bromhexine has been researched along with Pregnancy in 37 studies
Bromhexine: A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744)
bromhexine : A substituted aniline that is 2,4-dibromoaniline which is substituted at position 6 by a [cyclohexyl(methyl)amino]methyl group. It is used (as the monohydrochloride salt) as a mucolytic for the treatment of respiratory disorders associated with productive cough (i.e. a cough characterised by the production of sputum).
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A prospective double-blind clinical trial was carried out to determine whether ambroxol (bromhexine metabolite VIII) treatment (1000 mg/day for a period of 5 days) reduces the risk of hyaline membrane disease (HMD) in potentially premature infants." | 9.05 | The antenatal use of ambroxol (bromhexine metabolite VIII) to prevent hyaline membrane disease: a controlled double-blind study. ( Böttcher, M; Fricke, U; Grauel, EL; Hinkel, GK; Jacobi, R; Koepke, E; Köppe, I; Kunze, D; Lachmann, B; Lampe, K; Menzel, K; Methfessel, G; Müller, K; Nitz, I; Plath, C; Reichmann, G; Schlegel, C; Schmalisch, G; Schmidt, W; Schröder, M; Severin, K; Sitka, U; Tiller, R; Wauer, RR, 1982) |
| "A prospective double-blind clinical trial was carried out to determine whether ambroxol (bromhexine metabolite VIII) treatment (1000 mg/day for a period of 5 days) reduces the risk of hyaline membrane disease (HMD) in potentially premature infants." | 5.05 | The antenatal use of ambroxol (bromhexine metabolite VIII) to prevent hyaline membrane disease: a controlled double-blind study. ( Böttcher, M; Fricke, U; Grauel, EL; Hinkel, GK; Jacobi, R; Koepke, E; Köppe, I; Kunze, D; Lachmann, B; Lampe, K; Menzel, K; Methfessel, G; Müller, K; Nitz, I; Plath, C; Reichmann, G; Schlegel, C; Schmalisch, G; Schmidt, W; Schröder, M; Severin, K; Sitka, U; Tiller, R; Wauer, RR, 1982) |
| "In order to assess the effects of Na 872 infusion on maternal endocrinology during late pregnancy, we measured serum estradiol, estriol, progesterone, human placental lactogen, follicle simulating hormone, prolactin, cyclic adenosine monophosphate, cortisol and insulin before, during and after Na 872 infusion (bromhexine 2 mg/min for one hour) in ten mothers." | 3.66 | Maternal hormone levels during Na 872 infusion in late pregnancy. ( Kauppila, AJ; Tuimala, RJ; Viinikka, L; Ylikorkala, O, 1981) |
| "Ambroxol was significantly more effective than betamethasone in twin births, in infants born before the 31st week, when ROM to delivery time was more than 48 hours, when treatment to delivery time was between 2 and 7 days and in female infants." | 2.66 | An alternative to steroids for prevention of respiratory distress syndrome (RDS): multicenter controlled study to compare ambroxol and betamethasone. ( Corbella, E; Lazzarin, A; Luerti, M; Zavattini, G, 1987) |
| "Ambroxol was administered for a maximum of 5 days - 1000 mg in an infusion solution; betamethasone was injected intramuscularly in 2 daily doses of 8 mg." | 2.66 | [Induction of fetal lung maturation using ambroxol and betamethasone. Results of an open multicenter study]. ( Ponnath, H; Wiest, W; Wolff, F, 1987) |
| "Bromhexine has shown interference in blastocyst attachment, conception, reduction in number of implantation sites and dwarfing of fetuses; hence, it is a potential candidate for antiimplantation." | 1.33 | Kinetics of bromhexine-mediated down-regulation of focal adhesive molecules of uterus and trophectoderm affecting conception in the rat. ( Malaviya, B; Singh, N, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (94.59) | 18.7374 |
| 1990's | 1 (2.70) | 18.2507 |
| 2000's | 1 (2.70) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Singh, N | 1 |
| Malaviya, B | 1 |
| Tuimala, RJ | 1 |
| Kauppila, AJ | 1 |
| Viinikka, L | 1 |
| Ylikorkala, O | 1 |
| Lazzarin, A | 3 |
| Luerti, M | 4 |
| Uberti-Foppa, C | 2 |
| Zavattini, G | 5 |
| Rossi, A | 1 |
| Tornaghi, R | 1 |
| Spagnolo, D | 1 |
| Bianchi, C | 1 |
| Barbera, AG | 1 |
| Corbella, E | 3 |
| Snell, NJ | 1 |
| Wauer, RR | 1 |
| Schmalisch, G | 1 |
| Menzel, K | 1 |
| Schröder, M | 1 |
| Müller, K | 2 |
| Tiller, R | 2 |
| Methfessel, G | 1 |
| Sitka, U | 1 |
| Koepke, E | 1 |
| Plath, C | 1 |
| Schlegel, C | 1 |
| Böttcher, M | 1 |
| Köppe, I | 1 |
| Fricke, U | 1 |
| Severin, K | 1 |
| Jacobi, R | 1 |
| Schmidt, W | 1 |
| Hinkel, GK | 1 |
| Nitz, I | 1 |
| Kunze, D | 1 |
| Reichmann, G | 1 |
| Lachmann, B | 2 |
| Lampe, K | 1 |
| Grauel, EL | 1 |
| Sepúlveda, J | 2 |
| Velásquez, BJ | 2 |
| Tischer, AB | 1 |
| Grossmann, G | 1 |
| Robertson, B | 1 |
| Maloney, JE | 1 |
| Brodecky, V | 1 |
| Blasini, R | 1 |
| Haas-Denk, S | 1 |
| Krieglsteiner, P | 4 |
| Wriedt-Lübbe, I | 2 |
| Erhardt, W | 2 |
| Endell, W | 1 |
| Grosspietzsch, R | 1 |
| Klink, F | 1 |
| von Klitzing, L | 1 |
| Oberheuser, F | 1 |
| Merkus, JM | 1 |
| Roozen, PH | 1 |
| Verhoeven, AG | 1 |
| Kock, HC | 1 |
| Gerner, R | 1 |
| Halberstadt, E | 1 |
| Van Petten, GR | 1 |
| Mears, GJ | 1 |
| Taylor, PJ | 1 |
| Lohninger, A | 3 |
| Strigl, R | 1 |
| Neiss, A | 2 |
| Blümel, G | 3 |
| Geibel, W | 1 |
| Rindt, W | 1 |
| Becker, H | 1 |
| Haas, S | 1 |
| Münnich, W | 1 |
| Egberts, J | 1 |
| Fontijne, P | 1 |
| Wamsteker, K | 1 |
| Noacke, VW | 1 |
| Elbrecht, B | 1 |
| Saule, H | 1 |
| Lorenz, U | 1 |
| Rüttgers, H | 1 |
| Schenk, D | 1 |
| Bierhalter, G | 1 |
| Kubli, F | 1 |
| Heytmanek, G | 1 |
| Salzer, H | 2 |
| Vityska-Binstorfer, E | 1 |
| Genger, H | 1 |
| Metka, M | 1 |
| Pfersmann, R | 1 |
| Wolff, F | 2 |
| Weidinger, H | 1 |
| Stepińska, J | 1 |
| Zbisławska, P | 1 |
| Skoczowska, W | 1 |
| Cretti, A | 1 |
| Novák, Z | 1 |
| Varga, SI | 1 |
| Kovács, L | 1 |
| Pál, A | 1 |
| Pataki, L | 1 |
| Matkovics, B | 1 |
| Woytoń, J | 1 |
| Gabryś, M | 1 |
| Regulska, B | 1 |
| Szymczak, J | 1 |
| Katnik, I | 1 |
| Bielanow, T | 1 |
| Vytiska-Binstorfer, E | 1 |
| Simbruner, G | 1 |
| Ponnath, H | 1 |
| Wiest, W | 1 |
| Capsoni, F | 1 |
| Galli, M | 1 |
| Renovanz, HD | 2 |
| Curti, PC | 1 |
| Simonsson, BG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Ambroxol as a Novel Disease Modifying Treatment for Parkinson's Disease Dementia[NCT02914366] | Phase 2 | 55 participants (Actual) | Interventional | 2015-11-30 | Active, not recruiting | ||
| Ambroxol as a Novel Disease Modifying Treatment for Lewy Body Dementia[NCT04405596] | Phase 1/Phase 2 | 15 participants (Anticipated) | Interventional | 2025-01-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for bromhexine and Pregnancy
| Article | Year |
|---|---|
[Anti-atelectasis factor (surfactant) and hyaline membrane disease in premature infants].
Topics: Adrenal Cortex Hormones; Animals; Bromhexine; Female; Gestational Age; Hot Temperature; Humans; Hyal | 1975 |
[Ambroxol and stimulation of the pulmonary surfactant].
Topics: Ambroxol; Animals; Bromhexine; Female; Membrane Lipids; Mice; Phospholipids; Pregnancy; Pulmonary Su | 1987 |
8 trials available for bromhexine and Pregnancy
| Article | Year |
|---|---|
The antenatal use of ambroxol (bromhexine metabolite VIII) to prevent hyaline membrane disease: a controlled double-blind study.
Topics: Ambroxol; Amniotic Fluid; Bromhexine; Clinical Trials as Topic; Double-Blind Method; Female; Gestati | 1982 |
Surfactant in the amniotic fluid and bromhexine metabolite VIII.
Topics: Ambroxol; Amniotic Fluid; Bromhexine; Clinical Trials as Topic; Double-Blind Method; Female; Gestati | 1978 |
[Ambroxol versus betamethasone for the promotion of antepartum lung maturity in pathological pregnancies].
Topics: Ambroxol; Betamethasone; Bromhexine; Double-Blind Method; Female; Fetal Organ Maturity; Gestational | 1990 |
An alternative to steroids for prevention of respiratory distress syndrome (RDS): multicenter controlled study to compare ambroxol and betamethasone.
Topics: Ambroxol; Betamethasone; Bromhexine; Clinical Trials as Topic; Female; Humans; Infant, Newborn; Male | 1987 |
An alternative to steroids for prevention of respiratory distress syndrome (RDS): multicenter controlled study to compare ambroxol and betamethasone.
Topics: Ambroxol; Betamethasone; Bromhexine; Clinical Trials as Topic; Female; Humans; Infant, Newborn; Male | 1987 |
An alternative to steroids for prevention of respiratory distress syndrome (RDS): multicenter controlled study to compare ambroxol and betamethasone.
Topics: Ambroxol; Betamethasone; Bromhexine; Clinical Trials as Topic; Female; Humans; Infant, Newborn; Male | 1987 |
An alternative to steroids for prevention of respiratory distress syndrome (RDS): multicenter controlled study to compare ambroxol and betamethasone.
Topics: Ambroxol; Betamethasone; Bromhexine; Clinical Trials as Topic; Female; Humans; Infant, Newborn; Male | 1987 |
[Ambroxol in comparison with betamethasone for the stimulation of antepartal lung maturity. A clinical double-blind study].
Topics: Ambroxol; Betamethasone; Bromhexine; Clinical Trials as Topic; Double-Blind Method; Female; Fetal Or | 1986 |
[Induction of fetal lung maturation using ambroxol and betamethasone. Results of an open multicenter study].
Topics: Ambroxol; Betamethasone; Bromhexine; Clinical Trials as Topic; Double-Blind Method; Female; Fetal Or | 1987 |
[Pharmacokinetics, drug availability and clinical pharmacology of bromhexine].
Topics: Absorption; Adult; Aged; Animals; Autoradiography; Bromhexine; Carbon Isotopes; Clinical Trials as T | 1973 |
Experimental studies on bronchial secretion. Therapeutical aspects of pathological bronchial secretion.
Topics: Acute Disease; Adult; Aged; Animals; Bromhexine; Bronchi; Bronchitis; Chronic Disease; Clinical Tria | 1974 |
27 other studies available for bromhexine and Pregnancy
| Article | Year |
|---|---|
Kinetics of bromhexine-mediated down-regulation of focal adhesive molecules of uterus and trophectoderm affecting conception in the rat.
Topics: Animals; Bromhexine; Corpus Luteum; Cytosol; Down-Regulation; Embryo Implantation; Female; Focal Adh | 2006 |
Maternal hormone levels during Na 872 infusion in late pregnancy.
Topics: Adult; Ambroxol; Bromhexine; Cyclic AMP; Estrogens; Female; Follicle Stimulating Hormone; Humans; Hy | 1981 |
Polymorphonuclear leucocytes functions from premature infants after prevention of respiratory distress syndrome with betamethasone and ambroxol.
Topics: Ambroxol; Betamethasone; Bromhexine; Female; Gestational Age; Humans; Infant, Newborn; Infant, Prema | 1984 |
Cord blood prolactin and thyroid hormone levels after antenatal administration of betamethasone or ambroxol for prevention of respiratory distress syndrome (RDS).
Topics: Ambroxol; Betamethasone; Bromhexine; Female; Fetal Blood; Gestational Age; Humans; Infant, Newborn; | 1984 |
Advances in respiratory distress syndrome.
Topics: Ambroxol; Bromhexine; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregnancy; Respirato | 1982 |
Study on the influence of NA-872 (ambroxol) and dexamethasone on the differentiation of Clara cells in albino mice.
Topics: Ambroxol; Animals; Bromhexine; Bronchi; Cell Differentiation; Dexamethasone; Female; Fetal Organ Mat | 1982 |
Influence of transplacental NA-872 and dexamethasone therapy on fetal and newborn mouse lung.
Topics: Ambroxol; Animals; Animals, Newborn; Bromhexine; Dexamethasone; Female; Fetus; Lung; Maternal-Fetal | 1982 |
Lung compliance and alveolar expansion in the artificially ventilated premature newborn rabbit after maternal treatment with ambroxol.
Topics: Ambroxol; Animals; Animals, Newborn; Bromhexine; Female; Lung; Lung Compliance; Maternal-Fetal Excha | 1981 |
[Obstetric and neonatological aspects relating to incidence and importance of respiratory distress syndrome in prematurely born infants (author's transl)].
Topics: Birth Weight; Bromhexine; Cesarean Section; Female; Germany, East; Humans; Infant, Newborn; Infant, | 1981 |
Influence of the compound NA872 on cardiopulmonary maturation in the unanaesthetised fetal lamb.
Topics: Ambroxol; Amniotic Fluid; Animals; Blood Pressure; Bromhexine; Female; Fetal Heart; Fetus; Lung; Pho | 1980 |
[Identification of tissue inhibitors of plasmin and the effect of betamethasone and ambroxol].
Topics: Ambroxol; Animals; Betamethasone; Bromhexine; Female; Fibrinolysin; Lung; Pregnancy; Rats | 1977 |
[Prevention and therapy of respiratory distress syndrome in premature infants by means of bromhexine metabolite VIII. Animal experimental studies on the therapeutic efficacy of bromhexine metabolite VIII in premature respiratory distress syndrome].
Topics: Ambroxol; Amniotic Fluid; Animals; Bile; Bromhexine; Female; Fetal Blood; Humans; Infant, Newborn; K | 1977 |
[Regarding the effect of bromhexine metabolite VII on lecithin synthesis in fetal lungs (author's transl)].
Topics: Ambroxol; Animals; Bromhexine; Choline; Female; In Vitro Techniques; Lung; Pregnancy; Pulmonary Surf | 1977 |
The effects of NA872 on pulmonary maturation in the fetal lamb and rabbit.
Topics: Ambroxol; Animals; Blood Pressure; Body Fluids; Bromhexine; Female; Heart Rate; Lung; Lung Volume Me | 1978 |
[Induction of fetal lung-maturity. Part III: surfactant-parameters in amniotic-fluid and fetal lung].
Topics: Amniotic Fluid; Animals; Betamethasone; Bromhexine; Carnitine; Female; Fetus; Lung; Phospholipids; P | 1979 |
[RDS prevention by prednilyden and ambroxol. A comparative study].
Topics: Ambroxol; Bromhexine; Female; Glucocorticoids; Humans; Infant, Newborn; Pregnancy; Respiratory Distr | 1979 |
[Animal experiments on the effect of various drugs on the lecithin content and fibrinolytic activity of the fetal lung].
Topics: Ambroxol; Animals; Betamethasone; Bromhexine; Carnitine; Female; Lung; Phosphatidylcholines; Pregnan | 1979 |
[Pharmacologic influencing of fetal phospholipide synthesis. Part I: Effect of betamethasone and bromohexine metabolit VIII (Ambroxol) (author's transl)].
Topics: Ambroxol; Amniotic Fluid; Animals; Betamethasone; Bromhexine; Female; Fetus; Lung; Phospholipids; Pr | 1978 |
Indication of increase of the lecithin/sphingomyelin (L/S) ratio in lung fluid of lambs maternally treated with metabolite VIII of Bisolvon.
Topics: Ambroxol; Animals; Bromhexine; Exudates and Transudates; Female; Fetus; Lung; Maternal-Fetal Exchang | 1976 |
[Electron microscopy studies on the effect of metabilite VIII of Bisolvon on the fetal lung (18th and 20th day a.p.)].
Topics: Animals; Bromhexine; Endoplasmic Reticulum; Epithelial Cells; Female; Fetus; Gestational Age; Golgi | 1975 |
[Induction of surfactant formation in the fetal lung using bromhexine metabolite VIII].
Topics: Amniotic Fluid; Bromhexine; Enzyme Induction; Female; Humans; Infant, Newborn; Lung; Phosphatidylcho | 1975 |
[Comparison of the effect of Lasolvan and betamethasone on lung maturity of fetal rabbits].
Topics: Ambroxol; Animals; Betamethasone; Body Weight; Bromhexine; Female; Fetal Organ Maturity; Infusions, | 1989 |
The effects of Oradexone and Ambroxol pretreatment of the oxidative sensitivity of the red blood cells in preterm infants.
Topics: Ambroxol; Antioxidants; Bromhexine; Dexamethasone; Erythrocytes; Female; Fetal Blood; Humans; Infant | 1989 |
[Evaluation of fetal maturity indices in pregnancy with Rh isoimmunization treated with a preparation of Lasolvan].
Topics: Ambroxol; Amniotic Fluid; Bromhexine; Embryonic and Fetal Development; Female; Humans; Pregnancy; Pr | 1986 |
A study of cellular immunity in newborns after prevention of respiratory distress syndrome (RDS).
Topics: Ambroxol; Betamethasone; Bromhexine; Chemotaxis, Leukocyte; Female; Humans; Immunity, Cellular; Infa | 1986 |
[Therapeutic study with metabolit 8 of bromhexine in deficiency of alveoli surface-active substance].
Topics: Aerosols; Animals; Bromhexine; Drug Evaluation, Preclinical; Female; Fetus; Histocytochemistry; Lung | 1974 |
The anti-atelectasis factor considered in relation to Bisolvon and its metabolite VIII.
Topics: Amniotic Fluid; Aniline Compounds; Animals; Bromhexine; Cyclohexylamines; Female; Humans; Infant, Ne | 1974 |