bromochloroacetic-acid and Sarcoma--Alveolar-Soft-Part

To describe a case of alveolar soft-part sarcoma (ASPS) affecting the tongue of a child and to study prognostic imunohistochemical markers for the disease.. Tissue sections were incubated with primary antibodies reactive to neuron-specific enolase (NSE), vimentin, desmin, S-100 protein, cytokeratins AE1-AE3, EMA, neurofilament, synaptophysin, and muscle-specific actin (MSA), and for prognostic markers, including Ki-67, p53, bcl-2, bax, and nm23.. Histologically, the tumor showed a proliferation of large polygonal cells with PAS-positive diastase-resistant intracytoplasmatic material, arranged in an alveolar growth pattern. Diffuse positive reaction for neuron specific enolase (NSE), focal reactivity for desmin and S-100 protein, strong positivity for nm23 and bax, but weak reaction for p53 and Ki-67 were found. No bcl-2-positive cells were noted.. These immunohistochemical findings may reflect the less aggressive behavior of ASPS in oral tissues.

Topics: Actins; Adolescent; Antigens, Neoplasm; bcl-2-Associated X Protein; Biomarkers, Tumor; Desmin; Female; Humans; Immunohistochemistry; Keratins; Ki-67 Antigen; Mucin-1; Neurofilament Proteins; NM23 Nucleoside Diphosphate Kinases; Nucleoside-Diphosphate Kinase; Phosphopyruvate Hydratase; Prognosis; Proto-Oncogene Proteins c-bcl-2; S100 Proteins; Sarcoma, Alveolar Soft Part; Synaptophysin; Tongue Neoplasms; Tumor Suppressor Protein p53; Vimentin