bromochloroacetic-acid and Facial-Dermatoses

Orally administered retinoids are synthetic derivatives of vitamin A. This new group of drugs (not yet available for general use in the United States) has been effective in experimental trials for treatment of a wide range of skin diseases. The current status of two of these drugs, isotretinoin (13-cis-retinoic acid) and etretinate (Ro 10-9359), is herein reviewed.

Topics: Acne Vulgaris; Administration, Oral; Child; Clinical Trials as Topic; Facial Dermatoses; Female; Humans; Isomerism; Isotretinoin; Keratins; Keratitis; Neoplasms; Psoriasis; Skin Diseases; Tretinoin; Xerostomia

A facial sebaceous cyst is a common benign epithelial tumor and surgical excision is frequently performed but may cause obvious scarring and may be esthetically troubling.. This study evaluated the clinical outcomes of the patients with facial sebaceous cyst enucleated by creating minimal elliptical incisions through a keratin-filled orifice.. Eleven patients with facial sebaceous cyst enucleated by creating minimal elliptical incisions through a keratin-filled orifice. We treated nine male and two female patients aged 25-52 years. The mean cyst size was 1.85 × 1.56 cm.. All cysts were successfully enucleated. The mean wound length was 0.93 cm. The mean operative time was 15.2 min. The mean follow-up duration was 41.5 months. No recurrence was noted, and all patients were very satisfied with their esthetic outcomes. All cysts were successfully enucleated. The mean elliptical wound length was 0.93 cm (range, 0.8-1.1 cm). The mean operative time was 15.2 min. We found no evidence of wound infection, or nerve or vascular injury.. Enucleation of facial sebaceous cyst via a minimal elliptical incision through the keratin-filled orifice was associated with high-level patient satisfaction, and the method is safe and useful for treating facial epidermoid cysts.

Topics: Adult; Dermatologic Surgical Procedures; Epidermal Cyst; Facial Dermatoses; Female; Humans; Keratins; Male; Middle Aged; Operative Time; Patient Satisfaction; Retrospective Studies; Treatment Outcome

Viral-associated trichodysplasia of immunosuppression is a newly described clinicopathologic entity found in patients who are undergoing drug-induced immunosuppression to prevent organ transplant rejection. Patients have numerous erythematous papules concentrated in the central portion of the face and variable degrees of hair loss, most severely affecting facial hair. Histologic findings of facial papules are highly distinctive and unique, and suggest that the entire machinery of the follicular bulb is devoted to the manufacture of inner root sheath-type keratin. Electron microscopy reveals intranuclear viral particles, but precise viral identification has not yet been achieved.

Topics: Adolescent; Alopecia; Erythema; Facial Dermatoses; Female; Hair Follicle; Humans; Immunocompromised Host; Immunosuppression Therapy; Immunosuppressive Agents; Keratins; Kidney Transplantation; Microscopy, Electron

Pseudofolliculitis barbae (PFB) is a common hair disorder characterized by a pustular foreign body inflammatory reaction that is induced by ingrown hairs of the facial and submental (barbea) regions after regular shaving. It occurs predominantly in black males, while it is rather rare and usually far less severe in Caucasian males. Black individuals have a higher propensity of developing PFB due to their genetic predisposition for curly hair which inherently possesses a much higher risk of growing back into the skin than straight or wavy hair. The PFB process is, however, not gender dependent nor restricted to the face, but can occur in any skin region once regular shaving, plucking, or other traumatic means of hair removal are instituted. Through a family study and a large-scale investigation of randomly sampled PFB-affected and -unaffected individuals, this study demonstrates that an unusual single-nucleotide polymorphism, which gives rise to a disruptive Ala12Thr substitution in the 1A alpha-helical segment of the companion layer-specific keratin K6hf of the hair follicle, is partially responsible for the phenotypic expression and represents an additional genetic risk factor for PFB.

Topics: Cells, Cultured; Facial Dermatoses; Folliculitis; Genetic Predisposition to Disease; Humans; Keratins; Male; Mutation; Polymorphism, Genetic; Protein Structure, Secondary; Risk Factors

Topics: Facial Dermatoses; Folliculitis; Humans; Keratins; Mutation; Polymorphism, Genetic

Erythrosis pigmentosa peribuccalis (Brocq) (or erythrosis pigmentosa mediofacialis) and erythromelanosis follicularis faciei et colli, have been regarded as different disorders, mainly because the first occurs on the mediofacial area and is common in women and the second mostly occurs pre-auricularly in men. Both conditions show histological signs of abnormal follicular keratinization with teleangiectasia and round cell infiltrate. An increase in the level of melanin has been seen in some patients. We describe here a woman in whom lesions started in the middle of the face and later became evident in the pre-auricular area. This suggests that the two conditions are in fact the same disease. As a neutral term for this not uncommon disorder we propose erythrosis pigmentosa faciei et colli.

Topics: Adult; Cheek; Facial Dermatoses; Female; Humans; Keratins; Melanosis; Neck; Pigmentation Disorders; Telangiectasis

Reactive perforating collagenosis is characterised by trans-epidermal elimination of collagen and is hypothesized to be both autosomally dominant and recessive. We report a family in which two brothers and a sister had lesions of reactive perforating collagenosis.

Topics: Adolescent; Child; Child, Preschool; Collagen; Collagen Diseases; Epithelium; Facial Dermatoses; Female; Genes, Dominant; Genes, Recessive; Hand Dermatoses; Humans; Hypopigmentation; Keratins; Keratosis; Male; Skin; Skin Diseases, Papulosquamous

Milia en plaque is an uncommon skin condition usually seen in adult women, typically in the retroauricular region. We report a new localization in a young child.. A 6-year-old girl with an uneventful history had developed over the last 7 months an erythematous plaque with numerous whitish-yellow microcysts on the left internal canthus. No local or general favoring factor was found. Skin biopsy showed numerous cystic cavities with an epidermal lining containing layers of keratin within a moderately inflammatory infiltration. The lesion resolved after enucleation of the cysts and no recurrence has been observed after 9 months follow-up.. Milia en plaque is a charateristic erythematous lesion covered with cysts. The usual localization is the retroauricular region, but other localizations have been reported, mainly on the head. This is the first report involving the internal canthus and also in such a young child. One case of a 15-year-old boy has been discribed. Milia en plaque is often a primary condition as in our case although local or general factors may rarely be inductive. Our case illustrates the different localizations possible for milia en plaque, with predominance on the head, and the possibility of childhood cases. We prefer the term milia en plaque rather than retroauricular milia en plaque.

Topics: Child; Diagnosis, Differential; Epidermal Cyst; Erythema; Facial Dermatoses; Female; Follow-Up Studies; Humans; Keratins; Skin Diseases

A case of actinic comedonal plaque is reported. We comment on the case as well as describe the skin surface microscopic features.

Topics: Acne Vulgaris; Aged; Carcinoma, Basal Cell; Diagnosis, Differential; Facial Dermatoses; Humans; Keratins; Male; Photosensitivity Disorders; Skin; Skin Neoplasms

Topics: Adolescent; Atrophy; Diagnosis, Differential; Facial Dermatoses; Female; Humans; Keratins; Prognosis; Skin

A 59-year-old woman presented with milia grouped in plaques, in the preauricular areas, bilaterally. Follicle-damaging dermatoses, tumours and external agents, can lead to this peculiar clinical pattern. We outline the clinical and histological features which allow accurate diagnosis of this condition.

Topics: Cysts; Facial Dermatoses; Female; Humans; Keratins; Middle Aged

A 62-year-old man presented with a nodule 2 cm in diameter on his left cheek, which he had had since childhood. Histological examination showed a circumscribed dermal nodule composed of sebaceous lobules attached to sebaceous ducts and to an infundibular cyst-like structure connected to the epidermis. The wall was lined with squamous epithelium with a stratum granulosum. This structure was reminiscent of a sebaceous follicle. In addition, a melanocytic naevus of the compound type was found. Immunohistological investigations of the tumour with various cytokeratins revealed a pattern of expression characteristic for the mature sebaceous follicle.

Topics: Biomarkers, Tumor; Cheek; Diagnosis, Differential; Epidermal Cyst; Facial Dermatoses; Hamartoma; Humans; Immunoenzyme Techniques; Keratins; Male; Middle Aged; Sebaceous Glands; Skin

A case of keratoacanthoma (KA) with glandular proliferation was reported. The tumor was a firm, dome-shaped, elevated nodule on the cheek of an 82-year-old Japanese male. Generally, the tumor showed the typical histopathological features of KA; slight nuclear atypia and mitotic figures were present in a cup-shaped proliferation of keratinocytes and, in the center of the lesion, a keratin-filled crater with nests of dyskeratotic and acantholytic cells was seen. In the bottom of the lesion, a glandular structure forming branching, thin lumina was observed. The epithelium of the lumina was made up of two or more layers of columnar or cuboidal cells without keratinization. Tall columnar cells with oval nuclei were located in the luminal row and small cuboidal cells with round nuclei and scanty cytoplasm were in the outer layer. Immunohistochemical staining revealed that only the glandular structure was carcinoembryonic antigen positive. Lectin binding patterns observed in the glandular proliferation were similar to those reported for the apocrine gland. KA sometimes exhibits an adenoid structure in its lesion because of acantholytic changes. However, KA associated with true glandular proliferation has not been reported as far as we know, and our case is the first reported one. KA is thought to be a tumor of follicular origin, and the glandular proliferation observed in the present case seemed to have certain characteristics that suggest its apocrine origin.

Topics: Aged; Aged, 80 and over; Apocrine Glands; Carcinoembryonic Antigen; Cheek; Epidermis; Epithelium; Facial Dermatoses; Humans; Keratinocytes; Keratins; Keratoacanthoma; Male

Favre-Racouchot disease often is reported to be characterized by the association of cysts and comedos with prominent solar elastosis. Our histological study of patients who rarely exposed themselves to solar irradiation revealed no association between these signs. We detected only the presence of kerosis, as well as closed and open comedos. There were no true cysts. Actinic damage to the epidermis was absent, and solar elastosis was moderate to discrete. Therefore, the characteristic follicular alterations in Favre-Racouchot disease appear to be independent of and not secondary to solar elastosis.

Topics: Adult; Elastic Tissue; Facial Dermatoses; Humans; Keratins; Male; Middle Aged; Sebaceous Glands; Skin Diseases; Sunlight

Inverted follicular keratosis, a benign tumor of the skin believed to arise from the infundibular portion of the hair follicle that can involve perioral skin, has a unique histologic picture. It can be confused with forms of skin cancer; with knowledge of this entity, oral and maxillofacial surgeons may be able to avoid unnecessary surgery. The clinical and microscopic findings of 12 cases of inverted follicular keratosis are reported.

Topics: Adult; Aged; Darier Disease; Diagnosis, Differential; Epithelium; Facial Dermatoses; Facial Neoplasms; Humans; Keratins; Keratosis; Lip Diseases; Male; Middle Aged

Topics: Alopecia; Brain Neoplasms; Cobalt Radioisotopes; Facial Dermatoses; Forehead; Glioma; Hair Diseases; Humans; Keratins; Male; Middle Aged; Scalp Dermatoses; Skin Pigmentation

Topics: Adolescent; Biopsy; Connective Tissue; Elastic Tissue; Facial Dermatoses; Female; Folliculitis; Humans; Keratins; Lip Diseases; Sebaceous Glands; Skin

Topics: Blister; Dermatitis, Atopic; Dermatitis, Exfoliative; Extremities; Facial Dermatoses; Foot Dermatoses; Genes, Dominant; Genes, Recessive; Hand Dermatoses; Humans; Ichthyosis; Keratins; Keratosis; Microscopy, Electron; Ribosomes; Scalp Dermatoses; Sex Chromosomes; Skin; Thorax