broussochalcone-a has been researched along with Pancreatic-Neoplasms* in 1 studies
1 other study(ies) available for broussochalcone-a and Pancreatic-Neoplasms
| Article | Year |
|---|---|
Broussochalcone A Is a Novel Inhibitor of the Orphan Nuclear Receptor NR4A1 and Induces Apoptosis in Pancreatic Cancer Cells.
The orphan nuclear receptor 4A1 (NR4A1) is overexpressed in pancreatic cancer and exhibits pro-oncogenic activity, and NR4A1 silencing and treatment with its inactivators has been shown to inhibit pancreatic cancer cells and tumor growth. In this study, we identified broussochalcone A (BCA) as a new NR4A1 inhibitor and demonstrated that BCA inhibits cell growth partly by inducing NR4A1-mediated apoptotic pathways in human pancreatic cancer cells. BCA downregulated specificity protein 1 (Sp1)-mediated expression of an anti-apoptotic protein, survivin, and activated the endoplasmic reticulum (ER) stress-mediated apoptotic pathway. These results suggest that NR4A1 inactivation contributes to the anticancer effects of BCA, and that BCA represents a potential anticancer agent targeting NR4A1 that is overexpressed in many types of human cancers. Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Chalcones; Endoplasmic Reticulum Stress; Humans; Nuclear Receptor Subfamily 4, Group A, Member 1; Pancreatic Neoplasms; Reactive Oxygen Species; Resorcinols | 2021 |