bromhexine has been researched along with Sicca Syndrome in 29 studies
Bromhexine: A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744)
bromhexine : A substituted aniline that is 2,4-dibromoaniline which is substituted at position 6 by a [cyclohexyl(methyl)amino]methyl group. It is used (as the monohydrochloride salt) as a mucolytic for the treatment of respiratory disorders associated with productive cough (i.e. a cough characterised by the production of sputum).
| Excerpt | Relevance | Reference |
|---|---|---|
| " In addition, the animals receiving the high dosage of bromhexine had a significantly higher survival rate than other hybrids." | 1.27 | Effect of bromhexine, ambroxol, and placebo on clinical and histopathological changes in "Sjögren" mice. ( Jensen, OA; Manthorpe, R; Prause, JU, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (93.10) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (3.45) | 29.6817 |
| 2010's | 1 (3.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hamzaoui, A | 1 |
| Harzallah, O | 1 |
| Attia, S | 1 |
| Njim, L | 1 |
| Attig, C | 1 |
| Kairallah, M | 1 |
| Zachama, A | 1 |
| Mahjoub, S | 1 |
| Gause, A | 1 |
| Nahir, AM | 2 |
| Scharf, Y | 3 |
| Ben-Aryeh, H | 1 |
| Szargel, R | 2 |
| Gutman, D | 2 |
| Zonis, S | 2 |
| Scharf, J | 1 |
| Magid, E | 1 |
| Frost-Larsen, K | 8 |
| Isager, H | 8 |
| Manthorpe, R | 13 |
| Prause, JU | 12 |
| Høj, L | 2 |
| Petersen, SH | 1 |
| Fossaluzza, V | 1 |
| Portacha, L | 1 |
| Avisar, R | 1 |
| Savir, H | 1 |
| Machtey, I | 1 |
| Ovaknin, L | 1 |
| Shaked, P | 1 |
| Menache, R | 1 |
| Allalouf, D | 1 |
| Scharf, JM | 1 |
| Obedeanu, N | 1 |
| Meshulam, T | 1 |
| Nahir, M | 1 |
| Merzbach, D | 1 |
| Scharf, JA | 1 |
| Tapper-Jones, LM | 1 |
| Aldred, MJ | 1 |
| Cadogan, SJ | 1 |
| Walker, DM | 2 |
| Dolby, AE | 1 |
| Hopkins, R | 1 |
| Nuki, G | 1 |
| Beck, L | 1 |
| Blandford, RL | 1 |
| Dowdle, JR | 1 |
| Stephens, MR | 1 |
| Aryeh, HB | 1 |
| Blaustein, Y | 1 |
| Westergaard, L | 1 |
| Mackie, I | 1 |
| Seal, DV | 1 |
| Kaarela, K | 1 |
| Kriegbaum, NJ | 3 |
| Oxholm, P | 3 |
| von Linstow, M | 2 |
| Ichikawa, Y | 1 |
| Tokunaga, M | 1 |
| Shimizu, H | 1 |
| Moriuchi, J | 1 |
| Takaya, M | 1 |
| Arimori, S | 1 |
| Kawashima, K | 1 |
| Elling, F | 1 |
| Jensen, OA | 2 |
1 review available for bromhexine and Sicca Syndrome
| Article | Year |
|---|---|
Treatment of Sjögren's syndrome: an overview.
Topics: Bromhexine; Clinical Trials as Topic; Double-Blind Method; Fatty Acids, Essential; Fatty Acids, Unsa | 1986 |
10 trials available for bromhexine and Sicca Syndrome
| Article | Year |
|---|---|
Lacrimal and salivary secretion in Sjögren's syndrome: the effect of systemic treatment with bromhexine.
Topics: Aged; Bromhexine; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Proteins; Random Allo | 1984 |
Mucosolvan in the treatment of patients with primary Sjögren's syndrome. Results from a double-blind cross-over investigation.
Topics: Adult; Aged; Ambroxol; Bromhexine; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Ma | 1984 |
Bromhexine treatment of Sjögren's syndrome: effect on lacrimal and salivary secretion, and on proteins in tear fluid and saliva.
Topics: Adult; Aged; Bromhexine; Clinical Trials as Topic; Female; Humans; Immunoglobulin M; Male; Middle Ag | 1981 |
Clinical trial of bromhexine in Sjögren's syndrome.
Topics: Bromhexine; Clinical Trials as Topic; Humans; Muramidase; Sjogren's Syndrome; Tears; Xerophthalmia; | 1981 |
Lack of lacrimal gland improvement by NA-872 in Sjögren's syndrome.
Topics: Ambroxol; Bromhexine; Clinical Trials as Topic; Humans; Lacrimal Apparatus; Random Allocation; Sjogr | 1981 |
Sjögren's syndrome treated with bromhexine: a reassessment.
Topics: Bromhexine; Humans; Saliva; Secretory Rate; Sjogren's Syndrome; Tears | 1980 |
Sjörgren's syndrome treated with bromhexine: a randomised clinical study.
Topics: Bromhexine; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Female; Hum | 1978 |
[Treatment of Sjogren's syndrome with bromhexine].
Topics: Adult; Bromhexine; Drug Evaluation; Humans; Middle Aged; Sjogren's Syndrome | 1978 |
Clinical trial of ambroxol (Mucosolvan) in Sjögren's syndrome.
Topics: Adult; Aged; Ambroxol; Bromhexine; Clinical Trials as Topic; Drug Eruptions; Female; Humans; Lacrima | 1988 |
Treatment of Sjögren's syndrome: an overview.
Topics: Bromhexine; Clinical Trials as Topic; Double-Blind Method; Fatty Acids, Essential; Fatty Acids, Unsa | 1986 |
19 other studies available for bromhexine and Sicca Syndrome
| Article | Year |
|---|---|
[Juvenile Gougerot Sjögren syndrome: report of 3 cases].
Topics: Adolescent; Antimalarials; Arthralgia; Bromhexine; Drug Therapy, Combination; Expectorants; Female; | 2010 |
[Revision of the recommendations of the Commission on Pharmacotherapy of the German Society for Rheumatology. Recommendations for supportive therapy for Sjögren's syndrome].
Topics: Bromhexine; Cyclosporine; Dry Eye Syndromes; Electric Stimulation Therapy; Expectorants; Humans; Mus | 2007 |
Effect of prolonged bromhexine therapy on Sjögren's syndrome.
Topics: Bromhexine; Humans; Immunoglobulin A; Middle Aged; Palliative Care; Saliva; Sjogren's Syndrome; Sodi | 1981 |
Serum isoamylases in Sjögren's syndrome. Concentration levels and intra-individual variation.
Topics: Adult; Aged; Amylases; Bromhexine; Female; Humans; Isoenzymes; Male; Middle Aged; Pancreas; Salivary | 1983 |
[Bromhexine in symptomatic treatment of Sjögren syndrome].
Topics: Adult; Aged; Bromhexine; Female; Humans; Middle Aged; Salivation; Sjogren's Syndrome; Tears | 1984 |
[Our experience with the treatment of ocular changes in Sjögren's syndrome].
Topics: Administration, Oral; Aged; Alcohols; Bromhexine; Female; Formaldehyde; Humans; Middle Aged; Neostig | 1984 |
Influence of bromhexine on tear lysozome level in keratoconjunctivitis sicca.
Topics: Adult; Aged; Bromhexine; Female; Humans; Keratoconjunctivitis; Male; Middle Aged; Muramidase; Sjogre | 1981 |
Sjögren's syndrome treated with bromhexine: a reassessment.
Topics: Bromhexine; Humans; Sjogren's Syndrome | 1980 |
Sicca syndrome associated with idiopathic haemochromatosis.
Topics: Bromhexine; Female; Hemochromatosis; Humans; Middle Aged; Salivary Glands; Sjogren's Syndrome | 1979 |
Sialochemistry in evaluating bromhexine treatment of Sjögren's syndrome.
Topics: Bromhexine; Humans; Middle Aged; Saliva; Sjogren's Syndrome | 1979 |
[The effect of bromhexin on the functional deficiency of the lacrimal apparatus and the salivary glands in Sjogren's syndrome].
Topics: Bromhexine; Humans; Keratoconjunctivitis; Lacrimal Apparatus; Male; Middle Aged; Saliva; Salivary Gl | 1977 |
[Bromhexine induced remission in a patient with Sjögren's syndrome].
Topics: Bromhexine; Drug Evaluation; Humans; Male; Middle Aged; Recurrence; Remission, Spontaneous; Sjogren' | 1977 |
Sjögren's syndrome, bromhexine, and tear secretion.
Topics: Bromhexine; Humans; Sjogren's Syndrome; Tears | 1978 |
Rose bengal score--a possible key parameter when evaluating disease level and progression in primary Sjögren's syndrome.
Topics: Adult; Aged; Bromhexine; Epithelium; Eye; Female; Humans; Immunoglobulins; Keratoconjunctivitis Sicc | 1989 |
A follow-up study of the progress of keratoconjunctivitis sicca and response to treatment in primary Sjögren's syndrome.
Topics: Adult; Aged; Bromhexine; Female; Follow-Up Studies; Humans; Keratoconjunctivitis; Keratoconjunctivit | 1989 |
Keratoconjunctivitis sicca in patients with primary Sjögren's syndrome. A longitudinal study of ocular parameters.
Topics: Adult; Aged; Bromhexine; Female; Follow-Up Studies; Humans; Keratoconjunctivitis; Keratoconjunctivit | 1988 |
Effect of bromhexine on Sjögren's syndrome accompanied by rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Bromhexine; Humans; Keratoconjunctivitis Sicca; Muramidase; Rabbits; | 1988 |
The effect of bromhexine on the kidney lesions in NZB-NZW-F1 mice.
Topics: Animals; Bromhexine; Disease Models, Animal; Glomerulonephritis; Humans; Mice; Sjogren's Syndrome | 1986 |
Effect of bromhexine, ambroxol, and placebo on clinical and histopathological changes in "Sjögren" mice.
Topics: Ambroxol; Animals; Bromhexine; Drug Evaluation, Preclinical; Ear; Exocrine Glands; Female; Mice; Mic | 1985 |