bryostatin-1 has been researched along with Urinary-Bladder-Neoplasms* in 1 studies
1 other study(ies) available for bryostatin-1 and Urinary-Bladder-Neoplasms
Article | Year |
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Novel cytotoxic compounds from the ascidian Lissoclinum bistratum.
The isolation and structures of two new cyclic hexapeptides and two new macrocyclic ethers from the aplousobranch ascidian Lissoclinum bistratum are described. Their structures were determined by two-dimensional NMR techniques. The hexapeptides, named bistratamide A and bistratamide B, differ only by the presence or absence of one double bond. They were tested for cytotoxicity toward human fibroblast and tumor cell lines and displayed similar toxicities to the octapeptides called patellamides from Lissoclinum patella. The peptides are found within the obligate algal symbiont Prochloron but clearly differ from peptides isolated from the same Prochloron of L. patella. The macrocyclic ethers isolated from L. bistratum are exceedingly potent in cytotoxicity. They have been named bistratenes A and B, and structures for these compounds are proposed. Topics: Acetamides; Animals; Cell Line, Transformed; Cell Survival; Chromatography, High Pressure Liquid; DNA; Ethers, Cyclic; Fibroblasts; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Conformation; Molecular Structure; Molecular Weight; Peptides, Cyclic; Pyrans; Spiro Compounds; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Urochordata | 1989 |