bromouracil has been researched along with Neoplasms in 6 studies
Bromouracil: 5-Bromo-2,4(1H,3H)-pyrimidinedione. Brominated derivative of uracil that acts as an antimetabolite, substituting for thymine in DNA. It is used mainly as an experimental mutagen, but its deoxyriboside (BROMODEOXYURIDINE) is used to treat neoplasms.
5-bromouracil : A pyrimidine having keto groups at the 2- and 4-positions and a bromo group at the 5-position. Used mainly as an experimental mutagen.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A toxicokinetic study was performed using rats to investigate the possible mechanism of 18 acute deaths in Japanese patients with cancer and herpes zoster by interactions of the new oral antiviral drug, sorivudine (SRV), with one of the oral 5-fluorouracil (5-FU) prodrugs within 40 days after approval of the use of SRV." | 3.70 | A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs. ( Kato, A; Ogura, K; Okuda, H; Takubo, H; Watabe, T, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| LIPETZ, J | 1 |
| STONIER, T | 1 |
| PAINTER, RB | 1 |
| RASMUSSEN, RE | 1 |
| Nimmagadda, S | 1 |
| Mangner, TJ | 1 |
| Sun, H | 1 |
| Klecker, RW | 1 |
| Muzik, O | 1 |
| Lawhorn-Crews, JM | 1 |
| Douglas, KA | 1 |
| Collins, JM | 1 |
| Shields, AF | 1 |
| Okuda, H | 1 |
| Ogura, K | 1 |
| Kato, A | 1 |
| Takubo, H | 1 |
| Watabe, T | 1 |
| Goffinet, DR | 1 |
| Bagshaw, MA | 1 |
| Hagen, U | 1 |
1 review available for bromouracil and Neoplasms
| Article | Year |
|---|---|
Clinical use of radiation sensitizing agents.
Topics: Animals; Antimetabolites, Antineoplastic; Bleomycin; Bromodeoxycytidine; Bromodeoxyuridine; Bromoura | 1974 |
5 other studies available for bromouracil and Neoplasms
| Article | Year |
|---|---|
Effect of 5-bromuracil on crown gall tumour induction.
Topics: Agrobacterium; Bromouracil; Infections; Neoplasms; Plant Tumors; Plants; Rhizobium; Uracil | 1961 |
ORGANIZATION OF THE DEOXYRIBONUCLEIC ACID REPLICATING SYSTEM IN MAMMALIAN CELLS AS REVEALED BY THE USE OF X-RADIATION AND BROMURACIL DEOXYRIBOSIDE.
Topics: Bromine; Bromodeoxyuridine; Bromouracil; Carbon Isotopes; Cricetinae; DNA; DNA Replication; Neoplasm | 1964 |
Biodistribution and radiation dosimetry estimates of 1-(2'-deoxy-2'-(18)F-Fluoro-1-beta-D-arabinofuranosyl)-5-bromouracil: PET imaging studies in dogs.
Topics: Animals; Body Burden; Bromouracil; Cell Line, Tumor; Dogs; Humans; Neoplasms; Organ Specificity; Pos | 2005 |
A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs.
Topics: Animals; Antimetabolites, Antineoplastic; Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Cau | 1998 |
[Molecular basis of radiosensitization].
Topics: Bromouracil; Chromosome Aberrations; DNA; DNA Repair; Humans; Neoplasms; Radiation Effects; Radiatio | 1972 |