bromochloroacetic-acid and Melanosis

Pigmented squamous cell carcinomas have been reported in the oral and ocular mucosae, but rarely in the skin. We present a case of pigmented squamous cell carcinoma of the forehead and review the current English literature. Pigmented squamous cell carcinoma can be confused with pigmented basal cell carcinomas and melanoma, especially those melanomas associated with pseudoepitheliomatous hyperplasia and should be included in the differential diagnosis of atypical pigmented lesions.

Topics: Carcinoma, Squamous Cell; Cell Differentiation; Diagnosis, Differential; Forehead; Humans; Keratins; Male; Melanins; Melanocytes; Melanoma; Melanosis; Middle Aged; Skin Neoplasms

Erythrosis pigmentosa peribuccalis (Brocq) (or erythrosis pigmentosa mediofacialis) and erythromelanosis follicularis faciei et colli, have been regarded as different disorders, mainly because the first occurs on the mediofacial area and is common in women and the second mostly occurs pre-auricularly in men. Both conditions show histological signs of abnormal follicular keratinization with teleangiectasia and round cell infiltrate. An increase in the level of melanin has been seen in some patients. We describe here a woman in whom lesions started in the middle of the face and later became evident in the pre-auricular area. This suggests that the two conditions are in fact the same disease. As a neutral term for this not uncommon disorder we propose erythrosis pigmentosa faciei et colli.

Topics: Adult; Cheek; Facial Dermatoses; Female; Humans; Keratins; Melanosis; Neck; Pigmentation Disorders; Telangiectasis

Nodular or tumoral melanosis consists of nodular or sheetlike deposits of melanophages in the dermis. When nodular melanosis is present, a completely regressed malignant melanoma is a major diagnostic consideration. We present a case of nodular melanosis due to regression of a pigmented basal cell carcinoma with pilar differentiation. In addition to this case, we present five additional cases of epithelial neoplasms with melanin deposition in the stroma. In each case, the source of the melanin was non-neoplastic dendritic melanocytes intermingled among the tumor cells. Therefore, if nodular melanosis is found, pigmented epithelial neoplasms should also be considered in the differential diagnosis.

Topics: Aged; Antibodies, Monoclonal; Antigens, Neoplasm; Biomarkers, Tumor; Carcinoma; Carcinoma, Basal Cell; Humans; Immunohistochemistry; Iron; Keratins; Male; Melanins; Melanoma-Specific Antigens; Melanosis; Middle Aged; Neoplasm Proteins; S100 Proteins; Skin Neoplasms; Vimentin

Topics: Cell Nucleus; Dose-Response Relationship, Radiation; Epidermis; Humans; Hyperplasia; Keratins; Lentigo; Melanocytes; Melanosis; Photochemotherapy; Psoriasis; PUVA Therapy; Skin Neoplasms

Topics: Adolescent; Adult; Female; Gingiva; Humans; Keratins; Male; Melanocytes; Melanosis; Microscopy, Electron; Middle Aged; Mouth Diseases; Smoking

Topics: Cheek; Endoplasmic Reticulum; Female; Golgi Apparatus; Humans; Keratins; Male; Melanins; Melanocytes; Melanosis; Microscopy, Electron; Middle Aged; Pigmentation; Precancerous Conditions