bromochloroacetic-acid and Mastitis

Topics: Breast Neoplasms; Cadherins; Carcinoma, Lobular; Catenins; Delta Catenin; Diagnosis, Differential; Female; Humans; Keratins; Lymphoma; Mastitis; Plasmacytoma

The purpose of this article is to highlight an unusual form of breast carcinoma and discuss its differential diagnosis. A 50-year-old woman underwent wide local excision of a breast lump. Microscopic examination revealed features of a lymphoepithelioma-like carcinoma. Individual tumor cells were present within an abundant lymphoid stroma. Immunohistochemistry revealed the epithelial nature of the cells and excluded a diagnosis of lymphoma. In addition, surrounding nontumorous breast tissue displayed the histologic features of sclerosing lymphocytic lobulitis or lymphocytic mastopathy. This is the second report of a lymphoepithelioma-like carcinoma of the breast, but to the best of our knowledge, it is the first description of coexistent sclerosing lymphocytic lobulitis.

Topics: Biomarkers, Tumor; Breast; Breast Neoplasms; Carcinoma, Squamous Cell; Diagnosis, Differential; Female; Humans; Keratins; Lymphoma; Mastitis; Middle Aged; Sclerosis

When a subareolar breast abscess (SBA) is incised and drained, an extraordinarily high frequency of recurrence is noted.. To develop a pathogenesis-based treatment plan, 24 women with a total of 84 abscesses were monitored.. In nine women SBA was under the left areola, under the right, in 7 and in eight the SBA occurred either simultaneously or sequentially under both areolae. In 11 of 24 patients a chronic lactiferous duct fistula also existed. In four of 24 patients four SBAs were treated with antibiotics; alone; all recurred. In 16 of 24 patients initial treatment was incision and drainage plus antibiotics; all recurred. When the abscess plus the plugged lactiferous duct was excised, there were no recurrences; however, in four patients a new abscess in a different duct occurred, which was treated by en bloc resection of all subareolar ampullae, without further recurrence. Patients with a fistulous tract had the fistula, its feeding abscess, and its plugged lactiferous duct excised, without recurrence. In first time SBA the organism was usually staphylococcus; in recurrences mixed flora was isolated. Pathologic findings ranged from squamous metaplasia with keratinization of lactiferous ducts to chronic abscess.. The cause of SBA is plugging of lactiferous duct within the nipple by keratin. To prevent recurrence the abscessed ampulla with its plugged proximal duct needs excision.

Topics: Abscess; Adult; Anti-Bacterial Agents; Breast; Combined Modality Therapy; Cutaneous Fistula; Disease Susceptibility; Female; Humans; Keratins; Mastitis; Metaplasia; Middle Aged; Nipples; Recurrence; Smoking; Staphylococcal Infections; Vitamin A Deficiency

Duct ectasias (n = 2) and different types of benign canine mammary tumours (n = 19) were studied immunohistochemically with monoclonal antibodies (MoAbs) directed against various human keratin types (K), alpha-smooth muscle actin, vimentin, and desmin. In the duct ectasias and in most tumours the epithelial structures revealed an inner and outer cell layer. The inner cell layer was characterized by labelling with K 7, 8, 18, 19 and mostly also with K 4 and/or K 10 MoAbs. The outer cell layer was almost invariably labelled by K 14, K 14 and 17, and a-smooth muscle actin MoAbs. The labelling patterns of both duct ectasias and tumours corresponded largely to the patterns observed in normal mammary gland tissue, although a more distinct heterogeneity was seen. Tumours histomorphologically assumed to be of a myoepithelial origin did not show immunohistochemical features of myoepithelial cells. The myoepithelial nature of the vast majority of spindle-shaped cells present in the adenomas of the complex type and in the fibroadenomas of the benign mixed type could not be confirmed immunohistochemically. These cells, however, unequivocally expressed vimentin, suggesting proliferation of stromal cells in these tumours, which in the fibroadenomas of the benign mixed type may show metaplasia to bone or cartilage. In the duct ectasias and in some tumours, a fraction of elongated stromal cells, probably representing myofibroblasts, was labelled with the alpha-smooth muscle actin MoAb.

Topics: Actins; Adenoma; Animals; Antibodies, Monoclonal; Desmin; Dilatation, Pathologic; Dog Diseases; Dogs; Female; Fibroadenoma; Immunoenzyme Techniques; Immunophenotyping; Intermediate Filament Proteins; Keratins; Male; Mammary Glands, Animal; Mammary Neoplasms, Animal; Mastitis; Papilloma, Intraductal; Vimentin

Staphylococcus aureus isolated from mastitis (14 bovine and 11 ovine strains) exhibited an ability to adhere to epithelial primary cultures from ovine mammary gland and to a rat epithelial cell line, RIE-1. Strain differences in the degree of adherence were observed in both cases. These differences were maintained when comparing different epithelial sources (rat vs. ovine). RIE-1 cells can thus be used as a model for studying staphylococcal adherence to epithelial cells. Changes in bacterial adherence were observed according to the bacterial growth phase. The magnitude of these changes differed among strains. Bacterial cell surface hydrophobicity was not related to the degree of adherence to mammalian epithelial cells.

Topics: Animals; Bacterial Adhesion; Cattle; Cell Line; Cells, Cultured; Epithelial Cells; Epithelium; Female; Fluorescent Antibody Technique; Intestines; Keratins; Mammary Glands, Animal; Mastitis; Mastitis, Bovine; Rats; Sheep; Sheep Diseases; Staphylococcal Infections; Staphylococcus aureus; Surface Properties

Topics: Adult; Breast Neoplasms; Diagnosis, Differential; Female; Granuloma; Humans; Keratins; Male; Mastitis; Metaplasia; Pregnancy