bromochloroacetic-acid and Monilethrix

Topics: Hair Follicle; Humans; Keratins; Keratins, Hair-Specific; Keratins, Type II; Monilethrix; Mutation; Phenotype

Monilethrix is a congenital hair shaft disorder with associated fragility. Many of the changes seen in monilethrix hair on light microscopy and scanning electron microscopy are also seen in hair weathering and cosmetic damage to hair.. We used monilethrix as a model to investigate the relationship between hair protein structure and hair strength and resistance to cosmetic insult.. We applied proteomic techniques to identify novel peptide damage markers for chemical oxidative damage to hair.. The findings suggest that specific sites in the protein structure of hair are targeted during oxidative damage from bleaching, a unique insight into how chemical damage compromises the structural integrity of the hair shaft at the molecular level.. Applying proteomics to the study of congenital and acquired hair shaft disorders can deliver new insights into hair damage and novel strategies to strengthen hair.

Topics: Electrophoresis, Gel, Two-Dimensional; Hair; Hair Preparations; Humans; Keratins; Mass Spectrometry; Monilethrix; Oxidative Stress; Proteins; Proteomics; Tensile Strength

Topics: Arginine; Citrulline; Hair; Histocytochemistry; Humans; Keratins; Metabolic Diseases; Monilethrix