bromochloroacetic-acid and Lip-Diseases

Topics: Epidermal Cyst; Humans; Keratins; Lip; Lip Diseases; Male; Middle Aged

We present the clinicopathological findings after reviewing 52 patients affected by multifocal epithelial hyperplasia (MEH), previously known as focal epithelial hyperplasia and the results of an immunocytochemical study.. We reviewed the clinical files and microscopic slides from 52 MEH-affected patients and new slides were immunostained with a polyclonal antibody against high molecular weight cytokeratins.. More than 95% of the patients were in poverty (<200 dollars monthly family income). Females comprised 71.1% of the MEH patients, 69.3% were in the first and second decades and buccal mucosa, lips, and tongue were more frequently affected. Ninety-two percent of the patients had a direct relative with similar lesions. In hematoxylin and eosin-stained slides, prominent multiple nucleoli were observed. Immunocytochemical study showed differences in immunostaining between lesional and normal cells. Cells with strongly immunostained cytoplasm were seen in the prickle layer of the lesional epithelium as well as in the clinically normal neighboring epithelial tissue. Cytokeratin-negative mitosis-like cells and koilocytes were identified within the lesions.. The name "multifocal epithelial hyperplasia" is more accurate than those previously proposed designations, because it is more precise to describe the clinical and microscopic features of the disease. Also, our results suggest that mitosis-like cells and koilocytes are degenerated cells unable to synthesize cytokeratins and that cells with strongly immunostained cytoplasm represent epithelial cells showing an altered cytokeratin metabolic profile.

Topics: Adolescent; Adult; Age Factors; Aged; Cell Nucleolus; Child; Child, Preschool; Cytoplasm; Epithelial Cells; Female; Focal Epithelial Hyperplasia; Humans; Immunohistochemistry; Keratins; Lip Diseases; Male; Mexico; Middle Aged; Mitosis; Mouth Mucosa; Poverty; Retrospective Studies; Sex Factors; Social Class; Tongue Diseases

Topics: Adult; Diagnosis, Differential; Epidermal Cyst; Humans; Keratins; Lip Diseases; Male

We report the apparent first case of a trichilemmal cyst presenting intraorally. Trichilemmal cysts are cysts of epithelial origin with a distinctive keratinization pattern that simulates that of the human anagen hair follicle between bulge and sebaceous gland and in the sac surrounding catagen hairs. This type of keratinization of outer root sheath epithelium occurs when it is freed from its internal cover of inner root sheath. This particular case showed evidence of mild epithelial proliferation and slight foci of "metaplastic" epidermoid keratinization, possibly related to mild trauma. The rarity of intraoral hairs undoubtedly accounts for the lack of reported cases of trichilemmal cysts in oral or perioral locations.

Topics: Adult; Epidermal Cyst; Hair Diseases; Hair Follicle; Humans; Keratins; Lip Diseases; Male; Sex Ratio

Immunohistochemically detected keratin proteins in mucoceles of oral mucosa were used to served as markers to identify epithelial-derived cells of minor salivary glands. Normal ducts of minor salivary glands showed an intense keratin staining. Epithelial lining and or epithelial fragments in cystic walls of mucoceles displayed a strong reaction to keratin proteins too, whereas granulation tissue or connective tissue fibers of the walls were not seen. Foamy macrophages present in cystic cavities signify higher staining with the use of keratin proteins. Mucoceles in oral minor salivary glands are probably caused by ductal obstructions leading to continuous mucous secretion. Keratin proteins were used as an epithelial marker of ductal segments.

Topics: Epithelium; Histocytochemistry; Humans; Immunoenzyme Techniques; Keratins; Lip Diseases; Mouth Mucosa; Mucocele; Salivary Glands; Salivary Glands, Minor

Inverted follicular keratosis, a benign tumor of the skin believed to arise from the infundibular portion of the hair follicle that can involve perioral skin, has a unique histologic picture. It can be confused with forms of skin cancer; with knowledge of this entity, oral and maxillofacial surgeons may be able to avoid unnecessary surgery. The clinical and microscopic findings of 12 cases of inverted follicular keratosis are reported.

Topics: Adult; Aged; Darier Disease; Diagnosis, Differential; Epithelium; Facial Dermatoses; Facial Neoplasms; Humans; Keratins; Keratosis; Lip Diseases; Male; Middle Aged

Pathologic changes of free sebaceous glands are rare compared to those of the skin. Two keratin-filled pseudocysts which developed in the excretory ducts of sebaceous glands in the vermilion border of the lower lip in an 86-year-old woman are described. The entity is probably related to milia of the skin.

Topics: Aged; Epidermal Cyst; Female; Humans; Keratins; Lip Diseases; Mouth Mucosa; Sebaceous Glands

Topics: Adolescent; Biopsy; Connective Tissue; Elastic Tissue; Facial Dermatoses; Female; Folliculitis; Humans; Keratins; Lip Diseases; Sebaceous Glands; Skin