Page last updated: 2024-11-06

bromouracil and Neoplasms

bromouracil has been researched along with Neoplasms in 6 studies

Bromouracil: 5-Bromo-2,4(1H,3H)-pyrimidinedione. Brominated derivative of uracil that acts as an antimetabolite, substituting for thymine in DNA. It is used mainly as an experimental mutagen, but its deoxyriboside (BROMODEOXYURIDINE) is used to treat neoplasms.
5-bromouracil : A pyrimidine having keto groups at the 2- and 4-positions and a bromo group at the 5-position. Used mainly as an experimental mutagen.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
"A toxicokinetic study was performed using rats to investigate the possible mechanism of 18 acute deaths in Japanese patients with cancer and herpes zoster by interactions of the new oral antiviral drug, sorivudine (SRV), with one of the oral 5-fluorouracil (5-FU) prodrugs within 40 days after approval of the use of SRV."3.70A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs. ( Kato, A; Ogura, K; Okuda, H; Takubo, H; Watabe, T, 1998)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19904 (66.67)18.7374
1990's1 (16.67)18.2507
2000's1 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
LIPETZ, J1
STONIER, T1
PAINTER, RB1
RASMUSSEN, RE1
Nimmagadda, S1
Mangner, TJ1
Sun, H1
Klecker, RW1
Muzik, O1
Lawhorn-Crews, JM1
Douglas, KA1
Collins, JM1
Shields, AF1
Okuda, H1
Ogura, K1
Kato, A1
Takubo, H1
Watabe, T1
Goffinet, DR1
Bagshaw, MA1
Hagen, U1

Reviews

1 review available for bromouracil and Neoplasms

ArticleYear
Clinical use of radiation sensitizing agents.
    Cancer treatment reviews, 1974, Volume: 1, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Bleomycin; Bromodeoxycytidine; Bromodeoxyuridine; Bromoura

1974

Other Studies

5 other studies available for bromouracil and Neoplasms

ArticleYear
Effect of 5-bromuracil on crown gall tumour induction.
    Nature, 1961, Jun-03, Volume: 190

    Topics: Agrobacterium; Bromouracil; Infections; Neoplasms; Plant Tumors; Plants; Rhizobium; Uracil

1961
ORGANIZATION OF THE DEOXYRIBONUCLEIC ACID REPLICATING SYSTEM IN MAMMALIAN CELLS AS REVEALED BY THE USE OF X-RADIATION AND BROMURACIL DEOXYRIBOSIDE.
    Nature, 1964, Jan-11, Volume: 201

    Topics: Bromine; Bromodeoxyuridine; Bromouracil; Carbon Isotopes; Cricetinae; DNA; DNA Replication; Neoplasm

1964
Biodistribution and radiation dosimetry estimates of 1-(2'-deoxy-2'-(18)F-Fluoro-1-beta-D-arabinofuranosyl)-5-bromouracil: PET imaging studies in dogs.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2005, Volume: 46, Issue:11

    Topics: Animals; Body Burden; Bromouracil; Cell Line, Tumor; Dogs; Humans; Neoplasms; Organ Specificity; Pos

2005
A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 287, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Antiviral Agents; Arabinofuranosyluracil; Bromouracil; Cau

1998
[Molecular basis of radiosensitization].
    Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 1972

    Topics: Bromouracil; Chromosome Aberrations; DNA; DNA Repair; Humans; Neoplasms; Radiation Effects; Radiatio

1972