bromochloroacetic-acid and Jaw-Diseases

The aims of the review were to evaluate the principal clinical and conventional radiographic features of orthokeratinized odontogenic cyst (OOC) by systematic review (SR), and to compare the frequency of OOC between four global groups.. The databases searched were the PubMed interface of MEDLINE and LILACS. Only those reports of OOCs that occurred in a consecutive series of OOCs in the reporting authors' caseload were considered.. 37 reports on 36 case series were included in the SR. OOC affected males twice as frequently and the mandible almost 2.5 times as frequently. Although the mean age at first presentation was 35 years, the largest proportion of cases first presented in the third decade for the Western, East Asian and Latin American global groups. Seven reports included details of at least one clinical finding. 11 reported case series included at least 1 radiological feature. All OOCs were radiolucent, 93% were unilocular and 68% were associated with unerupted teeth. 28% of the reported case series included follow up. 4% of OCC recurred and all of these were in the Western global group.. Although one feature of OOCs is that they are unlikely to recur, some do. Not only is there a lack of long-term follow up of large series with long-term outcomes of OOC, but there is a paucity of clinical and radiological details of OOC at initial presentation.

Topics: Africa South of the Sahara; Asia, Eastern; Europe; Humans; Jaw Diseases; Keratins; Latin America; North America; Odontogenic Cysts; Radiography; Sex Ratio

The odontogenic keratocyst is the third most common cyst of the jaws, after the follicular and radicular cyst. Keratocysts most commonly occur as single lesions in the jaw of otherwise healthy persons. Multiple odontogenic keratocysts are a well-recognized feature of the nevoid basal cell carcinoma syndrome. The mandible, especially the third molar region, the angle of the mandible and the ascending ramus are involved far more frequently than the maxilla. Clinically, the cysts often remain asymptomatic and there are two specific histological entities: the orthokeratinized and the parakeratinized odontogenic keratocyst. Different surgical treatment options like marsupialization, enucleation with curettage or peripheral ostectomy, and osseous resection (marginal or segmental) have been discussed in the literature with variable rates of recurrence. Besides a predilection for recurrence, the keratocysts, in contrast to other odontogenic cysts, show a more aggressive clinical behavior and demonstrate a high mitotic count and higher turnover rate of the epithelium. This led to the tentative suggestion that the keratocyst might be a benign cystic neoplasm rather than simply an odontogenic cyst.

Topics: Basal Cell Nevus Syndrome; Diagnosis, Differential; Humans; Jaw Diseases; Jaw Neoplasms; Keratins; Odontogenic Cysts; Odontogenic Tumors; Recurrence

Numerous studies of keratin expression by the more common odontogenic cysts were done to determine whether patterns of cytokeratin staining could provide accurate diagnostic markers for the different varieties; to see whether comparative studies with oral mucosa and developing odontogenic epithelium could explain the pathogenesis of the cysts; and whether cytokeratin patterns could provide clues in elucidating the aggressive nature of the OKC. This review was a complex task with a range of at least 19 different cytokeratins being studied and also a broad range of antibodies in use for the same cytokeratin or group of cytokeratins. Moreover, there was not always standardisation of laboratory techniques in the selection and preparation of material. These difficulties were, in general, recognised by the different workers in the field, particularly when there was disagreement on results and caution was expressed about drawing conclusions from some positive findings. It would be fair to conclude that cytokeratin immunocytochemistry has not advanced to any meaningful extent, its use as a diagnostic marker for the OKC nor in eludidating its pathogenesis. With regard to OKC behaviour, it has been pointed out that there was strong reaction of OKC lining for keratin 16, a cytokeratin that has been associated with high proliferative activity. Yet other studies have also shown keratin 16 expression in dentigerous and radicular cysts. Differences in cytokeratin, EMA and CEA immunocytochemical reactivity between the parakeratinised and orthokeratinised varieties of cyst were demonstrated and the suggestion made that the orthokeratinised type has a considerably less aggressive behaviour, is a different entity and should bear a different name. Furthermore, Ki67 positive cells in the parakeratinised OKC linings were considerably more frequent than in the orthokeratinised linings.OKC, dentigerous and radicular cyst epithelium reacted positively for epithelial growth factor receptor (EGFr) but a trend indicating the most intense staining in the OKCs, followed by the dentigerous and then the radicular cyst linings led to the conclusion that the OKCs have an intrinsic growth potential not present in other odontogenic cysts.

Topics: Biomarkers; Epidermal Growth Factor; Humans; Jaw Diseases; Keratins; Odontogenic Cysts; Transforming Growth Factors

Glandular odontogenic cyst (GOC) demonstrates a significant predilection toward localized biologic aggressiveness and recurrence. GOC shares certain histopathologic features with intraosseous mucoepidermoid carcinoma (IMEC). The current investigation evaluates a group of recurrent, biologically aggressive GOCs to determine whether any cases demonstrated unique histologic features or mastermind-like2 (MAML2) rearrangements common to IMEC.. Microscopic slides from 11 previously diagnosed GOCs were stained with hematoxylin and eosin and assessed by 2 study participants for 10 classic histopathologic features required to establish a diagnosis of GOC. Cases were evaluated utilizing break-apart fluorescent in situ hybridization (FISH) analysis for the presence of MAML2 gene rearrangements. Clinical and demographic data on all patients were recorded.. The mean age for patients included in the study was 55.27 years with a range of 36 to 72 years. The most common presenting symptom was a jaw expansion, and all cysts presented initially as a unilocular or multilocular radiolucency. Cysts displayed a minimum of 6 of 10 histologic parameters necessary for a diagnosis of GOC. One case demonstrated MAML2 rearrangements by FISH. That case also showed marked ciliation of cyst-lining epithelial cells and extensive mucous-secreting goblet cell proliferation.. Findings in the current study are in concert with previous investigations, and although this study finds only limited molecular evidence to support the premise that recurrent biologically aggressive GOCs are a precursor to IMEC, detection of MAML2 rearrangements in 1 case suggests that such a theoretic transition, while rare, is possible.

Topics: Adult; Aged; Biomarkers, Tumor; Carcinoma, Mucoepidermoid; DNA-Binding Proteins; Epithelial Cells; Female; Gene Rearrangement; Humans; In Situ Hybridization, Fluorescence; Jaw Diseases; Jaw Neoplasms; Keratins; Male; Mandible; Maxilla; Middle Aged; Neoplasm Recurrence, Local; Nuclear Proteins; Odontogenic Cysts; Radiography; Trans-Activators; Transcription Factors

The aim of the present study was to analyze the expression levels of Cyclin D1 (CCD1), a nuclear protein that plays a crucial role in cell cycle progression, in a series of keratin-producing odontogenic cysts.. A total of 58 keratin-producing odontogenic cysts, diagnosed over ten years and classified according to the WHO 2005 criteria, were immunohistochemically analyzed in terms of CCD1 expression, which was quantified in the basal, suprabasal and intermediate/superficial epithelial compartments. The extent of immunostaining was measured as a proportion of total epithelial thickness. Quantified immunohistochemical data were correlated with clinicopathological features and clinical recurrence.. Keratin-producing odontogenic cysts were classified as 6 syndromic keratocystic odontogenic tumors (S-KCOT), 40 sporadic or non-syndromic KCOT (NS-KCOT) and 12 orthokeratinized odontogenic cysts (OOC). Immunohistochemically, CCD1 staining was evident predominantly in the parabasal region of all cystic lesions, but among-lesion differences were apparent, showing a clear expansion of parabasal compartment especially in the S-KCOT, followed to a lesser extent in the NS-KCOT, and being much more reduced in the OOC, which had the greatest average epithelial thickness.. The differential expression of CCD1 noted in the present study suggests that dysregulation of cell cycle progression from G1 to the S phase contributes to the different aggressiveness of these lesions. However, CCD1 expression levels did not predict NS-KCOT recurrence, which is likely influenced by factors unrelated to lesion biology.

Topics: Adult; Cyclin D1; Female; Humans; Jaw Diseases; Keratins; Male; Middle Aged; Odontogenic Cysts; Retrospective Studies

The odontogenic keratocyst (OKC, currently designated by the World Health Organization as a keratocystic odontogenic tumor) is a locally aggressive, cystic jaw lesion with a putative high growth potential and a propensity for recurrence. Although it is generally agreed that some features of OKCs are those of a neoplasia, notably the relatively high proliferative rate of epithelial cells, controversies over the behavior and management of OKCs still exist. This article is intended to review this intriguing entity and to summarize the findings of recent studies related to the nature of OKCs and their clinical and therapeutic implications. Recent advances in genetic and molecular research, i.e., PTCH1 mutations and involvement of the Hedgehog signaling pathway, have led to increased knowledge of OKC pathogenesis which hints at potential new treatment options, although the question of whether the OKC is a cyst or a cystic neoplasm is yet to be answered with certainty. Since some advocate a more conservative treatment for OKCs, notably marsupialization and decompression, future treatment strategies may focus on molecular approaches and eventually reduce or eliminate the need for aggressive surgeries.

Topics: Cell Proliferation; Epithelial Cells; Gene Expression Regulation, Neoplastic; Genes, p53; Hedgehog Proteins; Humans; Jaw Diseases; Keratins; Mutation; Odontogenic Cysts; Odontogenic Tumors; Patched Receptors; Patched-1 Receptor; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Signal Transduction; Smoothened Receptor

The purpose of this paper is to review the features and behaviour of the odontogenic keratocyst (OKC), now officially known as the keratocystic odontogenic tumour (KCOT); to analyze a series of histologically confirmed KCOT cases; and to review and discuss the redesignation of KCOT and the implications for treatment. Redesignation of the OKC as the KCOT by the World Health Organization (WHO) is based on the well-known aggressive behaviour of this lesion, its histology and new information regarding its genetics. Abnormal function of PTCH, a tumour suppressor gene, is noted to be involved in both nevoid basal cell carcinoma syndrome and sporadic KCOTs. Normally, PTCH forms a receptor complex with the oncogene SMO for the SHH ligand. PTCH binding to SMO inhibits growth-signal transduction. SHH binding to PTCH releases inhibition of the signal transduction pathway. If normal functioning of PTCH is lost, the proliferation-stimulating effects of SMO are permitted to predominate. A review of the literature was conducted and results were tabulated to determine whether treatment modality is related to recurrence rate. More aggressive treatment - resection or enucleation supplemented with Carnoy"s solution with or without peripheral ostectomy - results in a lower recurrence rate than enucleation alone or marsupialization. Notably, the recurrence rate after marsupialization followed by enucleation is not significantly higher than that following the so-called aggressive modalities. Our case series consists of 21 patients treated for KCOTs. Results were organized to demonstrate recurrence as it relates to size of lesion and time since treatment and incidence as it relates to patient age and location in the jaws. In our series, the average KCOT surface area measured radiographically was 14 cm

Topics: Acetic Acid; Age Distribution; Aged; Aged, 80 and over; Chloroform; Ethanol; Humans; International Classification of Diseases; Jaw Diseases; Jaw Neoplasms; Keratins; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Odontogenic Cysts; Odontogenic Tumors; Retrospective Studies

Central mucoepidermoid carcinoma (MEC) is an entity whose origin is still controversial. Glandular odontogenic cyst (GOC) is a recently described lesion whose relationship to low-grade central MEC has been reported in the literature. Our aim was to assess the cytokeratin (CK) profile of central MEC and GOC, and compare the results with CK expression in salivary gland MEC and odontogenic cysts and tumors. Eighty-five cases, including 6 central MECs, 23 salivary gland MECs, 10 GOCs, 34 odontogenic cysts and 12 ameloblastomas, were studied through immunohistochemistry using eleven monoclonal anti-CK antibodies. All central MECs expressed CKs 5, 7, 8, 14, and 18 and all GOCs expressed CKs 5, 7, 8, 13, 14, and 19. Comparing CK expression from GOC and central MEC we found differences in CKs 18 (30% vs 100%) and 19 (100% vs 50%). Central MEC and GOC are probably distinct entities with CK profiles similar to lesions of glandular and odontogenic origins, respectively, and expression of CKs 18 and 19 could be useful in their differential diagnosis.

Topics: Adult; Aged; Carcinoma, Mucoepidermoid; Female; Humans; Immunohistochemistry; Jaw Diseases; Keratins; Male; Mandibular Diseases; Maxillary Diseases; Middle Aged; Odontogenic Cysts; Salivary Gland Neoplasms

Sections of tissue embedded in paraffin wax from 18 selected odontogenic cysts were studied both histologically and immunohistochemically with antibodies to cytokeratins using the indirect peroxidase technique. The cysts were divided on a clinical and histological basis into two equal groups comprising dentigerous cysts and odontogenic keratocysts. It was possible to differentiate the two cyst types in every case by the pattern of staining using the monoclonal antibody LP34 for cytokeratins of intermediate molecular weight. The monoclonal antibody CAM 5.2 for cytokeratins of low molecular weight was not discriminatory. Such a clear distinction may prove useful diagnostically in distinguishing between two cysts of similar appearance but very different behaviour.

Topics: Dentigerous Cyst; Diagnosis, Differential; Epithelium; Humans; Jaw Diseases; Keratins; Odontogenic Cysts; Recurrence

The epithelia lining the cyst of five cases of calcifying odontogenic cyst (COC) were evaluated immunohistochemically with the use of monoclonal antibodies (MoAb's) against keratin (PKK1, KL1, K4.62, K8.12) and vimentin, and polyclonal antisera agonist involucrin and filaggrin. Epithelial lining of COC was classified into 1) thin squamous-cell epithelium, 2) ameloblastoma-like, and 3) thin or 4) thick calcifying odontogenic epithelium. Foci consisting of ghost cells or calcified cells were categorized as calcifying epithelial odontogenic tumor (CEOT). Thin squamous-cell epithelium reacted with PKK1, KL1, K4.62, K8.12, and anti-vimentin MoAb's, thus demonstrating the co-expression of keratin and vimentin. Ameloblastoma-like cells showed positive staining with PKK1, KL1, and sometimes with anti-vimentin. Thick calcifying odontogenic epithelial lining showed stratification of cell layers, and the most strikingly reactive zone was the upper intermediate layer, which showed the presence of keratin, involucrin, and a small amount of filaggrin. Cells of this layer might be the most differentiated type of cells in COC. Undifferentiated odontogenic cells of COC masses were characterized by co-expression of keratin and vimentin, and by the absence of involucrin and filaggrin. All ghost cells were devoid of any immunostaining except for filaggrin, which was rarely positive, but eosinophilic or basophilic cells surrounding the ghost cells showed intense staining for all keratin proteins except vimentin.

Topics: Adolescent; Adult; Cell Transformation, Neoplastic; Epithelium; Female; Filaggrin Proteins; Humans; Immunohistochemistry; Intermediate Filament Proteins; Jaw Diseases; Keratins; Male; Odontogenic Tumors; Protein Precursors

Sixty odontogenic keratocysts were clinically, radiographically, and histologically examined to determine whether any significant relationships existed between the radiographic appearance of the odontogenic keratocyst (unilocular versus multilocular) and its corresponding clinical and histologic features. The odontogenic keratocysts identified as multilocular appeared to be larger, contain a more severe inflammation, and exhibit the presence of cholesterol granulomas more often than those identified as unilocular.

Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Cholesterol; Female; Granuloma; Humans; Jaw Diseases; Keratins; Male; Middle Aged; Odontogenic Cysts; Radiography

The expression of keratins, CEA, EMA, and rat liver antigen (RLA) and the presence of Ki67+ proliferating cells were studied in the epithelial linings of 50 odontogenic cysts using an indirect immunoperoxidase method on acetone-fixed frozen sections. All cysts were positive with monoclonal antibodies of broad keratin specificity (CK1, AE1-3), and between 40 and 100 per cent of epithelial cells expressed keratins 13 and 19. Keratins 7, 8, and 18 were rarely expressed although surface cells in areas of mucous metaplasia often expressed keratins 7 and 18. Expression of keratin 10/11 was related to the presence of a well-ordered epithelial lining and was detected in isolated cells in 4/32 non-keratinizing cysts and in the upper suprabasal cell layers of 17/18 keratocysts. Although CEA, EMA, and RLA were detected in the epithelium of all specimens, the pattern of expression of CEA and EMA differed between cyst types. Ki67+ proliferating cells were most prevalent in keratocyst epithelia, where they were usually found within lower suprabasal layers which were negative or weakly positive for keratins 10/11 and 13. These results indicate differences in keratin, CEA, and EMA expression between cyst types which appear to be dependent on epithelial differentiation/structure rather than cyst type or histogenesis. Although these differences may not be of diagnostic significance, the consistent expression of both keratins 13 and 19 may provide a useful marker of odontogenic epithelium in general.

Topics: Antigens, Neoplasm; Antigens, Surface; Carcinoembryonic Antigen; Epitopes; Humans; Jaw Diseases; Keratins; Membrane Glycoproteins; Mitosis; Mucin-1; Odontogenic Cysts

An animal model has been developed in which implantation cysts have been produced very close to developing teeth within the jaws of Vervet monkeys. Various deciduous teeth were extracted from both the maxilla and the mandible of 6 young Vervet monkeys. After 4 weeks, full thickness mucoperiosteal flaps were raised in these areas, up to 6 recipient sites were prepared in each monkey by drilling holes in the alveolar bone and small pieces of autogenous palatal mucosa were placed in these graft recipient sites. One monkey was killed after 5, 8, 22 and 25 weeks respectively and 2 after 52 weeks. Of the 33 implants placed, cyst formation occurred from 11 (33%). The distribution of the cysts was irregular in that 4 cysts were produced in each of 2 animals while no cysts were found in another 2 animals. The cysts produced were filled with keratin and lined partly by a thick keratinising epithelium and partly by a thin non-keratinising epithelium only a few cell layers thick. In one of the animals killed after 52 weeks, the follicle of an erupting premolar tooth had collided with one of the cysts resulting in the cyst lining becoming incorporated into the follicle, partly replacing the follicular reduced enamel epithelium and forming now an integral part of the follicle. This observation supports the hypothesis that the follicular odontogenic keratocyst has an extra-follicular origin arising after the eruption of a tooth into a pre-existing cyst cavity.

Topics: Animals; Cercopithecus; Female; Jaw Diseases; Keratins; Male; Odontogenesis; Odontogenic Cysts; Tooth Eruption

Immunostaining with monoclonal antibodies was used to study and compare the cytokeratin content of odontogenic cysts and normal gingival epithelium. Two monoclonal antibodies, PKK2 and KA1, stained the whole epithelium in all cyst samples. In gingiva, PKK2 gave a suprabasal staining and KA1 reacted with all epithelial cell layers. Antibodies PKK1, KM 4.62 and KS 8.12 gave a heterogeneous staining in follicular and radicular cysts. In keratocysts and in gingiva PKK1 and KM 4.62 reacted mainly with basal cells and KS 8.12 gave a suprabasal staining. Antibodies reacting with the simple epithelial cytokeratin polypeptide No. 18 (PKK3, KS 18.18) recognized in gingiva only solitary cells compatible with Merkel cells. In a case of follicular ameloblastoma a distinct staining of tumor epithelium was revealed with these antibodies. In 2 follicular cysts, but not in other cyst types, a layer of cytokeratin 18-positive cells was revealed. KA5 and KK 8.60 antibodies, reacting exclusively with keratinizing epithelia, including normal gingiva, gave no reaction in radicular cysts, keratocysts and ameloblastoma. Two of the follicular cysts, were negative for PKK3 and KS 18.18, but reacted strongly with KA5 and KK 8.60. The present results show that odontogenic jaw cysts have distinct differences in their cytokeratin content. With the exception of some follicular cysts, they lack signs of keratinizing epithelial differentiation. Only follicular cysts appear to share with some types of ameloblastoma the expression of cytokeratin polypeptide No. 18.

Topics: Ameloblastoma; Antibodies, Monoclonal; Epithelium; Follicular Cyst; Gingiva; Humans; Jaw Diseases; Jaw Neoplasms; Keratins; Microscopy, Fluorescence; Odontogenic Cysts; Radicular Cyst

Topics: Humans; Jaw Diseases; Keratins; Odontogenic Cysts

Topics: Adult; Aged; Dentigerous Cyst; Female; Follow-Up Studies; Humans; Jaw Diseases; Keratins; Male; Middle Aged; Odontogenic Cysts; Osteolysis; Radicular Cyst; Radiography; Recurrence; Retrospective Studies

Three hundred nineteen odontogenic keratocysts from 255 patients (167 males and 88 females, a 2:1 ratio) were histologically and clinically examined. The cysts sometimes occurred as multiple or recurrent lesions or in association with Gorlin's syndrome. The rate of recurrence for the total population was 27%. The 116 patients who were tentatively diagnosed as having keratocyst prior to surgery had a recurrence rate of 26%. There was no direct correlation between a large number of different histopathologic parameters and the propensity of a lesion to recur. Based on these data, a theory for the growth mechanism of these lesions is presented, and it is that the odontogenic keratocyst should be regarded as a benign cystic neoplasm and treated accordingly.

Topics: Adolescent; Adult; Aged; Basal Cell Nevus Syndrome; Child; Diagnosis, Differential; Epithelium; Female; Humans; Jaw Diseases; Keratins; Male; Middle Aged; Odontogenic Cysts; Recurrence

Topics: Adolescent; Adult; Aged; Child; Cysts; Female; Humans; Jaw Diseases; Keratins; Male; Middle Aged; Odontogenic Cysts; Recurrence

Topics: Adolescent; Adult; Aged; Child; Female; Humans; Jaw Diseases; Keratins; Male; Middle Aged; Odontogenic Cysts; Recurrence

The histopathologic and clinical features of sixty cases of orthokeratinized odontogenic cysts were compared with those of odontogenic keratocysts (typically parakeratinized). According to the results of this study, the orthokeratinized odontogenic cyst appears to be a distinct clinicopathologic entity. This cyst is histologically characterized by a thin, uniform, epithelial lining with orthokeratinization and a subjacent granular cell layer. The basal cells are usually cuboidal or flattened. Clinically, the orthokeratinized cyst is a single cyst, shows a predilection for males, and is most often found in the second to the fifth decade, it appears most commonly as a dentigerous cyst in the posterior mandible. The orthokeratinized cyst shows little clinical aggressiveness. Follow-up of twenty-four patients revealed only one recurrence; of nineteen patients evaluated, none had features of the basal cell nevus-bifid rib syndrome. It is suggested that this cyst be called odontogenic keratocyst, orthokeratinized variant.

Topics: Adolescent; Adult; Aged; Connective Tissue; Dentigerous Cyst; Epithelium; Female; Humans; Jaw Diseases; Keratins; Male; Mandibular Diseases; Middle Aged; Odontogenic Cysts

Topics: Adolescent; Adult; Age Factors; Aged; Child; Female; Humans; Jaw Diseases; Keratins; Male; Middle Aged; Odontogenic Cysts; Retrospective Studies; Sex Factors

Topics: Adult; Aged; Diagnosis, Differential; Female; Humans; Jaw Diseases; Keratins; Male; Middle Aged; Odontogenic Cysts; Radiography

The technique for registration of fluid pressure in jaw cysts by means of pressure transducer and cannulation of the cyst cavity or cementation of a two-way valve into a tooth communicating with the cyst is described. Twenty-six closed cysts were subjected to registration of intracystic pressure. Subsequent histologic examination showed that all cysts were non-keratinized. Initial pressure values in apical periodontal cysts averaged +47 mmHg, in follicular cysts +44 mmHg, and in residual cysts +38 mmHg. A median palatine cyst exhibited a pressure of +81 mmHg. Most cysts showed intracystic pulsation corresponding to the number of heart beats on electrocardiograms obtained simultaneously. The intracystic pulsation disappeared when the intracystic pressure was experimentally increased and reappeared when it was lowered. In three cases in which registration of pressure was performed 7-14 days after the aspiration of the cyst fluid, an intracystic pressure in the same range as the initial one was found. The findings indicate deficient lymphatic drainage of non-keratinizing jaw cysts.

Topics: Bone Cysts; Humans; Jaw Diseases; Keratins; Lymphatic System; Mouth Diseases; Odontogenic Cysts; Periodontal Cyst; Pressure

Topics: Adolescent; Adult; Aged; Bone Regeneration; Child; Female; Humans; Jaw Diseases; Keratins; Male; Middle Aged; Odontogenic Cysts; Radiography; Wound Healing

Topics: Adult; Aged; Animals; Cysts; Dentigerous Cyst; Female; Fetus; Haplorhini; Humans; Jaw Diseases; Jaw Neoplasms; Keratins; Macaca; Male; Mandible; Middle Aged; Molar; Mouth Mucosa; Nonodontogenic Cysts; Pregnancy

Topics: Jaw Diseases; Keratins; Odontogenic Cysts

Topics: Abnormalities, Multiple; Adult; Carcinoma, Basal Cell; Chromosome Aberrations; Chromosome Disorders; Creatinine; Female; Humans; Jaw Diseases; Keratins; Male; Meningioma; Metabolic Clearance Rate; Middle Aged; Odontogenic Cysts; Phosphates; Syndrome

Topics: Adult; Aged; Bone Resorption; Denture, Partial, Removable; Elastic Tissue; Female; Humans; Jaw Diseases; Keratins; Male; Middle Aged; Mouth Mucosa

Topics: Acid Phosphatase; Adolescent; Adult; Aged; Alkaline Phosphatase; Child; Cholesterol; Dentigerous Cyst; Enzymes; Female; Humans; Jaw Diseases; Keratins; Male; Middle Aged; Odontogenic Cysts; Radicular Cyst

Topics: Adolescent; Adult; Child; Dentigerous Cyst; Humans; Jaw Diseases; Jaw Neoplasms; Keratins; Middle Aged; Nonodontogenic Cysts; Odontogenic Cysts; Radicular Cyst; Radiography; Recurrence

Topics: Calcinosis; Humans; Jaw Diseases; Keratins; Odontogenic Cysts

Topics: Adolescent; Adult; Aged; Child; Female; Humans; Jaw Diseases; Keratins; Male; Mandible; Methods; Middle Aged; Odontogenic Cysts; Tooth Avulsion

Topics: Aging; Candidiasis, Oral; Climacteric; Deficiency Diseases; Dentures; Epithelium; Gingiva; Humans; Interprofessional Relations; Jaw Diseases; Keratins; Masticatory Muscles; Mouth Mucosa; Nutritional Physiological Phenomena; Osteopetrosis; Periodontium; Salivation; Taste

Topics: Bone Cysts; Dentigerous Cyst; Humans; Jaw Diseases; Jaw Neoplasms; Keratins; Lymphatic System; Methods; Nonodontogenic Cysts; Odontogenic Cysts; Osmosis; Recurrence

Topics: Adult; Bone Cysts; Carcinoma, Basal Cell; Diagnosis, Differential; Epidermal Cyst; Humans; Jaw Diseases; Keratins; Male; Ribs; Skin; Skin Neoplasms; Syndrome

Topics: Adolescent; Adult; Aged; Child; Female; Follow-Up Studies; Humans; Jaw Diseases; Keratins; Male; Middle Aged; Odontogenic Cysts; Radiography