bromhexine has been researched along with Asthma in 22 studies
Bromhexine: A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744)
bromhexine : A substituted aniline that is 2,4-dibromoaniline which is substituted at position 6 by a [cyclohexyl(methyl)amino]methyl group. It is used (as the monohydrochloride salt) as a mucolytic for the treatment of respiratory disorders associated with productive cough (i.e. a cough characterised by the production of sputum).
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fourteen patients with acute severe asthma necessitating hospital admission were all treated with a standard therapeutic regimen, and in addition received either bromhexine or placebo (initially intravenously and subsequently orally) double-blind." | 9.04 | Bromhexine in severe asthma. ( Grant, BJ; Maberly, DJ; Riordan, JF; Rudolf, M; Saunders, KB, 1978) |
| "Bromhexine was not superior to saline for this purpose." | 6.66 | Nebulization treatment with saline compared to bromhexine in treating chronic sinusitis in asthmatic children. ( Bosmans, J; Stevens, WJ; Van Bever, HP, 1987) |
| "Fourteen patients with acute severe asthma necessitating hospital admission were all treated with a standard therapeutic regimen, and in addition received either bromhexine or placebo (initially intravenously and subsequently orally) double-blind." | 5.04 | Bromhexine in severe asthma. ( Grant, BJ; Maberly, DJ; Riordan, JF; Rudolf, M; Saunders, KB, 1978) |
| "The action of ambroxol was tested in an in vivo guinea pig asthma model." | 3.67 | Failure of ambroxol to influence the allergen induced bronchial constriction in sensitized guinea pigs. ( Barleben, A; Becher, G; Winsel, K, 1989) |
| "Ambroxol is a new compound which increases secretion of phosphatidylcholine by type II pneumocytes." | 2.66 | Ambroxol decreases bronchial hyperreactivity. ( Cocco, G; Melillo, G, 1986) |
| "Bromhexine was not superior to saline for this purpose." | 2.66 | Nebulization treatment with saline compared to bromhexine in treating chronic sinusitis in asthmatic children. ( Bosmans, J; Stevens, WJ; Van Bever, HP, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| CONDEGARGOLLO, E | 1 |
| BUERGI, H | 1 |
| Vendemmia, S | 1 |
| Maurino, G | 1 |
| Goglia, R | 1 |
| Della Peruta, A | 1 |
| Rudolf, M | 1 |
| Riordan, JF | 1 |
| Grant, BJ | 1 |
| Maberly, DJ | 1 |
| Saunders, KB | 1 |
| von Harnack, GA | 1 |
| Knoop, U | 1 |
| Dold, U | 1 |
| Petersen, KF | 1 |
| Heilborn, H | 1 |
| Odeblad, E | 1 |
| Biskup, L | 1 |
| Renovanz, VK | 1 |
| Becher, G | 1 |
| Winsel, K | 1 |
| Barleben, A | 1 |
| Solopov, VN | 3 |
| Lunichkina, IV | 1 |
| Plisko, LF | 2 |
| König, G | 1 |
| Kolganova, NA | 2 |
| Chuchalin, AG | 1 |
| Melillo, G | 1 |
| Cocco, G | 1 |
| Van Bever, HP | 1 |
| Bosmans, J | 1 |
| Stevens, WJ | 1 |
| von Wichert, P | 1 |
| Brogan, TD | 1 |
| Ryley, HC | 1 |
| Hutt, H | 1 |
| Neale, L | 1 |
| Bürgi, H | 1 |
| Bamford, TM | 1 |
9 trials available for bromhexine and Asthma
| Article | Year |
|---|---|
Bromhexine in severe asthma.
Topics: Acute Disease; Adult; Aged; Asthma; Bromhexine; Clinical Trials as Topic; Double-Blind Method; Femal | 1978 |
Effect of bromhexine and guaiphenesine on clinical state, ventilatory capacity and sputum viscosity in chronic asthma.
Topics: Airway Resistance; Asthma; Bromhexine; Chronic Disease; Clinical Trials as Topic; Female; Guaifenesi | 1976 |
[Effectiveness of lasolvan and bromhexine in chronic nonspecific lung diseases].
Topics: Ambroxol; Asthma; Bromhexine; Bronchitis; Clinical Trials as Topic; Humans; Mucociliary Clearance; P | 1989 |
[Comparative evaluation of the effectiveness of lasolvan and mucodine in chronic nonspecific lung diseases].
Topics: Ambroxol; Asthma; Bromhexine; Bronchitis; Carbocysteine; Chronic Disease; Clinical Trials as Topic; | 1988 |
[Effect of lasolvan on the rheologic properties of sputum].
Topics: Ambroxol; Asthma; Bromhexine; Bronchitis; Clinical Trials as Topic; Humans; Sputum | 1987 |
Ambroxol decreases bronchial hyperreactivity.
Topics: Adult; Ambroxol; Asthma; Bromhexine; Bronchi; Clinical Trials as Topic; Depression, Chemical; Double | 1986 |
Nebulization treatment with saline compared to bromhexine in treating chronic sinusitis in asthmatic children.
Topics: Adolescent; Asthma; Bromhexine; Child; Child, Preschool; Chronic Disease; Clinical Trials as Topic; | 1987 |
The effect of bromhexine on sputum from patients with chronic bronchitis and asthma.
Topics: Albumins; Asthma; Bromhexine; Bronchitis; Chronic Disease; Clinical Trials as Topic; Female; Gels; G | 1974 |
Changes in the fibre system and viscosity of the sputum of bronchitis during treatment with bromhexine and guaiphenesin (guaiacol glyceryl ether).
Topics: Adult; Aged; Asthma; Bromhexine; Bronchitis; Clinical Trials as Topic; Depression, Chemical; DNA; Fe | 1974 |
13 other studies available for bromhexine and Asthma
| Article | Year |
|---|---|
[CLINICAL EVALUATION OF THE DRUG NA-274 IN NON-TUBERCULOUS RESPIRATORY PATHOLOGY].
Topics: Amines; Asthma; Balneology; Biomedical Research; Bromhexine; Bronchiectasis; Bronchitis; Pharmacolog | 1964 |
[PRELIMINARY CLINICO-EXPERIMENTAL EXPERIENCES WITH BISOLVON, A MUCOLYTIC AGENT].
Topics: Aerosols; Asthma; Bromhexine; Bronchitis; DNA; DNA, Bacterial; Drug Therapy; Expectorants; Glycosami | 1965 |
[Clinical study of the properties of Bisolvon in the therapy of respiratory diseases in children].
Topics: Adolescent; Asthma; Bromhexine; Child; Child, Preschool; Expectorants; Humans; Infant; Laryngitis; R | 1981 |
[Indication for drug therapy].
Topics: Adolescent; Age Factors; Analgesics; Antitussive Agents; Asthma; Bromhexine; Child; Child, Preschool | 1977 |
[Management of severe asthma in childhood (author's transl)].
Topics: Acetylcysteine; Age Factors; Airway Obstruction; Albuterol; Aminophylline; Asthma; Bromhexine; Child | 1977 |
[Rifampicin concentrations in the sputum before and after administration of bromohexine (author's transl)].
Topics: Adult; Asthma; Bromhexine; Bronchitis; Humans; Male; Middle Aged; Rifampin; Sputum | 1978 |
[Therapy of severe status asthmaticus in the child].
Topics: Ammonium Chloride; Asthma; Autogenic Training; Breathing Exercises; Bromhexine; Bronchodilator Agent | 1976 |
Mucodyne as an expectorant.
Topics: Acetylcysteine; Asthma; Bromhexine; Bronchitis; Cysteine; Expectorants; Humans | 1975 |
[Results of some clinical-pharmacological studies on ambroxol (NA 872)].
Topics: Adolescent; Adult; Aged; Asthma; Bromhexine; Bronchitis; Bronchopneumonia; Child; Child, Preschool; | 1975 |
Failure of ambroxol to influence the allergen induced bronchial constriction in sensitized guinea pigs.
Topics: Allergens; Ambroxol; Animals; Asthma; Bromhexine; Guinea Pigs | 1989 |
[Therapy of status asthmaticus].
Topics: Adrenal Cortex Hormones; Ambroxol; Asthma; Bromhexine; Clorazepate Dipotassium; Histamine H1 Antagon | 1985 |
[Therapy of bronchial asthma].
Topics: Adrenal Cortex Hormones; Aminophylline; Asthma; Breathing Exercises; Bromhexine; Cromolyn Sodium; Cy | 1974 |
Letter: Effect of Bisolvon.
Topics: Asthma; Bromhexine; Bronchiectasis; Bronchitis; Humans; Sinusitis | 1974 |