bromhexine has been researched along with Chronic Disease in 48 studies
Bromhexine: A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744)
bromhexine : A substituted aniline that is 2,4-dibromoaniline which is substituted at position 6 by a [cyclohexyl(methyl)amino]methyl group. It is used (as the monohydrochloride salt) as a mucolytic for the treatment of respiratory disorders associated with productive cough (i.e. a cough characterised by the production of sputum).
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a double-blind, randomized, controlled trial using parallel groups, we evaluated the effects of two dose levels of ambroxol (60 and 120 mg daily) versus placebo by means of pulmonary function tests, patients' diary cards, interviews on current airway symptoms and subjective drug effects in 92 subjects with simple hypersecretory chronic bronchitis." | 9.06 | Ambroxol and simple chronic bronchitis. Effects on subjective symptoms and ventilatory function. ( Ericsson, CH; Jönsson, E; Juhasz, J; Mossberg, B, 1987) |
| "In a 6-month, double-blind multicenter trial conducted over the winter, the effects of daily administration of ambroxol retard (75 mg) were compared with those of placebo in preventing exacerbations and improving symptoms and clinical signs in chronic bronchitis patients." | 9.06 | Ambroxol for the prevention of chronic bronchitis exacerbations: long-term multicenter trial. Protective effect of ambroxol against winter semester exacerbations: a double-blind study versus placebo. ( Bonsignore, G; Carnimeo, N; Catena, E; Chianese, R; Daniotti, S; Ferrara, G; Marcatili, S; Olivieri, D; Tomasini, G; Zavattini, G, 1987) |
| "Twenty-three patients with exacerbations of chronic bronchitis were divided in two groups in a randomized fashion receiving either amoxicillin 1500 mg/d (n = 13) or amoxicillin 1500 mg/d associated with the mucolytic drug ambroxol 90 mg/d (n = 10)." | 9.06 | Ambroxol plus amoxicillin in the treatment of exacerbations of chronic bronchitis. ( Corazza, C; Fernández, M; Guerreiro, RB; Peralta, J; Poderoso, JJ; Wiemeyer, JC, 1987) |
| "Controlled clinical research has been carried out on the activity and tolerance of a new active principle, guacetisal (Broncaspin) obtained from the esterification of acetylsalicylic acid with guaiacol, in the treatment of chronic bronchitis." | 9.05 | [Controlled clinical study of the treatment of chronic bronchitis with guacetisal]. ( Caltagirone, S; Crimi, N; Cusmano, F; Di Maria, GU; Palermo, F; Vagliasindi, M, 1981) |
| "The results of a double-blind crossover trial of bromhexine (Bisolvon) in the treatment of chronic bronchitis are reported." | 9.04 | Double-blind crossover trial of bromhexine (Bisolvon) in the treatment of chronic bronchitis. ( Armstrong, ML, 1976) |
| "Bromhexine was not superior to saline for this purpose." | 6.66 | Nebulization treatment with saline compared to bromhexine in treating chronic sinusitis in asthmatic children. ( Bosmans, J; Stevens, WJ; Van Bever, HP, 1987) |
| "Ambroxol was associated with a 25% reduction of the average bronchial flow resistance." | 6.64 | [Clinical results in the treatment of chronic obstructive bronchitis with ambroxol in comparison with bromhexine (author's transl)]. ( Niemeyer, K; Wiessmann, KJ, 1978) |
| "In a double-blind, randomized, controlled trial using parallel groups, we evaluated the effects of two dose levels of ambroxol (60 and 120 mg daily) versus placebo by means of pulmonary function tests, patients' diary cards, interviews on current airway symptoms and subjective drug effects in 92 subjects with simple hypersecretory chronic bronchitis." | 5.06 | Ambroxol and simple chronic bronchitis. Effects on subjective symptoms and ventilatory function. ( Ericsson, CH; Jönsson, E; Juhasz, J; Mossberg, B, 1987) |
| "In a 6-month, double-blind multicenter trial conducted over the winter, the effects of daily administration of ambroxol retard (75 mg) were compared with those of placebo in preventing exacerbations and improving symptoms and clinical signs in chronic bronchitis patients." | 5.06 | Ambroxol for the prevention of chronic bronchitis exacerbations: long-term multicenter trial. Protective effect of ambroxol against winter semester exacerbations: a double-blind study versus placebo. ( Bonsignore, G; Carnimeo, N; Catena, E; Chianese, R; Daniotti, S; Ferrara, G; Marcatili, S; Olivieri, D; Tomasini, G; Zavattini, G, 1987) |
| "Twenty-three patients with exacerbations of chronic bronchitis were divided in two groups in a randomized fashion receiving either amoxicillin 1500 mg/d (n = 13) or amoxicillin 1500 mg/d associated with the mucolytic drug ambroxol 90 mg/d (n = 10)." | 5.06 | Ambroxol plus amoxicillin in the treatment of exacerbations of chronic bronchitis. ( Corazza, C; Fernández, M; Guerreiro, RB; Peralta, J; Poderoso, JJ; Wiemeyer, JC, 1987) |
| "Controlled clinical research has been carried out on the activity and tolerance of a new active principle, guacetisal (Broncaspin) obtained from the esterification of acetylsalicylic acid with guaiacol, in the treatment of chronic bronchitis." | 5.05 | [Controlled clinical study of the treatment of chronic bronchitis with guacetisal]. ( Caltagirone, S; Crimi, N; Cusmano, F; Di Maria, GU; Palermo, F; Vagliasindi, M, 1981) |
| "The results of a double-blind crossover trial of bromhexine (Bisolvon) in the treatment of chronic bronchitis are reported." | 5.04 | Double-blind crossover trial of bromhexine (Bisolvon) in the treatment of chronic bronchitis. ( Armstrong, ML, 1976) |
| "The clinical activity of trans-4-[(2-amino-3,5-dibromo-benzyl)-amino]-cyclohexanol-hydrochloride (ambroxol, NA 872) as well as its influence on lung function was examined in a total of 63 patients (34 suffering from silicosis, 28 from chronic obstructive bronchitis and 1 from cryptococcosis)." | 3.66 | [Therapeutic study on ambroxol in chronic bronchopulmonary diseases (author's transl)]. ( Curti, PC; Renovanz, HD, 1978) |
| "Bromhexine was not superior to saline for this purpose." | 2.66 | Nebulization treatment with saline compared to bromhexine in treating chronic sinusitis in asthmatic children. ( Bosmans, J; Stevens, WJ; Van Bever, HP, 1987) |
| "Ambroxol was associated with a 25% reduction of the average bronchial flow resistance." | 2.64 | [Clinical results in the treatment of chronic obstructive bronchitis with ambroxol in comparison with bromhexine (author's transl)]. ( Niemeyer, K; Wiessmann, KJ, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 45 (93.75) | 18.7374 |
| 1990's | 2 (4.17) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (2.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hibino, M | 1 |
| Mutsuga, M | 1 |
| Oshima, H | 1 |
| Narita, Y | 1 |
| Abe, T | 1 |
| Fujimoto, K | 1 |
| Tokuda, Y | 1 |
| Usui, A | 1 |
| Stockley, RA | 1 |
| Afford, SC | 1 |
| Wiggins, J | 1 |
| Mirrakhimov, MM | 1 |
| Brimkulov, NN | 1 |
| Rafibekova, ZhS | 1 |
| Caltagirone, S | 1 |
| Vagliasindi, M | 1 |
| Palermo, F | 1 |
| Di Maria, GU | 1 |
| Crimi, N | 1 |
| Cusmano, F | 1 |
| Zanierato, G | 1 |
| Ranghino, E | 1 |
| Negri, L | 1 |
| Morandini, GC | 1 |
| Schöpp, W | 1 |
| Mossberg, B | 3 |
| Philipson, K | 1 |
| Strandberg, K | 1 |
| Camner, P | 1 |
| Badimón, JJ | 1 |
| Escolar, G | 1 |
| Martínez, JC | 1 |
| Borruel, MT | 1 |
| Villaverde, CA | 1 |
| Owsiński, J | 1 |
| Ciezarek, M | 1 |
| Kamińska, M | 1 |
| Lukasiewicz, W | 1 |
| Maternowska, W | 1 |
| Walaszek, K | 1 |
| Nikodemowicz, E | 1 |
| Tkachishin, VS | 1 |
| Aurnhammer, W | 1 |
| Konietzko, N | 1 |
| Matthys, H | 1 |
| Wiessmann, KJ | 1 |
| Niemeyer, K | 1 |
| Curti, PC | 1 |
| Renovanz, HD | 1 |
| Böhlau, V | 1 |
| Schildwächter, G | 1 |
| Armstrong, ML | 1 |
| Heilborn, H | 1 |
| Odeblad, E | 1 |
| Löllgen, H | 1 |
| Löllgen-Horres, I | 1 |
| von Nieding, G | 1 |
| Bristow, V | 1 |
| Lal, S | 1 |
| Bhalla, KK | 1 |
| Schachtner, J | 1 |
| Alexy, G | 1 |
| Lukács, I | 1 |
| Sárdi, F | 1 |
| Aliperta, A | 1 |
| Bellissimo, U | 1 |
| Turco, D | 1 |
| Antinolfi, G | 1 |
| Solopov, VN | 2 |
| Kolganova, NA | 2 |
| Cegla, UH | 1 |
| Ericsson, CH | 2 |
| Juhasz, J | 2 |
| Jönsson, E | 2 |
| Olivieri, D | 1 |
| Zavattini, G | 1 |
| Tomasini, G | 1 |
| Daniotti, S | 1 |
| Bonsignore, G | 1 |
| Ferrara, G | 1 |
| Carnimeo, N | 1 |
| Chianese, R | 1 |
| Catena, E | 1 |
| Marcatili, S | 1 |
| Disse, BG | 1 |
| Calero del Castillo, JB | 1 |
| Pérez Martínez, F | 1 |
| Piqueras Pérez, F | 1 |
| Redondo Luciáñez, ER | 1 |
| Van Bever, HP | 1 |
| Bosmans, J | 1 |
| Stevens, WJ | 1 |
| Peralta, J | 1 |
| Poderoso, JJ | 1 |
| Corazza, C | 1 |
| Fernández, M | 1 |
| Guerreiro, RB | 1 |
| Wiemeyer, JC | 1 |
| Di Stefano, F | 1 |
| Patanè, S | 1 |
| Giglio, A | 1 |
| Raciti, T | 1 |
| Vinci, M | 1 |
| Heinig, JH | 1 |
| Pedersen, B | 1 |
| Andersen, I | 1 |
| Dalgaard, CE | 1 |
| Rasmussen, O | 1 |
| Weeke, ER | 1 |
| Enk, B | 1 |
| Watson, EW | 2 |
| Thomson, ML | 2 |
| Pavia, D | 2 |
| Gregg, I | 2 |
| Stark, JE | 2 |
| Harris, PG | 1 |
| Aylward, M | 1 |
| Brogan, TD | 1 |
| Ryley, HC | 1 |
| Hutt, H | 1 |
| Neale, L | 1 |
| Kampmann, JP | 1 |
| Matts, SG | 1 |
| Simonsson, BG | 1 |
| Palmer, KN | 1 |
| Andreasen, T | 1 |
| Kjer, J | 1 |
3 reviews available for bromhexine and Chronic Disease
| Article | Year |
|---|---|
[Optimal use of expectorants (current trends)].
Topics: Biological Transport; Bromhexine; Bronchi; Bronchitis; Carbocysteine; Chronic Disease; Cysteine; Ela | 1981 |
The pharmacology of ambroxol--review and new results.
Topics: Airway Resistance; Ambroxol; Animals; Bromhexine; Bronchitis; Chronic Disease; Humans; Infant, Newbo | 1987 |
[Bromhexine (Bisolvon). An evaluation from the literature].
Topics: Adult; Aged; Animals; Bromhexine; Bronchitis; Cats; Chronic Disease; Depression, Chemical; Humans; M | 1974 |
27 trials available for bromhexine and Chronic Disease
| Article | Year |
|---|---|
[Controlled clinical study of the treatment of chronic bronchitis with guacetisal].
Topics: Adult; Aged; Aspirin; Bromhexine; Bronchitis; Chronic Disease; Clinical Trials as Topic; Cough; Fema | 1981 |
[Treatment of bronchial inflammatory disorders with guacetisal].
Topics: Acute Disease; Aspirin; Bromhexine; Bronchitis; Carbonates; Chronic Disease; Clinical Trials as Topi | 1981 |
Clearance by voluntary coughing and its relationship to subjective assessment and effect of intravenous bromhexine.
Topics: Adult; Aged; Airway Obstruction; Bromhexine; Chronic Disease; Cough; Female; Humans; Male; Microsphe | 1981 |
Problems in evaluating the effect of secretolytic agents on the mucociliary system by means of radioactive particles.
Topics: Airway Obstruction; Airway Resistance; Bromhexine; Bronchi; Bronchitis; Chronic Disease; Clinical Tr | 1977 |
[Clinical results in the treatment of chronic obstructive bronchitis with ambroxol in comparison with bromhexine (author's transl)].
Topics: Adult; Aged; Airway Resistance; Ambroxol; Bromhexine; Bronchitis; Chronic Disease; Clinical Trials a | 1978 |
Double-blind crossover trial of bromhexine (Bisolvon) in the treatment of chronic bronchitis.
Topics: Adult; Aged; Bromhexine; Bronchitis; Chronic Disease; Clinical Trials as Topic; Family Practice; Fem | 1976 |
Effect of bromhexine and guaiphenesine on clinical state, ventilatory capacity and sputum viscosity in chronic asthma.
Topics: Airway Resistance; Asthma; Bromhexine; Chronic Disease; Clinical Trials as Topic; Female; Guaifenesi | 1976 |
[Therapeutic possibilities in chronic non-specific respiratory tract diseases. 1. Modification of secretion, inhalation- and respiration therapy, therapy of bronchial obstruction].
Topics: Acetylcysteine; Bromhexine; Bronchi; Chronic Disease; Clinical Trials as Topic; Expectorants; Humans | 1976 |
Double-blind crossover trial of bisolvon in the treatment of chronic bronchitis.
Topics: Bromhexine; Bronchitis; Chronic Disease; Clinical Trials as Topic; Humans | 1976 |
A controlled trial of bromhexine ('Bisolvon') in out-patients with chronic bronchitis.
Topics: Adult; Aged; Bromhexine; Bronchitis; Bronchodilator Agents; Chronic Disease; Clinical Trials as Topi | 1975 |
Prevention of chronic bronchitis exacerbations with ambroxol (mucosolvan retard). An open, long-term, multicenter study in 5,635 patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambroxol; Bromhexine; Bronchitis; Chronic Disease; Doubl | 1989 |
[Comparative evaluation of the effectiveness of lasolvan and mucodine in chronic nonspecific lung diseases].
Topics: Ambroxol; Asthma; Bromhexine; Bronchitis; Carbocysteine; Chronic Disease; Clinical Trials as Topic; | 1988 |
[Long-term therapy over 2 years with ambroxol (Mucosolvan) retard capsules in patients with chronic bronchitis. Results of a double-blind study of 180 patients].
Topics: Administration, Oral; Adult; Ambroxol; Bromhexine; Bronchitis; Chronic Disease; Clinical Trials as T | 1988 |
Ambroxol and simple chronic bronchitis. Effects on subjective symptoms and ventilatory function.
Topics: Adult; Ambroxol; Bromhexine; Bronchitis; Chronic Disease; Clinical Trials as Topic; Double-Blind Met | 1987 |
Ambroxol for the prevention of chronic bronchitis exacerbations: long-term multicenter trial. Protective effect of ambroxol against winter semester exacerbations: a double-blind study versus placebo.
Topics: Adult; Ambroxol; Bacterial Infections; Bromhexine; Bronchitis; Chronic Disease; Clinical Trials as T | 1987 |
Ambroxol therapy in simple chronic bronchitis: effects on subjective symptoms and ventilatory function.
Topics: Adult; Ambroxol; Bromhexine; Bronchitis; Chronic Disease; Clinical Trials as Topic; Double-Blind Met | 1986 |
Nebulization treatment with saline compared to bromhexine in treating chronic sinusitis in asthmatic children.
Topics: Adolescent; Asthma; Bromhexine; Child; Child, Preschool; Chronic Disease; Clinical Trials as Topic; | 1987 |
Ambroxol plus amoxicillin in the treatment of exacerbations of chronic bronchitis.
Topics: Adult; Aged; Aged, 80 and over; Ambroxol; Amoxicillin; Blood Gas Analysis; Bromhexine; Bronchitis; C | 1987 |
[The mucolytic effects of acetylcysteine compared with bromhexine and a placebo in patients with chronic bronchitis].
Topics: Acetylcysteine; Adult; Aged; Bromhexine; Bronchitis; Chronic Disease; Clinical Trials as Topic; Doub | 1985 |
A between-patient, double-blind comparison of S-carboxymethylcysteine and bromhexine in chronic obstructive bronchitis.
Topics: Administration, Oral; Adult; Aged; Amino Acids, Dicarboxylic; Amino Acids, Sulfur; Bromhexine; Bronc | 1973 |
The effect of bromhexine on sputum from patients with chronic bronchitis and asthma.
Topics: Albumins; Asthma; Bromhexine; Bronchitis; Chronic Disease; Clinical Trials as Topic; Female; Gels; G | 1974 |
A comparative trial of bromhexine HCl and oxytetracycline in acute and chronic bronchitis.
Topics: Acute Disease; Adolescent; Adult; Aged; Bromhexine; Bronchitis; Chronic Disease; Clinical Trials as | 1974 |
Experimental studies on bronchial secretion. Therapeutical aspects of pathological bronchial secretion.
Topics: Acute Disease; Adult; Aged; Animals; Bromhexine; Bronchi; Bronchitis; Chronic Disease; Clinical Tria | 1974 |
The short-term clinical evaluation of bromhexine in chronic bronchitis.
Topics: Administration, Oral; Adult; Bromhexine; Bronchi; Bronchitis; Bronchopneumonia; Chronic Disease; Cli | 1974 |
Mucolytic treatment of chronic bronchitis during two winter periods.
Topics: Bromhexine; Bronchitis; Chronic Disease; Clinical Trials as Topic; Drug Evaluation; Female; Follow-U | 1974 |
Respirophonographical measurements of the effect of bromhexin in the treatment of chronic bronchitis.
Topics: Aged; Auscultation; Bromhexine; Bronchitis; Chronic Disease; Clinical Trials as Topic; Humans; Male; | 1974 |
Bromhexine and mucociliary clearance in chronic bronchitis.
Topics: Aerosols; Aged; Bromhexine; Bronchitis; Chronic Disease; Cilia; Female; Humans; Lung; Male; Polystyr | 1974 |
18 other studies available for bromhexine and Chronic Disease
| Article | Year |
|---|---|
[Total Arch Replacement Using Manufactured Frozen Elephant Trunk after Acute Type-A Dissection Repair].
Topics: Aged; Aorta, Thoracic; Aortic Aneurysm, Thoracic; Aortic Dissection; Blood Vessel Prosthesis; Bromhe | 2017 |
The effect of bromhexine on sputum sol phase proteins.
Topics: Blood Proteins; Bromhexine; Bronchitis; Chronic Disease; Humans; Proteins; Sputum | 1983 |
[Long-term treatment of chronic bronchitis with ambroxol].
Topics: Adult; Aged; Ambroxol; Bromhexine; Bronchitis; Chronic Disease; Drug Administration Schedule; Drug E | 1981 |
[Synergistic action of sodium thiophencarboxylate and bromhexine in chronic bronchitis in rats].
Topics: Animals; Bromhexine; Bronchitis; Carboxylic Acids; Chronic Disease; Drug Synergism; Drug Therapy, Co | 1981 |
[Flegamin - Polish equivalent of bisolvon. Results of clinical studies].
Topics: Acute Disease; Adult; Bromhexine; Bronchitis; Chronic Disease; Female; Humans; Male; Middle Aged; Po | 1980 |
[Effectiveness of nondrug treatment of chronic bronchitis in persons exposed to radiation due to Chernobyl AES accident].
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aminophylline; Bromhexine; Bronchitis; Bronchodilator Ag | 1999 |
[Therapeutic study on ambroxol in chronic bronchopulmonary diseases (author's transl)].
Topics: Ambroxol; Bromhexine; Bronchitis; Chronic Disease; Cryptococcosis; Humans; Lung Diseases; Lung Disea | 1978 |
[Modern therapy of chronic bronchitis].
Topics: Adult; Bromhexine; Bronchitis; Chronic Disease; Drug Combinations; Ethanolamines; Fenoterol; Humans; | 1978 |
[The treatment of a chronic purulent bronchitis with a new drug combination].
Topics: Administration, Oral; Aged; Ampicillin; Bromhexine; Bronchiectasis; Bronchitis; Chronic Disease; Dru | 1976 |
Clinical observations with Paxirasol aerosol in patients suffering from chronic bronchitis accompanying silicosis.
Topics: Administration, Inhalation; Aerosols; Bromhexine; Bronchitis; Chronic Disease; Drug Evaluation; Huma | 1992 |
Normalization of bronchial exocrine pathology after endobronchial treatment with ambroxol.
Topics: Adult; Aged; Ambroxol; Biopsy; Bromhexine; Bronchi; Bronchitis; Bronchoscopy; Chronic Disease; Exocr | 1986 |
[Incorporation of a stimulant of the synthesis and secretion of pulmonary surfactant (ambroxol) in the medical treatment of serous otitis].
Topics: Acoustic Impedance Tests; Acute Disease; Adolescent; Adult; Ambroxol; Bromhexine; Child; Child, Pres | 1988 |
[Effect of lasolvan on mucociliary transport in patients with chronic nonspecific lung diseases].
Topics: Adhesiveness; Ambroxol; Bromhexine; Chronic Disease; Drug Evaluation; Humans; Lung Diseases; Mucocil | 1988 |
[An antibiotic-mucolytic combination in the treatment of exacerbated chronic bronchitis: a retrospective study].
Topics: Aged; Bromhexine; Bronchitis; Cephalexin; Chronic Disease; Drug Therapy, Combination; Female; Humans | 1986 |
Letter: Bisolvon in chronic respiratory disease.
Topics: Adult; Aged; Bromhexine; Child; Chronic Disease; Dyspnea; Female; Humans; Lung Diseases, Obstructive | 1974 |
The effect of bromhexine on mucociliary clearance from the human lung in chronic bronchitis.
Topics: Adult; Bromhexine; Bronchitis; Chronic Disease; Female; Humans; Lung; Male; Middle Aged; Respiration | 1974 |
A comparison of bisolvomycin and oxytetracycline in the treatment of acute infective sinusitis.
Topics: Acute Disease; Adult; Bromhexine; Chronic Disease; Drug Combinations; Drug Therapy, Combination; Fem | 1974 |
Letter: "Bisolvon" in chronic respiratory disease.
Topics: Bromhexine; Chronic Disease; Humans; Lung Diseases, Obstructive; Male | 1974 |