brimonidine-tartrate--timolol-maleate-drug-combination and Ocular-Hypertension

This study was undertaken to compare the ocular haemodynamic effects of Combigan(®) versus placebo in patients with ocular hypertension (OHT).. Thirty patients with OHT were included in a controlled, randomised, double blind study in two parallel groups; 15 were randomised to receive Combigan(®) and 15 to receive placebo for a period of 3 months. At baseline and at 3 months retrobulbar blood flowmeasurements of the ophthalmic artery (OA) and central retinal artery (CRA) were taken using colour Doppler imaging(CDI) ultrasound, concurrently with intraocular pressure (IOP).. Combigan(®) significantly reduced IOP after 3 months of treatment (P = 0.001), whereas placebo showed no significant change in IOP. The baseline haemodynamic parameters were similar between treatment and placebo groups. Patients treated with Combigan® showed a statistically significant decrease in CRA resistive index (P = 0.007).. Patients treated for 3 months with Combigan(®) showed a significant decrease of CRA resistive index that could be explained by the decrease in IOP.

Topics: Aged; Brimonidine Tartrate, Timolol Maleate Drug Combination; Double-Blind Method; Drug Combinations; Female; Follow-Up Studies; Humans; Intraocular Pressure; Laser-Doppler Flowmetry; Male; Middle Aged; Ocular Hypertension; Ophthalmic Artery; Ophthalmic Solutions; Prospective Studies; Quinoxalines; Regional Blood Flow; Retinal Vessels; Timolol; Ultrasonography, Doppler, Color; Vascular Resistance

To emphasize the importance of anticipation of pressure-induced stromal keratopathy (PISK) in eyes with a previous history of LASIK.. A 40-year-old man developed LASIK-related pressure-induced stromal keratopathy after uneventful phacoemulsification (Phaco) and intraocular lens (IOL) implantation in his left eye. With immediate discontinuation of the steroid drops and initiation of antiglaucoma medication, his visual acuity, interface edema, and haze improved rapidly. One year later, during Phaco with IOL implantation in his other eye, with anticipation of a similar LASIK-related pressure-induced stromal keratopathy, a very brief course of soft steroid therapy was given together with antiglaucoma medication. Intraocular pressure elevation was avoided, and no interface edema or haze was observed.. This case illustrates that the risk for LASIK-related pressure-induced stromal keratopathy may be reduced with appropriate precautions.

Topics: Acetazolamide; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Brimonidine Tartrate, Timolol Maleate Drug Combination; Corneal Edema; Corneal Stroma; Diuretics; Humans; Intraocular Pressure; Keratomileusis, Laser In Situ; Lens Implantation, Intraocular; Male; Ocular Hypertension; Phacoemulsification; Postoperative Complications; Visual Acuity