bromochloroacetic-acid and Duodenal-Ulcer

Liver penetration is a rare but serious complication of peptic ulcer disease. We report a case of a 33-year-old woman who took large doses of nonsteroidal antiinflammatory drugs and developed a giant duodenal ulcer that penetrated into her liver. The diagnosis was based on histologic examination of endoscopic biopsies. She was initially treated with a proton pump inhibitor, but, within 5 weeks, she developed a symptomatic postbulbar stricture that required surgical correction. We also review 11 other reported cases of endoscopically and histologically diagnosed peptic ulcer penetration into the liver.

Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Diclofenac; Duodenal Ulcer; Duodenoscopy; Duodenum; Female; Humans; Immunoenzyme Techniques; Intervertebral Disc Displacement; Keratins; Liver; Liver Diseases; Liver Function Tests; Peptic Ulcer Hemorrhage; Peptic Ulcer Perforation