bromochloroacetic-acid has been researched along with Amyotrophic-Lateral-Sclerosis* in 3 studies
3 other study(ies) available for bromochloroacetic-acid and Amyotrophic-Lateral-Sclerosis
| Article | Year |
|---|---|
Quantitative determination of concentration profiles of skin components and topically applied oils by tailored multivariate curve resolution-alternating least squares using in vivo confocal Raman micro-spectroscopy.
The main components of the stratum corneum (SC), water, lipids, and proteins, are non-homogeneously distributed throughout the depth. The quantitative determination of their concentration profiles and penetration depth of topically applied substances are urgent topics of dermatological and cosmetic research. Confocal Raman micro-spectroscopy has distinct advantages when determining semi-quantitative concentrations of SC components and topically applied substances non-invasively and in vivo. In this work, we applied a tailored multivariate curve resolution-alternating least squares (tMCR-ALS) method to analyze Raman spectra of the SC in the 2000-4000 cm Topics: Amyotrophic Lateral Sclerosis; Epidermis; Humans; Keratins; Least-Squares Analysis; Lipids; Oils; Skin; Spectrum Analysis, Raman; Water | 2023 |
Keratinous biomarker of mercury exposure associated with amyotrophic lateral sclerosis risk in a nationwide U.S. study.
Topics: Amyotrophic Lateral Sclerosis; Animals; Biomarkers; Case-Control Studies; Female; Humans; Keratins; Mercury; Neurodegenerative Diseases | 2020 |
Truncated desmin in PtK2 cells induces desmin-vimentin-cytokeratin coprecipitation, involution of intermediate filament networks, and nuclear fragmentation: a model for many degenerative diseases.
The earliest expression of truncated desmin in transfected PtK2 cells results in the formation of dispersed microprecipitates containing not only the truncated desmin, but also endogenous vimentin and cytokeratin proteins. Desmin microprecipitates without vimentin or vimentin microprecipitates without desmin are not observed. The microprecipitates involving cytokeratin invariably are also positive for desmin and vimentin. Over time, the precipitates enlarge into 1- to 2-microns spheroids and then fuse into amorphous chimeric juxtanuclear masses that can occupy > 30% of the cell volume. Concurrently, first the vimentin and then the cytokeratin networks are resorbed. The chimeric precipitates are not recognized or marked for degradation by the lysosomal system. Ultimately the cell nucleus fragments and the cell dies. Similar protein complexes appear in many human and animal pathologies, suggesting that a similar protein-precipitation sequence initiated by the introduction of a mutationally or environmentally altered protein molecule is at work. Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Cell Nucleus; Cells, Cultured; Chemical Precipitation; Desmin; Intermediate Filaments; Keratins; Macropodidae; Vimentin | 1994 |