharmacologic constituents of traditional Chinese medicine Chan'su, which is frequently used clinically for cancer treatment in China. Motivated by reducing or avoiding the cardiac toxicity of bufadienolides, we have designed, synthesized, and evaluated the fibroblast activation protein α (FAPα) activated tripeptide arenobufagin prodrugs with the purpose of improving the safety of arenobufagin (a representative bufadienolide). Among these FAPα-activated prodrugs, 3f exhibited the best hydrolytic efficiency by recombinant human FAPα (rhFAPα) and was activated in tumors. The LD

Topics: Animals; Antineoplastic Agents; Bufanolides; Cardiotoxicity; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Endopeptidases; Female; Gelatinases; Humans; Membrane Proteins; Mice; Mice, Inbred BALB C; Molecular Structure; Neoplasms, Experimental; Oligopeptides; Prodrugs; Recombinant Proteins; Serine Endopeptidases; Structure-Activity Relationship

2017