bromochloroacetic-acid and Medulloblastoma

bromochloroacetic-acid has been researched along with Medulloblastoma* in 5 studies

Other Studies

5 other study(ies) available for bromochloroacetic-acid and Medulloblastoma

ArticleYear
[Atypical teratoid/rhabdoid tumors of central nervous system in childhood: a clinical and histopathologic study of 6 cases].
    Zhonghua bing li xue za zhi = Chinese journal of pathology, 2012, Volume: 41, Issue:4

    To study the clinicopathologic features, immunohistochemical findings, diagnosis and differential diagnosis of atypical teratoid/rhabdoid tumors (AT/RT) of central nervous system in childhood.. The clinicopathologic data, morphologic features and immunophenotypes were reviewed in 6 cases of AT/RT. EnVision method was applied. Antibodies include cytokeratin (CK), epithelial membrane antigen (EMA), vimentin, smooth muscle actin (SMA), muscle specific actin (MSA), glial fibrinary acid protein (GFAP), desmin, placental alkaline phosphatase (PLAP) and INI1.. Five of the six cases of AT/RT occurred in infancy and early childhood. Histologically, the predominant component was rhabdoid cells. Cytoplasmic inclusions were present in all cases. Primitive neuroectodermal tumor (PNET) component was also identified in 5 of the 6 cases studied. Immunohistochemically, the tumor cells were positive for cytokeratin, epithelial membrane antigen and vimentin. The staining for INI1, desmin and PLAP was negative. Smooth muscle actin was expressed in 2 cases and glial fibrillary acidic protein in 5 cases. The proliferative index as demonstrated by Ki-67 staining was high.. AT/RT is not a particularly uncommon malignancy in childhood. The histologic hallmark is the presence of rhabdoid cells with cytoplasmic inclusions. The tumor cells are positive for cytokeratin, epithelial membrane antigen and vimentin, and negative for INI1. Differential diagnosis includes PNET, medulloblastoma and medullomyoblastoma.

    Topics: Brain Neoplasms; Child, Preschool; Diagnosis, Differential; Female; Humans; Infant; Keratins; Male; Medulloblastoma; Mucin-1; Neuroectodermal Tumors, Primitive; Rhabdoid Tumor; Teratoma; Vimentin

2012
Large cell medulloblastoma with myogenic and melanotic differentiation: a case report with molecular analysis.
    Journal of neuro-oncology, 2008, Volume: 88, Issue:2

    We present a case of large cell medulloblastoma with myogenic and melanotic differentiation arising in the cerebellar vermis of a 2-year-old boy and following an aggressive clinical course. Histologic and immunohistochemical features of this tumor include primitive neuronal, rhabdomyoblastic, and pigmented epithelial elements, along with large cell features. Immunohistochemical and molecular data (c-myc gene amplification and the presence of isochromosome 17q) support the contention that this histologically diverse tumor represents a pattern of medulloblastoma with striated muscle and pigmented epithelial differentiation, rather than a teratoma or a cerebellar variant of melanotic neuroectodermal tumor of infancy ('progonoma').

    Topics: Antigens, Neoplasm; Cell Differentiation; Cerebellar Neoplasms; Child, Preschool; Chromosomes, Human, Pair 17; Epithelium; Glial Fibrillary Acidic Protein; Humans; Karyotyping; Keratins; Male; Medulloblastoma; Melanoma-Specific Antigens; Muscle Development; Neoplasm Proteins; Neoplasms, Muscle Tissue; Neuroectodermal Tumors, Primitive; Proto-Oncogene Proteins c-myc

2008
Age-related immunoreactivity pattern in medulloblastoma.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 1992, Volume: 8, Issue:6

    Thirty-five paraffin-embedded medulloblastomas (19 from children and 16 from adults; 24 classic medulloblastomas, 10 desmoplastic medulloblastomas, 1 tumor with neuronal differentiation) were examined for reactions with antibodies against glial fibrillary acidic protein (GFAP), cytokeratins KL1 and MNF116, desmin, and vimentin. Only the tumor from the youngest patient, a 152-day-old boy, showed a positive immunoreaction for cytokeratins. Because of this age-related expression of cytokeratins in medulloblastomas primarily in very young children, cytokeratin positivity was interpreted as a sign of tumor immaturity. Five medulloblastomas showed scattered GFAP-positive reactive astrocytes and/or other positive, probably neoplastic, cells. Only two tumors showed GFAP immunoreactivity in unequivocally neoplastic cells. Of six tumors that reacted with vimentin, three showed strong reactivity throughout, one being the tumor from the 152-day-old boy. The remaining three demonstrated nests of vimentin-positive cells with weak or intense somatic immunoreactivity for vimentin. None of the 35 cases showed positivity for desmin; indicating that mesenchymal differentiation is restricted to the rare so-called medullomyoblastomas.

    Topics: Adolescent; Adult; Cerebellar Neoplasms; Child; Child, Preschool; Cytoplasm; Desmin; Female; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Infant; Keratins; Male; Medulloblastoma; Microscopy, Electron; Vimentin

1992
Desmoplastic primitive neuroectodermal tumor with divergent differentiation. Broadening the spectrum of desmoplastic infantile neuroepithelial tumors.
    The American journal of surgical pathology, 1992, Volume: 16, Issue:10

    We report an unusual large, multicystic, posterior fossa neuroepithelial neoplasm involving the cerebellum, brain-stem, and quadrigeminal cistern of a 9-month-old girl. The neoplasm consisted of variably sized, sharply demarcated nests of small cells with a high nuclear-cytoplasmic ratio and moderately basophilic nuclei, embedded in a desmoplastic, immature-appearing, mesenchymal stroma. The nests contained mitoses but none were seen in the stroma. Glial fibrillary acidic protein (GFAP), neurofilament protein, synaptophysin, and cytokeratin (AE-1) were expressed in the nests. Mesenchymal cells were negative for neural markers but positive for vimentin and desmin. The neoplasm was interpreted as a mixed mesenchymal and primitive neuroectodermal tumor (PNET) with histologic features reminiscent of a recently described intraabdominal desmoplastic small cell tumor. The tumor responded poorly to chemotherapy and a second operation was performed 1 year later. The second specimen bore no resemblance to the original and consisted of epithelial-like nests and clusters of neoplastic cells frequently interrupted by sinusoidal vessels. Tumor cells had medium-sized vesicular nuclei with small nucleoli, and a granular cytoplasm. Occasional less cellular islands of neuropil-like tissue contained larger cells having eccentric, vesicular nuclei with prominent nucleoli and abundant pink cytoplasm. Mitoses were not conspicuous. Many cells expressed synaptophysin, neurofilament protein, and GFAP. Neurofilament protein was strongly positive in the larger, neuron-like cells and synaptophysin stained the neuropil-like areas strongly but was less prominent in the neuronal perikarya. Unexpectedly, the neuropil-like areas expressed epithelial membrane antigen, whereas the neuronal cells were negative for chromogranin A. The peculiar histologic picture, combination of phenotypic markers, and remarkable biologic behavior of this unusual tumor defies classification according to existing nomenclature and exemplifies the broad range of phenotypes expressed by primitive neuro-epithelial neoplasms.

    Topics: Brain Neoplasms; Cell Nucleus; Cell Transformation, Neoplastic; Cytoplasm; Desmin; Female; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Infant; Karyotyping; Keratins; Medulloblastoma; Neoplasms, Germ Cell and Embryonal; Phenotype; Synaptophysin; Terminology as Topic; Vimentin

1992
Spinal cord tumors in children. Current status of early diagnosis in this potentially curable neoplasm.
    Clinical pediatrics, 1968, Volume: 7, Issue:12

    Topics: Cauda Equina; Child; Glioma; Humans; Keratins; Male; Medulloblastoma; Meningitis; Myelography; Neuroblastoma; Physical Examination; Retinoblastoma; Spinal Cord Neoplasms; Spinal Puncture; Steroids

1968
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