bromhexine has been researched along with Sjogren's Syndrome in 29 studies
Bromhexine: A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744)
bromhexine : A substituted aniline that is 2,4-dibromoaniline which is substituted at position 6 by a [cyclohexyl(methyl)amino]methyl group. It is used (as the monohydrochloride salt) as a mucolytic for the treatment of respiratory disorders associated with productive cough (i.e. a cough characterised by the production of sputum).
Sjogren's Syndrome: Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In addition, the animals receiving the high dosage of bromhexine had a significantly higher survival rate than other hybrids." | 1.27 | Effect of bromhexine, ambroxol, and placebo on clinical and histopathological changes in "Sjögren" mice. ( Jensen, OA; Manthorpe, R; Prause, JU, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (93.10) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (3.45) | 29.6817 |
| 2010's | 1 (3.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hamzaoui, A | 1 |
| Harzallah, O | 1 |
| Attia, S | 1 |
| Njim, L | 1 |
| Attig, C | 1 |
| Kairallah, M | 1 |
| Zachama, A | 1 |
| Mahjoub, S | 1 |
| Gause, A | 1 |
| Nahir, AM | 2 |
| Scharf, Y | 3 |
| Ben-Aryeh, H | 1 |
| Szargel, R | 2 |
| Gutman, D | 2 |
| Zonis, S | 2 |
| Scharf, J | 1 |
| Magid, E | 1 |
| Frost-Larsen, K | 8 |
| Isager, H | 8 |
| Manthorpe, R | 13 |
| Prause, JU | 12 |
| Høj, L | 2 |
| Petersen, SH | 1 |
| Fossaluzza, V | 1 |
| Portacha, L | 1 |
| Avisar, R | 1 |
| Savir, H | 1 |
| Machtey, I | 1 |
| Ovaknin, L | 1 |
| Shaked, P | 1 |
| Menache, R | 1 |
| Allalouf, D | 1 |
| Scharf, JM | 1 |
| Obedeanu, N | 1 |
| Meshulam, T | 1 |
| Nahir, M | 1 |
| Merzbach, D | 1 |
| Scharf, JA | 1 |
| Tapper-Jones, LM | 1 |
| Aldred, MJ | 1 |
| Cadogan, SJ | 1 |
| Walker, DM | 2 |
| Dolby, AE | 1 |
| Hopkins, R | 1 |
| Nuki, G | 1 |
| Beck, L | 1 |
| Blandford, RL | 1 |
| Dowdle, JR | 1 |
| Stephens, MR | 1 |
| Aryeh, HB | 1 |
| Blaustein, Y | 1 |
| Westergaard, L | 1 |
| Mackie, I | 1 |
| Seal, DV | 1 |
| Kaarela, K | 1 |
| Kriegbaum, NJ | 3 |
| Oxholm, P | 3 |
| von Linstow, M | 2 |
| Ichikawa, Y | 1 |
| Tokunaga, M | 1 |
| Shimizu, H | 1 |
| Moriuchi, J | 1 |
| Takaya, M | 1 |
| Arimori, S | 1 |
| Kawashima, K | 1 |
| Elling, F | 1 |
| Jensen, OA | 2 |
1 review available for bromhexine and Sjogren's Syndrome
| Article | Year |
|---|---|
Treatment of Sjögren's syndrome: an overview.
Topics: Bromhexine; Clinical Trials as Topic; Double-Blind Method; Fatty Acids, Essential; Fatty Acids, Unsa | 1986 |
10 trials available for bromhexine and Sjogren's Syndrome
| Article | Year |
|---|---|
Lacrimal and salivary secretion in Sjögren's syndrome: the effect of systemic treatment with bromhexine.
Topics: Aged; Bromhexine; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Proteins; Random Allo | 1984 |
Mucosolvan in the treatment of patients with primary Sjögren's syndrome. Results from a double-blind cross-over investigation.
Topics: Adult; Aged; Ambroxol; Bromhexine; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Ma | 1984 |
Bromhexine treatment of Sjögren's syndrome: effect on lacrimal and salivary secretion, and on proteins in tear fluid and saliva.
Topics: Adult; Aged; Bromhexine; Clinical Trials as Topic; Female; Humans; Immunoglobulin M; Male; Middle Ag | 1981 |
Clinical trial of bromhexine in Sjögren's syndrome.
Topics: Bromhexine; Clinical Trials as Topic; Humans; Muramidase; Sjogren's Syndrome; Tears; Xerophthalmia; | 1981 |
Lack of lacrimal gland improvement by NA-872 in Sjögren's syndrome.
Topics: Ambroxol; Bromhexine; Clinical Trials as Topic; Humans; Lacrimal Apparatus; Random Allocation; Sjogr | 1981 |
Sjögren's syndrome treated with bromhexine: a reassessment.
Topics: Bromhexine; Humans; Saliva; Secretory Rate; Sjogren's Syndrome; Tears | 1980 |
Sjörgren's syndrome treated with bromhexine: a randomised clinical study.
Topics: Bromhexine; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Female; Hum | 1978 |
[Treatment of Sjogren's syndrome with bromhexine].
Topics: Adult; Bromhexine; Drug Evaluation; Humans; Middle Aged; Sjogren's Syndrome | 1978 |
Clinical trial of ambroxol (Mucosolvan) in Sjögren's syndrome.
Topics: Adult; Aged; Ambroxol; Bromhexine; Clinical Trials as Topic; Drug Eruptions; Female; Humans; Lacrima | 1988 |
Treatment of Sjögren's syndrome: an overview.
Topics: Bromhexine; Clinical Trials as Topic; Double-Blind Method; Fatty Acids, Essential; Fatty Acids, Unsa | 1986 |
19 other studies available for bromhexine and Sjogren's Syndrome
| Article | Year |
|---|---|
[Juvenile Gougerot Sjögren syndrome: report of 3 cases].
Topics: Adolescent; Antimalarials; Arthralgia; Bromhexine; Drug Therapy, Combination; Expectorants; Female; | 2010 |
[Revision of the recommendations of the Commission on Pharmacotherapy of the German Society for Rheumatology. Recommendations for supportive therapy for Sjögren's syndrome].
Topics: Bromhexine; Cyclosporine; Dry Eye Syndromes; Electric Stimulation Therapy; Expectorants; Humans; Mus | 2007 |
Effect of prolonged bromhexine therapy on Sjögren's syndrome.
Topics: Bromhexine; Humans; Immunoglobulin A; Middle Aged; Palliative Care; Saliva; Sjogren's Syndrome; Sodi | 1981 |
Serum isoamylases in Sjögren's syndrome. Concentration levels and intra-individual variation.
Topics: Adult; Aged; Amylases; Bromhexine; Female; Humans; Isoenzymes; Male; Middle Aged; Pancreas; Salivary | 1983 |
[Bromhexine in symptomatic treatment of Sjögren syndrome].
Topics: Adult; Aged; Bromhexine; Female; Humans; Middle Aged; Salivation; Sjogren's Syndrome; Tears | 1984 |
[Our experience with the treatment of ocular changes in Sjögren's syndrome].
Topics: Administration, Oral; Aged; Alcohols; Bromhexine; Female; Formaldehyde; Humans; Middle Aged; Neostig | 1984 |
Influence of bromhexine on tear lysozome level in keratoconjunctivitis sicca.
Topics: Adult; Aged; Bromhexine; Female; Humans; Keratoconjunctivitis; Male; Middle Aged; Muramidase; Sjogre | 1981 |
Sjögren's syndrome treated with bromhexine: a reassessment.
Topics: Bromhexine; Humans; Sjogren's Syndrome | 1980 |
Sicca syndrome associated with idiopathic haemochromatosis.
Topics: Bromhexine; Female; Hemochromatosis; Humans; Middle Aged; Salivary Glands; Sjogren's Syndrome | 1979 |
Sialochemistry in evaluating bromhexine treatment of Sjögren's syndrome.
Topics: Bromhexine; Humans; Middle Aged; Saliva; Sjogren's Syndrome | 1979 |
[The effect of bromhexin on the functional deficiency of the lacrimal apparatus and the salivary glands in Sjogren's syndrome].
Topics: Bromhexine; Humans; Keratoconjunctivitis; Lacrimal Apparatus; Male; Middle Aged; Saliva; Salivary Gl | 1977 |
[Bromhexine induced remission in a patient with Sjögren's syndrome].
Topics: Bromhexine; Drug Evaluation; Humans; Male; Middle Aged; Recurrence; Remission, Spontaneous; Sjogren' | 1977 |
Sjögren's syndrome, bromhexine, and tear secretion.
Topics: Bromhexine; Humans; Sjogren's Syndrome; Tears | 1978 |
Rose bengal score--a possible key parameter when evaluating disease level and progression in primary Sjögren's syndrome.
Topics: Adult; Aged; Bromhexine; Epithelium; Eye; Female; Humans; Immunoglobulins; Keratoconjunctivitis Sicc | 1989 |
A follow-up study of the progress of keratoconjunctivitis sicca and response to treatment in primary Sjögren's syndrome.
Topics: Adult; Aged; Bromhexine; Female; Follow-Up Studies; Humans; Keratoconjunctivitis; Keratoconjunctivit | 1989 |
Keratoconjunctivitis sicca in patients with primary Sjögren's syndrome. A longitudinal study of ocular parameters.
Topics: Adult; Aged; Bromhexine; Female; Follow-Up Studies; Humans; Keratoconjunctivitis; Keratoconjunctivit | 1988 |
Effect of bromhexine on Sjögren's syndrome accompanied by rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Bromhexine; Humans; Keratoconjunctivitis Sicca; Muramidase; Rabbits; | 1988 |
The effect of bromhexine on the kidney lesions in NZB-NZW-F1 mice.
Topics: Animals; Bromhexine; Disease Models, Animal; Glomerulonephritis; Humans; Mice; Sjogren's Syndrome | 1986 |
Effect of bromhexine, ambroxol, and placebo on clinical and histopathological changes in "Sjögren" mice.
Topics: Ambroxol; Animals; Bromhexine; Drug Evaluation, Preclinical; Ear; Exocrine Glands; Female; Mice; Mic | 1985 |