bryostatin-5 and Leukemia--Promyelocytic--Acute

bryostatin-5 has been researched along with Leukemia--Promyelocytic--Acute* in 1 studies

Other Studies

1 other study(ies) available for bryostatin-5 and Leukemia--Promyelocytic--Acute

ArticleYear
Bryostatin-5 stimulates normal human hematopoiesis and inhibits proliferation of HL60 leukemic cells.
    Leukemia research, 1995, Volume: 19, Issue:1

    In this study we explored the effects of bryostatin-5 on the clonogenic response of normal bone marrow mononuclear (BM) cells and HL60 myeloid leukemia cells. Leukemic HL60 colony formation was strongly inhibited by bryostatin-5 depending on dose and schedule. An inhibitory effect on HL60 colony formation was readily demonstrated after 1 h of exposure, reaching a maximal inhibitory effect at 96 h. Normal BM cells differed in their clonogenic response: short-term exposure to bryostatin-5 resulted in increased clonogenicity while longstanding exposure to bryostatin-5 permitted the survival of a substantial fraction of committed progenitors. This differential modulation of normal and leukemic myeloid clonogenicity by bryostatin-5 suggests a possible role for bryostatin-5 in the treatment of acute myeloid leukemia.

    Topics: Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Bryostatins; Cell Division; Cell Survival; Hematopoiesis; Humans; Lactones; Leukemia, Promyelocytic, Acute; Macrolides; Stimulation, Chemical; Tumor Cells, Cultured

1995