bromochloroacetic-acid and Hemorrhagic-Fever-with-Renal-Syndrome

bromochloroacetic-acid has been researched along with Hemorrhagic-Fever-with-Renal-Syndrome* in 1 studies

Other Studies

1 other study(ies) available for bromochloroacetic-acid and Hemorrhagic-Fever-with-Renal-Syndrome

Article	Year
Loss of cell membrane integrity in puumala hantavirus-infected patients correlates with levels of epithelial cell apoptosis and perforin. Journal of virology, 2006, Volume: 80, Issue:16 Hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome are two diseases caused by hantaviruses. Capillary leakage is a hallmark of hantavirus infection. Pathogenic hantaviruses are not cytotoxic, but elevated levels of serum lactate dehydrogenase (LDH), indicative of cellular damage, are observed in patients. We report increased levels of serum perforin, granzyme B, and the epithelial cell apoptosis marker caspase-cleaved cytokeratin-18 during Puumala hantavirus infection. Significant correlation was observed between the levels of LDH and perforin and the levels of LDH and caspase-cleaved cytokeratin-18, suggesting that tissue damage is due to an immune reaction and that epithelial apoptosis contributed significantly to the damage. Topics: Apoptosis; Caspases; Cell Membrane; Epithelial Cells; Granzymes; Hemorrhagic Fever with Renal Syndrome; Humans; Keratins; L-Lactate Dehydrogenase; Membrane Glycoproteins; Perforin; Pore Forming Cytotoxic Proteins; Puumala virus; Serine Endopeptidases	2006

Article

Year

Loss of cell membrane integrity in puumala hantavirus-infected patients correlates with levels of epithelial cell apoptosis and perforin.

Journal of virology, 2006, Volume: 80, Issue:16

Hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome are two diseases caused by hantaviruses. Capillary leakage is a hallmark of hantavirus infection. Pathogenic hantaviruses are not cytotoxic, but elevated levels of serum lactate dehydrogenase (LDH), indicative of cellular damage, are observed in patients. We report increased levels of serum perforin, granzyme B, and the epithelial cell apoptosis marker caspase-cleaved cytokeratin-18 during Puumala hantavirus infection. Significant correlation was observed between the levels of LDH and perforin and the levels of LDH and caspase-cleaved cytokeratin-18, suggesting that tissue damage is due to an immune reaction and that epithelial apoptosis contributed significantly to the damage.

Topics: Apoptosis; Caspases; Cell Membrane; Epithelial Cells; Granzymes; Hemorrhagic Fever with Renal Syndrome; Humans; Keratins; L-Lactate Dehydrogenase; Membrane Glycoproteins; Perforin; Pore Forming Cytotoxic Proteins; Puumala virus; Serine Endopeptidases

2006