brucine and Skin-Neoplasms

Natural products have been extensively used for treating a wide variety of disorders. In recent times, Brucine (BRU) as one of the natural medications extracted from seeds of nux vomica, was investigated for its anticancer activity. As far as we know, this is the first study on BRU anticancer activity against skin cancer. Thus, the rational of this work was implemented to develop, optimize and characterize the anticancer activity of BRU loaded ethosomal gel. Basically, thin film hydration method was used to formulate BRU ethosomal preparations, by means of Central composite design (CCD), which were operated to construct (3

Topics: Administration, Cutaneous; Animals; Ethanol; Gels; Male; Phospholipids; Rats; Rats, Wistar; Skin; Skin Absorption; Skin Neoplasms; Strychnine