bromochloroacetic-acid has been researched along with Hydronephrosis* in 1 studies
1 other study(ies) available for bromochloroacetic-acid and Hydronephrosis
| Article | Year |
|---|---|
Renal epithelial miR-205 expression correlates with disease severity in a mouse model of congenital obstructive nephropathy.
Congenital obstructive nephropathy (CON) is a leading cause of pediatric chronic kidney disease (CKD). Despite optimal surgical and medical care, there is a high rate of CKD progression. Better understanding of molecular and cellular changes is needed to facilitate development of improved biomarkers and novel therapeutic approaches in CON.. The megabladder (mgb) mouse is an animal model of CKD with impaired bladder emptying, hydronephrosis, and progressive renal injury. In this study, we characterize a particular microRNA, miR-205, whose expression changes with the degree of hydronephrosis in the mgb(-/-) kidney.. Expression of miR-205 is progressively increased in the adult mgb(-/-) mouse with worsening severity of hydronephrosis. miR-205 expression is correlated with altered expression of cytokeratins and uroplakins, which are markers of cellular differentiation in urothelium. We describe the spatial pattern of miR-205 expression, including increased expression in renal urothelium and novel miR-205 expression in medullary collecting duct epithelium in the congenitally obstructed kidney.. miR-205 is increased with severity of CON and CKD in the mgb(-/-) mouse and may regulate urothelial differentiation. Topics: Animals; Biomarkers; Cell Differentiation; Disease Models, Animal; Disease Progression; Epithelium; Female; Gene Expression Regulation; Hydronephrosis; Keratins; Kidney; Kidney Diseases; Kidney Failure, Chronic; Kidney Tubules, Collecting; Male; Mice; Mice, Transgenic; MicroRNAs; Tight Junctions; Uroplakins; Urothelium | 2016 |