bromochloroacetic-acid and Down-Syndrome

Topics: Adolescent; Adult; Alopecia; Alopecia Areata; Anemia, Sickle Cell; Animals; Autoradiography; Child; Child, Preschool; Down Syndrome; Female; Hair; Humans; Infant; Infant, Newborn; Keratins; Male; Pregnancy; Puerperal Disorders; Rats; Stress, Physiological; Zinc

Topics: Adult; Biomarkers, Tumor; Cardiac Tamponade; Diagnosis, Differential; Down Syndrome; Dyspnea; Fatal Outcome; Heart Neoplasms; Humans; Keratins; Male; Mesothelioma; Microvilli; Neoplasm Proteins; Pericarditis; Pericardium; Ventricular Fibrillation; Vimentin

The localization of three monoclonal (A,B,C) anti-cytokeratin antibodies and of an anti-thymostimulin antibody were studied in normal children's thymuses, aged from 2 months to 10 1/2 years and in Down's children thymuses, aged from 5 months to 6 1/2 years. Two anti-cytokeratins were positive in the thymus: the anti-B was found in the epithelial cells of all thymic zones, the anti-C only in the external cells of Hassall's corpuscles. The distribution and the intensity of immuno-reactions were the same in normal and in Down's thymuses. The distribution of anti-thymostimulin was superimposed to the distribution of anti-cytokeratin B and was similar in normal and in the youngest Down's thymuses, whereas in the 6 1/2 years-old Down's thymuses there was a loss of anti-TS reaction in the subcapsular zone. A relationship between the reduction of anti-thymostimulin immuno-reaction and the beginning of an eventual loss of T-lymphocyte differentiation was supposed.

Topics: Antibodies; Antibodies, Monoclonal; Child; Child, Preschool; Down Syndrome; Female; Humans; Immunohistochemistry; Infant; Keratins; Male; Thymus Extracts; Thymus Gland