bromochloroacetic-acid has been researched along with Postoperative-Complications* in 32 studies
1 review(s) available for bromochloroacetic-acid and Postoperative-Complications
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Prognostic significance of circulating tumour cells following surgical resection of colorectal cancers: a systematic review.
The role of adjuvant chemotherapy after resection of colorectal cancers (CRCs) is well understood for patients with stage-I or stage-III disease. Its efficacy for those with stage-II disease remains much less clear. Many investigators have sought to identify prognostic markers that might clarify which patients have the highest risk of recurrence and would, therefore, be most likely to benefit from chemotherapy. This systematic review examines evidence for the use of peripherally sampled, circulating tumour cells (CTCs) as such a prognostic marker.. A comprehensive literature search was used to identify studies reporting on the significance of CTCs in the postoperative blood of CRC patients.. Fourteen studies satisfied the inclusion criteria. Six of the nine studies that took blood samples 24 h or more postoperatively found detection of postoperative CTCs to be an independent predictor of cancer recurrence.. The presence of CTCs in peripheral blood at least 24 h after resection of CRCs is an independent prognostic marker of recurrence. Further studies are needed to clarify the optimal time point for blood sampling and determine the benefit of chemotherapy in CTC-positive patients with stage-II disease. Topics: Aged; Carcinoembryonic Antigen; Chemotherapy, Adjuvant; Colorectal Neoplasms; Humans; Keratins; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Patient Selection; Postoperative Complications; Prognosis; Recurrence; Treatment Outcome | 2010 |
5 trial(s) available for bromochloroacetic-acid and Postoperative-Complications
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Keratin gel improves poor scarring following median sternotomy.
Linear hypertrophic scarring is a common surgical problem that can be difficult to manage. This article evaluates median sternotomy wounds that have often been reported to scar poorly resulting in hypertrophic scar formation.. This study is a single-blinded, open-labelled pilot study of 20 patients using keratin gel as the intervention and aqueous cream as the control, which are each applied to a different half of the wound daily over 6 months. We use the Patient and Observer Scar Assessment Scale (POSAS) and the Manchester Scar Score (MSS) to assess the scarring.. At the 6-month assessment the MSS, patient-POSAS and observer-POSAS were 12.00, 16.70 and 15.00 in the treatment half and 12.58, 17.85 and 16.55 in the control half respectively. Overall, we found that there was a decrease in all score scales after 6 months (P = 0.005). Furthermore, in the subset of patients with poor scarring, decreases in the MSS, patient-POSAS and observer-POSAS were statistically significant (P = 0.025, <0.01 and 0.01) with scores of 12.22, 17.33 and 15.33 in the treatment half and 14.22, 23.67 and 22.33 in the control half respectively.. In patients who scar more poorly than average, there were significant improvements in scarring. This demonstrates a simple, well-tolerated intervention that reduces problematic scarring following surgery. Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cicatrix, Hypertrophic; Dermatologic Agents; Humans; Keratins; Middle Aged; Pilot Projects; Postoperative Complications; Single-Blind Method; Sternotomy; Wound Healing; Young Adult | 2015 |
Does the dimension of the graft influence patient morbidity and root coverage outcomes? A randomized controlled clinical trial.
Primary aim of this study was to evaluate if patient morbidity was improved by diminishing graft thickness and height; secondary objective was to evaluate if such graft modifications influence root coverage and aesthetic outcomes.. 60 Miller class I and II gingival recessions (GR) (≥ 3 mm in depth) were treated with the coronally advanced flap plus extraoral de-epithelialized free gingival graft (FGG). In 30 randomly selected control GRs ("big graft group"), the FGG thickness was ≥ 2 mm and the height was equal to bone dehiscence (BD); in the other 30 test defects ("small graft group"), the thickness of the FGG was <2 mm and the height was 4 mm. The post-operative patient morbidity was assessed 1 week after the surgery. The clinical and aesthetic evaluations were performed 1 year after the surgery.. Lower analgesic assumption, better post-operative course evaluations, better patient colour match scores and better periodontist aesthetic assessments were reported in the "small graft" group. No statistically significant differences were demonstrated between the two groups in terms of recession reduction, CRC and increase in KTH. Greater GT increase was obtained in the control-treated sites.. Coronally advanced flap plus CTG of reduced thickness and height was associated with less patient morbidity, better aesthetic evaluations with no difference in RC outcomes. Topics: Alveolar Process; Analgesics, Non-Narcotic; Double-Blind Method; Esthetics, Dental; Follow-Up Studies; Free Tissue Flaps; Gingiva; Gingival Recession; Humans; Ibuprofen; Keratins; Pain, Postoperative; Patient Satisfaction; Periodontal Attachment Loss; Periodontal Pocket; Pilot Projects; Postoperative Complications; Postoperative Hemorrhage; Surgical Flaps; Tooth Root; Treatment Outcome | 2014 |
Surgical microscope may enhance root coverage with subepithelial connective tissue graft: a randomized-controlled clinical trial.
Minimally invasive techniques have broadened the horizons of periodontal plastic surgery to improve treatment outcomes. Thus, the purpose of this clinical trial was to compare root coverage, postoperative morbidity, and esthetic outcomes of subepithelial connective tissue graft (SCTG) technique with or without the use of a surgical microscope in the treatment of gingival recessions.. In this split-mouth study, twenty-four patients with bilateral Miller's Class I or II buccal gingival recessions ≥2.0 mm in canines or premolars were selected. Gingival recessions were randomly designated to receive treatment with SCTG with or without the assistance of the surgical microscope (test and control groups, respectively). Clinical parameters evaluated included the following: depth (RH) and width (RW) of the gingival defect, width (WKT) and thickness (TKT) of keratinized tissue, probing depth (PD), and clinical attachment level (CAL). Postoperative morbidity was evaluated by means of an analog visual scale and questionnaire. Patient satisfaction was also evaluated with a questionnaire. Descriptive statistics were expressed as mean ± SD. Repeated-measures analysis of variance was used for examination of differences regarding PD, CAL, and TKT. The Wilcoxon test was used to detect differences between groups and the Friedman test to detect differences within group regarding WKT, RH, and RW.. The average percentages of root coverage for test and control treatments, after 12 months, were 98.0% and 88.3%, respectively (P <0.05). Complete root coverage was achieved in 87.5% and 58.3% of teeth treated in test and control groups, respectively. For all parameters except recession height, there was an improvement in the final examination but without difference between treatments. For the RH, a lower value was found in the test group compared to the control group (P <0.05). In the test group, all patients were satisfied with the esthetics obtained, and 19 patients (79.1%) were satisfied in the control group. For postoperative morbidity, 14 patients in each of the two treatment groups did not use analgesics for pain control.. Both approaches were capable of producing root coverage; however, use of the surgical microscope was associated with additional clinical benefits in the treatment of teeth with gingival recessions. Topics: Adolescent; Adult; Bicuspid; Connective Tissue; Cuspid; Esthetics, Dental; Female; Follow-Up Studies; Gingiva; Gingival Recession; Humans; Keratins; Male; Microsurgery; Middle Aged; Minimally Invasive Surgical Procedures; Pain Measurement; Pain, Postoperative; Patient Satisfaction; Periodontal Attachment Loss; Periodontal Pocket; Postoperative Complications; Tooth Root; Treatment Outcome; Young Adult | 2012 |
Width of keratinized tissue after gingivoplasty of healed subepithelial connective tissue grafts.
The subepithelial connective tissue graft has markedly broadened clinicians' abilities to treat gingival recession. Frequently, however, bulky soft tissue contours are sequelae of this procedure, and post-healing gingivoplasty is often performed to improve esthetics of the grafted site. As a secondary benefit, it is believed that the zone of keratinized tissue is additionally increased after gingivoplasty.. To further investigate this clinical impression, 16 bilateral pairs of sites with recession in 6 consecutive patients (mean age = 38 +/- 9 years) were studied. At the time of initial grafting, one site in each pair was randomly assigned to receive either gingivoplasty 2 months later (GP+) or no further treatment (GP-). Clinical measurement of recession and keratinized tissue width was standardized using customized acrylic stents and Schiller iodine solution, which stains epithelia; values were recorded at baseline (day of graft) and at 2, 3, and 5 months after grafting. Mean clinical gingival widths over time between GP+ and GP- sites, as well as within GP+ sites, were analyzed by t test.. At 5 months, both the GP+ and GP- sites demonstrated a mean root coverage of 87.4% and increased keratinized tissue width (1.2 mm) when compared to their respective baseline measures. No differences in recession depth and width of keratinized tissue were seen at 5 months between the GP+ and GP- groups. In addition, no differences in recession or gingival width were found between 2- and 5-month observations for either the GP+ or GP- groups.. These data suggest that the observed clinical improvements are the outcome of the initial graft surgery and that the gingivoplasty procedure does not result in additional (or "rebound") increases in keratinized tissue width. Topics: Adult; Analysis of Variance; Cell Movement; Connective Tissue; Epithelial Cells; Female; Gingiva; Gingival Recession; Gingivoplasty; Humans; Keratins; Male; Middle Aged; Postoperative Complications; Regression Analysis; Transplantation, Autologous; Treatment Outcome; Wound Healing | 2000 |
The use of allogeneic freeze-dried skin grafts in the oral environment. A clinical and histologic evaluation.
Topics: Alveolar Process; Animals; Clinical Trials as Topic; Connective Tissue; Epithelial Cells; Fibroblasts; Freeze Drying; Gingiva; Gingivectomy; Graft vs Host Reaction; Haplorhini; Inflammation; Keratins; Macaca; Mouth Mucosa; Osteoclasts; Postoperative Complications; Skin Transplantation; Transplantation Immunology; Transplantation, Homologous; Wound Healing | 1974 |
26 other study(ies) available for bromochloroacetic-acid and Postoperative-Complications
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Trichodysplasia spinulosa mimicking lichen nitidus in a renal transplant patient.
Trichodysplasia spinulosa (TS) is a rare cutaneous condition associated with the TSPyV and characterized by skin-colored, folliculocentric papules with keratin spicule formation. TS is seen almost exclusively in immunosuppressed individuals, often presenting in patients with a history of solid organ transplantation or chemotherapy for a lymphoreticular malignancy. We report a case of widespread TS in a 9-year-old girl with a history of renal transplantation complicated by BK viremia, which is also caused by a polyomavirus, BKPyV. The clinical presentation of TS in this case morphologically resembled the more common, harmless skin condition known as "lichen nitidus," and was more extensive than expected for TS, creating a diagnostic challenge. This case illustrates an important presentation of severe TS of which transplant teams, oncologists, primary care providers, and dermatologists should be aware. Topics: BK Virus; Child; Congenital Abnormalities; Diagnosis, Differential; Female; Humans; Immunocompromised Host; Immunosuppressive Agents; Keratins; Kidney; Kidney Diseases; Kidney Transplantation; Lichen Nitidus; Polyomavirus; Polyomavirus Infections; Postoperative Complications; Skin; Skin Diseases; Tumor Virus Infections | 2019 |
An unusual mass at the abdominal site of a ventriculoperitoneal shunt.
Topics: Abdomen; Cysts; Epithelium; Female; Humans; Hydrocephalus; Keratins; Meningocele; Postoperative Complications; Ventriculoperitoneal Shunt; Young Adult | 2013 |
Clinical outcomes in the presence and absence of keratinized mucosa in mandibular guided implant surgeries: a pilot study with a proposal for the modification of the technique.
To test the hypothesis of the outcome of complete arch flapless guided implant surgery mandibular rehabilitations in the presence or absence of a residual band of keratinized mucosa (KM) < 6 mm wide in the vestibular-lingual aspect, with and without a modification of the surgical protocol.. Thirty-nine patients were included in this study (12 men and 27 women), with a mean age of 62.5 years (range, 42 to 79 years), divided into 3 groups of 13 patients according to the status of residual band of KM: group 1, KM < 6 mm rehabilitated through a modified guided surgical protocol with flap opening to preserve KM; group 2, KM ≥ 6 mm; and group 3, KM < 6 mm; patients from both groups 2 and 3 were rehabilitated through flapless guided implant surgery without modification of the protocol. Group 2 and 3 patients were age- and sex-matched with group 1. Outcome measures were clinical attachment loss (CAL) ≥ 2 mm after 1 year (backward conditional regression), incidence of dehiscences, dental plaque, bleeding, and implant infections. The level of significance chosen was 5%.. Thirty-nine patients with 156 implants were followed for 1 year, and no dropouts occurred. Absence of a residual band of KM ≥ 6 mm in the vestibular-lingual aspect was significantly associated with CAL (odds ratio, 39.1; P = .036) and dehiscences (P = .003).. Within the limitations of this study, the absence of a residual band of KM ≥ 6 mm wide in the vestibular-lingual aspect in patients rehabilitated in the complete edentulous mandible with flapless guided implant surgery may be associated with CAL and a higher incidence of dehiscences after 1 year of follow-up. This possible association needs to be confirmed in studies with stronger designs and longer follow-ups. Topics: Adult; Aged; Case-Control Studies; Dental Implantation, Endosseous; Dental Plaque; Female; Follow-Up Studies; Gingiva; Gingival Hemorrhage; Humans; Immediate Dental Implant Loading; Jaw, Edentulous; Keratins; Male; Mandible; Middle Aged; Patient Care Planning; Peri-Implantitis; Periodontal Attachment Loss; Pilot Projects; Postoperative Complications; Surgery, Computer-Assisted; Surgical Flaps; Surgical Wound Dehiscence; Treatment Outcome | 2013 |
A novel approach to root coverage: the pinhole surgical technique.
Free connective tissue graft techniques are currently considered the most predictable surgical method for root coverage. However, morbidity associated with secondary graft sites has generated interest in other methods. The purpose of this study was to investigate the feasibility of a novel surgical approach to root coverage: the pinhole surgical technique (PST). This retrospective study examined the results of PST used for 43 consecutive patients on 121 recession sites, of which 85 were Class I or II and 36 were Class III. Mean initial recession for all sites was 3.4 ± 1.0 mm. The mean assessment period was 18 ± 6.7 months. No secondary surgical site was necessary, and only bioresorbable membrane or acellular dermal matrix was used as graft material. PST required no releasing incision, sharp dissection, or suturing (when a bioresorbable membrane was used). Only one incision of 2 to 3 mm (for entry) was necessary for the entire procedure. Predictability of PST for Class I and II sites, measured as frequency of complete root coverage, was 81.2%. Effectiveness of PST for Class I and II sites, measured as mean percent defect reduction, was 94.0% ± 14.8%. When data from Class I, II, and III sites were combined, predictability and effectiveness were 69.4% and 88.4% ± 19.8%, respectively. The mean duration per procedure was 22.3 ± 10.1 minutes. The mean level of patient subjective esthetic satisfaction was 95.1% and was realized within a mean 7.34 ± 13.5 days. Postoperative complications were minimal. These results indicate that PST holds promise as a minimally invasive, predictable, effective, and time- and cost-effective method for obtaining optimal patient-based outcomes. Topics: Absorbable Implants; Acellular Dermis; Adult; Aged; Aged, 80 and over; Esthetics, Dental; Feasibility Studies; Female; Follow-Up Studies; Forecasting; Gingiva; Gingival Recession; Humans; Keratins; Male; Membranes, Artificial; Middle Aged; Operative Time; Patient Satisfaction; Periodontal Attachment Loss; Periodontal Pocket; Postoperative Complications; Retrospective Studies; Surgical Flaps; Tooth Cervix; Tooth Root; Treatment Outcome | 2012 |
Histomorphologic and molecular features of pouch and peripouch adenocarcinoma: a comparison with ulcerative colitis-associated adenocarcinoma.
The occurrence of adenocarcinoma after ileal pouch-anal anastomosis for ulcerative colitis (UC) is an infrequent but potentially lethal complication. Neither histomorphologic nor molecular features of pouch adenocarcinoma after ileal pouch-anal anastomosis have been fully investigated. We report the largest series of 12 pouch and peripouch adenocarcinomas and compared them with 58 randomly selected UC-associated adenocarcinomas. The mean age of patients with pouch/peripouch adenocarcinoma was 55.2 years (SD 14.8), which was not significantly different from that of controls (P=0.52). Pouch/peripouch adenocarcinoma and UC-associated adenocarcinoma had a comparable frequency of tumor-infiltrating lymphocytes, lack of dirty necrosis, mucin differentiation, signet ring cell differentiation, heterogeneity, and well differentiation (P>0.05 for all). Pouch/peripouch adenocarcinoma was more likely to show Crohn-like reaction compared with UC-associated adenocarcinoma (P=0.047). Loss of at least 1 mismatch repair protein was noted in 9% of pouch/peripouch adenocarcinomas and 9.6% of UC-related adenocarcinomas (P=1.0). There was no significant difference in the frequency of p53 overexpression (36.4% vs. 61.1%, P=0.184) or nuclear immunoreactivity for β-catenin (9% vs. 7.4%, P=0.99) in pouch/peripouch versus UC-associated adenocarcinomas, respectively. Pouch/peripouch and UC-associated adenocarcinoma had a comparable positive rate for CK7 (54.5% vs. 55.5%, P=0.99), CK20 (100% vs. 98.1%, P=0.99), and CDX2 (72.8% vs. 72.2%, P=0.99) by immunohistochemistry. In summary, pouch and peripouch adenocarcinoma can occur in patients without colorectal neoplasia and in those with idiopathic inflammatory bowel disease, can be potentially lethal, and has histomorphologic and molecular features similar to those of UC-associated adenocarcinoma. Topics: Adenocarcinoma; Biomarkers, Tumor; CDX2 Transcription Factor; Colectomy; Colitis, Ulcerative; Colonic Pouches; Colorectal Neoplasms; DNA-Binding Proteins; Female; Homeodomain Proteins; Humans; Keratins; Lymphocytes, Tumor-Infiltrating; Male; Middle Aged; MutS Homolog 3 Protein; Neoplasm Staging; Postoperative Complications; Proctocolectomy, Restorative; Tissue Array Analysis | 2012 |
Descemet's stripping endothelial keratoplasty: an effective treatment for toxic anterior segment syndrome with histopathologic findings.
To report Descemet's stripping endothelial keratoplasty (DSEK) as a treatment for corneal edema associated with toxic anterior segment syndrome.. A 75-year-old woman presented with decreased vision in her left eye after uneventful phacoemulsification. She was diagnosed with toxic anterior segment syndrome and a DSEK was performed. Histologic sections were examined after staining with hematoxylin and eosin, periodic acid Schiff, and Masson trichrome; immunoperoxidase reactions were used to identify cytokeratins, vimentin, and alpha-smooth muscle actin.. The corneal endothelium was selectively replaced by the DSEK technique. Descemet's membrane and endothelium were stripped from the recipient's stroma, and an 8-mm-diameter donor button consisting of posterior stroma and healthy endothelium was folded and implanted through a 5-mm incision. An air bubble was used to press the donor tissue against the recipient cornea, allowing it to attach without sutures. Corneal edema and visual acuity improved. Histopathologic evaluation of the DSEK specimen disclosed a multilaminar retro-Descemet's fibrous membrane in which many of the constituent fibroblasts contained scattered pigment granules and stained for both vimentin and cytokeratin with immunoperoxidase methods.. To the best of our knowledge, this is the first reported case of successful DSEK in a patient with corneal decompensation resulting from toxic anterior segment syndrome exhibiting a retrocorneal fibrous membrane. Visual recovery was rapid, and refractive changes were minimal compared with traditional penetrating keratoplasty. The immunoperoxidase staining strongly suggests that the retrocorneal fibrous membrane was created by dysplastic corneal endothelial cells. Topics: Aged; Anterior Eye Segment; Corneal Edema; Descemet Stripping Endothelial Keratoplasty; Female; Humans; Immunoenzyme Techniques; Keratins; Phacoemulsification; Postoperative Complications; Syndrome; Treatment Outcome; Vimentin; Visual Acuity | 2010 |
Epithelial downgrowth following Descemet's-stripping automated endothelial keratoplasty.
Topics: Aged; Corneal Diseases; Corneal Transplantation; Descemet Membrane; Endothelium, Corneal; Epithelium, Corneal; Female; Humans; Immunoenzyme Techniques; Keratins; Microscopy, Confocal; Postoperative Complications; Visual Acuity | 2008 |
Histopathological findings after intracorneal ring segment implantation in keratoconic human corneas.
To evaluate histopathological changes induced in keratoconic corneas after implantation of Intacs intracorneal ring segments (Addition Technology, Inc.).. Departments of Ophthalmology and Pathology, Hospital Pellegrin, Bordeaux, France.. This retrospective study included 8 keratoconic, contact-lens-intolerant eyes of 8 patients who had penetrating keratoplasty (PKP) after removal of Intacs inserts because of a poor refractive outcome or insert extrusion. Light microscopy was performed on all specimens after conventional staining. Immunohistochemistry was performed to identify cell types located next to the tunnel using AE1/AE3 cytokeratins, CD34, vimentin, collagen IV, and alpha-smooth muscle actin monoclonal antibodies.. Conventional histology showed hypoplasia of the epithelium immediately surrounding the channel. There was no evidence of an inflammatory response or foreign-body granuloma. Keratocyte density was decreased above and below the tunnel, and collagen IV synthesis was seen in the scar area. All samples stained negatively with alpha-smooth muscle actin, indicating that myofibroblasts were not present. These changes were no longer visible when PKP was performed more than 6 months after Intacs explantation.. Intacs induced keratocyte apoptosis, probably through a switch to a collagenous synthetic phenotype. Although histological changes seem to be entirely reversible after implant removal, longer follow-up is necessary to determine whether they accelerate corneal thinning and keratoconus progression via apoptosis and release of metalloprotease. Topics: Actins; Adult; Antigens, CD34; Apoptosis; Collagen Type IV; Corneal Stroma; Device Removal; Disease Progression; Female; Fibroblasts; Humans; Immunohistochemistry; Keratins; Keratoconus; Keratoplasty, Penetrating; Male; Middle Aged; Postoperative Complications; Prostheses and Implants; Prosthesis Implantation; Retrospective Studies; Vimentin | 2007 |
Fine needle aspiration diagnosis of metastatic Merkel cell carcinoma with multinucleated bizarre tumour cells in a post-renal transplant patient.
Topics: Biomarkers, Tumor; Biopsy, Fine-Needle; Carcinoma, Merkel Cell; Chromogranin A; Female; Giant Cells; Humans; Immunocompromised Host; Keratins; Kidney Transplantation; Lymph Nodes; Lymphatic Metastasis; Middle Aged; Postoperative Complications; Skin Neoplasms | 2006 |
[Ingrown nails: a complication of surgery for an in-growing toe-nail using the Zadik procedure].
Topics: Female; Giant Cells, Foreign-Body; Granuloma, Giant Cell; Humans; Keratins; Middle Aged; Nails, Ingrown; Postoperative Complications | 2006 |
Antibodies against cytokeratin 8/18 in a patient with de novo autoimmune hepatitis after living-donor liver transplantation.
Graft dysfunction mimicking autoimmune hepatitis rarely develops after liver transplantation for nonautoimmune disease. The mechanism(s) and causes of de novo autoimmune hepatitis are unknown. We examined autoantibodies serially in a patient with de novo autoimmune hepatitis and in patients without de novo autoimmune hepatitis after liver transplantation. Anticytokeratin 8/18 antibodies were detected in the first patient's sera after the onset of de novo autoimmune hepatitis, whereas other patients without de novo autoimmune hepatitis were seronegative throughout the follow-up period even with acute cellular rejection or other cause of liver dysfunction. In conclusion, the changes in cytokeratin 8/18 in hepatocytes might be one of the sources of pathogenesis of de novo autoimmune hepatitis after liver transplantation. Topics: Adolescent; Adult; Autoantibodies; Child; Child, Preschool; Female; Follow-Up Studies; Hepatitis, Autoimmune; Hepatocytes; Humans; Keratins; Liver Failure; Liver Transplantation; Living Donors; Male; Postoperative Complications | 2005 |
Primary adenocarcinoma of cutaneous vesicostomy 40 years later: a rare case.
We present a case of adenocarcinoma developing at the vesicocutaneous edge of a vesicostomy, 40 years after it was created, in a patient who underwent cadaveric kidney transplant. Although transitional and squamous cell carcinoma of a vesicostomy have been reported, to our knowledge, the presence of adenocarcinoma at the vesicostomy edge has not been reported previously. Topics: Abnormalities, Multiple; Adenocarcinoma; Adult; Biomarkers, Tumor; Cell Transformation, Neoplastic; Cystostomy; Dermatologic Surgical Procedures; Female; Humans; Immunosuppression Therapy; Intermediate Filament Proteins; Keratin-20; Keratin-7; Keratins; Kidney Failure, Chronic; Kidney Transplantation; Neoplasm Proteins; Postoperative Complications; Surgical Stomas; Time Factors; Urinary Bladder Neoplasms; Urinary Bladder, Neurogenic; Urogenital Abnormalities; Urothelium | 2004 |
[Intraocular epithelial downgrowth - report on 14 cases from 1986 to 2000].
Diffuse and cystic epithelial downgrowth occur rarely, but they represent a mostly preventable potential cause of blindness as sequels to trauma and surgery. The aim of this study is to report on the etiology and course of disease in patients with histologically verified epithelial downgrowth.. From 1986 until 2000 the ophthalmopathological laboratory of the University Eye Hospital Hamburg-Eppendorf received 13 (4 external) referrals. Ten patients with cystic of diffuse intraocular epithelial downgrowth were treated and 9 eyes were operated on in the Hospital.. At presentation 4/10 patients had a visual acuity of < or = 0.1, and 2/10 had no light perception. A cystic epithelial downgrowth was verified histologically in 9/13, and a diffuse form in 4/13 patients. Mucin production was proven histochemically in 1/9 intraocular epithelial downgrowth sections. In one case a spontaneous iris cyst was detected by the immunohistological examinations. Trauma (10/14) and surgery (3/14) were the most frequent causes and were symptomatic on average 17 years after the primary event. A curative surgery was done in 13/14 patients (5 x en bloc excision, 2 x penetrating keratoplasty, 1 x iridectomy, 2 x enucleations, 3 x external) resulting in no recurrences during the follow-up of 4(1/2) years (1 - 12 years). The postoperative visual acuity was ameliorated in 5/9, worsened in 2 patients, and 2 were enucleated.. Epithelial downgrowth is a rare but preventable cause of blindness. The most important prophylaxis is meticulous primary surgery including a sufficient wound closure. The visual outcome depends on the preoperative conditions. Topics: Adolescent; Adult; Aged; Blindness; Cell Division; Child; Choristoma; Ciliary Body; Conjunctiva; Cysts; Epithelium; Epithelium, Corneal; Eye; Eye Diseases; Eye Enucleation; Eye Injuries; Female; Humans; Keratins; Male; Middle Aged; Postoperative Complications; Reoperation; Visual Acuity | 2004 |
Nondébridement of laser char after two carbon dioxide laser passes results in faster reepithelialization.
Skin repair following laser injury can be accelerated by using techniques that promote rapid reepithelialization. In this article, the benefit of intraoperative nondébridement of laser debris after two laser passes is discussed. After carbon dioxide laser resurfacing of the face, skin specimens were examined using indirect immunofluorescence with antibodies to specific epidermal and basement membrane proteins. Biopsy specimens obtained immediately after resurfacing showed a greater injury to epidermal and basement membrane proteins when skin was wiped with saline-soaked gauze after laser passes than when there was no débridement after two passes. Later examination of skin specimens obtained from nine patients 2 days after carbon dioxide resurfacing showed that nondébrided, occluded skin had faster reepithelialization than the other treatments. Nondébridement of the skin at the time of resurfacing along with the use of postoperative occlusive dressings led to the rapid reestablishment of a multilayered epidermis only 2 days after resurfacing. Nondébridement along with occlusive dressings results in rapid reepithelialization of the skin after two carbon dioxide laser passes for skin rejuvenation. Topics: Biopsy; Blepharoplasty; Combined Modality Therapy; Debridement; Epithelium; Follow-Up Studies; Humans; Keratin-14; Keratins; Low-Level Light Therapy; Microscopy, Fluorescence; Postoperative Complications; Regeneration; Rhytidoplasty; Skin; Skin Aging; Wound Healing | 2003 |
Hematogenous dissemination of lung cancer cells during surgery: quantitative detection by flow cytometry and prognostic significance.
Shedding of neoplastic cells into the circulation is an essential event for the hematogenous metastasis of solid tumors. Recently, several studies reported that a high frequency of cancer cells could be detected in the bloodstream during surgery. The intraoperative detection of hematogenous dissemination of cancer cells was able to identify a subset of patients with malignant diseases at high risk for postoperative metastasis and to predict a poor prognosis. In order to evaluate the association between intraoperative dissemination of cancer cells and postsurgical survival of patients with non-small cell lung cancer (NSCLC), we developed a flow cytometric assay for specific detection of lung cancer cells in the blood. The monocyte-enriched population in the blood was separated by a modified Ficoll-Hypaque density centrifugation and then labeled with a combination of monoclonal antibodies specific for CD45, cytokeratin (CK) and two antigens expressed on lung cancer cells (2F7 and S5A). The assay could detect quantitatively lung cancer cells (defined as CD45(-1) CK(+) 2F7/S5A(+) cells), with the sensitivity limit of one cancer cell in 10(5) normal leukocytes. The specificity for lung cancer was 97%, which was calculated from the results of healthy subjects (20 cases) and patients affected with benign pulmonary diseases (26 cases) or esophageal cancer (14 cases). Blood samples of 31 NSCLC patients were collected from pulmonary vein during open thoracic surgery. Fifteen of them (48.4%) were found to have positive test results. The average cancer cell counts in these cases were 0.306 x 10(6)/l. Patients under 55 years of age had a significantly higher percentage of positive findings than those over 55 years of age (P < 0.05). The positive rate increased over the stages and lymph node status, but the differences were not statistically significant. Moreover, patients with squamous cell carcinoma at later stages (stages III and IV) had an increased frequency of positive test results than those at earlier stages (stages I and II, P < 0.05). In contrast, no such a difference was found in cases with adenocarcinoma. On the basis of 30-months follow-up date, the median survival time and 2-year survival rate for patients with positive and negative findings were 11 vs. 27 months, and 26.7 vs. 62.5%, respectively. There was a statistically significant difference between overall survival curves that favored the patients with negative test results (P = 0.023). Multivariate Topics: Aged; Antibodies, Monoclonal; Antigens, Neoplasm; Carcinoma, Non-Small-Cell Lung; Female; Flow Cytometry; Follow-Up Studies; Humans; Keratins; Leukocyte Common Antigens; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Neoplastic Cells, Circulating; Postoperative Complications; Prognosis; Survival | 2002 |
Proliferation of lens epithelial cells on the Acrysof intraocular lens: clinical and histological features of a case.
Postoperative deposits on the surface of intraocular lenses (IOLs) have been demonstrated in vivo for many IOL material types. The Acrysof acrylic lens develops a granular material extending from the capsulorhexis margin onto the IOL's anterior surface during the first 4 weeks after surgery in a significant proportion of cases. Complete resolution of this membrane occurs by 3 months in almost all cases. The case is presented of an 81-year-old woman who had a persisting membrane coverng the IOL surface at 6 months. This membrane was removed surgically and pathology showed the constituent cells to be of lens epithelial cell origin. Topics: Acrylic Resins; Aged; Aged, 80 and over; Cell Division; Epithelial Cells; Female; Humans; Immunoenzyme Techniques; Keratins; Lens Implantation, Intraocular; Lens, Crystalline; Lenses, Intraocular; Membranes; Phacoemulsification; Postoperative Complications; Reoperation; Visual Acuity | 2001 |
Conjunctival epithelial inclusion cyst.
Topics: Aged; Anterior Chamber; Cataract Extraction; Conjunctival Diseases; Cysts; Epithelium; Humans; Keratins; Male; Postoperative Complications; Suppuration | 1997 |
Cytokeratin in lens epithelial cells and its effect on anterior lens capsule opacification.
Postoperative lens capsule opacification is a complication of extracapsular cataract extraction. To avoid this problem, we aspirated the epithelial cells lining the internal surface of the capsular bag. Anterior capsule specimens collected three and six years after the first surgical intervention (extracapsular cataract extraction with intercapsular implantation of a poly[methyl methacrylate] intraocular lens) and in vitro studies of epithelial cell cultures revealed the presence of intracellular and extracellular cytokeratin. After several years, the cytokeratin layers were arranged in a pattern analogous to that of liquid crystalline phases and many nonhuman extraocular tissues. Topics: Cataract; Cataract Extraction; Epithelium; Humans; Keratins; Lens Capsule, Crystalline; Lens, Crystalline; Lenses, Intraocular; Microscopy, Electron, Scanning; Postoperative Complications | 1993 |
Management of labyrinthine fistulas caused by cholesteatoma.
The surgical management of labyrinthine fistulas caused by cholesteatoma remains controversial. Forty cases (41 ears) of labyrinthine fistulas were reviewed. This represented 10% of our total series of cholesteatomas in adults and children (426 ears). Clinical presentation, extent of disease, results of fistula testing and audiometric studies, and radiographic findings were analyzed. A canal wall-down procedure was performed in all but one patient. Generally an attempt was made to completely remove the cholesteatoma, to graft the fistulous area, and to reconstruct the middle ear mechanism in one stage. The matrix was preserved in patients with large fistulas where the involved ear was the only hearing one, when the matrix was adherent to the underlying optic duct, and in selected elderly persons. Long-term followup did not reveal a significant difference in hearing, degree of vertigo, or incidence of recidivism when those patients in whom the matrix was removed were compared with those in whom the matrix was preserved. The importance of recognizing the presence of a labyrinthine fistula preoperatively is stressed, along with the need to be prepared for an unexpected fistula. Operative management is described. Topics: Adolescent; Adult; Aged; Child; Cholesteatoma; Fistula; Hearing Loss, Conductive; Hearing Loss, Sensorineural; Humans; Keratins; Labyrinth Diseases; Mastoid; Middle Aged; Postoperative Complications; Recurrence; Retrospective Studies; Vertigo | 1991 |
[Significance of epithelial-mesenchyme interactions in microvascular pedicled small intestine transplants replacing oral mucosa].
Topics: Adult; Cell Differentiation; Epithelium; Female; Fluorescent Antibody Technique; Humans; Intestinal Mucosa; Jejunum; Keratins; Male; Microsurgery; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Postoperative Complications | 1990 |
Clinical, electron microscopic, and monoclonal antibody studies of intraocular epithelial downgrowth.
Epithelial downgrowth developed in three patients following cataract extraction and keratoplasty. Light and electron microscopy of the downgrowth tissue disclosed stratified squamous epithelium, but could not determine whether they were derived from conjunctival or corneal epithelium. The epithelial downgrowth contained cells that were connected laterally by desmosomal junctions and displayed well-defined basement membranes. Surface epithelial cells exhibited myriad microvillous processes scant to moderate mitochondria. In one case, prominent hemidesmosomal junctions were present. Immunohistochemical staining with monoclonal antikeratin antibodies revealed immunoreactivity with AE1, AE3, and AE11 in all cases, but with a cornea-specific antibody, AE5, in only one case. We concluded that in this last case, the epithelial downgrowth appears to have originated from the corneal epithelium. Topics: Adult; Aged; Antibodies, Monoclonal; Conjunctiva; Cornea; Epithelium; Female; Humans; Immunochemistry; Iris; Keratins; Male; Middle Aged; Ophthalmologic Surgical Procedures; Postoperative Complications | 1986 |
Management of complications following dermis-fat grafting for anophthalmic socket reconstruction.
Sixty consecutive cases of dermis-fat grafts for anophthalmic socket reconstruction were reviewed to examine the frequency, severity, and management of postoperative complications. In seven patients, the conjunctiva failed to resurface the graft and central ulceration developed. Ten cases resulted in enophthalmos. Two patients developed keratinized sockets with chronic discharge and desquamation. Three patients required excision of conjunctival granulomas. One patient developed a primary graft infection. A donor site hematoma occurred in one patient. Secondary surgical intervention was required in ten patients. Nine complications in eight patients were managed in the office; five complications in four patients were observed and subsequently resolved without surgical intervention. Most complications occurred in patients with severely traumatized sockets who had undergone extensive earlier ocular surgery, or who had a systemic disease contributing to defective wound healing. Topics: Adipose Tissue; Adult; Aged; Anophthalmos; Child; Conjunctiva; Conjunctival Diseases; Eye Diseases; Granuloma; Hematoma; Humans; Infant; Keratins; Middle Aged; Postoperative Complications; Skin Transplantation; Surgery, Plastic; Surgical Wound Infection; Ulcer | 1985 |
Complications of the healing process after periodontal surgery.
Topics: Gingivectomy; Gingivoplasty; Granuloma; Humans; Keratins; Periodontitis; Postoperative Complications; Recurrence; Subgingival Curettage; Suppuration; Surgical Wound Infection; Tooth Mobility; Wound Healing | 1972 |
Free autogenous gingival grafts. II. Supplemental findings--histology of the graft site.
Topics: Calcinosis; Cysts; Gingiva; Humans; Keratins; Postoperative Complications; Transplantation, Autologous; Wound Healing | 1968 |
Keratin cysts in phalangeal bones. Report of an unusual case.
Topics: Adolescent; Adult; Age Factors; Aged; Bone Cysts; Child; Chondroma; Curettage; Diagnosis, Differential; Female; Fingers; Humans; Keratins; Male; Middle Aged; Postoperative Complications; Radiography; Sex Factors | 1968 |
Glucosteroid treatment of keratin meningitis following removal of a fourth ventricle epidermoid tumour.
Topics: Adult; Cerebral Angiography; Cerebral Ventricle Neoplasms; Cranial Fossa, Posterior; Humans; Keratins; Male; Meningitis; Postoperative Complications; Prednisolone | 1968 |