bromochloroacetic-acid and Deficiency-Diseases

Weanling rats fed a zinc-deficient diet (less than 1 part/10(6)) for 4 weeks develop parakeratotic and hyperplastic buccal epithelium with increased mitotic activity. Normal buccal epithelium contains major keratin polypeptides of 56, 46 and 43 kDa. Four-week zinc-deficient rats lacked the 43 kDa keratin. It appears that the 46 and 43 kDa keratins are related, differing as a result of some post-translation modification. A proteolytic cleavage of the 46 kDa keratin to the 43 kDa species is the most likely mechanism. The findings point to a decrease of keratinolytic enzyme activity in the zinc-deficient rats.

Topics: Animals; Deficiency Diseases; Electrophoresis, Agar Gel; Evaluation Studies as Topic; Keratins; Mouth Diseases; Mouth Mucosa; Peptide Hydrolases; Peptides; Phosphorylation; Rats; Rats, Inbred Strains; Zinc

Topics: Animals; Brain Diseases; Child; Copper; Deficiency Diseases; Growth Disorders; Hair; Humans; Intellectual Disability; Keratins; Proteins; Sheep; Syndrome; Wool

Topics: Autopsy; Biopsy; Brain Diseases; Child, Preschool; Copper; Deficiency Diseases; Erythrocytes; Growth Disorders; Hair; Humans; Hypothermia; Infant; Intellectual Disability; Keratins; Liver; Oxidoreductases; Sulfhydryl Compounds; Time Factors

Topics: Aging; Candidiasis, Oral; Climacteric; Deficiency Diseases; Dentures; Epithelium; Gingiva; Humans; Interprofessional Relations; Jaw Diseases; Keratins; Masticatory Muscles; Mouth Mucosa; Nutritional Physiological Phenomena; Osteopetrosis; Periodontium; Salivation; Taste