bromhexine has been researched along with Respiratory Distress Syndrome, Newborn in 18 studies
Bromhexine: A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744)
bromhexine : A substituted aniline that is 2,4-dibromoaniline which is substituted at position 6 by a [cyclohexyl(methyl)amino]methyl group. It is used (as the monohydrochloride salt) as a mucolytic for the treatment of respiratory disorders associated with productive cough (i.e. a cough characterised by the production of sputum).
Respiratory Distress Syndrome, Newborn: A condition of the newborn marked by DYSPNEA with CYANOSIS, heralded by such prodromal signs as dilatation of the alae nasi, expiratory grunt, and retraction of the suprasternal notch or costal margins, mostly frequently occurring in premature infants, children of diabetic mothers, and infants delivered by cesarean section, and sometimes with no apparent predisposing cause.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ambroxol was significantly more effective than betamethasone in twin births, in infants born before the 31st week, when ROM to delivery time was more than 48 hours, when treatment to delivery time was between 2 and 7 days and in female infants." | 2.66 | An alternative to steroids for prevention of respiratory distress syndrome (RDS): multicenter controlled study to compare ambroxol and betamethasone. ( Corbella, E; Lazzarin, A; Luerti, M; Zavattini, G, 1987) |
| "Ambroxol was administered for a maximum of 5 days - 1000 mg in an infusion solution; betamethasone was injected intramuscularly in 2 daily doses of 8 mg." | 2.66 | [Induction of fetal lung maturation using ambroxol and betamethasone. Results of an open multicenter study]. ( Ponnath, H; Wiest, W; Wolff, F, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (94.44) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lazzarin, A | 3 |
| Luerti, M | 4 |
| Uberti-Foppa, C | 2 |
| Zavattini, G | 4 |
| Rossi, A | 1 |
| Tornaghi, R | 1 |
| Spagnolo, D | 1 |
| Bianchi, C | 1 |
| Barbera, AG | 1 |
| Corbella, E | 3 |
| Snell, NJ | 1 |
| Müller, K | 1 |
| Tiller, R | 1 |
| Endell, W | 1 |
| Grosspietzsch, R | 1 |
| Klink, F | 1 |
| von Klitzing, L | 1 |
| Oberheuser, F | 1 |
| Geibel, W | 1 |
| Rindt, W | 1 |
| Becker, H | 1 |
| Lachmann, B | 1 |
| Bergmann, KC | 1 |
| Winsel, K | 1 |
| Müller, E | 1 |
| Petro, W | 1 |
| Schäfer, C | 1 |
| Vogel, J | 1 |
| Lorenz, U | 1 |
| Rüttgers, H | 1 |
| Schenk, D | 1 |
| Bierhalter, G | 1 |
| Kubli, F | 1 |
| Heytmanek, G | 1 |
| Salzer, H | 2 |
| Vityska-Binstorfer, E | 1 |
| Genger, H | 1 |
| Metka, M | 1 |
| Pfersmann, R | 1 |
| Wolff, F | 2 |
| Weidinger, H | 1 |
| Colombo, ML | 1 |
| Dogliani, P | 1 |
| Ulla, L | 1 |
| Marini, A | 1 |
| Franzetti, M | 1 |
| Gios, G | 1 |
| Flauto, U | 1 |
| Arosio, A | 1 |
| Maccabruni, M | 1 |
| Rondini, G | 1 |
| Chirico, G | 1 |
| Giancola, A | 1 |
| Console, V | 1 |
| Disse, BG | 1 |
| Vytiska-Binstorfer, E | 1 |
| Simbruner, G | 1 |
| Ponnath, H | 1 |
| Wiest, W | 1 |
| Bajorek, J | 1 |
| Czeszyńska, M | 1 |
| Gizejowska, M | 1 |
| Baryła-Pankiewicz, E | 1 |
| Capsoni, F | 1 |
| Galli, M | 1 |
| Renovanz, HD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ambroxol as a Novel Disease Modifying Treatment for Parkinson's Disease Dementia[NCT02914366] | Phase 2 | 55 participants (Actual) | Interventional | 2015-11-30 | Active, not recruiting | ||
| Ambroxol as a Novel Disease Modifying Treatment for Lewy Body Dementia[NCT04405596] | Phase 1/Phase 2 | 15 participants (Anticipated) | Interventional | 2025-01-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for bromhexine and Respiratory Distress Syndrome, Newborn
| Article | Year |
|---|---|
The pharmacology of ambroxol--review and new results.
Topics: Airway Resistance; Ambroxol; Animals; Bromhexine; Bronchitis; Chronic Disease; Humans; Infant, Newbo | 1987 |
5 trials available for bromhexine and Respiratory Distress Syndrome, Newborn
| Article | Year |
|---|---|
[Ambroxol versus betamethasone for the promotion of antepartum lung maturity in pathological pregnancies].
Topics: Ambroxol; Betamethasone; Bromhexine; Double-Blind Method; Female; Fetal Organ Maturity; Gestational | 1990 |
Ambroxol in the treatment of idiopathic respiratory distress syndrome. An interim report on a controlled double-blind multicenter study versus placebo.
Topics: Ambroxol; Blood Gas Analysis; Bromhexine; Clinical Trials as Topic; Double-Blind Method; Humans; Inf | 1987 |
An alternative to steroids for prevention of respiratory distress syndrome (RDS): multicenter controlled study to compare ambroxol and betamethasone.
Topics: Ambroxol; Betamethasone; Bromhexine; Clinical Trials as Topic; Female; Humans; Infant, Newborn; Male | 1987 |
An alternative to steroids for prevention of respiratory distress syndrome (RDS): multicenter controlled study to compare ambroxol and betamethasone.
Topics: Ambroxol; Betamethasone; Bromhexine; Clinical Trials as Topic; Female; Humans; Infant, Newborn; Male | 1987 |
An alternative to steroids for prevention of respiratory distress syndrome (RDS): multicenter controlled study to compare ambroxol and betamethasone.
Topics: Ambroxol; Betamethasone; Bromhexine; Clinical Trials as Topic; Female; Humans; Infant, Newborn; Male | 1987 |
An alternative to steroids for prevention of respiratory distress syndrome (RDS): multicenter controlled study to compare ambroxol and betamethasone.
Topics: Ambroxol; Betamethasone; Bromhexine; Clinical Trials as Topic; Female; Humans; Infant, Newborn; Male | 1987 |
[Ambroxol in comparison with betamethasone for the stimulation of antepartal lung maturity. A clinical double-blind study].
Topics: Ambroxol; Betamethasone; Bromhexine; Clinical Trials as Topic; Double-Blind Method; Female; Fetal Or | 1986 |
[Induction of fetal lung maturation using ambroxol and betamethasone. Results of an open multicenter study].
Topics: Ambroxol; Betamethasone; Bromhexine; Clinical Trials as Topic; Double-Blind Method; Female; Fetal Or | 1987 |
12 other studies available for bromhexine and Respiratory Distress Syndrome, Newborn
| Article | Year |
|---|---|
Polymorphonuclear leucocytes functions from premature infants after prevention of respiratory distress syndrome with betamethasone and ambroxol.
Topics: Ambroxol; Betamethasone; Bromhexine; Female; Gestational Age; Humans; Infant, Newborn; Infant, Prema | 1984 |
Cord blood prolactin and thyroid hormone levels after antenatal administration of betamethasone or ambroxol for prevention of respiratory distress syndrome (RDS).
Topics: Ambroxol; Betamethasone; Bromhexine; Female; Fetal Blood; Gestational Age; Humans; Infant, Newborn; | 1984 |
Advances in respiratory distress syndrome.
Topics: Ambroxol; Bromhexine; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregnancy; Respirato | 1982 |
[Obstetric and neonatological aspects relating to incidence and importance of respiratory distress syndrome in prematurely born infants (author's transl)].
Topics: Birth Weight; Bromhexine; Cesarean Section; Female; Germany, East; Humans; Infant, Newborn; Infant, | 1981 |
[Prevention and therapy of respiratory distress syndrome in premature infants by means of bromhexine metabolite VIII. Animal experimental studies on the therapeutic efficacy of bromhexine metabolite VIII in premature respiratory distress syndrome].
Topics: Ambroxol; Amniotic Fluid; Animals; Bile; Bromhexine; Female; Fetal Blood; Humans; Infant, Newborn; K | 1977 |
[RDS prevention by prednilyden and ambroxol. A comparative study].
Topics: Ambroxol; Bromhexine; Female; Glucocorticoids; Humans; Infant, Newborn; Pregnancy; Respiratory Distr | 1979 |
[Experimental respiratory distress syndrome after injection anti-pulmonary serum. III. Respiratory-mechanical, blood gas-analysis, physico-chemical and biochemical findings in chronic tests: attempts at therapy].
Topics: Airway Resistance; Animals; Antigen-Antibody Reactions; Bromhexine; Guinea Pigs; Humans; Immune Sera | 1975 |
[Induction of surfactant formation in the fetal lung using bromhexine metabolite VIII].
Topics: Amniotic Fluid; Bromhexine; Enzyme Induction; Female; Humans; Infant, Newborn; Lung; Phosphatidylcho | 1975 |
[Use of ambroxol in the therapy of neonatal respiratory insufficiency].
Topics: Ambroxol; Bromhexine; Drug Evaluation; Humans; Infant, Newborn; Pneumonia, Aspiration; Pulmonary Ate | 1988 |
[Effect of Lasolvan on the course of respiratory distress syndrome in newborn infants].
Topics: Ambroxol; Bromhexine; Female; Humans; Infant, Newborn; Male; Respiratory Distress Syndrome, Newborn | 1987 |
A study of cellular immunity in newborns after prevention of respiratory distress syndrome (RDS).
Topics: Ambroxol; Betamethasone; Bromhexine; Chemotaxis, Leukocyte; Female; Humans; Immunity, Cellular; Infa | 1986 |
The anti-atelectasis factor considered in relation to Bisolvon and its metabolite VIII.
Topics: Amniotic Fluid; Aniline Compounds; Animals; Bromhexine; Cyclohexylamines; Female; Humans; Infant, Ne | 1974 |