bretylium has been researched along with Ventricular Fibrillation in 23 studies
bretylium: RN given refers to parent cpd
bretylium : A quaternary ammonium cation having 2-bromobenzyl, ethyl and two methyl groups attached to the nitrogen. It blocks noradrenaline release from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation.
Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors compared bretylium and lidocaine for reducing the incidence and persistence of ventricular fibrillation following aortic cross-clamp release performed during coronary artery bypass surgery." | 9.06 | Comparison of bretylium and lidocaine in the prevention of ventricular fibrillation after aortic cross-clamp release in coronary artery bypass surgery. ( Briggs, R; Goglin, W; Grishkin, B; Helsel, R; Kirlangitis, J; Knight, R; Middaugh, R, 1990) |
| "The changes produced by verapamil, bretylium and flecainide in both ventricular fibrillation threshold (VFT) and ventricular repetitive response threshold (VRRT) were studied in 20 closed-chest dogs anaesthetized with pentobarbital." | 7.68 | Changes in canine ventricular fibrillation threshold induced by verapamil, flecainide and bretylium. ( Alberola, A; Burguera, MA; Chorro, FJ; Lopez-Merino, V; Quesada, A; Sanchis, J; Such, L, 1993) |
| " Recently, amiodarone has been shown to be rapidly effective in suppressing sustained, incessant ventricular tachycardia and ventricular fibrillation in this setting." | 7.68 | Amiodarone versus bretylium for suppression of reperfusion arrhythmias in dogs. ( Horrigan, TP; Mostow, ND; Noon, DL; Rosalion, A; Snow, NJ, 1991) |
| "2 degrees F) during intravenous administration of bretylium for refractory ventricular fibrillation." | 7.67 | Extreme pyrexia during bretylium administration. ( Adams, WG; Perlman, PE; Ridgeway, NA, 1989) |
| "Bretylium was removed from Advanced Cardiac Life Support guidelines, and, to date, efficacy of amiodarone in hypothermia is unknown." | 5.32 | Amiodarone and bretylium in the treatment of hypothermic ventricular fibrillation in a canine model. ( Ehlers, J; Martin, G; O'Mara, K; Stoner, J; Tomlanovich, M, 2003) |
| "The authors compared bretylium and lidocaine for reducing the incidence and persistence of ventricular fibrillation following aortic cross-clamp release performed during coronary artery bypass surgery." | 5.06 | Comparison of bretylium and lidocaine in the prevention of ventricular fibrillation after aortic cross-clamp release in coronary artery bypass surgery. ( Briggs, R; Goglin, W; Grishkin, B; Helsel, R; Kirlangitis, J; Knight, R; Middaugh, R, 1990) |
| "Biphasic defibrillation and intravenous amiodarone are useful in shock-resistant ventricular fibrillation." | 4.82 | Strategies for reversing shock-resistant ventricular fibrillation. ( Dorian, P; Sarkozy, A, 2003) |
| " Recently, amiodarone has been shown to be rapidly effective in suppressing sustained, incessant ventricular tachycardia and ventricular fibrillation in this setting." | 3.68 | Amiodarone versus bretylium for suppression of reperfusion arrhythmias in dogs. ( Horrigan, TP; Mostow, ND; Noon, DL; Rosalion, A; Snow, NJ, 1991) |
| "2 degrees F) during intravenous administration of bretylium for refractory ventricular fibrillation." | 3.67 | Extreme pyrexia during bretylium administration. ( Adams, WG; Perlman, PE; Ridgeway, NA, 1989) |
| "The effect of intravenous lidocaine, 2 mg/kg, and bretylium, 5 mg/kg, on defibrillation threshold (DFT) was investigated in alpha-chloralose anesthetized dogs undergoing conventional closed chest cardiopulmonary resuscitation (CPR) following induced ventricular fibrillation." | 3.67 | The effect of lidocaine and bretylium on the defibrillation threshold during cardiac arrest and cardiopulmonary resuscitation. ( Chow, MS; Fieldman, A; Kluger, J; Lawrence, R, 1986) |
| "This study was performed to assess the role of cardiac sympathetic nerves in the in vivo antifibrillatory action of bretylium using the technique of electrically induced ventricular fibrillation." | 3.67 | Antifibrillatory action of bretylium: role of the sympathetic nervous system. ( Kopia, GA; Lucchesi, BR, 1987) |
| "The antifibrillatory effects of lidocaine and bretylium in the postcardiopulmonary resuscitation (CPR) setting were examined using ventricular fibrillation threshold (VFT) determinations in anesthetized dogs." | 3.67 | Antifibrillatory effects of lidocaine and bretylium immediately postcardiopulmonary resuscitation. ( Chow, MS; DiPersio, DM; Fieldman, A; Kluger, J; Lawrence, R, 1985) |
| "Bretylium was removed from Advanced Cardiac Life Support guidelines, and, to date, efficacy of amiodarone in hypothermia is unknown." | 1.32 | Amiodarone and bretylium in the treatment of hypothermic ventricular fibrillation in a canine model. ( Ehlers, J; Martin, G; O'Mara, K; Stoner, J; Tomlanovich, M, 2003) |
| "Ventricular fibrillation is the leading cause of sudden cardiac death." | 1.31 | Preventing ventricular fibrillation by flattening cardiac restitution. ( Chen, PS; Garfinkel, A; Karagueuzian, HS; Kil, JR; Kim, YH; Lee, MH; Qu, Z; Voroshilovsky, O; Weiss, JN, 2000) |
| "Within 97 +/- 163 s, aconitine induced ventricular tachycardia (VT) with a mean cycle length 268 +/- 37 ms, which accelerated before converting to VF." | 1.31 | Action potential duration restitution and ventricular fibrillation due to rapid focal excitation. ( Chen, PS; Garfinkel, A; Karagueuzian, HS; Lee, MH; Lin, SF; Ohara, T; Qu, Z; Swissa, M; Weiss, JN, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (30.43) | 18.7374 |
| 1990's | 10 (43.48) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nakstad, AR | 1 |
| Eek, C | 1 |
| Aarhus, D | 1 |
| Larsen, A | 1 |
| Haugaa, KH | 1 |
| Stoner, J | 1 |
| Martin, G | 1 |
| O'Mara, K | 1 |
| Ehlers, J | 1 |
| Tomlanovich, M | 1 |
| Sarkozy, A | 1 |
| Dorian, P | 1 |
| Kapoor, JR | 1 |
| Batsford, WP | 1 |
| Foody, JM | 1 |
| Usui, M | 1 |
| Inoue, H | 1 |
| Saihara, S | 1 |
| Sugimoto, T | 1 |
| Jones, DL | 1 |
| Kim, YH | 2 |
| Natale, A | 1 |
| Klein, GJ | 1 |
| Varin, F | 1 |
| Quesada, A | 1 |
| Sanchis, J | 1 |
| Chorro, FJ | 1 |
| Burguera, MA | 1 |
| Alberola, A | 1 |
| Such, L | 1 |
| Lopez-Merino, V | 1 |
| Olshansky, B | 1 |
| Garfinkel, A | 2 |
| Voroshilovsky, O | 1 |
| Qu, Z | 2 |
| Kil, JR | 1 |
| Lee, MH | 2 |
| Karagueuzian, HS | 2 |
| Weiss, JN | 2 |
| Chen, PS | 2 |
| Swissa, M | 1 |
| Ohara, T | 1 |
| Lin, SF | 1 |
| von Planta, M | 1 |
| Chamberlain, D | 1 |
| Chamberlain, DA | 1 |
| Waller, DG | 1 |
| Koerner, JE | 1 |
| Dage, RC | 1 |
| Rosalion, A | 1 |
| Snow, NJ | 1 |
| Horrigan, TP | 1 |
| Noon, DL | 1 |
| Mostow, ND | 1 |
| Kirlangitis, J | 1 |
| Middaugh, R | 1 |
| Knight, R | 1 |
| Goglin, W | 1 |
| Helsel, R | 1 |
| Grishkin, B | 1 |
| Briggs, R | 1 |
| Bacaner, MB | 1 |
| Clay, JR | 1 |
| Shrier, A | 1 |
| Brochu, RM | 1 |
| Perlman, PE | 1 |
| Adams, WG | 1 |
| Ridgeway, NA | 1 |
| Chow, MS | 3 |
| Kluger, J | 3 |
| Lawrence, R | 2 |
| Fieldman, A | 3 |
| Hanyok, JJ | 1 |
| Rodgers, GP | 1 |
| Cromeens, DM | 1 |
| Minor, ST | 1 |
| Swindle, MM | 1 |
| Kopia, GA | 1 |
| Lucchesi, BR | 1 |
| DiPersio, DM | 1 |
3 reviews available for bretylium and Ventricular Fibrillation
| Article | Year |
|---|---|
Strategies for reversing shock-resistant ventricular fibrillation.
Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Bretylium Compounds; Cardiopulmonar | 2003 |
Lignocaine and bretylium as adjuncts to electrical defibrillation.
Topics: Animals; Anti-Arrhythmia Agents; Bretylium Compounds; Cardiopulmonary Resuscitation; Electric Counte | 1991 |
Treatment and prevention of ventricular fibrillation: are there better agents?
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Bretylium Compounds; Cardiopulmonary R | 1991 |
1 trial available for bretylium and Ventricular Fibrillation
| Article | Year |
|---|---|
Comparison of bretylium and lidocaine in the prevention of ventricular fibrillation after aortic cross-clamp release in coronary artery bypass surgery.
Topics: Aged; Bretylium Compounds; Constriction; Double-Blind Method; Female; Humans; Lidocaine; Male; Middl | 1990 |
19 other studies available for bretylium and Ventricular Fibrillation
| Article | Year |
|---|---|
Survival after prolonged resuscitation with 99 defibrillations due to Torsade De Pointes cardiac electrical storm: a case report.
Topics: Anti-Arrhythmia Agents; Bretylium Compounds; Cardiopulmonary Resuscitation; Female; Heart Arrest; Hu | 2010 |
Amiodarone and bretylium in the treatment of hypothermic ventricular fibrillation in a canine model.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Bretylium Compounds; Disease Models, Animal; Dogs; Hypo | 2003 |
Refractory Electrical Storm suppression by bretylium.
Topics: Adult; Anti-Arrhythmia Agents; Bretylium Compounds; Heart Ventricles; Humans; Male; Recurrence; Synd | 2006 |
Antifibrillatory effects of class III antiarrhythmic drugs: comparative study with flecainide.
Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Bretylium Compounds; Dogs; Electric Stimulati | 1993 |
Bretylium decreases and verapamil increases defibrillation threshold in pigs.
Topics: Animals; Blood Pressure; Bretylium Compounds; Defibrillators, Implantable; Dose-Response Relationshi | 1994 |
Changes in canine ventricular fibrillation threshold induced by verapamil, flecainide and bretylium.
Topics: Animals; Bretylium Compounds; Cardiac Pacing, Artificial; Dogs; Electrocardiography; Flecainide; Ven | 1993 |
Ventricular arrhythmias and the use of antiarrhythmic drugs after cardiovascular surgery.
Topics: Amiodarone; Anti-Arrhythmia Agents; Bretylium Compounds; Cardiovascular Surgical Procedures; Clinica | 1998 |
Preventing ventricular fibrillation by flattening cardiac restitution.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Bretylium Compounds; Cardiac Pacing, Artificial; | 2000 |
Action potential duration restitution and ventricular fibrillation due to rapid focal excitation.
Topics: Aconitine; Action Potentials; Animals; Anti-Arrhythmia Agents; Bretylium Compounds; Computer Simulat | 2002 |
Drug treatment of arrhythmias during cardiopulmonary resuscitation. A statement for the Advanced Life Support Working Party of the European Resuscitation Council.
Topics: Amiodarone; Animals; Arrhythmias, Cardiac; Atropine; Bretylium Compounds; Calcium; Cardiopulmonary R | 1992 |
Antiarrhythmic and electrophysiologic effects of MDL 11,939, a novel class III antiarrhythmic agent in anesthetized dogs.
Topics: Animals; Anti-Arrhythmia Agents; Bretylium Compounds; Dogs; Drug Therapy, Combination; Electrocardio | 1990 |
Amiodarone versus bretylium for suppression of reperfusion arrhythmias in dogs.
Topics: Amiodarone; Animals; Arrhythmias, Cardiac; Blood Pressure; Bretylium Compounds; Dogs; Drug Evaluatio | 1991 |
Potassium channel blockade: A mechanism for suppressing ventricular fibrillation.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Bethanidine; Bretylium Compounds; Cesium; Chickens; Decapo | 1986 |
Extreme pyrexia during bretylium administration.
Topics: Bretylium Compounds; Female; Fever; Humans; Infusions, Intravenous; Middle Aged; Ventricular Fibrill | 1989 |
The effect of lidocaine and bretylium on the defibrillation threshold during cardiac arrest and cardiopulmonary resuscitation.
Topics: Animals; Bicarbonates; Bretylium Compounds; Carbon Dioxide; Dogs; Electric Countershock; Female; Hea | 1986 |
Antifibrillatory effects of high dose bretylium and a lidocaine-bretylium combination during cardiopulmonary resuscitation.
Topics: Animals; Blood Pressure; Bretylium Compounds; Carbon Dioxide; Dogs; Drug Combinations; Electric Coun | 1988 |
Bretylium and diltiazem in porcine cardiac procedures.
Topics: Animals; Bretylium Compounds; Cardiovascular Diseases; Cardiovascular Surgical Procedures; Diltiazem | 1988 |
Antifibrillatory action of bretylium: role of the sympathetic nervous system.
Topics: Animals; Anti-Arrhythmia Agents; Bretylium Compounds; Dogs; Electric Stimulation; Heart; Hemodynamic | 1987 |
Antifibrillatory effects of lidocaine and bretylium immediately postcardiopulmonary resuscitation.
Topics: Animals; Bretylium Compounds; Dogs; Dose-Response Relationship, Drug; Female; Lidocaine; Male; Resus | 1985 |