bromochloroacetic-acid and Seizures

Secretory meningioma (SM) is a rare histologic subtype known to cause disproportional peritumoral brain edema. Although meningiomas are defined by slow growth and mostly manifest with benign clinical symptoms, SMs can cause life-threatening deterioration. The aim of this study was to characterize the potential pitfalls in treatment of SMs by illustrating their characteristic clinical features.. We analyzed 69 patients with SM who underwent surgery at our institution and compared them with a matched nonsecretory meningioma cohort. Retrospective data were analyzed for frequency of seizures as the first presenting symptom, maximum corticosteroid use, intensive care unit stay, and hospital stay. In addition, histologic and radiographic data were evaluated for the extent of peritumoral brain edema formation, tumor location, and tumor size and correlated to clinical presentation.. Seizures were observed at a significantly higher rate as the first presenting symptom leading to clinical admission in patients with SM (33.3%) compared with the matched nonsecretory meningioma cohort (13%, P = 0.008). In patients with SM, seizures were associated with increased edema formation, whereas seizures in patients with nonsecretory meningioma correlated with tumor size (P = 0.007). The clinically more complicated course in patients with SM was reflected by increased demand for corticosteroids and a prolonged intensive care unit stay (P < 0.001). SM further showed a higher recurrence rate of 35.9% compared with a cohort of 320 World Health Organization grade I meningiomas resected at our institution (P < 0.001).. Our results illustrate the complicated clinical course of this rare histologic meningioma subtype. The increased frequency of seizures may enable raised awareness of clinicians for potential complications and treatment adjustments perioperatively early at clinical admission.

Topics: Adult; Aged; Aged, 80 and over; Brain; Brain Edema; Cohort Studies; Female; Humans; Image Processing, Computer-Assisted; Keratins; Magnetic Resonance Imaging; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Mucin-1; Seizures; Stage-Specific Embryonic Antigens

A case of meningioma coexisting with both lipomatous and secretory components, the latter characterized by hyaline inclusion bodies, is reported. The neuroradiological features of lipomeningioma are reevaluated, and the possible pathogenetic mechanisms of this unique combination in the present case are discussed.

Topics: Adipose Tissue; Adult; Carcinoembryonic Antigen; Cerebral Angiography; Female; Humans; Hyalin; Inclusion Bodies; Keratins; Lipoma; Magnetic Resonance Imaging; Meningeal Neoplasms; Meningioma; Mucin-1; Neoplasm Proteins; Periodic Acid-Schiff Reaction; Seizures; Tomography, X-Ray Computed

Topics: Alexander Disease; Brain Diseases; Diffuse Cerebral Sclerosis of Schilder; Histocytochemistry; Humans; Hydrocephalus; Infant; Intellectual Disability; Keratins; Nerve Tissue Proteins; Pathology; Seizures; Tuberous Sclerosis