bromochloroacetic-acid has been researched along with Mucopolysaccharidosis-IV* in 8 studies
1 trial(s) available for bromochloroacetic-acid and Mucopolysaccharidosis-IV
| Article | Year |
|---|---|
Biomarker analysis of Morquio syndrome: identification of disease state and drug responsive markers.
This study was conducted to identify potential biomarkers that could be used to evaluate disease progression and monitor responses to enzyme replacement therapy (ERT) in patients with mucopolysaccharidosis (MPS) IVA.. Levels of 88 candidate biomarkers were compared in plasma samples from 50 healthy controls and 78 MPSIVA patients not receiving ERT to test for significant correlations to the presence of MPSIVA. MPSIVA samples were also tested for correlations between candidate biomarkers and age, endurance, or urinary keratin sulfate (KS) levels. Then, levels of the same 88 analytes were followed over 36 weeks in 20 MPSIVA patients receiving ERT to test for significant correlations related to ERT, age, or endurance.. Nineteen candidate biomarkers were significantly different between MPSIVA and unaffected individuals. Of these, five also changed significantly in response to ERT: alpha-1-antitrypsin, eotaxin, lipoprotein(a), matrix metalloprotein (MMP)-2, and serum amyloid P. Three of these were significantly lower in MPSIVA individuals versus unaffected controls and were increased during ERT: alpha-1-antitrypsin, lipoprotein(a), and serum amyloid P.. Candidate biomarkers alpha-1-antitrypsin, lipoprotein(a), and serum amyloid P may be suitable markers, in addition to urinary KS, to follow the response to ERT in MPSIVA patients. Topics: Adult; Aged; alpha 1-Antitrypsin; Biomarkers; Chondroitinsulfatases; Disease Progression; Dose-Response Relationship, Drug; Enzyme Replacement Therapy; Female; Humans; Keratins; Lipoprotein(a); Male; Middle Aged; Mucopolysaccharidoses; Mucopolysaccharidosis IV; Serum Amyloid P-Component; Treatment Outcome; Young Adult | 2011 |
7 other study(ies) available for bromochloroacetic-acid and Mucopolysaccharidosis-IV
| Article | Year |
|---|---|
Perioperative implications of Morquio syndrome in a 31-year-old woman undergoing aortic valve replacement.
Topics: Adult; Anesthesia, General; Aortic Valve Insufficiency; Female; Heart Valve Prosthesis Implantation; Humans; Keratins; Mucopolysaccharidosis IV; Treatment Outcome | 2009 |
Beta galactosidase and the Morquio syndrome.
Topics: Genetic Variation; Humans; Keratins; Lactose Intolerance; Mucopolysaccharidosis IV | 1977 |
The Morquio syndrome--light and electron microscopic findings from two corneas.
Topics: Adult; Biopsy; Collagen; Cornea; Corneal Dystrophies, Hereditary; Female; Glycosaminoglycans; Histocytochemistry; Humans; Keratins; Male; Microscopy, Electron; Middle Aged; Mucopolysaccharidosis IV | 1974 |
Glycosaminoglycans of iliac crest cartilage in spondyloepiphyseal dysplasia congenita.
Topics: Cartilage; Child; Chondroitin; Chromatography; Chromatography, DEAE-Cellulose; Disaccharides; Electrophoresis; Female; Glycosaminoglycans; Hexosamines; Humans; Ilium; Keratins; Male; Mucopolysaccharidosis IV; Uronic Acids | 1974 |
Morquio's disease.
Topics: Child; Child, Preschool; Connective Tissue; Glycosaminoglycans; Humans; Keratins; Male; Mucopolysaccharidosis IV; Radiography | 1972 |
Morquio's disease and mucopolysaccharide excretion.
Topics: Adolescent; Child; Child, Preschool; Chromatography; Diagnosis, Differential; Electrophoresis; Female; Galactose; Glycosaminoglycans; Hexoses; Humans; Keratins; Male; Methods; Mucopolysaccharidosis IV; Oxidoreductases; Sulfates | 1970 |
[Ultrastructural study of the liver in Morquio's disease].
Topics: Child; Child, Preschool; Cytoplasmic Granules; Female; Histocytochemistry; Humans; Keratins; Liver; Macrophages; Male; Membranes; Microscopy, Electron; Mucopolysaccharidoses; Mucopolysaccharidosis IV; Sulfates | 1969 |