brij-58 and Skin-Diseases

brij-58 has been researched along with Skin-Diseases* in 2 studies

Other Studies

2 other study(ies) available for brij-58 and Skin-Diseases

ArticleYear
Peptide mimetics of immunoglobulin A (IgA) and FcαRI block IgA-induced human neutrophil activation and migration.
    European journal of immunology, 2017, Volume: 47, Issue:10

    The cross-linking of the IgA Fc receptor (FcαRI) by IgA induces release of the chemoattractant LTB4, thereby recruiting neutrophils in a positive feedback loop. IgA autoantibodies of patients with autoimmune blistering skin diseases therefore induce massive recruitment of neutrophils, resulting in severe tissue damage. To interfere with neutrophil mobilization and reduce disease morbidity, we developed a panel of specific peptides mimicking either IgA or FcαRI sequences. CLIPS technology was used to stabilize three-dimensional structures and to increase peptides' half-life. IgA and FcαRI peptides reduced phagocytosis of IgA-coated beads, as well as IgA-induced ROS production and neutrophil migration in in vitro and ex vivo (human skin) experiments. Since topical application would be the preferential route of administration, Cetomacrogol cream containing an IgA CLIPS peptide was developed. In the presence of a skin permeation enhancer, peptides in this cream were shown to penetrate the skin, while not diffusing systemically. Finally, epitope mapping was used to discover sequences important for binding between IgA and FcαRI. In conclusion, a cream containing IgA or FcαRI peptide mimetics, which block IgA-induced neutrophil activation and migration in the skin may have therapeutic potential for patients with IgA-mediated blistering skin diseases.

    Topics: Administration, Topical; Antigens, CD; Autoantibodies; Autoimmune Diseases; Cetomacrogol; Epitope Mapping; Half-Life; Humans; Immune System Diseases; Immunoglobulin A; Leukocyte Disorders; Leukotriene B4; Neutrophil Activation; Neutrophil Infiltration; Neutrophils; Peptide Library; Peptidomimetics; Phagocytosis; Protein Binding; Reactive Oxygen Species; Receptors, Fc; Skin; Skin Absorption; Skin Diseases

2017
The use of non-ionic detergents in sanitary cleansing: a report of a preliminary trial.
    Journal of advanced nursing, 1978, Volume: 3, Issue:4

    A preliminary trial was carried out to establish the most suitable hygienic wipe for sanitary cleansing in incontinence and to study and compare the difference between cleansing with soap and non-ionic detergents in incontinent patients. Four non-ionic detergents were tested against National Health toilet soap in 290 incontinent episodes. Other observations were made on the skin condition following cleansing, the ease of cleansing, odour control, detergency, and allergenicity. The results showed that a scrim wipe was the best for this purpose and also indicated that the non-ionic detergent Cetomacrogol 1000 B.P.C. to be preferential to all other creams and soap in the time taken for cleansing. The skin condition, odour control and detergent ability were all superior with this cream. It was revealed by the trial that in cleansing faecal incontinence with non-ionic detergent, an initial wipe, followed by about 7.0 grams of detergent on a moistened wipe to achieve emulsification and than followed by another dry wipe, is all that is required. The condition of the skin was recorded as excellent and the figures indicated a possible saving of 20% in nursing time.

    Topics: Cetomacrogol; Fecal Incontinence; Humans; Hygiene; Ions; Polyethylene Glycols; Skin Diseases; Soaps

1978
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