bromfenacoum and Factor-X-Deficiency

We report the case of a 17-year-old boy with a significant history of drug and alcohol abuse, which included smoking marijuana mixed with brodifacoum. As a consequence, the patient developed a prolonged coagulopathy that persisted for more than 1 year. To our knowledge, this is the first case reported in the literature in which super-warfarin intoxication has been associated with marijuana smoking. This report should increase the awareness of pathologists and clinicians when examining a patient with a history of drug abuse who exhibits persistent vitamin K1-dependent coagulopathy.

Topics: 4-Hydroxycoumarins; Adolescent; Blood Coagulation; Blood Coagulation Factors; Factor X Deficiency; Humans; Male; Marijuana Smoking; Prothrombin Time; Rodenticides; Vitamin K 1