bromochloroacetic-acid and Fanconi-Anemia

The association of congenital anomalies and pancytopenia is encountered in several clinical syndromes. Among these, Fanconi anemia is by far the most prevalent, and consequently best known. As a result, other similar conditions, such as dyskeratosis congenita and particularly WT syndrome, are often mistaken for Fanconi anemia. However, at a closer look, the type of congenital anomalies, the mode of inheritance, cytogenic and other laboratory findings allow clear differentiation between these 3 syndromes.

Topics: Abnormalities, Multiple; Anemia, Aplastic; Diagnosis, Differential; Fanconi Anemia; Female; Humans; Keratins; Male; Pancytopenia; Skin Diseases; Syndrome

Fanconi anemia (FA) patients frequently develop oral squamous cell carcinoma (OSCC). This cancer in FA patients is diagnosed within the first 3-4 decades of life, very often preceded by lesions that suffer a malignant transformation. In addition, they respond poorly to current treatments due to toxicity or multiple recurrences. Translational research on new chemopreventive agents and therapeutic strategies has been unsuccessful partly due to scarcity of disease models or failure to fully reproduce the disease. Here we report that Fanca gene knockout mice (Fanca

Topics: Animals; Carcinoma, Squamous Cell; Disease Models, Animal; Fanconi Anemia; Head and Neck Neoplasms; Keratins; Mice; Mice, Knockout; Mouth Neoplasms; Squamous Cell Carcinoma of Head and Neck