bromochloroacetic-acid and Fallopian-Tube-Neoplasms

Topics: Adenocarcinoma, Clear Cell; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Fallopian Tube Neoplasms; Female; Humans; Keratins; Middle Aged; Neoplasm Recurrence, Local; Paclitaxel; Parovarian Cyst; Salpingectomy

An example of a unique oncocytic and mucinous lesion of the fallopian tube epithelium, found incidentally in the postpartum period, is presented. The histogenetic nature of this lesion and its ultrastructural and immunohistochemical features are discussed.

Topics: Adult; Carcinoembryonic Antigen; Epithelium; Fallopian Tube Neoplasms; Female; Humans; Immunohistochemistry; Keratins; Membrane Glycoproteins; Microscopy, Electron; Mucin-1; Pregnancy; Pregnancy Complications, Neoplastic

Primary cancer of the fallopian tube is a very rare tumor nowadays, accounting for approximately 0.14-0.3% of all tumors of the female genital tract. From these, bilateral primary cancer is found in less than 25% of all cases. We report here a case of bilateral primary cancer of the fallopian tube in a 48-year-old woman, associating uterine fibromatosis.

Topics: Adenocarcinoma; Cell Differentiation; Estrogens; Fallopian Tube Neoplasms; Female; Humans; Immunohistochemistry; Keratins; Middle Aged; Progesterone; Proliferating Cell Nuclear Antigen; Tumor Suppressor Protein p53

Primary fallopian tube carcinoma is a rare malignancy, representing about 1% of female genital tract malignancies. We present a case report and compare the medical performance with accessible data from the literature as well as present immunohistochemical analysis of estrogen, progesterone, and proliferative together with basic cytokeratin reactions. We found that immunohistochemical expression of ER-beta was dominant over ER-alpha which encourages further evaluations to be performed on a larger number of samples, especially taking into account the very scant progesterone receptor expression we noted. On the basis of the course of disease under study, etiological problems and the possibility of clinical misdiagnosis have been discussed. The low prevalence rate and lack of clear symptoms of this type of carcinoma makes the final clinical diagnosis almost impossible without an intraoperative histopathological study. Multicenter studies are needed to improve the understanding of possible risk factors.

Topics: Aged; Carcinoma, Papillary; Estrogen Receptor alpha; Estrogen Receptor beta; Fallopian Tube Neoplasms; Female; Humans; Immunohistochemistry; Keratins; Receptors, Progesterone

A very rare case of hepatoid carcinoma with serous component arising in the fallopian tube of a 79-year-old woman is presented. The lesion was a 5.0-cm unencapsulated, yellowish-white soft mass. The tumor was composed of hepatoid carcinoma (90%) and serous carcinoma (10%) components. The hepatoid carcinoma was histologically characterized by a proliferation of round to polygonal cells arranged in a trabecular, tubular, sinusoidal, papillary, or solid pattern. The serous component in the fallopian tube also showed in situ lesions. Both components showed an infiltration into the surface of the left ovary, omentum, peritoneum including the pouch of the Douglas, and serosa of the colon. Immunohistochemically, the hepatoid carcinoma was positive for alpha-fetoprotein, polyclonal carcinoembryonic antigen (CEA), hepatocyte paraffin 1, albumin, epithelial membrane antigen, and cytokeratin (CAM5.2). Ultrastructurally, the cytoplasm contained abundant ribosomes, moderate amounts of mitochondria, and rough endoplasmic reticulum that developed into a meshwork and contained mitochondria within it. Microbile channel-like structures and desmosomes were occasionally observed. The association with serous carcinoma indicates mullerian origin rather than germ cell origin. The patient received chemotherapy and was alive without disease at 10 months after surgery.

Topics: Aged; alpha-Fetoproteins; Carcinoma, Hepatocellular; Diagnosis, Differential; Fallopian Tube Neoplasms; Female; Humans; Immunohistochemistry; Keratins; Microscopy, Electron, Transmission

Cystadenofibromas of the fallopian tube are rare tumors of the female genital tract. These tumors are usually asymptomatic and are found incidentally. The authors present an incidentally found fallopian serous cystadenofibroma in a 48-year-old woman with leiomyoma uteri. The topographic localization of the lesion, histopathologic findings of müllerian-type epithelium, immunophenotypic profile of vimentin-cytokeratin coexpression, and diffuse apical epithelial membrane antigen (EMA) immunoreactivity suggested that the tumor was an embryologic remnant originating from the müllerian duct.

Topics: Cystadenoma, Serous; Fallopian Tube Neoplasms; Female; Humans; Immunohistochemistry; Keratins; Leiomyoma; Middle Aged; Mullerian Ducts; Vimentin

A 55-year-old woman, who was found to have malignant squamous cells on a routine cervical smear, underwent a conization biopsy, followed by hysterectomy with bilateral salpingo-oophorectomy. No gross tumor was present in the uterus, but both ovaries, which were of normal size, contained multiple cysts filled with light brown, soft material. Microscopic examination showed squamous cell carcinoma in situ of the cervix with contiguous spread to the endometrium, fallopian tubes, and ovaries; squamous cell carcinoma extensively replaced the endometrial and tubal epithelium, focally invaded the wall of the fallopian tubes, and involved the parenchyma of both ovaries. Although an invasive cervical carcinoma occasionally spreads to the ovary, this case illustrates that exceptionally an in situ tumor spreads along the epithelium of the upper genital tract and the ovarian surface and invades the ovary and tubes. The detection of human papillomavirus DNA in the cervical, endometrial, tubal, and ovarian tumors by the polymerase chain reaction suggests a role for human papilloma virus infection in this case.

Topics: Carcinoma in Situ; Carcinoma, Squamous Cell; Endometrial Neoplasms; Fallopian Tube Neoplasms; Female; Humans; Immunohistochemistry; In Situ Hybridization; Keratins; Middle Aged; Ovarian Neoplasms; Papillomaviridae; Uterine Cervical Neoplasms

A middle-aged woman presented with a pelvic mass. Pathologic examination of the resected specimen revealed a primary adenosquamous carcinoma of the left fallopian tube. Special studies supported the concept of the neoplastic cells differentiating along two major pathways, squamous cell carcinoma and mucin-producing adenocarcinoma.

Topics: Adenocarcinoma; Adult; Carcinoma, Squamous Cell; Fallopian Tube Neoplasms; Fallopian Tubes; Female; Humans; Immunohistochemistry; Keratins; Microscopy, Electron; Mucins; Necrosis