bromochloroacetic-acid and Herpes-Zoster

Varicella zoster virus, the worldwide infectious human virus responsible for acute varicella and chickenpox, commonly spreads from exposure through contact with a skin lesion or airborne respiratory droplets. Keratinocytes, major targets and source of transmission of the virus present in the skin, represent an ideal choice of cell to stop early virus progression. In their recent study, Tommasi et al. show regulatory mechanisms of cytokeratin 10 through the protease kallikrein-6 as a suitable and druggable pathway to reduce varicella zoster virus dissemination.

Topics: Chickenpox; Herpes Zoster; Herpesvirus 3, Human; Humans; Kallikreins; Keratins; Varicella Zoster Virus Infection

The case of an 83-year-old woman with an uncommon presentation of cutaneous metastases from muscle-invasive transitional cell carcinoma of the urinary bladder is reported. The band-like eruption of the metastatic lesion can often be misdiagnosed and treated initially as herpes zoster. A detailed immunohistochemical analysis is also described to differentiate metastatic lesions from other sources.

Topics: Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Transitional Cell; Diagnosis, Differential; Fatal Outcome; Female; Herpes Zoster; Humans; Keratins; Neoplasm Proteins; Skin Neoplasms; Urinary Bladder Neoplasms

Topics: Acne Vulgaris; Acyclovir; Adult; Aged; Antiviral Agents; Epithelium; Female; Follow-Up Studies; Hair Follicle; Herpes Zoster; Humans; Keratins; Lymphocytes; Male; Middle Aged; Skin Diseases, Viral

Topics: Cytotoxicity Tests, Immunologic; Epidermis; Granulocytes; Herpes Simplex; Herpes Zoster; Humans; Keratins; Lymphocytes; Rosette Formation; Skin Diseases; Skin Diseases, Vesiculobullous